Prof. Dr. Peter Brust - Department of Neuroradiopharmaceuticals

Bild Prof. Dr. Brust

Research Interest  -   Projects  -   Selected Publications  -   Work Experience   -   Memberships

Current Research Interests

Radiotracer Development for Brain Imaging with Positron Emission Tomography (PET)

  • Brain tumor imaging (glioblastoma, brain metastases)
  • Neuroimaging of the cholinergic system (nicotinic acetylcholine receptors, vesicular acetylcholine transporter)
  • Neuroimaging of second messenger systems (phosphodiesterases 2, 5 and 10)
  • Neuroimaging of neuromodulatory processes (sigma and cannabinoid receptors, adenosine signalling)
  • Blood-brain barrier transport of radiopharmaceuticals


Ongoing Projects

Completed projects

  • Neuroimaging of experimental brain trauma: Characterization of potential targets for radiotracer development within the cholinergic and cannabinoid receptor system of the brain. In cooperation with Department of Neurosurgery and Paul Flechsig Institute of Brain Research, University of Leipzig and Institute of Molecular Cell Biology, Friedrich Schiller University Jena.
  • PET imaging of GABAergic neurotransmission: Development and biological characterization of new subtype specific 18F-labelled radiotracers for imaging the GABAA receptor. In cooperation with Department of Neurology, University of Leipzig and ABX GmbH Radeberg.
  • PET tracers for imaging the serotonin transporter, Part 2 Indolylcyclohexylamines Development and biological characterization of new 18F-labelled radiotracers for serotonin transporter imaging. In cooperation with Department of Nuclear Medicine, University of Leipzig and the Hebrew University Jerusalem, Israel.
  • PET tracers for imaging the serotonin transporter, Part 1 McN5652 derivatives The 18F-labelled derivative of McN5652 is superior to [11C]McN5652 for serotonin transporter imaging in preclinical studies.
  • PET tracers for tumor imaging, Part 2 thymidine kinase: Evidence that radiolabelled FIAU should be preferred as reporter probe for PET imaging of HSV1-tk gene expression compared to FHPG. Research Center Dresden-Rossendorf in cooperation with Department of Nuclear Medicine, Technische Universität München.
  • PET tracers for tumor imaging, Part 1 estrone sulfatase: The estrone sulfatase inhibitor FESDS was found to bind with high affinity also to carbonic anhydrase precluding the use of this compound for tumor imaging.  Research Center Dresden-Rossendorf in cooperation with the Hans Knöll Institute Jena.
  • PET studies of dopamine synthesis and metabolism during hypoxia: The activity of the enzyme aromatic amio acid decarboxylase is increased, the monoamine oxidase acitivity is decreased in newborn piglets during hypoxia. Research Center Dresden-Rossendorf in cooperation with the , Friedrich Schiller University Jena.
  • 99mTc-labelled receptor and transporter ligands: Characterization of serotonin receptor, dopamine receptor and dopamine transporter binding of 99m. Research Center Dresden-Rossendorf.
  • In vitro model of the blood-brain barrier: Expression of serotonin transporter, P-glycoprotein, and carnitine transporter at immortalized rat brain endothelial cells. Research Center Dresden-Rossendorf in cooperation with Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta USA.
  • PET studies of blood-brain barrier transport: Vasopressin alters the blood-brain barrier transport of methionine in dogs. Institute of Biology, University of Leipzig in cooperation with the Montreal Neurological Institute and Johns Hopkins University Baltimore.
  • Effects of nootropics on the blood-brain barrier: Reversal of ethanol-induced effects on blood-brain barrier permeability by nootropics. Institute of Biology, University of Leipzig in cooperation with drug industry (Arzneimittelwerk Dresden).
  • Intestinal amino acid transport: Beta-casomorphin increases the intestinal transport of amino acids in rats. Institute of Biology, University of Leipzig in cooperation with Department of Biochemistry, Martin-Luther-University Halle-Wittenberg.
  • Water permeability of the blood-brain barrier: Atriopeptin increases the water permeability of the blood-brain barrier in rats. Institute of Biology University of Leipzig in cooperation with Institute for Surgical Research, Ludwig-Maximilians-University, Munich.
  • Blood-brain barrier permeability for amino acids: The neuropeptide vasopressin modulates the transport of large neutral amino acids across the blood-brain barrier in rats. PhD Theses at the Institute of Biology, University of Leipzig, in cooperation with Academy of Sciences of the Czech Republik, Prague.
  • Immune tolerance: Induction of immune tolerance against human lymphocytes in mice. Diploma Thesis at the Institute of Biology of Leipzig

