Publications of Institute of Radiopharmaceutical Cancer Research
286 Publications2024
64Cu tumor labeling with hexadentate picolinic acid-based bispidine immunoconjugates
Kubeil, M.; Neuber, C.; Starke, M.; Arndt, C.; Rodrigues Loureiro, L. R.; et al. (11 authors)
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Chemistry - A European Journal (2024)
DOI: 10.1002/chem.202400366
The crystal structure of (2-diphenylphosphanylphenyl) 2-[7-(dimethylamino)-2-oxochromen-4-yl]acetate, C31H26NO4P
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Zeitschrift für Kristallographie - New Crystal Structures 239(2024), 511
DOI: 10.1515/ncrs-2024-0065
Alpha-emitting Radionuclides: Current Status and Future Perspectives
Miederer, M.; Benešová-Schäfer, M.; Mamat, C.; Kästner, D.; Pretze, M.; et al. (11 authors)
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Pharmaceuticals 17(2024), 76
DOI: 10.3390/ph17010076
Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold
Paßler, F.; Belke, L.; Reissig, F.; Kopka, K.; Mamat, C.
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Chemical Papers 78(2024), 4157-4164
DOI: 10.1007/s11696-024-03376-8
2023
Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment
Rodrigues Loureiro, L. R.; Hoffmann, L.; Neuber, C.; Rupp, L.; Arndt, C.; et al. (12 authors)
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Journal of Experimental & Clinical Cancer Research 42(2023), 341
DOI: 10.1186/s13046-023-02912-w
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents
Kubeil, M.; Suzuki, Y.; Casulli, M. A.; Kamal, R.; Hashimoto, T.; et al. (8 authors)
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Advanced Healthcare Materials 13(2023)1, 2301404
DOI: 10.1002/adhm.202301404
Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide and Main Group Metal Ions
Kopp, I.; Cieslik, P.; Anger, K.; Josephy, T.; Neupert, L.; et al. (15 authors)
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Inorganic Chemistry 62(2023)50, 20754-20768
DOI: 10.1021/acs.inorgchem.3c02340
Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest
Blei, M. K.; Waurick, L.; Reissig, F.; Kopka, K.; Stumpf, T.; et al. (8 authors)
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Inorganic Chemistry 62(2023)50, 20699-20709
DOI: 10.1021/acs.inorgchem.3c01983
Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5
Striese, F.; Neuber, C.; Gräßel, S.; Arndt, C.; Ullrich, M.; et al. (13 authors)
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International Journal of Molecular Sciences 24(2023)11, 9420
DOI: 10.3390/ijms24119420
Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction
Brühlmann, S. A.; Walther, M.; Kreller, M.; Reissig, F.; Pietzsch, H.-J.; et al. (7 authors)
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Pharmaceuticals 16(2023), 314
DOI: 10.3390/ph16020314
The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
Heerwig, A.; Kick, A.; Sommerfeld, P.; Eimermacher, S.; Hartung, F.; et al. (13 authors)
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International Journal of Molecular Sciences 24(2023), 1650
DOI: 10.3390/ijms24021650
Copper-free click bioconjugation of technetium-99m complexes using strained cyclononyne derivatives
Schlesinger, M.; Jentschel, C.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.
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Dalton Transactions 52(2023), 3024-3032
DOI: 10.1039/D2DT03965F
Enzymological characterization of ⁶⁴Cu-labeled neprilysin substrates and their application for modulating the renal clearance of targeted radiopharmaceuticals
Brandt, F.; Ullrich, M.; Wodtke, J.; Kopka, K.; Bachmann, M.; et al. (9 authors)
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Journal of Medicinal Chemistry 66(2023)1, 516-537
DOI: 10.1021/acs.jmedchem.2c01472
Calix[4]crowns with perfluoroalkylsulfonylcarboxamide functions: a complexation approach for heavy group 2 metal ions
Reissig, F.; Bauer, D.; Al-Ameed, K.; Luber, S.; Köckerling, M.; et al. (8 authors)
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Inorganic Chemistry Frontiers 10(2023), 370-382
Online First (2022) DOI: 10.1039/d2qi01637k
2022
Synthesis and preclinical evaluation of rhenium and technetium-99m “4 + 1” mixed-ligand complexes bearing quinazoline derivatives as potential EGFR imaging agents
Kiritsis, C.; Shegani, A.; Makrypidi, K.; Roupa, I.; Lazopoulos, A.; et al. (12 authors)
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Bioorganic & Medicinal Chemistry 73(2022), 117012
DOI: 10.1016/j.bmc.2022.117012
Towards personalized medicine: one chelator for imaging and therapy with lutetium-177 and actinium-225
Cieslik, P.; Kubeil, M.; Zarschler, K.; Ullrich, M.; Brandt, F.; et al. (12 authors)
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Journal of the American Chemical Society 144(2022)47, 21555-21567
DOI: 10.1021/jacs.2c08438
Efficient Production of the PET radionuclide 133La for Theranostic Purposes in Targeted Alpha Therapy using the 134Ba(p,2n)133La Reaction
Brühlmann, S. A.; Kreller, M.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.; et al. (7 authors)
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Pharmaceuticals 15(2022), 1167
DOI: 10.3390/ph15101167
Cyclam with a phosphinate-bis(phosphonate) pendant arm is a bone-targeting carrier of copper radionuclides
Pazderová, L.; Benešová, M.; Havlíčková, J.; Vojtíčková, M.; Kotek, J.; et al. (15 authors)
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Dalton Transactions 51(2022), 9541-9555
DOI: 10.1039/d2dt01172g
Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin
Reissig, F.; Zarschler, K.; Novy, Z.; Petrik, M.; Bendova, K.; et al. (14 authors)
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Theranostics 12(2022), 7203-7215
DOI: 10.7150/thno.78043
Introducing micro physiological systems to evaluate new radiopharmaceuticals: First attempts with radiolabeled cetuximab
Sihver, W.; Nitt-Weber, A.-K.; Behrens, S.; Ullrich, M.; Pietzsch, H.-J.; et al. (8 authors)
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Current Directions in Biomedical Engineering 8(2022)2, 532-535
DOI: 10.1515/cdbme-2022-1136
Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives
Kubeil, M.; Santana Martinez, I. I.; Bachmann, M.; Kopka, K.; Tuck L., K.; et al. (6 authors)
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Pharmaceuticals 15(2022), 432
DOI: 10.3390/ph15040432
Strained Ammonium Precursors for Radiofluorinations
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ChemistryOpen 11(2022), e202200039
DOI: 10.1002/open.202200039
Bis(amido)bis(oxinate)diamine ligands for theranostic radiometals
Southcott, L.; Whetter, J. N.; Wharton, L.; Patrick, B. O.; Zarschler, K.; et al. (9 authors)
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Journal of Inorganic Biochemistry 231(2022), 111789
DOI: 10.1016/j.jinorgbio.2022.111789
“Clickable” albumin binders for modulating the tumor uptake of targeted radiopharmaceuticals
Brandt, F.; Ullrich, M.; Laube, M.; Kopka, K.; Bachmann, M.; et al. (10 authors)
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Journal of Medicinal Chemistry 66(2022)1, 710-733
Online First (2021) DOI: 10.1021/acs.jmedchem.1c01791
Preparation of calix[4]arenes for chelation of selected divalent cations
Blumberg, M.; Al-Ameed, K.; Eiselt, E.; Luber, S.; Mamat, C.
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Molecules 27(2022)5, 1478
DOI: 10.3390/molecules27051478
2021
Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC).
