Contact
Dr. Toni Kögler
Group Leader, Prompt Gamma-Ray based Treatment Verification
Medical Radiation Physics
t.koegler
hzdr.de
Phone: +49 351 4587414
+49 351 260 3614
List of Publications
Articles in refereed journals
2025
Performance of a CeBr₃ scintillator coupled to a photomultiplier tube with an active voltage divider under high bremsstrahlung fluences
García Rivas, I.; Fernández Prieto, A.; Vázquez Regueiro, P.; García Fernández, D.; Kögler, T.; et al. (7 authors)
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Journal of Instrumentation 20(2025)11, P11016
DOI: 10.1088/1748-0221/20/11/P11016
Range verification in proton therapy with computational prompt gamma-ray spectroscopy: A Monte Carlo study
Skjerdal, K.; Kögler, T.; Lionheart, W.; Ytre-Hauge, K.; Meric, I.
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Radiation Physics and Chemistry 238(2025), 113096
DOI: 10.1016/j.radphyschem.2025.113096
ISSN: 0969-806X
Machine-learning-based integration of temporal and spectral prompt gamma-ray information for proton range verification
Kieslich, A. M.; Schellhammer, S.; Zwanenburg, A.; Kögler, T.; Löck, S.
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Physics and Imaging in Radiation Oncology 35(2025), 100788
DOI: 10.1016/j.phro.2025.100788
2024
The Backscatter Gating method for time, energy, and position resolution characterization of long form factor organic scintillators
Ratliff, H. N.; Kögler, T.; Pausch, G.; Setterdahl, L. M.; Skjerdal, K.; et al. (7 authors)
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Journal of Instrumentation 19(2024)07, P07002
DOI: 10.1088/1748-0221/19/07/P07002
ISSN: 1748-0221
Proton bunch monitors for the clinical translation of prompt gamma-ray timing
Makarevich, K.; Schellhammer, S.; Pausch, G.; Römer, K.; Tiebel, J.; et al. (8 authors)
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Physics in Medicine and Biology 69(2024), 225013
DOI: 10.1088/1361-6560/ad8c96
Characterisation of a high granularity multi-channel prompt γ-ray detection system prototype for proton range verification based on the PETsys TOFPET2 ASIC
Novgorodova, O.; Glatte, A.; Hentges, R.; Kögler, T.; Lutz, B.; et al. (9 authors)
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Journal of Instrumentation 19(2024), P02030
DOI: 10.1088/1748-0221/19/02/P02030
2023
Hybrid treatment verification based on prompt gamma-rays and fast neutrons: Multivariate modelling for proton range determination
Schellhammer, S.; Meric, I.; Löck, S.; Kögler, T.
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Frontiers in Physics 11(2023), 1295157
DOI: 10.3389/fphy.2023.1295157
ISSN: 2296-424X
A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy
Meric, I.; Alagoz, E.; Hysing, L.; Kögler, T.; Lathouwers, D.; et al. (19 authors)
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Scientific Reports 13(2023)1, 6709
DOI: 10.1038/s41598-023-33777-w
2022
Multivariate statistical modelling to improve particle treatment verification: Implications for prompt gamma-ray timing
Schellhammer, S.; Wiedkamp, J.; Löck, S.; Kögler, T.
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Frontiers in Physics 10(2022), 932950
DOI: 10.3389/fphy.2022.932950
2020
Classification of the source of treatment deviation in proton therapy using prompt-gamma imaging information
Khamfongkhruea, C.; Berthold, J.; Janssens, G.; Petzoldt, J.; Smeets, J.; et al. (7 authors)
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Medical Physics 47(2020)10, 5102-5111
DOI: 10.1002/mp.14393
Detection Systems for Range Monitoring in Proton Therapy: Needs and Challenges
Pausch, G.; Berthold, J.; Enghardt, W.; Römer, K.; Straessner, A.; et al. (8 authors)
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Nuclear Instruments and Methods in Physics Research A 954(2020), 161227
Online First (2018) DOI: 10.1016/j.nima.2018.09.062
ISSN: 0168-9002
2019
Processing of prompt gamma-ray timing data for proton range measurements at a clinical beam delivery
Werner, T.; Berthold, J.; Hueso-Gonzalez, F.; Koegler, T.; Petzoldt, J.; et al. (11 authors)
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Physics in Medicine and Biology 64(2019)10, 105023
DOI: 10.1088/1361-6560/ab176d
2017
Prompt gamma spectroscopy for range control with CeBr3.