Selected Publications

  • Wagner S., Deuther-Conrad W., Scheunemann M., Teodoro R., Fischer S., Wenzel B., Egerland U., Hoefgen N., Steinbach J., Brust P. (2017) Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A. J. Labelled Compd. Rad. 60, 36-48.

  • Hankir M. K., Seyfried F., Hintschich C. A., Diep T. A., Kleberg K., Kranz M., Deuther-Conrad W., Tellez L. A., Rullmann M., Patt M., Teichert S., Sabri O., Brust P., Hansen H. S., de Araujo I. E., Krügel U., Fenske W. K. (2017) Gastric Bypass Surgery Recruits a Gut – Striatal Dopamine Pathway to Reduce Fat Appetite in Obese Rats. Cell Metabolism 25, 335-344.

  • Moldovan R.-P., Deuther-Conrad W., Horti A. G., Brust P. (2017) Synthesis of potent Indol-3-yl-oxoacetamides for PET Imaging of Cannabinoid Receptor Type 2. Molecules 22, 77.

  • Hankir M., Patt M., Patt J., Becker G., Rullmann M., Kranz M., Deuther-Conrad W., Schichke K., Seyfried F., Brust P., Hesse S., Sabri O., Krügel U., Fenske W.  (2017) Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain µ-opioid Receptor Availability in Diet-Induced Obese Male Rats. Frontiers in Neuroscience 10, 620.

  • Moldovan R.-P., Els-Heindl S., Worm D. J., Kniess T., Kluge M., Beck-Sickinger A. G., Deuther-Conrad W., Krügel U., Brust P. (2017) Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging. Int J Molec Sci 18, 768.

  • Sarasamkan J., Fischer S., Deuther-Conrad W., Ludwig F.-A., Scheunemann M., Arunrungvichian K., Vajragupta O., Brust P. (2017) Radiosynthesis of (S)-[18F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors. Appl. Radiat. Isotopes 124, 106-113.

  • Wenzel B., Mollitor J., Deuther-Conrad W., Dukic-Stefanovic S., Kranz M., Vraka C., Teodoro R., Günther R., Donat C., Ludwig F.-A., Fischer S., Smits R., Wadsak W. , Mittelhauser M., Steinbach J., Hoepping A., Brust P. (2016) Development of a novel non-peptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography. J. Med. Chem. 59, 1800–1817.

  • Hankir M., Kranz M., Gnad T., Weiner J., Wagner S., Deuther-Conrad W., Bronisch F., Steinhoff K., Luthardt J., Klöting N., Hesse S., Seibyl J. P., Sabri O., Heiker J. T., Blüher M., Pfeifer A., Brust P., Fenske W. K. (2016) A novel thermoregulatory role for PDE10A in mouse and human adipocytes. EMBO Mol. Med. 8, 796-812.

  • Hillmer A. T., Zheng M.-Q., Li S., Scheunemann M., Lin S., Holden D., Labaree D., Ropchan J., Teodoro R., Deuther-Conrad W., Carson R. E., Brust P., Huang Y. (2016) PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. Eur. J. Nucl. Med. Mol. I. 43, 537-547.

  • Moldovan R.-P., Teodoro R., Deuther-Conrad W., Kranz M., Wang Y., Kuwabara H., Nakano M., Valentine H., Fischer S., Pomper M. G., Wong D. F., Dannals R. F., Brust P., Horti A. G. (2016) Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor. J. Med. Chem. 59, 7840-7855.

  • Weiner J., Kranz M., Klöting N., Kunath A., Steinhoff K., Rijntjes E., Köhrle J., Zeisig V., Hankir M., Gebhardt C., Deuther-Conrad W., Heiker J. T., Kralisch S., Stumvoll M., Blüher M., Sabri O., Hesse S., Brust P., Tönjes A. (2016) Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice. Scientific Reports 6:38124, 1-10.