Rassamegevanon, T.; Feindt, L.; Koi, L.; Müller, J.; Freudenberg, R.; et al. (16 authors)
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Cancers 13(2021)22, 5595
DOI: 10.3390/cancers13225595
Chelators for treatment of iron and copper overload: Shift from low-molecular-weight compounds to polymers
Hruby, M.; Santana Martinez, I. I.; Stephan, H.; Pouckova, P.; Benes, J.; et al. (6 authors)
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Polymers 13(2021), 3969
DOI: 10.3390/polym13223969
[nat/89Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications
Southcott, L.; Li, L.; Brian, P.; Stephan, H.; de Guadalupe Jaraquemeda-Pelaez, M.; et al. (6 authors)
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Inorganic Chemistry 60(2021), 18082-18093
DOI: 10.1021/acs.inorgchem.1c02709
Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core
Mamat, C.; Jentschel, C.; Köckerling, M.; Steinbach, J.
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Molecules 26(2021), 6629
DOI: 10.3390/molecules26216629
Aktuelle Entwicklungen aus den Radiopharmazeutischen Wissenschaften für theranostische Anwendungen - Editorial
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Der Nuklearmediziner 44(2021), 100
DOI: 10.1055/a-1463-6602
H2pyhox - Octadentate Bis(pyridyloxine)
Southcott, L.; Wang, X.; Choudhary, N.; Wharton, L.; Patrick, B.; et al. (11 authors)
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Inorganic Chemistry 60(2021), 12186-12196
DOI: 10.1021/acs.inorgchem.1c01412
Towards Targeted Alpha Therapy with Actinium 225: Chelators for Mild Condition Radiolabeling and Targeting PSMA – a Proof of Concept Study
Reissig, F.; Bauer, D.; Zarschler, K.; Novy, Z.; Bendova, K.; et al. (9 authors)
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Cancers 13(2021)8, 1974
DOI: 10.3390/cancers13081974
Radiotherapy enhances uptake and efficacy of 90Y-cetuximab: A preclinical trial
Dietrich, A.; Andreeff, M.; Koi, L.; Bergmann, R.; Schubert, M.; et al. (15 authors)
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Radiotherapy and Oncology 155(2021), 285-292
Online First (2020) DOI: 10.1016/j.radonc.2020.11.013
The Impact of Barium Isotopes in Radiopharmacy and Nuclear Medicine – from Past to Presence
Reissig, F.; Kopka, K.; Mamat, C.
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Nuclear Medicine and Biology 98(2021), 59-68
DOI: 10.1016/j.nucmedbio.2021.05.003
Die Bedeutung des Elementes Barium in der Nuklearmedizin
Reissig, F.; Kopka, K.; Mamat, C.
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Der Nuklearmediziner 44(2021), 127-134
DOI: 10.1055/a-1382-2812
Metal ion size profoundly affects H3glyox chelate chemistry
Choudhary, N.; Barett, K.; Kubeil, M.; Radchenko, V.; Engle, J.; et al. (8 authors)
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RSC Advances 11(2021), 15663-15674
DOI: 10.1039/d1ra01793d
High denticity oxinate-linearbackbone chelating ligand for diagnostic radiometal ions [111In]In3+ and [89Zr]Zr4+
Southcott, L.; Wang, X.; Wharton, L.; Yang, H.; Radchenko, V.; et al. (9 authors)
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Dalton Transactions 50(2021), 3874-3886
DOI: 10.1039/D0DT04230G
Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics
Gilpin, I. M.; Ullrich, M.; Wünsche, T.; Zarschler, K.; Lebeda, O.; et al. (8 authors)
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ChemMedChem 16(2021)17, 2645-2649
DOI: 10.1002/cmdc.202100131
Polyoxometalates in Extraction and Sorption Processes
Jelinek, L.; Mištová, E.; Kubeil, M.; Stephan, H.
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Solvent Extraction and Ion Exchange 39(2021), 455-476
DOI: 10.1080/07366299.2021.1874107
2020
Recent insights in barium-131 as a diagnostic match for radium-223: cyclotron production, separation, labeling and imaging
Reissig, F.; Bauer, D.; Ullrich, M.; Kreller, M.; Pietzsch, J.; et al. (9 authors)
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Pharmaceuticals 13(2020)10, 272
DOI: 10.3390/ph13100272
A radiopharmacologist's and radiochemist's view on targeting the Eph/ephrin receptor tyrosine kinase system
Neuber, C.; Belter, B.; Mamat, C.; Pietzsch, J.
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ACS Omega 5(2020)27, 16318-16331
DOI: 10.1021/acsomega.0c01058
Light-Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes
Geri, S.; Krunclova, T.; Janouskova, O.; Panek, J.; Hruby, M.; et al. (11 authors)
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Chemistry - A European Journal 26(2020), 10992-11006
DOI: 10.1002/chem.202002139
Cation exchange protocols to radiolabel aqueous stabilized ZnS, ZnSe and CuFeS2 nanocrystals with 64Cu for dual radio- and photo-thermal therapy
Avellini, T.; Soni, N.; Silvestri, N.; Fiorito, S.; de Donato, F.; et al. (12 authors)
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Advanced Functional Materials 30(2020), 2002362
DOI: 10.1002/adfm.202002362
Contemporary Synthesis of Ultrasmall (sub-10 nm) Upconverting Nanomaterials
Joshi, T.; Mamat, C.; Stephan, H.
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ChemistryOpen 9(2020), 703-712
DOI: 10.1002/open.202000073
Rapid Thermodynamically Stable Complex Formation of [nat/111In]In3+, [nat/90Y]Y3+, and [nat/177Lu]Lu3+ with H6dappa
Kostelnik, T.; Xiaozhu, W.; Southcott, L. D.; Wagner, H.; Kubeil, M.; et al. (8 authors)
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Inorganic Chemistry 59(2020), 7238-7251
DOI: 10.1021/acs.inorgchem.0c00671
Chelation in One Fell Swoop: Optimizing Ligands for Smaller Radiometal Ions
Choudhary, N.; Jaraquemada-Pelaez, M.; Zarschler, K.; Wang, X.; Radchenko, V.; et al. (8 authors)
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Inorganic Chemistry 59(2020), 5728-5741
DOI: 10.1021/acs.inorgchem.0c00509
Recombinant expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 4 (NPP4) and development of a luminescence-based assay to identify inhibitors
Lopez, V.; Lee, S.-Y.; Stephan, H.; Müller, C. E.
