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Biophysics
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PhD / Mas­ter
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Contact

Prof. Dr. Karim Fahmy

Head
Biophysics
k.fahmyAthzdr.de
Phone: +49 351 260 2952
+49 351 260 3601

Selected publications

2024

Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C-H activation

Tsushima, S.; Kretzschmar, J.; Doi, H.; Okuwaki, K.; Kaneko, M.; et al. (7 authors)

Cold denaturation of DNA origami nanostructures

Dornbusch, D.; Hanke, M.; Tomm, E.; Grundmeier, G.; Keller, A.; et al. (7 authors)

2023

Large-Scale Formation of DNA Origami Lattices on Silicon

Tapio, K.; Kielar, C.; Parikka, J. M.; Keller, A.; Järvinen, H.; et al. (7 authors)

Molecular Adhesion of a Pilus-derived Peptide Involved in Pseudomonas aeruginosa Biofilm Formation on non-polar ZnO Surfaces

Prüßner, T.; Meinderink, D.; Zhu, S.; Orive, A. G.; Kielar, C.; et al. (9 authors)

Fate of Oxidation States at Actinide Centers in Redox-Active Ligand Systems Governed by Energy Levels of 5f Orbitals

Takeyama, T.; Tsushima, S.; Gericke, R.; Kaden, P.; März, J.; et al. (6 authors)

Superstructure-dependent stability of DNA origami nanostructures in the presence of chaotropic denaturants

Hanke, M.; Dornbusch, D.; Tomm, E.; Grundmeier, G.; Fahmy, K.; et al. (6 authors)

Interaction between the transferrin protein and plutonium (and thorium), what’s new?

Zurita, C.; Tsushima, S.; Lorenzo Solari, P.; Menut, D.; Dourdain, S.; et al. (8 authors)

Special Issue “Advances in Monitoring Metabolic Activities of Microorganisms by Calorimetry”

Matulis, D.; Wadsö, L.; Fahmy, K.

Distinct Effects of Chemical Toxicity and Radioactivity on Metabolic Heat of Cultured Cells Revealed by “Isotope-Editing”

Oertel, J.; Sachs, S.; Flemming, K.; Hassan Obeid, M.; Fahmy, K.

Utility of redox-active ligands for reversible multi-electron transfer in uranyl(VI) complexes

Takeyama, T.; Tsushima, S.; Takao, K.

2022

Interdisciplinary biophysical studies of membrane proteins bacteriorhodopsin and rhodopsin

Fahmy, K.; Sakmar, T.

Simple Growth–Metabolism Relations Are Revealed by Conserved Patterns of Heat Flow from Cultured Microorganisms

Fahmy, K.

Lanmodulin peptides – unravelling the binding of the EF-Hand loop sequences stripped from the structural corset

Gutenthaler, S. M.; Tsushima, S.; Steudtner, R.; Gailer, M.; Hoffmann-Röder, A.; et al. (7 authors)

Anion-specific structure and stability of guanidinium-bound DNA origami

Hanke, M.; Dornbusch, D.; Hadlich, C.; Roßberg, A.; Hansen, N.; et al. (9 authors)

Salting-Out of DNA Origami Nanostructures by Ammonium Sulfate

Hanke, M.; Hansen, N.; Ruiping, C.; Grundmeier, G.; Fahmy, K.; et al. (6 authors)

Fully Chelating N3O2-Pentadentate Planar Ligands Designed for Strongest and Selective Capture of Uranium from Seawater

Mizumachi, T.; Sato, M.; Kaneko, M.; Takeyama, T.; Tsushima, S.; et al. (6 authors)

Hydrophobic Core Formation and Secondary Structure Elements in Uranyl(VI)–Binding Peptides

Tsushima, S.; Takao, K.

Synthesis and characterization of a uranyl(vi) complex with 2,6-pyridine-bis(methylaminophenolato) and its ligand-centred aerobic oxidation mechanism to a diimino derivative

Takeyama, T.; Iwatsuki, S.; Tsushima, S.; Takao, K.

Interaction of Th(IV), Pu(IV) and iron(III) with ferritin protein : how similar ?

Zurita, C.; Tsushima, S.; Lorenzo Solari, P.; Jeanson, A.; Creff, G.; et al. (6 authors)

2021

Effects of Substituents on the Molecular Structure and Redox Behavior of Uranyl(V/VI) Complexes with N3O2‑Donating Schiff Base Ligands

Takeyama, T.; Tsushima, S.; Takao, K.

DNA-Mediated Stack Formation of Nanodiscs

Subramanian, M.; Kielar, C.; Tsushima, S.; Fahmy, K.; Oertel, J.

Fluorite-like hydrolyzed hexanuclear coordination clusters of Zr(IV) and Hf(IV) with syn-syn bridging N,N,N-trimethylglycine in soft crystal structures exhibiting cold-crystallization

Matsuoka, M.; Tsushima, S.; Takao, K.

How does iron storage protein ferritin interact with plutonium (and thorium) ?

Zurita, C.; Tsushima, S.; Bresson, C.; Garcia-Cortes, M.; Solari, P. L.; et al. (8 authors)

2020

A metabolic switch regulates the transition between growth and diapause in C. elegans

Penkov, S.; Raghuraman, B. K.; Erkut, C.; Oertel, J.; Galli, R.; et al. (12 authors)

C. elegans possess a general program to enter cryptobiosis that allows dauer larvae to survive different kinds of abiotic stress

Gade, V. R.; Traikov, S.; Oertel, J.; Fahmy, K.; Kurzchalia, T. V.