  • Ludwig F. A., Smits R., Fischer S., Donat C. K., Hoepping A., Brust P., Steinbach J. (2016) LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[18F]Flubatine – a Positron Emission Tomography Radioligand for Imaging α4β2-Nicotinic Acetylcholine Receptors. Molecules 21, 1200.

  • Li D., Chen Y. Y., Wang X., Deuther-Conrad W., Chen X., Jia B., Dong C. Y., Steinbach J., Brust P., Liu B. L., Jia H. M. (2016) 99mTc -Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma-2 Receptor Ligands for Tumor Imaging. J. Med. Chem. 59, 934- 946.

  • Sarasamkan J.,  Scheunemann M., Apaijai N., Palee S., Parichatikanond W., Arunrungvichian K., Fischer S., Chattipakorn S., Deuther-Conrad W., Schüürmann G., Brust P., Vajragupta O. (2016) Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes – Selective Binding of Quinuclidine Triazole Compounds. ACS Med. Chem. Lett. 7, 890-895.
  • Kranz M., Sattler B., Tiepolt S., Wilke S., Deuther-Conrad W., Donat C. K., Fischer S., Patt M., Schildan A., Patt J., Smits R., Hoepping A., Steinbach J., Sabri O., Brust P. (2016) Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results. EJNMMI Physics 3:25.

  • Kranz M., Sattler B., Wüst N., Deuther-Conrad W., Patt M., Meyer P. M., Fischer S., Donat C. K., Wünsch B., Hesse S., Steinbach J., Brust P., Sabri O. (2016) Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine – A New Tracer in Clinical Translation for Imaging of σ1 Receptors. Molecules 21, 1164.

  • Schröder S., Wenzel B., Deuther-Conrad W., Teodoro R., Egerland U., Kranz M., Scheunemann M., Höfgen N., Steinbach J., Brust P. (2015) Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography. Molecules 20, 9591-9615.

  • Teodoro R., Scheunemann M., Deuther-Conrad W., Wenzel B., Colombo S., Gotti C., Kranz M., Donat C., Patt M., Hillmer A., Zheng M., Peters D., Steinbach J., Sabri O., Huang Y., Brust P. (2015) A promising PET tracer for imaging of α7 nicotinic acetylcholine receptors in the brain: Design, synthesis, and in vivo evaluation of a dibenzothiophene-based radioligand. Molecules 20, 18387-18421.

  • Sabri O., Becker G.-A., Meyer P. M., Hesse S., Wilke S., Graef S., Patt M., Luthardt J., Wagenknecht G., Hoepping A., Smits R., Franke A., Sattler B., Habermann B., Neuhaus P., Fischer S., Tiepolt S., Deuther-Conrad W., Barthel H., Schönknecht P., Brust P. (2015) First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F]Flubatine. NeuroImage 118, 199-208.

  • Brust P., Deuther-Conrad W., Lehmkuhl K., Jia H., Wünsch B. (2014) Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives. Curr. Med. Chem. 21, 35-69.

  • Brust, P. (2014) Development of [18F]-labeled radiotracers for neuroreceptor imaging with positron emission tomography. Neuroscience Bulletin 30, 777-811.

  • Brust P., Deuther-Conrad W., Becker G., Patt M., Donat C. K., Sittsworth S., Fischer S., Hiller A., Wenzel B., Dukic-Stefanovic S., Hesse S., Steinbach J., Wünsch B., Lever S., Sabri O. (2014) Distinctive In Vivo Kinetics of the New Sigma1 Receptor Ligands (R)-(+) and (S)-(-)- 18F-Fluspidine in Porcine Brain. J Nucl Med 55, 1730-1736.

  • Donat C. K., Fischer F., Walter B., Deuther-Conrad W., Brodhun M., Bauer R., Brust P. (2014) Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet. Acta Neurobiologiae Experimentalis 74, 197-210.