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Analytical Biochemistry 603(2020), 113774
DOI: 10.1016/j.ab.2020.113774
Synthesis, radiolabeling and first biological characterization of 18F-labeled xanthine derivatives for PET imaging of Eph receptors
Pretze, M.; Neuber, C.; Kinski, E.; Belter, B.; Köckerling, M.; et al. (9 authors)
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Organic & Biomolecular Chemistry 18(2020)16, 3104-3116
DOI: 10.1039/D0OB00391C
Sub-10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy
Reissig, F.; Zarschler, K.; Hübner, R.; Pietzsch, H.-J.; Kopka, K.; et al. (6 authors)
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ChemistryOpen 9(2020), 797-805
DOI: 10.1002/open.202000126
Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging
Kritee, P.; Neuber, C.; Zarschler, K.; Wodtke, J.; Meister, S.; et al. (8 authors)
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Small 16(2020)7, 1905013
Online First (2019) DOI: 10.1002/smll.201905013
Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia
van Heusden, C.; Button, B.; Anderson, W. H.; Ceppe, A.; Morton, L. C.; et al. (12 authors)
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American Journal of Physiology - Lung Cellular and Molecular Physiology 318(2020)2, L356-L365
DOI: 10.1152/ajplung.00449.2019
Versatile Bispidine-based Bifunctional Chelators for 64CuII-Labelling of Biomolecules
Singh, G.; Zarschler, K.; Hunoldt, S.; Santana Martinez, I. I.; Rühl, C.; et al. (12 authors)
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Chemistry - A European Journal 26(2020), 1989-2001
DOI: 10.1002/chem.201904654
Ultrasmall silicon nanoparticles as a promising platform for multimodal imaging
Singh, G.; Ddungu, J. L. Z.; Licciardello, N.; Bergmann, R.; de Cola, L.; et al. (6 authors)
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Faraday Discussions 222(2020), 362-383
DOI: 10.1039/C9FD00091G
Synthesis and Characterization of an Epidermal Growth Factor Receptor selective Ru(II) Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy
Karges, J.; Jakubaszek, M.; Mari, C.; Zarschler, K.; Goud, B.; et al. (7 authors)
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ChemBioChem 21(2020)4, 531-542
Online First (2019) DOI: 10.1002/cbic.201900419
Formation of calix[4]arenes with acyloxycarboxylate functions
Bauer, D.; Stipurin, S.; Köckerling, M.; Mamat, C.
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Tetrahedron 76(2020), 131395
DOI: 10.1016/j.tet.2020.131395
2019
Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf
Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; et al. (9 authors)
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Instruments 3(2019)1, 9
DOI: 10.3390/instruments3010009
Synthesis, Structural Characterisation, and Cytotoxicity Studies of Bi, W, and Mo containing Homo- and Hetero-bimetallic Polyoxometalates
Senevirathna, D.; Werrett, M.; Kubeil, M.; Stephan, H.; Andrews, P.
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Dalton Transactions 48(2019), 15962-15969
DOI: 10.1039/C9DT03288F
A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest
Bauer, D.; Blumberg, M.; Köckerling, M.; Mamat, C.
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RSC Advances 7(2019)55, 32357-32366
DOI: 10.1039/C9RA07293D
Tetranuclear Cu(II)-chiral complexes: Synthesis, characterization and biological activity
Peewasan, K.; Merkel, M. P.; Zarschler, K.; Stephan, H.; Anson, C. E.; et al. (6 authors)
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RSC Advances 9(2019)42, 24087-24091
DOI: 10.1039/c9ra03586a
Editorial for special issue "Jörg Steinbach"
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 350-351
DOI: 10.1002/jlcr.3773
A 224Ra-labeled polyoxopalladate as putative radiopharmaceutical
Gott, M.; Yang, P.; Kortz, U.; Stephan, H.; Pietzsch, H.-J.; et al. (6 authors)
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Chemical Communications 55(2019), 7631-7634
DOI: 10.1039/C9CC02587A
Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 –insights from co-culture experiments
Neuber, C.; Laube, M.; Mamat, C.; Belter, B.; Pietzsch, J.
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Journal of Cellular Biotechnology 5(2019)1, 27-42
DOI: 10.3233/JCB-189011
ISSN: 2352-3689
Radiochemical and radiopharmacological characterization of a 64Cu-labeled α-MSH analog conjugated with different chelators
Gao, F.; Sihver, W.; Bergmann, R.; Walther, M.; Stephan, H.; et al. (11 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 495-509
DOI: 10.1002/jlcr.3728
Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy
Reissig, F.; Hübner, R.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.
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Inorganic Chemistry Frontiers 6(2019), 1341-1349
DOI: 10.1039/c9qi00208a
Synthesis, Structural Characterization and Photodecarbonylation Study of a Dicarbonyl Ruthenium(II)-Bisquinoline Complex
Kubeil, M.; Joshi, T.; Wood, B. R.; Stephan, H.
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ChemistryOpen 8(2019), 637-642
DOI: 10.1002/open.201900111
Tarnkappen-Technologie für leuchtende Nanopartikeln
Stephan, H.; Zarschler, K.
- GIT Labor-Fachzeitschrift (2019)8, 55-57
Expression of Glypican-3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes
Rahbari, M.; Pecqueux, M.; Aust, D.; Stephan, H.; Tiebel, O.; et al. (14 authors)
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Journal of Clinical Medicine 8(2019), 696
DOI: 10.3390/jcm8050696
2018
Towards Utilising Photocrosslinking of Polydiacetylenes for the Preparation of “Stealth” Upconverting Nanoparticles
Nsubuga, A.; Zarschler, K.; Sgarzi, M.; Graham, B.; Stephan, H.; et al. (6 authors)
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Angewandte Chemie - International Edition 57(2018), 16036
DOI: 10.1002/anie.201811003
Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators
David, T.; Hlinová, V.; Kubíček, V.; Bergmann, R.; Striese, F.; et al. (12 authors)
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Journal of Medicinal Chemistry 61(2018), 8774-8796
DOI: 10.1021/acs.jmedchem.8b00932
NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution
Steinberg, J.; Köckerling, M.; Wodtke, R.; Löser, R.; Mamat, C.
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RSC Advances 8(2018), 40921-40933
DOI: 10.1039/C8RA09152H
Synthesis, characterization and initial biological evaluation of [⁹⁹ᵐTc]Tc-tricarbonyl labeled DPA-α-MSH peptide derivatives for potential melanoma imaging
Gao, F.; Sihver, W.; Bergmann, R.; Belter, B.; Bolzati, C.; et al. (9 authors)
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ChemMedChem 13(2018)11, 1146-1158
DOI: 10.1002/cmdc.201800110
Exploring pitfalls of 64Cu‑labeled EGFR‑targeting peptide GE11 as a potential PET tracer
Striese, F.; Sihver, W.; Gao, F.; Bergmann, R.; Walther, M.; et al. (8 authors)
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Amino Acids 50(2018)10, 1415-1431
DOI: 10.1007/s00726-018-2616-5
Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)
Lee, S.-Y.; Luo, X.; Namasivayam, V.; Geiss, J.; Mirza, S.; et al. (9 authors)
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Analyst 143(2018), 5417-5430
DOI: 10.1039/c8an01108g
Preyssler-Pope-Jeannin Polyanions [NaP5W30O110]14- and [AgP5W30O110]14-: Synthesis, Structural Characterization, Electrochemistry, Antiproliferative and Antibacterial Activity
Haider, A.; Zarschler, K.; Joshi, S. A.; Smith, R.; Lin, Z.; et al. (10 authors)
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Zeitschrift für Anorganische und Allgemeine Chemie 644(2018), 752-758
DOI: 10.1002/zaac.201800113
Harnessing the Coordination Chemistry of 1,4,7-Triazacyclononane for Biomimicry and Radiopharmaceutical Applications
Joshi, T.; Kubeil, M.; Nsubuga, A.; Singh, G.; Gasser, G.; et al. (6 authors)
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ChemPlusChem 83(2018), 554-564
DOI: 10.1002/cplu.201800103
Biodistribution studies of ultrasmall silicon nanoparticles and carbon dots in experimental rats and tumor mice
Licciardello, N.; Hunoldt, S.; Bergmann, R.; Singh, G.; Mamat, C.; et al. (11 authors)
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Nanoscale 10(2018), 9880-9891
DOI: 10.1039/C8NR01063C
Overexpression of receptor tyrosine kinase EphB4 triggers tumor growth and hypoxia in A375 melanoma xenografts: insights from multitracer small animal imaging experiments
Neuber, C.; Belter, B.; Meister, S.; Hofheinz, F.; Bergmann, R.; et al. (7 authors)
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Molecules 23(2018), 444
DOI: 10.3390/molecules23020444
Modified Calix[4]crowns as Molecular Receptors for Barium
Steinberg, J.; Bauer, D.; Reissig, F.; Köckerling, M.; Pietzsch, H.-J.; et al. (6 authors)
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ChemistryOpen 7(2018)6, 432-438
DOI: 10.1002/open.201800019
Facile Preparation of Multifunctionalisable ‘Stealth’ Upconverting Nanoparticles for Biomedical Applications
Nsubuga, A.; Sgarzi, M.; Zarschler, K.; Kubeil, M.; Hübner, R.; et al. (9 authors)
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Dalton Transactions 47(2018), 8595-8604
DOI: 10.1039/C8DT00241J
Rapid synthesis of sub-10 nm hexagonal NaYF4-based upconverting nanoparticles using Therminol 66
Hesse, J.; Klier, D. T.; Sgarzi, M.; Nsubuga, A.; Bauer, C.; et al. (11 authors)
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ChemistryOpen 7(2018)2, 159-168
DOI: 10.1002/open.201700186
Chelation of heavy group 2 (radio)metals by p-tert-butylcalix[4]arene-1,3-crown-6 and logK determination via NMR
Bauer, D.; Gott, M.; Steinbach, J.; Mamat, C.