Martins, P. M.; Bello, R. D.; Rinscheid, A.; Roemer, K.; Werner, T.; et al. (8 authors)
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Current Directions in Biomedical Engineering 3(2017), 113-117
DOI: 10.1515/cdbme-2017-0023
Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification
Nenoff, L.; Priegnitz, M.; Janssens, G.; Petzoldt, J.; Trezza, A.; et al. (8 authors)
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Radiotherapy and Oncology 125(2017)3, 534-540
DOI: 10.1016/j.radonc.2017.10.013
Prompt gamma rays detected with a BGO block Compton camera reveal range deviations of therapeutic proton beams
Hueso-González, F.; Pausch, G.; Petzoldt, J.; Römer, K. E.; Enghardt, W.
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IEEE Transactions on Radiation and Plasma Medical Sciences 1(2017)1, 76-86
Online First (2016) DOI: 10.1109/TNS.2016.2622162
2016
First clinical application of a prompt gamma based in vivo proton range verification
Richter, C.; Pausch, G.; Barczyk, S.; Priegnitz, M.; Keitz, I.; et al. (15 authors)
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Radiotherapy and Oncology 118(2016)2, 232-237
DOI: 10.1016/j.radonc.2016.01.004
Compton camera and prompt gamma ray timing: two methods for in vivo range assessment in proton therapy
Hueso-González, F.; Fiedler, F.; Golnik, C.; Kormoll, T.; Pausch, G.; et al. (8 authors)
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Frontiers in Oncology 6(2016), 80
DOI: 10.3389/fonc.2016.00080
2015
Comparison of LSO and BGO block detectors for prompt gamma imaging in ion beam therapy
Hueso González, F.; Biegun, A. K.; Dendooven, P.; Enghardt, W.; Fiedler, F.; et al. (13 authors)
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Journal of Instrumentation 10(2015)09, P09015
DOI: 10.1088/1748-0221/2015/9/P09015
First test of the prompt gamma ray timing method with heterogeneous targets at a clinical proton therapy facility
Hueso Gonzalez, F.; Enghardt, W.; Fiedler, F.; Golnik, C.; Janssens, G.; et al. (13 authors)
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Physics in Medicine and Biology 60(2015)16, 6247
DOI: 10.1088/0031-9155/60/16/6247
Abstracts in refereed journals
2020
First systematic clinical study on detection of anatomical changes in PT using prompt-gamma imaging
Berthold, J.; Jost, A.; Khamfongkhruea, C.; Petzoldt, J.; Thiele, J.; et al. (11 authors)
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Abstract in refereed journal
Radiotherapy and Oncology 152(2020)Supplement, S244-S245
DOI: 10.1016/S0167-8140(21)00465-5
First-in-man validation of CT-based stopping-power prediction using prompt-gamma range verification
Berthold, J.; Khamfongkhruea, C.; Jost, A.; Petzoldt, J.; Thiele, J.; et al. (12 authors)
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Abstract in refereed journal
Radiotherapy and Oncology 152(2020)Supplement, S390-S391
DOI: 10.1016/S0167-8140(21)00720-9
2019
Range verification in proton therapy: Can prompt-gamma imaging identify the source of deviation?
Khamfongkhruea, C.; Janssens, G.; Petzoldt, J.; Smeets, J.; Pausch, G.; et al. (6 authors)
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Abstract in refereed journal
Radiotherapy and Oncology 133(2019), S296-S297
DOI: 10.1016/S0167-8140(19)30986-7
2017
Sensitivity evaluation of prompt γ-ray based range verification with a slit camera
Nenoff, L.; Priegnitz, M.; Trezza, A.; Smeets, J.; Janssens, G.; et al. (11 authors)
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Abstract in refereed journal
Radiotherapy and Oncology 123(2017)Suppl 1, S76-S77
DOI: 10.1016/S0167-8140(17)30596-0
2016
First clinical application of a prompt gamma based in vivo proton range verification using a knife-edge slit camera
Richter, C.; Pausch, G.; Barczyk, S.; Priegnitz, M.; Keitz, I.; et al. (15 authors)
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Abstract in refereed journal
Radiotherapy and Oncology 118(2016)Suppl. 1, S89-S90
DOI: 10.1016/S0167-8140(16)30184-0
Theses
PhD theses
- Krystsina Makarevich, Evaluation of the Prompt Gamma-Ray Timing Method under Clinically Relevant Conditions, PhD thesis (to be submitted), TUD Dresden University of Technology (2026)
- Joeseph Alexander Bunker Turko, Characterization and first tests of a hybrid neutron and gamma ray imaging system for range verification in particle therapy, PhD thesis (to be submitted), TUD Dresden University of Technology (2026)