  • Rötering S., Deuther-Conrad W., Cumming P., Donat C. K., Scheunemann M., Fischer S., Xiong G., Steinbach J., Peters D., Sabri O., Bucerius J.,  Brust P. (2014) Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490. Europ. J. Nucl. Med. Mol. Imag. Res. 4, 1-11.

  • Pfeifer A., Gnad T., Scheibler S., von Kügelgen I., Scheele C., Kilic A., Glöde A., Hoffmann L., Reverte L., Horn P., Mutlu S., El-Tayeb A., Kranz M., Deuther-Conrad W., Brust P., Lidell M., Betz M., Enerbäck S., Schrader J., Yegutkin G., Mueller C. (2014) Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395–399.

  • Wang X., Li D., Deuther-Conrad W., Lu J., Cie Y., Jia B., Cui M., Steinbach J., Brust P., Liu B., Jia H. (2014) Novel Cyclopentadienyl Tricarbonyl 99mTc Complexes Containing 1-Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma-1 Receptors. J. Med. Chem. 57, 7113-7125.

  • Chen Y.-Y., Wang X., Zhang J.-M., Deuther-Conrad W., Zhang X.-J., Huang Y., Li Y., Ye Y., Cui M.-C., Steinbach J., Brust P., Liu B.-L. (2014) Synthesis and evaluation of a <sup>18</sup>F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent. Bioorg. Med. Chem. 22, 5270-5278.

  • Sattler B., Kranz M., Starke A., Wilke S., Donat C. K., Deuther-Conrad W., Patt M., Schildan A., Patt J., Smits R., Hoepping A., Schoenknecht P., Steinbach J., Brust P., Sabri (2014) Internal Dose Assessment of (-)-18F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results. J. Nucl. Med. 55, 1885-1892.

  • Fischer S., Hiller A., Smits R., Hoepping A., Funke U., Wenzel B., Cumming P., Sabri O., Steinbach J., Brust P. (2013) Radiosynthesis of racemic and enantiomerically pure (-)-[18F]flubatine – a promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors. Appl. Radiat. Isot. 74, 128-136.

  • Li Y., Wang X., Zhang J., Deuther-Conrad W., Xie F., Zhang X., Liu J., Qiao J., Cui M., Steinbach J., Brust P., Liu B.-L., Jia H. (2013) Synthesis and Evaluation of Novel 18F-Labeled Spirocyclic Piperidine Derivatives as σ1 Receptor Ligands for Positron Emission Tomography Imaging. J. Med. Chem. 56, 3478-3491.

  • Lueg C., Schepmann D., Günther R., Brust P., Wünsch B. (2013) Development of fluorinated CB2 receptor agonists for PET studies. Bioorg. Med. Chem. 21, 7481-7498.