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Spectrochimica Acta Part A 199(2018), 50-56
DOI: 10.1016/j.saa.2018.03.029
Facile Silylation of Cyclitols using Silyl-bis(triflates)
Topp, A.; Köckerling, M.; Reinke, H.; Miethchen, R.; Mamat, C.
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European Journal of Inorganic Chemistry (2018), 1302-1308
DOI: 10.1002/ejic.201701327
Recent Progress using the Staudinger Ligation for Radiolabeling Applications
Mamat, C.; Gott, M.; Steinbach, J.
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Journal of Labelled Compounds and Radiopharmaceuticals 61(2018), 165-178
DOI: 10.1002/jlcr.3562
Structural and kinetic considerations for the application of the traceless Staudinger ligation to future 18F radiolabeling using XRD and 19F-NMR
Köckerling, M.; Mamat, C.
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International Journal of Chemical Kinetics 50(2018), 31-40
DOI: 10.1002/kin.21137
2017
Preparation of 18F-labeled building blocks for peptide conjugation using the "minimalist" approach
Omrane, M. A.; Zlatopolskiy, B. D.; Urusova, E.; Mamat, C.; Feni, L.; et al. (7 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S261
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Evaluation of Ba/Ra Polyoxopalladates for Radiopharmaceutical Applications
Gott, M.; Yang, P.; Kortz, U.; Pietzsch, H.-J.; Steinbach, J.; et al. (6 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S559
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Novel Functionalized Calixarenes as Host Molecules for Complexation with Alkaline Earth Metals
Steinberg, J.; Gott, M.; Pietzsch, H.-J.; Steinbach, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S488
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Detection of Auger Electron Induced Strand Breaks on Plasmid DNA Caused by Technetium-99m Labeled Pyrene Derivatives
Wunderlich, G.; Reissig, F.; Mamat, C.; Pietzsch, H.-J.; Kotzerke, J.; et al. (6 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S365
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Studies of carbon monoxide release from ruthenium(II) bipyridine carbonyl complexes upon UV light exposure
Kubeil, M.; Vernooij, R. R.; Kubeil, C.; Wood, B. R.; Graham, B.; et al. (7 authors)
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Inorganic Chemistry 56(2017)10, 5941-5952
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Expression of ecto-nucleoside triphosphate diphosphohydrolases-2 and -3 by the enteric nervous system impacts inflammation in experimental colitis and Crohn’s disease
Feldbrügge, L.; Moss, A. C.; Yee, E. U.; Csizmadia, E.; Mitsuhashi, S.; et al. (13 authors)
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Journal of Crohn's and Colitis 11(2017), 1113-1123
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Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor
Wiemer, J.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017), 489-498
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Surface charge and particle size determine the metabolic fate of dendritic polyglycerols
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Nanoscale 9(2017), 8723-8739
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OncoImmunology 6(2017)4, e1287246
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Schubert, M.; Bergmann, R.; Förster, C.; Sihver, W.; Vonhoff, S.; et al. (12 authors)
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Bioconjugate Chemistry 28(2017)4, 1176-1188
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X-ray Structures of Succinimidyl Halobenzoates
Mamat, C.; Weiss, D.-H.; Köckerling, M.
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Crystals 7(2017), 90
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Zwitterionic Modification of Ultra-Small Iron Oxide Nanoparticles for Reduced Protein Corona Formation
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ChemPlusChem 82(2017), 638-646
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Scientific Reports 7(2017), 3756
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Frontiers in Pharmacology 8(2017), 54
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Radiolabelled polymeric materials for imaging and treatment of cancer: Quo Vadis?
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Advanced Healthcare Materials 6(2017)6, 1601115
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2016
New insights into the pretargeting approach to image and treat tumours
Patra, M.; Zarschler, K.; Pietzsch, H.-J.; Stephan, H.; Gasser, G.
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Chemical Society Reviews 45(2016), 6415-6431
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Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties
Carta, D.; Salvarese, N.; Morellato, N.; Gao, F.; Sihver, W.; et al. (12 authors)
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Nuclear Medicine and Biology 43(2016)12, 788-801
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Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility
Pombo-García, K.; Weiss, S.; Zarschler, K.; Ang, C.-S.; Hübner, R.; et al. (12 authors)
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ChemNanoMat 2(2016)10, 959-971
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Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments
Albrecht, R.; Fehse, S.; Pant, K.; Nowag, S.; Stephan, H.; et al. (7 authors)
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Macromolecular Bioscience 16(2016), 412-419
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Direct and Auger electron-induced, single- and double-strand breaks on plasmid DNA caused by 99mTc-labeled pyrene derivatives and the effect of bonding distance
Reissig, F.; Mamat, C.; Steinbach, J.; Pietzsch, H.-J.; Freudenberg, R.; et al. (7 authors)
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PLOS ONE 10(2016)9, e0161973
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Ultrasmall inorganic nanoparticles: state-of-the-art and perspectives for biomedical applications
Zarschler, K.; Rocks, L.; Licciardello, N.; Boselli, L.; Polo, E.; et al. (9 authors)
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Nanomedicine: Nanotechnology, Biology, and Medicine 12(2016)6, 1663-1701
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Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling
Mamat, C.; Pretze, M.; Gott, M.; Köckerling, M.
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Beilstein Journal of Organic Chemistry 12(2016), 2479-2489
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The Radiochemical and radiopharmaceutical applications of radium
Gott, M.; Steinbach, J.; Mamat, C.