- Felicia Fibiani Permatasari, Development of a clinically applicable technique for range verification in proton therapy based on the prompt gamma-ray timing (PGT) method, PhD thesis, TUD Dresden University of Technology (2023)
- Theresa Werner, Reichweiteverifizierung an einem klinischen Protonenstrahl mittels Prompt Gamma-ray Timing Methode: eine Sensitivitätsanalyse, PhD thesis, TUD Dresden University of Technology (2020)
- David Weinberger, Detektionsmethoden für Gammastrahlung in der therapeutischen Medizin mit CdZnTe-Detektoren, PhD thesis, TUD Dresden University of Technology (2018)
- Johannes Petzold, Toward the Clinical Application of the Prompt Gamma-Ray Timing Method for Range Verification in Proton Therapy, PhD thesis, TUD Dresden University of Technology (2017)
- Fernando Hueso Gonzales, Nuclear methods for real-time range verification in proton therapy based on prompt gamma-ray imaging, PhD thesis, TUD Dresden University of Technology (2016)
- Christian Golnik, Treatment verification in proton therapy based on the detection of prompt gamma-rays, PhD thesis, TUD Dresden University of Technology (2016)
- Heide Rohling, Simulation studies for the in-vivo dose verification of particle therapy, PhD thesis, TUD Dresden University of Technology (2014)
- Thomas Kormoll, A Compton Camera for In-vivo Dosimetry in Ion-beam Radiotherapy, PhD thesis, TUD Dresden University of Technology (2013)
Master theses
- Franziska Wecker, Bestimmung der Zeitauflösung von Szintillationsdetektoren für die Multi-Feature Behandlungsverifikation in der Protonentherapie, TUD Dresden University of Technology (2025)
- Markus Hommel, Vergleich hoch-performanter digitaler Datenaufnahmen für die Prompt Gamma basierte Behandlungsverifikation der nächsten Generation, TUD Dresden University of Technology (2025)
- Noah Ritscher, Analyse von Prompt Gamma-Ray Timing Spektren mit Deep-Learning Methoden zur Behandlungsverifikation in der Protonentherapie, TUD Dresden University of Technology (2024)
- Konstantin Urban, Implementierung und Validierung eines Monte-Carlo-Teilchentransport-Modells für das Prompt Gamma-Ray Timing-System, TUD Dresden University of Technology (2023)
- Theresa Schröter, Analyse von Energie-Zeit-Verteilungen prompter Gammastrahlung für die Behandlungsverifikation in der Protonentherapie, TUD Dresden University of Technology (2022)
- Milena Simic, Modeling of an experimental setup for range verification in proton therapy utilizing the prompt gamma ray timing method, University of Niš (2022)
- Rahel-Debora Werner, Charakterisierung eines schnellen Diamantdetektors als Protonen-Bunch-Monitor für die Reichweiteverifikation in der Protonentherapie, Martin Luther University Halle-Wittenberg (2021)
- Julia Wiedkamp, Statistische Modellierung der Verifikation der Protonentherapie mittels Prompt Gamma Ray Timing, TUD Dresden University of Technology (2022)
- Max Küchler (IKTP), Entwicklung einer Methode zur Bestimmung der lokalen Energiedepositionen in der Protonentherapie durch Prompt-Gamma-Signale, TUD Dresden University of Technology (2019)
- Dominik Kornek, Anwendung von Maximum-Likelihood-Expectation-Maximation und Origin Ensemble zur Rekonstruktion von Aktivitätsverteilungen beim Single Plane Compton Imaging (SPCI), TUD Dresden University of Technology (2019)
- Maximilian Schmidt, Messung des lateralen Profils und der Zeitstruktur von Protonenstrahlen im Experimentierraum der Universitäts Protonen Therapie Dresden, TUD Dresden University of Technology (2019)
- Felix Buch, Messung des Emissionsspektrums prompter Photonen bei der Bestrahlung homogener Targets mit Protonen, TUD Dresden University of Technology (2018)
- Jonathan Berthold, Konzeptioneller Test einer Single Plane Compton Camera für die Reichweitemessung in der Protonentherapie, TUD Dresden University of Technology (2017)
- Nadja Kohlhase, Charakterisierung eines Proton Bunch Monitors hinsichtlich der Prompt Gamma-Ray Timing Methode, TUD Dresden University of Technology (2017)
- Clara Müller, Untersuchung des Verhaltens eines Detektorsystems unter Lastwechseln im Hinblick auf die Prompt Gamma-Ray Timing Methode, TUD Dresden University of Technology (2017)
- Andreas Rinscheid, Steps towards the clinical implementation of a digital spectrometer system for range verification in proton therapy, Martin Luther University Halle-Wittenberg (2016)