  • Brust P., Peters D., Deuther-Conrad W. (2012) Development of radioligands for α7 nAChR imaging with positron emission tomography. Curr Drug Targets 13, 594-601.
  • Rühl T.,Deuther-Conrad W., Fischer S., Günther R., Hennig L., Krautscheid H., Brust P. (2012) Cannabinoid receptor type 2 (CB2) selective N-arylamide oxadiazoles: synthesis, biological evaluation and molecular modeling. Org. Med. Chem. Lett 2: 32,
  • Maisonial A., Grosse Maestrup E., Wiese C., Hiller A., Schepmann D., Deuther-Conrad W., Fischer S., Brust P., and Wünsch B., (2012) Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for central σ1 receptors and comparison with fluoralkyl homologues. Bioorg. Med. Chem.  20, 257–269.
  • Hesse S., Brust P., Mäding P., Becker G.-A., Seese A., Patt M., Sorger D., Zessin J., Sacher J., Lobsien D., Habermann B., Meyer PM., Füchtner F., Luthardt J., Bresch A., Steinbach J., Sabri O. (2012) Imaging of the brain serotonin transporters (SERT) with the new fluorine-18 labelled fluoromethyl-McN5652 and PET in humans. Eur. J. Nucl. Med. 39, 1001-1011.
  • Fischer S., Wiese C., Grosse Maestrup E., Hiller A., Deuther-Conrad W., Scheunemann M., Schepmann D., Steinbach J., Wünsch B., Brust P. (2011) Molecular imaging of sigma receptors: synthesis and evaluation of the potent sigma1 selective radioligand [18F]fluspidine. Eur. J. Nucl. Med. Mol. Imaging 38, 540-551.
  • Hesse S., Stengler K., Regenthal R., Patt M., Becker G.-A., Franke A., Knüpfer H., Meyer P.M., Luthardt J. , Jahn I., Lobsien D., Heinke W., Brust P., Hegerl U., Sabri O. (2011) The serotonin transporter availability in untreated early and late onset patients with obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 14, 6606-617.
  • Grosse Maestrup E., Wiese C., Schepmann D., Brust P., Wünsch B. (2011) Synthesis, pharmacological activity and structure-affinity relationships of spirocyclic sigma1 receptor ligands with a (2-fluoroethyl) residue in 3-position. Bioorg. Med. Chem. 19, 393-405.
  • Wiese C., Grosse Maestrup E., Schepmann D., Grimme S., Humpf H., Brust P., Wünsch B. (2011) Enantioselective sigma1 receptor binding and biotransformation of the spirocyclic PET tracer [1’-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4’-piperidine]. Chirality 23, 148-154.
  • Hoffmeister P.-G., Donat C.K., Schuhmann M.S., Voigt C., Walter B., Nieber K., Meixensberger J., Bauer R., Brust P. (2011) Alterations of alpha7 nicotinic receptors after traumatic brain injury are similar in newborn and adult animals. Neuromol. Med. 13, 44-53.
  • Donat C.K., Walter B., Deuther-Conrad W., Nieber K., Bauer R., Brust P. (2010) Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets. Neuropathol. Appl. Neurobiol. 36,225-236.
  • Wenzel, B., Fischer, S., Brust P., and Steinbach J. (2010) Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases. J. Chromatography A 1217, 3855-3862.
  • Donat C.K., Walter B., Kayser T., Deuther-Conrad W., Schliebs R., Nieber K., Bauer R., Härtig W., Brust P. (2010) Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet. Int. J. Dev, Neurosci. 28, 31-38.
  • Meyer P, Strecker K, Kendziorra K, Becker G, Hesse S, Woelpl D, Hensel A, Patt M, Sorger D, Wegner F, Lobsien D, Barthel H, Brust P., Gertz HJ, Sabri O, Schwarz J, (2009) Reduced alpha4beta2* nicotinic acetylcholine receptor binding and its relationship to cognitive and depressive symptoms in Parkinson’s disease. Arch. Gen. Psychiat. 66, 866-877.
  • Große Maestrup, E., Fischer, S., Wiese, C., Schepmann, D., Hiller, A., Deuther-Conrad, W., Steinbach, J., Wünsch, B., Brust P. (2009) Evaluation of spirocyclic 3-(3-fluoropropyl)-2-benzofurans as sigma1 receptor ligands for neuroimaging with positron emission tomography. J. Med. Chem. 52, 6062-6072.
  • Deuther-Conrad, W., Fischer, S., Hiller, A., Østergaard Nielsen, E., Brunicardi Timmermann, D., Steinbach, J., Sabri, O., Peters, D., Brust P. (2009) Molecular imaging of α7 nAChR: design and evaluation of the potent radioligand [18F]NS10743. Eur. J. Nucl. Med. 93, 791-800.
  • Donat C.K., Schuhmann M.U., Voigt C., Nieber K., Deuther-Conrad W., Brust P. (2008) Time-dependent alterations of cholinergic markers after experimental traumatic brain injury. Brain Res. 1246, 167-177.
  • Ben Daniel R.; Deuther-Conrad W., Scheunemann M., Steinbach J., Brust P., Mishani E. (2008) Carbon-11 labeled indolylcyclohexylamine analogues as new potential PET agents for imaging of the serotonin transporter. Bioorg. Med. Chem. 16, 6364-6370 .
  • Brust P., Patt J.T., Deuther-Conrad W., Becker G., Patt M., Schildan A., Sorger D., Kendziorra K., Meyer P., Steinbach J., Sabri O. (2008) In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine (NCFHEB). Synapse 62, 205-218 .
  • Hoepping A., Scheunemann M., Fischer S., Deuther-Conrad W., Hiller A., Wegner F., Diekers M., Steinbach J., Brust P. (2007) Radiosynthesis and biological evaluation of a 18F-labelled derivative of the novel pyrazolopyrimidine sedative-hypnotic agent indiplon. Nucl Med. Biol. 34, 559-570 .