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Open Chemistry 14(2016), 118-129
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Radiopharmacological characterization of 64Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma
Gao, F.; Sihver, W.; Jurischka, C.; Bergmann, R.; Haase-Kohn, C.; et al. (12 authors)
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Amino Acids 48(2016)3, 833-847
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Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato−Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications
David, T.; Kubićek, V.; Gutten, O.; Lubal, P.; Kotek, J.; et al. (8 authors)
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Inorganic Chemistry 54(2015), 11751-11766
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18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent
Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; et al. (11 authors)
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Journal of Medicinal Chemistry 58(2015), 5395-5407
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Methods to increase the metabolic stability of 18F-radiotracers
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Molecules 20(2015), 16186-16220
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In vivo Demonstration of an Active Tumor Pretargeting Approach with Peptide Nucleic Acid Bioconjugates as Complementary System
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Chemical Science 6(2015), 5601-5616
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Copper(II) cyclam complexes with N-propionic acid pendant arms
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European Journal of Inorganic Chemistry 2015(2015), 4013-4023
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Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity
Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; et al. (12 authors)
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MedChemComm 6(2015), 1093-1103
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Synthesis and Molecular Structure of 2-(Diphenylphosphano) phenyl Benzoate Borane Adduct
Mamat, C.; Köckerling, M.
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Crystals 5(2015), 9-13
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CuII-selective bispidine–dye conjugates
Bronx, D.; Comba, P.; Herten, D.-P.; Kimmle, E.; Morgen, M.; et al. (10 authors)
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Synthesis and Biodistribution Studies of 3H- and 64Cu-labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate
Pant, K.; Gröger, D.; Bergmann, R.; Pietzsch, J.; Steinbach, J.; et al. (13 authors)
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Bioconjugate Chemistry 26(2015), 906-918
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Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands and potential PET-radiotracers
Ebert, K.; Wiemer, J.; Caballero, J.; Köckerling, M.; Steinbach, J.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry 23(2015), 6025-6035
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Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy
Walther, M.; Preusche, S.; Bartel, S.; Wunderlich, G.; Freudenberg, R.; et al. (7 authors)
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Applied Radiation and Isotopes 97(2015), 177-181
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Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation – Thermodynamic and Kinetic Studies
Paúrová, M.; Havlíčková, J.; Pospíšilová, A.; Vetrík, M.; Císařová, I.; et al. (10 authors)
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Chemistry - A European Journal 21(2015), 4671-4687
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Polyoxometalates - potent and selective ecto-nucleotidase inhibitors
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Evaluation of Novel Fluorescence Probes for Conjugation Purposes Using the Traceless Staudinger Ligation
Wodtke, R.; König, J.; Pigorsch, A.; Köckerling, M.; Mamat, C.
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Dyes and Pigments 113(2015), 263-273
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Preparation of 4-Halobenzoate Containing Phosphane Based Building Blocks for Labeling Reactions Using the Traceless Staudinger Ligation
Mamat, C.; Köckerling, M.
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X-ray structure of 2-(diphenylphosphano)phenyl-4-(hydroxymethyl)benzoate
Mamat, C.; Flemming, A.; Köckerling, M.
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Acta Crystallographica Section E E70(2014), o1288-o1289
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Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma
Jiang, Z. G.; Wu, Y.; Csizmadia, E.; Feldbrügge, L.; Enjyoji, K.; et al. (12 authors)
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Purinergic Signalling 10(2014), 611-618
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The Ti7-Containing, Tetrahedral 36-Tungsto-4-Arsenate(III)[Ti6(TiO6)(AsW9O33)4]20-
Wang, K.-Y.; Bassil, B. S.; Lin, Z. G.; Haider, A.; Cao, J.; et al. (8 authors)
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Dalton Transactions 43(2014), 16143-16146
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Bispidines for dual imaging
Stephan, H.; Walther, M.; Fähnemann, S.; Ceroni, P.; Molloy, J.; et al. (10 authors)
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Chemistry - A European Journal 20(2014), 17011-17018
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Zwitterionic-Coated "Stealth" Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System
Pombo Garcia, K.; Zarschler, K.; Barbaro, L.; Barreto, J. A.; O'Malley, W.; et al. (8 authors)
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Small 10(2014), 2516-2529
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Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M = 99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)
Carta, D.; Jentschel, C.; Thieme, S.; Salvarese, N.; Morellato, N.; et al. (10 authors)
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Nuclear Medicine and Biology 41(2014), 570-581
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Bispidine dioxotetraaza macrocycles: a new class of bispidines for 64Cu PET imaging
Comba, P.; Kubeil, M.; Pietzsch, J.; Rudolf, H.; Stephan, H.; et al. (6 authors)
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Inorganic Chemistry 53(2014), 6698-6707
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Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-based ligand targeting EphA2
Pretze, M.; Mosch, B.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; et al. (6 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 57(2014), 660-665
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EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry
Viehweger, K.; Barbaro, L.; Pombo García, K.; Joshi, T.; Geipel, G.; et al. (9 authors)
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Bioconjugate Chemistry 25(2014)5, 1011-1022
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Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies
Zarschler, K.; Prapainop, K.; Mahon, E.; Rocks, L.; Bramini, M.; et al. (8 authors)
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Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m Anti-CD4-mAb fragment scintigraphy
Steinhoff, K.; Pierer, M.; Siegert, J.; Pigla, U.; Laub, R.; et al. (15 authors)
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Nuclear Medicine and Biology 41(2014), 350-354
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Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential
Koi, L.; Bergmann, R.; Brüchner, K.; Pietzsch, J.; Pietzsch, H.-J.; et al. (9 authors)
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Radiotherapy and Oncology 110(2014), 362-369
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Establishment of two complementary in vitro assays for radiocopper complexes achieving reliable and comparable evaluation of in vivo stability
Zarschler, K.; Kubeil, M.; Stephan, H.
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2013
Regioselective Synthesis of Trichloromethyl-Substituted Salicylates and Cyclohexenones by One-Pot Cyclizations of 1,3-Bis(trimethylsilyloxy)buta-1,3-dienes
Reimann, S.; Bunescu, A.; Petrosyana, A.; Sharif, M.; Erfle, S.; et al. (11 authors)
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Helvetica Chimica Acta 96(2013), 1955-1967
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High-yield production of functional soluble single-domain antibodies in the cytoplasm of Escherichia coli
Zarschler, K.; Witecy, S.; Kapplusch, F.; Foerster, C.; Stephan, H.
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Microbial Cell Factories 12(2013), 97
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Synthesis and radiopharmacological evaluation of 64Cu-labeled bombesin analogs featuring a bis(2-pyridylmethyl) 1,4,7-triazacyclononane chelator
Bergmann, R.; Ruffani, A.; Graham, B.; Spiccia, L.; Steinbach, J.; et al. (7 authors)
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European Journal of Medicinal Chemistry 70(2013), 434-446
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Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally stable, 64Cu(II)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines
Pombo Garcia, K.; Zarschler, K.; Barreto, J. A.; Hesse, J.; Spiccia, L.; et al. (7 authors)
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RSC Advances 3(2013), 22443-22454
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Quantitative Structure Property Relationship of logP for Radiopharmaceutical Technetium and Rhenium Complexes by using Molecular Dynamics Calculations
Yoshizuka, K.; Pietzsch, H.-J.; Seifert, S.; Stephan, H.
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Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Pretze, M.; Pietzsch, D.; Mamat, C.
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Molecules 18(2013), 8618-8665
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ISSN: 1420-3049
Optimization of Pentadentate Bispidines as Bifunctional Chelators for 64Cu Positron Emission Tomography (PET)
Comba, P.; Hunoldt, S.; Morgen, M.; Pietzsch, J.; Stephan, H.; et al. (6 authors)
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Inorganic Chemistry 52(2013), 8131-8143
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The computation of lipophilicities of 64Cu PET systems based on a novel approach for fluctuating charges
Comba, P.; Martin, B.; Sanyal, A.; Stephan, H.