Essential Role of Heterocyclic Structure of N-Alkylated 2-Pyrrolidone Derivatives for Recycling Uranium from Spent Nuclear Fuels

Inoue, T.; Kazama, H.; Tsushima, S.; Takao, K.

Crystallization of colourless hexanitratoneptunate(IV) with anhydrous H+ countercations trapped into hydrogen bond polymer with diamide linkers

Takao, K.; März, J.; Matsuoka, M.; Mashita, T.; Kazama, H.; et al. (6 authors)

2019

Crystallization of Anhydrous Proton from Acidic Aqueous Solution with Diamide Building Block

Kazama, H.; Tsushima, S.; Takao, K.

Lanthanide–induced conformational change of methanol dehydrogenase involving coordination change of cofactor pyrroloquinoline quinone

Tsushima, S.

Calcium binding to a disordered domain of a type III-secreted protein from a coral pathogen promotes secondary structure formation and catalytic activity

Hoyer, E.; Knöppel, J.; Liebmann, M.; Steppert, M.; Raiwa, M.; et al. (12 authors)

Photocatalytic Oxygenation of Cyclohexene Initiated by Excitation of [UO2(OPCyPh2)4]2+ under Visible Light

Mashita, T.; Tsushima, S.; Takao, K.

Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

Thommen, A.; Werner, S.; Frank, O.; Philipp, J.; Knittelfelder, O.; et al. (11 authors)

Crystal Structure of Regularly Th-Symmetric [U(NO3)6]2− Salts with Hydrogen Bond Polymers of Diamide Building Blocks

Takao, K.; Kazama, H.; Ikeda, Y.; Tsushima, S.

Cm3+/ Eu3+ Induced Structural, Mechanistic and Functional Implications for Calmodulin

Drobot, B.; Schmidt, M.; Mochizuki, Y.; Abe, T.; Okuwaki, K.; et al. (13 authors)

2018

Ultrafast transient absorption spectroscopy of UO22+ and [UO2Cl]+

Haubitz, T.; Tsushima, S.; Steudtner, R.; Drobot, B.; Geipel, G.; et al. (7 authors)

Controlling the lability of uranyl(VI) through intramolecular π-π Stacking

Mashita, T.; Tsushima, S.; Takao, K.

DNA-encircled lipid bilayers

Iric, K.; Subramanian, M.; Oertel, J.; Agarwal, N. P.; Matthies, M.; et al. (10 authors)

Layer-by-Layer assembly of heparin and peptide-polyethylene glycol conjugates to form hybrid nanothin films of biomatrices

Thomas, A. K.; Wieduwild, R.; Zimmermann, R.; Lin, W.; Friedrichs, J.; et al. (9 authors)

The oxidation of borohydrides by photoexcited [UO2(CO3)3]4−

Takao, K.; Tsushima, S.

2017

Molecular and Crystal Structures of Uranyl Nitrate Coordination Polymers with Double-headed 2-Pyrrolidone Derivatives

Kazama, H.; Tsushima, S.; Ikeda, Y.; Takao, K.

Dipolar Relaxation Dynamics at the Active Site of an ATPase Regulated by Membrane Lateral Pressure

Fischermeier, E.; Pospíšil, P.; Sayed, A.; Hof, M.; Solioz, M.; et al. (6 authors)

2016

The molecular switching mechanism at the conserved D(E)RY motif in class-A GPCRs

Sandoval, A.; Eichler, S.; Madathil, S.; Reeves, P. J.; Fahmy, K.; et al. (6 authors)

Rational Structure-Based Rescaffolding Approach to de Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics

Ruiz-Gómez, G.; Hawkins, J. C.; Philipp, J.; Künze, G.; Wodtke, R.; et al. (8 authors)

Mechanism of attenuation of uranyl toxicity by glutathione in Lactococcus lactis

Obeid, M. H.; Oertel, J.; Solioz, M.; Fahmy, K.

Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion

Oertel, J.; Keller, A.; Prinz, J.; Schreiber, B.; Hübner, R.; et al. (8 authors)

Uranyl(VI) binding by bis(2-hydroxyaryl)diimine and bis(2-hydroxyaryl)diamine ligand derivatives. Synthetic, X-ray, DFT and solvent extraction studies

Jeazet, H. B. T.; Gloe, K.; Doert, T.; Mizera, J.; Kataeva, O. N.; et al. (10 authors)

2015

A single-strand annealing protein clamps DNA to detect and secure homology

Ander, M.; Subramaniam, S.; Fahmy, K.; Stewart, F.; Schäffer, E.

2014

The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans

Abusharkh, S. E.; Erkut, C.; Oertel, J.; Kurzchalia, T. V.; Fahmy, K.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

Petrovska, I.; Nüske, E.; Munder, M. C.; Kulasegaran, G.; Malinovska, L.; et al. (11 authors)

Paramagnetic Decoration of DNA origami Nanostructures by Eu3+ Coordination

Opherden, L.; Oertel, J.; Barkleit, A.; Fahmy, K.; Keller, K.

Experimental and Theoretical Approaches to Redox Innocence of Ligands in Uranyl Complexes: What is Formal Oxidation State of Uranium in Reductant of Uranyl(VI)?

Takao, K.; Tsushima, S.; Ogura, T.; Tsubomura, T.; Ikeda, Y.

Uranium(VI) Chemistry in Strong Alkaline Solution: Speciation and Oxygen Exchange Mechanism

Moll, H.; Rossberg, A.; Steudtner, R.; Drobot, B.; Müller, K.; et al. (6 authors)