  • Makrides V., R. Bauer, W. Weber, H.-J. Wester, S. Fischer, R. Hinz, K. Huggel, T. Opfermann, M. Herzau, V. Ganapathy, F. Verrey, P. Brust (2007) Preferred transport of O-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) compared to [18F]L-FET and 3-O-methyl-6-[18F]fluoro-L-DOPA. Brain Res 1147, 25-33.
  • Brust P., Hesse S., Müller U., Szabo Z. (2006) Neuroimaging of the serotonin transporter - possibilities and pitfalls. Curr. Psychiat. Rev., 2, 111-149
  • Deuther-Conrad W., Wevers A., Schildan A., Becker G., Patt M., Sabri. O., Steinbach J., Brust P. (2006) Autoradiography of nicotinic acetylcholine receptors in the porcine brain in vitro. Synapse, 59, 201-210.
  • Bauer R., Walter B., Vorwieger G., Fritz A., Füchtner F., Zwiener U., Brust P. (2005) Effect of moderate hypercapnic hypoxia on cerebral dopaminergic activity and brain O2 uptake in intrauterine growth restricted newborn piglets. Pediat. Res., 57, 363-370.
  • Walter B., Brust P., Füchtner F., Müller M., Hinz R., Kuwabara H., Fritz H., Zwiener U., Bauer R. (2004) Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs. J. Neurotrauma, 21, 1076-1089.
  • Kretzschmar M., Brust P., Zessin J., Cumming P., Bergmann R., Johannsen B. (2003) Autoradiographic imaging of the serotonin transporter in the brain of rats and pigs using S-([18F]Fluoromethyl)-(+)-McN5652. Eur. Neuropsychopharmacol. 13, 387-397.
  • Brust P., Hinz R., Kuwabara H., Hesse S., Zessin J., Pawelke B., Stephan H., Bergmann R., Steinbach J. and Sabri O. (2003) In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652. Neuropsychopharmacology 28, 2010-2019.
  • Friedrich A., Prasad P.D., Freyer D., Ganapathy V., Brust P. (2003) Molecular cloning and characterization of the OCTN2 transporter at the blood-brain barrier. Brain Res. 968, 69-79.
  • Brust P., Zessin J., Kuwabara H., Pawelke B., Kretzschmar M., Hinz R., Bergman J., Eskola O., Solin O., Steinbach J., Johannsen B. (2003) Positron emission tomography imaging of the serotonin transporter in the pig brain using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652. Synapse.47, 143-151.
  • Brust P.,Haubner R., Friedrich A., Scheunemann M., Anton M., Koufaki O.N., Hauses M., Noll S., Noll B., Haberkorn U., Schackert G., Schackert H.K., Avril N., Johannsen B. (2001) Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur. J. Nucl. Med. 28, 721-729.
  • Cumming P, Kretzschmar M, Brust P, Smith DF (2001) Quantitative radioluminography of serotonin uptake sites in the porcine brain. Synapse 39, 351-355.
  • Bauer R., Walter B, Vorwieger G, Bergmann R., Füchtner F., Brust P. (2001) Intrauterine growth restriction induces upregulation of AADC activity in newborn piglets - A [18F]Fluoro-DOPA -PET study. Pediat.Res. 49, 474-480.
  • Brust P., Friedrich A., Krizbai I.A., Bergmann R., Roux F., Ganapathy V., Johannsen B. (2000) Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells. J. Neurochem. 74, 1241-1248.
  • Brust P., Scheffel U., Szabo Z. (1999) Radioligands for the study of the 5-HT transporter in vivo. IDrugs 2, 129-145.
  • Srinivas P., Brust P., Subramanian A.R., Raghavan S.A.V., Rangisetty J.B., Gupta C.N.V.H.B., Parimoo P. (1999) Synthesis and preliminary binding affinities of 1-(1,2-dihydro-2-acenaphthylenyl) piperazine- a new arylpiperazine. Pharm. Acta Helv. 74, 73-76.
  • Brust P., Bauer R., Vorwieger G., Walter B., Bergmann R., Füchtner F., Steinbach J., Zwiener U., Johannnsen B. (1999) Upregulation of the aromatic amino acid decarboxylase under neonatal asphyxia. Neurobiol. Dis. 6, 131-139.
  • Hoepping A., Reisgys M., Brust P., Seifert S., Spies H., Alberto R., B. Johannsen (1998) TROTEC-1: A new high-affinity ligand for labeling of the dopamine transporter. J. Med. Chem. 41, 4429-4432.
  • Hoepping A., Brust P., Berger R., Spies H., Machill S., Scheller D., Johannsen B. (1998) Novel rhenium complexes derived from a-tropanole as potential ligands for the dopamine transporter Bioorg. Med. Chem. 6, 1663-1672.
  • Brust P., Bergmann R., Johannsen B. (1996) High-affinity binding of [3H]paroxetine to caudate nucleus and microvessels from porcine brain. Neuroreport 7, 1405-1408.
  • Brust P., Bech A., Kretzschmar R., Bergmann R. (1994) Developmental changes of enzymes involved in peptide degradation in isolated rat brain microvessels. Peptides 15, 1085-1088.
  • Ermisch A., Brust P., Kretzschmar R., Rühle H.-J. (1993) Peptides and blood-brain barrier transport. Physiol. Rev. 73, 489-527.
  • Brust P., Shaya E. K., Jeffries K. J., Dannals R. F., Ravert H. T., Wilson A. A., Conti P. S., Wagner H. N. Jr ., Gjedde A., Ermisch A., Wong D. F. (1992) Effects of vasopressin on blood-brain transfer of methionine in dogs. J. Neurochem. 59: 1421-1429.
  • Brust P., Christensen T., Diemer N. H. (1992) Decrease of extracellular taurine in the rat dorsal hippocampus after central nervous administration of vasopressin. J. Neurochem. 58, 1427-1431.
  • Brust P.,Baethmann A., Gjedde A., Ermisch A. (1991) Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. Brain Res.564, 91-96.
  • Brust P. (1986) Changes in regional blood-brain transfer of L-leucine elicited by arginine-vasopressin. J. Neurochem. 46:534-541.