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Dalton Transactions 42(2013)31, 11066-11110
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Condensation of the dianion of ethyl acetoacetate with perfluoroalkyl iodides. Application to the synthesis of 3-perfluoroalkylsalicylic acids
Mamat, C.; Langer, P.
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Monatshefte für Chemie 144(2013), 1057-1061
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Automated preparation of [18F]AFP and [18F]BFP: Two novel bifunctional 18F-labeling building blocks for Huisgen-click
Pretze, M.; Mamat, C.
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Journal of Fluorine Chemistry 150(2013), 25-35
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An Efficient Bioorthogonal Strategy Using CuAAC Click Chemistry for Radiofluorinations of SNEW Peptides and the Role of Copper Depletion
Pretze, M.; Kuchar, M.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; et al. (6 authors)
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ChemMedChem 8(2013), 935-945
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Design and Development of 99mTc-‘4 + 1’-Labeled Dextran-Mannose Derivatives as Potential Radiopharmaceuticals for Sentinel Lymph Node Detection
Giglio, J.; Fernandez, S.; Jentschel, C.; Pietzsch, H.-J.; Papadopoulos, M.; et al. (9 authors)
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Cancer Biotherapy and Radiopharmaceuticals 28(2013), 541-551
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Dendrimers as Nb3+ ligands: effect of generation on the efficiency of the sensitized lanthanide emission
Pillai, Z. S.; Ceroni, P.; Kubeil, M.; Heldt, J.-M.; Stephan, H.; et al. (6 authors)
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Chemistry - An Asian Journal 8(2013), 771-777
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Ga-68- and Cu-64-Labeled NOTA-Albumin Conjugates for PET Sentinel Lymph Node Imaging
Schiller, E.; Bergmann, R.; Wunderlich, G.; Andreeff, M.; Jacob, A.; et al. (6 authors)
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ISRN Molecular Imaging (2013), 386976
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Synthesis of Short and Versatile Heterobifunctional Linkers for Conjugation Purposes of Bioactive Molecules with (Radio-)Labels
Heldt, J.-M.; Kerzendörfer, O.; Mamat, C.; Starke, F.; Pietzsch, H.-J.; et al. (6 authors)
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Synlett 4(2013), 432-436
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Inactivation of HNSCC Cells by 90Y-Labeled Cetuximab Strictly Depends on the Number of Induced DNA Double-Strand Breaks
Saker, J.; Kriegs, M.; Zenker, M.; Heldt, J.-M.; Eke, I.; et al. (13 authors)
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Journal of Nuclear Medicine 54(2013), 416-423
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Copper(II) chemistry of the functionalized macrocycle cyclam tetrapropionic acid
Comba, P.; Emmerling, F.; Jakob, M.; Kraus, W.; Kubeil, M.; et al. (8 authors)
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Dalton Transactions 42(2013), 6142-6148
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Polyoxometalates as versatile enzyme inhibitors
Stephan, H.; Kubeil, M.; Emmerling, F.; Müller, C. E.
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European Journal of Inorganic Chemistry 10-11(2013), 1585-1594
Online First (2012) DOI: 10.1002/ejic.201201224
[68Ga]NS3-RGD and [68Ga] Oxo-DO3A-RGD for imaging αvβ3 integrin expression: synthesis, evaluation, and comparison
Knetsch, P. A.; Petrik, M.; Rangger, C.; Seidel, G.; Pietzsch, H.-J.; et al. (8 authors)
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Nuclear Medicine and Biology 40(2013), 65-72
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High specific activity 61Cu via 64Zn(p,α)61Cu reaction at low proton energies
Thieme, S.; Walther, M.; Preusche, S.; Rajander, J.; Pietzsch, H.-J.; et al. (7 authors)
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Applied Radiation and Isotopes 72(2013), 169-176
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2012
Cellular and molecular properties of 90Y-labeled cetuximab in combination with radiotherapy on human tumor cells in vitro
Saki, M.; Toulany, M.; Sihver, W.; Zenker, M.; Heldt, J.-M.; et al. (10 authors)
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Strahlentherapie und Onkologie 9(2012), 823-832
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Fluorine-18-Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine as a Radiotracer Targeting the Receptor Tyrosine Kinase EphB4
Mamat, C.; Mosch, B.; Neuber, C.; Köckerling, M.; Bergmann, R.; et al. (6 authors)
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ChemMedChem 7(2012)11, 1991-2003
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Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S)
Peruzzo, V.; Pretzsch, C.; Tisato, F.; Porchia, M.; Refosco, F.; et al. (10 authors)
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Inorganica Chimica Acta 387(2012), 163-172
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Synthesis, in vitro and in vivo characterization of novel 99mTc-‘4+1’-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia
Giglio, J.; Fernández, S.; Pietzsch, H.-J. D.; Dematteis, S.; Moreno, M.; et al. (8 authors)
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Nuclear Medicine and Biology 39(2012), 679-686
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Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum
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Experimental Neurology 233(2012), 193-204
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Module-assisted preparation of 64Cu with high specific activity
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Applied Radiation and Isotopes 70(2012), 602-608
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Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate
Mamat, C.; Flemming, A.; Köckerling, M.
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Crystals 2(2012), 90-95
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ISSN: 2073-4352
The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole
Ebert, K.; Köckerling, M.; Mamat, C.
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Crystals 2(2012), 176-181
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The Molecular Structure of 1,2:5,6-Di-O-isopropylidene-3-O-toluenesulfonyl-a-D-glucofuranose
Mamat, C.; Peppel, T.; Köckerling, M.
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Crystals 2(2012), 105-109
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2011
Synthesis, colloidal stability and 64Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands
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Impact of functionalized coligands on the pharmacokinetics of 99mTc(III) ‘4+1’ mixed-ligand complexes conjugated to bombesin
Künstler, J.-U.; Bergmann, R.; Gniazdowska, E.; Kozminski, P.; Walther, M.; et al. (6 authors)
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Journal of Inorganic Biochemistry 105(2011), 1383-1390
DOI: 10.1016/j.jinorgbio.2011.07.002
Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
Förster, C.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.
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Molecules 16(2011), 5228-5240
DOI: 10.3390/molecules16065228
ISSN: 1420-3049
Synthesis, characterization and biological evaluation of [188Re(N)(cys∼)(PNP)]+/0 mixed-ligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals
Thieme, S.; Agostini, S.; Bergmann, R.; Pietzsch, J.; Pietzsch, H.-J.; et al. (9 authors)
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Nuclear Medicine and Biology 38(2011), 399-415
DOI: 10.1016/j.nucmedbio.2010.09.006
Imidazole Containing Bispidine Ligands: Synthesis, Structure and Cu(II)-Complexation
Walther, M.; Matterna, M.; Juran, S.; Fähnemann, S.; Stephan, H.; et al. (7 authors)
- Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 66b(2011), 721-728
A Novel Tetrabranched Neurotensin(8-13) Cyclam Derivative: Synthesis, 64Cu-Labeling and Biological Evaluation
Röhrich, A.; Bergmann, R.; Kretzschmann, A.; Noll, S.; Steinbach, J.; et al. (7 authors)
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Journal of Inorganic Biochemistry 105(2011), 821-832
DOI: 10.1016/j.jinorgbio.2011.02.011
Nanomaterials: applications in cancer imaging and therapy
Barreto, J. A.; O'Malley, W.; Kubeil, M.; Graham, B.; Stephan, H.; et al. (6 authors)
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Advanced Materials 23(2011)12, H18-H40
DOI: 10.1002/adma.201190041
Synthesis, structure determination and (radio-) fluorination of novel functionalized phosphanes suitable for the traceless Staudinger ligation
Mamat, C.; Franke, M.; Peppel, T.; Köckerling, M.; Steinbach, J.