- Theresa Werner, Studies of a Proton Bunch Monitor for Range Verification in Proton Therapy, TUD Dresden University of Technology (2015)
- Alexander Schulz, Untersuchung eines alternativen Konzepts der nuklearmedizinischen Bildgebung mittels kollimatorfreier Detektionssysteme, TUD Dresden University of Technology (2015)
- Frauke Beyer, Untersuchung eines neuen Konzepts für eine Bildgebung anhand der richtungsauflösenden Gammadetektion, TUD Dresden University of Technology (2014)
Bachelor theses
- Jessica Tiebel, Charakterisierung des Phasenmonitors Uφ als Protonen-Bunch-Monitor zur Behandlungsverifikation in der Protonentherapie, TUD Dresden University of Technology (2022)
- Anna Franke, Einsatz eines Diamantdetektors als Proton Bunch Monitor in der Protonentherapie, TUD Dresden University of Technology (2022)
- Florian Rost, Bestimmung und Optimierung der Ortsauflösung eines granularen Szintillationsdetektors mit einem pixelierten Silizium-Photomultiplier-Sensor für Anwendungen im Single-Plane Compton-Imaging (SPCI) für die Protonenstrahl-Tumortherapie und in der Winkelkorrelationsmessung von Annihilationsphotonen, TUD Dresden University of Technology (2019)
- Max Küchler, Einfluss starker Lastwechsel auf die Zeitnahme von Szintillationsdetektoren, TUD Dresden University of Technology (2018)
- Jonathan Berthold, Analyse von Pencil Beam Bestrahlungen für die Reichweitenkontrolle in der Protonentherapie mittels Prompt Gamma Timing, TUD Dresden University of Technology (2015)
- Paul Jannusch, Untersuchung eines alternativen Konzepts zur bildgebenden Messung von Gammastrahlung in der Nuklearmedizin, TUD Dresden University of Technology (2014)
Invited Talks
2021
16O(n,α) and nat-Fe transmission experiments at GELINA & nELBE
Beyer, R.; Fan, X.; Junghans, A. R.; Kögler, T.; Stach, D.; et al. (18 authors)
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Invited lecture (Conferences)
(Online presentation)
JEFF Nuclear Data Week, 22.-26.11.2021, Paris, France
2019
Single Plane Compton Imaging for Radionuclide and Prompt Gamma-Ray Imaging
Kögler, T.; Berthold, J.; Deneva, B.; Enghardt, W.; Römer, K.; et al. (9 authors)
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Invited lecture (Conferences)
International Conference on Nuclear Data for Science and Technology 2019, 19.-24.05.2019, Beijing, China
2017
Fission measurements at nELBE
Beyer, R.; Dietz, M.; Junghans, A. R.; Kögler, T.; Schwengner, R.; et al. (6 authors)
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Invited lecture (Conferences)
LANL FIESTA Fission School & Workshop, 17.-22.09.2017, Santa Fe, New Mexico, USA
The determination of the fast neutron-induced fission cross section of Pu(242) at nELBE
Kögler, T.; Beyer, R.; Junghans, A. R.; Müller, S. E.; Schwengner, R.; et al. (6 authors)
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Invited lecture (Conferences)
Scientific Workshop on Nuclear Fission dynamics and the Emission of Prompt Neutrons and Gamma Rays, 19.-23.06.2017, Varna, Bulgaria
2016
Inelastic scattering of fast neutrons from 56Fe
Beyer, R.; Birgersson, E.; Dietz, M.; Hannaske, R.; Junghans, A. R.; et al. (10 authors)
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Invited lecture (Conferences)
International Conference on Nuclear Data for Science and Technology - ND2016, 11.-16.09.2016, Bruges, Belgium
E1 and M1 strength functions at low energy
Schwengner, R.; Massarczyk, R.; Bemmerer, D.; Beyer, R.; Junghans, A. R.; et al. (10 authors)
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Invited lecture (Conferences)
International Conference on Nuclear Data for Science and Technology, 11.-16.09.2016, Brugge, Belgien
2014
System Integration and Application of CdZnTe Detectors in a Compton Camera for Medical Use
Fiedler, F.; Enghardt, W.; Golnik, C.; Hueso-Gonzalez, F.; Kormoll, T.; et al. (11 authors)
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Invited lecture (Conferences)
IEEE NSS MIC, 21st Symposium on room-temperature Semiconductor and Gamma-Ray detectors, 08.-15.11.2014, Seattle, WA, USA
Neutron-induced fission measurements at the time-of-flight facility nELBE
Kögler, T.; Beyer, R.; Junghans, A. R.; Massarczyk, R.; Schwengner, R.; et al. (6 authors)
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Invited lecture (Conferences)
Scientific Workshop on Nuclear Fission dynmaics and the Emission of Prompt Neutrons and Gamma Rays, THEORY-3, 16.-18.09.2014, Opatija, Kroatien