Work Experience

Institution Period Country
Helmholtz-Zentrum Dresden-Rossendorf
Institute of Radiopharmaceutical Cancer  Research
Research Site Leipzig (former IIF e.V.)
Department of Neuroradiopharmaceuticals, Head

at present,
since 2005

Institute of Interdisciplinary Isotope Research, Leipzig 
Senior scientist
2002 - 2005 Germany
Aarhus University, PET center Aarhus
Guest scientist
December 1996 Denmark
Senior scientist, Research Center Dresden-Rossendorf (HZDR) 1992-2001 Germany
Laboratory of Neurophysiology, NIMH, Bethesda
Guest scientist
November-December 1991 USA
Research Assistant, University of Leipzig, Institute of Biology 1991-1992 Germany
Department of Radiology, Johns Hopkins University
Guest scientist
January-June 1991 USA
Post-doc, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University 1990-1991 Canada
Research Assistant, University of Leipzig, Institute of Biology 1986-1990 Germany
University of Copenhagen, Laboratory of Neuropathology; Guest scientist September-November 1988 Denmark
Academy of Sciences of the Czech Republik, Prague;
Guest scientist
May 1984 Czech Republik
University of Leipzig, Institute of Biology, Leipzig 1981 - 1986 Germany
University of Leipzig, Institute of Biology, Leipzig
Diploma in Biology
1976 - 1981 Germany


  • German Society of Neurosciences NWG 
  • German Society of Nuclear Medicine DGN
  • Federation of European Neuroscience Societies FENS
  • International Brain Research Organization IBRO
  • European Society of Neurochemistry ESN
  • International Society of Neurochemistry ISN
  • Society of Radiopharmaceutical Sciences SRS