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Tetrahedron 67(2011), 4521-4529
DOI: 10.1016/j.tet.2011.04.091
Synthesis and biological evaluation of new [Tc(N)(PS)]-based mixed-ligand compounds useful in design of target-specific radiopharmaceuticas: the 2-methoxyphenylpiperazine dithiocarbamate derivatives as example
Bolzati, C.; Salvarese, N.; Carta, D.; Refosco, F.; Dolmella, A.; et al. (8 authors)
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Journal of Biological Inorganic Chemistry 16(2011), 137-155
DOI: 10.1007/s00775-010-0712-4
[18F]1-(3-fluoropropyl)piperazines as model compounds for the radiofluorination of pyrido[2,3-d]pyrimidines
Grosse-Gehling, P.; Wuest, F. R.; Peppel, T.; Köckerling, M.; Mamat, C.
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Radiochimica Acta 99(2011), 365-373
DOI: 10.1524/ract.2011.1834
Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers
Pretze, M.; Große-Gehling, P.; Mamat, C.
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Molecules 16(2011), 1129-1165
DOI: 10.3390/molecules16021129
2010
Sugar-decorated dendritic nanocarriers: Encapsulation and release of the octahedral rhenium cluster complex [Re6S8(OH)6]4-
Kubeil, M.; Stephan, H.; Pietzsch, H.-J.; Geipel, G.; Appelhans, D.; et al. (11 authors)
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Chemistry - An Asian Journal 5(2010), 2507-2514
DOI: 10.1002/asia.201000284
Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)
Wunderlich, G.; Schiller, E.; Bergmann, R.; Pietzsch, H.-J.
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Nuclear Medicine and Biology 37(2010), 861-867
DOI: 10.1016/j.nucmedbio.2010.05.004
The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers
Pretze, M.; Wuest, F.; Peppel, T.; Köckerling, M.; Mamat, C.
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Tetrahedron Letters 51(2010), 6410-6414
DOI: 10.1016/j.tetlet.2010.09.134
Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2′-dipicolylamine
Gasser, G.; Jäger, K.; Zenker, M.; Bergmann, R.; Steinbach, J.; et al. (7 authors)
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Journal of Inorganic Biochemistry 104(2010), 1133-1140
DOI: 10.1016/j.jinorgbio.2010.06.011
A novel Dibenzoazacyclooctyne precursor in regioselective Copper-free click chemistry. An innovative 3-step synthesis.
Starke, F.; Walther, M.; Pietzsch, H.-J.
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ARKIVOC (2010), 350-359
ISSN: 1551-7012
Synthesis and Radiofluorination of Iodophenyl Esters as Tool for the Traceless Staudinger Ligation
Pretze, M.; Flemming, A.; Köckerling, M.; Mamat, C.
- Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 65(2010), 1128-1136
A new hexanuclear rhenium cluster complex with six terminal acetate ligands: Synthesis, structure, and properties of K4[Re6S8(CH3COO)6]·8H2O
Brylev, K. A.; Mironov, Y. V.; Fedorov, V. E.; Kim, S.-J.; Pietzsch, H.-J.; et al. (8 authors)
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Inorganica Chimica Acta 363(2010)11, 2686-2691
DOI: 10.1016/j.ica.2010.04.042
Novel 99mTc '4 + 1' peptide conjugates: Tuning the biodistribution by variation of coligands
Künstler, J.-U.; Seidel, G.; Bergmann, R.; Gniazdowska, E.; Walther, M.; et al. (11 authors)
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European Journal of Medicinal Chemistry 45(2010), 3645-3655
DOI: 10.1016/j.ejmech.2010.05.010
Crystal structure of N-benzyl-4-fluorobenzamide, C14H12FNO, at 173 K
Mamat, C.; Flemming, A.; Köckerling, M.
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Zeitschrift für Kristallographie - New Crystal Structures 225(2010), 345-346
DOI: 10.1524/ncrs.2010.0150
Efficient preparation of 99mTc(III) 4+1 mixed-ligand complexes for peptide labeling with high specific activity
Künstler, J.-U.; Seidel, G.; Pietzsch, H.-J.
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Applied Radiation and Isotopes 68(2010), 1728-1733
DOI: 10.1016/j.apradiso.2010.04.008
2009
Recent Application of Click Chemistry for the Synthesis of Radiotracers for Molecular Imaging
Mamat, C.; Ramenda, T.; Wuest, F.
- Mini-Reviews in Organic Chemistry 6(2009), 21-34
NMR Studies and Crystal Structure Determinations of CF3 Group-containing Bicyclic phenolates
Mamat, C.; Reinke, H.; Langer, P.
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Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 64(2009)4, 423-426
ISSN: 0932-0776
Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging
Bourkoula, A.; Paravatou-Petsotas, M.; Papadopoulos, A.; Santos, I.; Pietzsch, H.-J.; et al. (9 authors)
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European Journal of Medicinal Chemistry 44(2009), 4021-4027
DOI: 10.1016/j.ejmech.2009.04.033
Isomerism in tetrahedral rhenium cluster complexes [Re4Q4(PMe2sub>Ph)4X8]·nCH2Cl2 (Q = Se, X = Br; Q = Te, X = Cl, Br).
Efremova, O. A.; Mironov, Y. V.; Brylev, K. A.; Fedorov, V. E.; Pietzsch, H.-J.; et al. (6 authors)
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Polyhedron 28(2009), 2973-2976
DOI: 10.1016/j.poly.2009.07.003
Synthesis of Benzoate-Functionalized Phosphanes as Novel Building Blocks for the Traceless Staudinger Ligation
Mamat, C.; Flemming, A.; Köckerling, M.; Steinbach, J.; Wuest, F.
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Synthesis 19(2009), 3311-3321
DOI: 10.1055/s-0029-1216947
Radiosynthesis of New [90Y]-DOTA-Based Maleimide Reagents Suitable for the Prelabeling of Thiol-Bearing L-Oligonucleotides and Peptides
Schlesinger, J.; Fischer, C.; Közle, I.; Vonhoff, S.; Klussmann, S.; et al. (8 authors)
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Bioconjugate Chemistry 20(2009), 1340-1348
DOI: 10.1021/bc900095k
Two Coordination Modes of Bidentate Aminopyrazine Ligands in Cubane-type Cluster Complex Re4Te4Cl8(C4N3H4)4 . 2DMF
Efremova, O. A.; Mironov, Y. V.; Pietzsch, H.-J.; Stephan, H.; Perrin, C.; et al. (6 authors)
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Journal of Cluster Science 20(2009), 77-81
DOI: 10.1007/s10876-008-0219-0
The First Octahedral Cluster Complexes With Terminal Formate Ligands: Synthesis, Structure, and Properties of K4[Re6S8(HCOO)6] and Cs4[Re6S8(HCOO)6]
Brylev, K. A.; Mironov, Y. V.; Kozlova, S. G.; Fedorov, V. E.; Kim, S.-J.; et al. (10 authors)
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Inorganic Chemistry 48(2009), 2309-2315
DOI: 10.1021/ic802178q
Hexadentate Bispidine Derivatives as Versatile Bifunctional Chelate Agents for Copper(II) Radioisotopes
Juran, S.; Walther, M.; Stephan, H.; Bergmann, R.; Steinbach, J.; et al. (8 authors)
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Bioconjugate Chemistry 20(2009), 347-359
DOI: 10.1021/bc800461e
Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 2: Subcellular distribution
Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; et al. (13 authors)
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Nuclear Medicine and Biology 36(2009), 845-852
DOI: 10.1016/j.nucmedbio.2009.06.003
Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 1: Myocardial extraction and biodistribution
Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; et al. (13 authors)
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Nuclear Medicine and Biology 36(2009), 833-843
DOI: 10.1016/j.nucmedbio.2009.06.009
Synthesis of modified pyrimidine bases and positive impact of the chemically reactive substituents on their in vitro antiproliferative activity
Noll, S.; Kralj, M.; Suman, L.; Stephan, H.; Piantanida, I.
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European Journal of Medicinal Chemistry 44(2009), 1172-1179
DOI: 10.1016/j.ejmech.2008.06.002
2008
Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging
Fernandes, C.; Santos, I. C.; Santos, I.; Pietzsch, H.-J.; Künstler, J.-U.; et al. (12 authors)
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Dalton Transactions (2008), 3215-3225
DOI: 10.1039/b802021c
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila; substrate specificity and requirement for virulence
Sansom, F. M.; Riedmaier, P.; Newton, H. J.; Dunstone, M. A.; Müller, C. E.; et al. (13 authors)
- Journal of Biological Chemistry 283(2008)19, 12909-12918
Yttrium-86-labelled human serum albumin microspheres: relation of surface structure with in vivo stability
Schiller, E.; Bergmann, R.; Pietzsch, J.; Noll, B.; Sterger, A.; et al. (8 authors)
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Nuclear Medicine and Biology 35(2008), 227-232
DOI: 10.1016/j.nucmedbio.2007.10.008
Hydrophilic oxybathophenanthroline ligands: Synthesis and copper(II) complexation
Stephan, H.; Juran, S.; Born, K.; Comba, P.; Geipel, G.; et al. (8 authors)
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New Journal of Chemistry 32(2008), 2016-2022
DOI: 10.1039/b805136d
An 86Y-Labeled Mirror-Image Oligonucleotide: Influence of Y-DOTA Isomers on the Biodistribution in Rats
Schlesinger, J.; Közle, I.; Bergmann, R.; Tamburini, S.; Bolzati, C.; et al. (12 authors)
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Bioconjugate Chemistry 19(2008), 928-939
DOI: 10.1021/bc700453h
Synthesis, Copper(II) Complexation, 64Cu-Labeling and Bioconjugation of a New Bis(2-pyridylmethyl) Derivative of 1,4,7-Triazacyclononane
Gasser, G.; Tjioe, L.; Graham, B.; Belousoff, M. J.; Juran, S.; et al. (10 authors)
- Bioconjugate Chemistry 19(2008)3, 719-730
Fragmentation Reactions of Singly and Doubly Protonated Thiourea- and Sugar-substituted Cyclams and their Transition Metal Complexes
Felder, T.; Röhrich, A.; Stephan, H.; Schalley, C. A.
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Journal of Mass Spectrometry 43(2008), 651-663
DOI: 10.1002/jms.1365
Labeling of Fatty Acid Ligands with the Strong Electrophilic Metal Fragment [99mTc(N)(PNP)]2+ (PNP = Diphosphane Ligand)
Cazzola, E.; Benini, E.; Pasquali, M.; Mirtschink, P.; Walther, M.; et al. (10 authors)
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Bioconjugate Chemistry 19(2008), 450-460
DOI: 10.1021/bc7002378
Modified 4+1 Mixed Ligand Technetium Labeled Fatty Acids for Myocardial Imaging: Evaluation of Myocardial Uptake and Biodistribution
Mirtschink, P.; Stehr, S. N.; Pietzsch, H.-J.; Bergmann, R.; Pietzsch, J.; et al. (12 authors)
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Bioconjugate Chemistry 19(2008), 97-108
DOI: 10.1021/bc700164c
2007
Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices
Coppi, E.; Pugliese, A. M.; Stephan, H.; Müller, C. E.; Pedata, F.
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Purinergic Signalling 3(2007), 203-219
DOI: 10.1007/s11302-006-9049-4
Two mononuclear Tc complexes: [2,2′-(3-phenylpropylimino)- and [2,2′-(propylimino)-bis(ethanethiolato)](4-methoxybenzenethiolato)-oxidotechnetate(V)
Emmerling, F.; Kraus, W.; Noll, B.; Noll, S.; Pietzsch, H.-J.
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Acta Crystallographica Section C 63(2007), m579-m582
DOI: 10.1107/S0108270107052870
(4-Methoxybenzenethiolato-κS)oxido-[2,2-propylimino)-bis(ethanethiolato)- κ3S,N,S]rhenium(V)
Kraus, W.; Emmerling, F.; Noll, B.; Noll, S.; Pietzsch, H.-J.
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Acta Crystallographica Section E 63(2007), m3018
DOI: 10.1107/S1600536807056814
Carbohydration of 1,4,8,11-tetraazacyclotetradecane (cyclam): synthesis and binding properties toward concanavalin A
Stephan, H.; Röhrich, A.; Noll, S.; Steinbach, J.; Kirchner, R.; et al. (6 authors)
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Tetrahedron Letters 48(2007), 8834-8838
DOI: 10.1016/j.tetlet.2007.10.071
Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues
Heintz, A. C.; Jung, C. M.; Stehr, S. N.; Mirtschink, P.; Walther, M.; et al. (12 authors)
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Nuclear Medicine Communications 28(2007)8, 637-647
ISSN: 0143-3636
Cluster Core Controlled Reactions of Substitution of Terminal Bromide Ligands by Triphenylphosphine in Octahedral Rhenium Chalcobromide Complexes
Shestopalov, M. A.; Brylev, K. A.; Kozlova, S. G.; Fedorov, V. E.; Spies, H.; et al. (9 authors)
- Journal of the American Chemical Society 129(2007), 3714-3721
Very stable 188Re-S4 chelates for labelling biomolecules, prepared with highly concentrated perrhenate eluates
Seifert, S.; Jentschel, C.; Bergmann, R.; Pietzsch, H.-J.; Wunderlich, G.; et al. (7 authors)
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Nuklearmedizin 5(2007), 181-184
ISSN: 0029-5566
Organometallic 99mTc(III) 4+1 Bombesin(7-14) Conjugates: Synthesis, Radiolabeling and In Vitro/In Vivo Studies
Künstler, J.-U.; Veerendra, B.; Figueroa, S. D.; Sieckmann, G. L.; Rold, T. L.; et al. (8 authors)
- Bioconjugate Chemistry 18(2007), 1651-1661
Extraction of radio-labelled xanthine derivatives by artificial receptors deep insight into the association behaviour
Bomkamp, M.; Siering, C.; Landrock, K.; Stephan, H.; Fröhlich, R.; et al. (6 authors)
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Chemistry - A European Journal 13(2007), 3724-3732
DOI: 10.1002/chem.200601231
Comparison of in vitro and in vivo properties of 99mTc-cRGD peptides labelled using different novel Tc-cores
Decristoforo, C.; Santos, I.; Pietzsch, H.-J.; Duatti, A.; Smith, C. J.; et al. (9 authors)
- Quarterly Journal of Nuclear Medicine and Molecular Imaging 51(2007), 33-41
Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging
Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; et al. (15 authors)
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Bioconjugate Chemistry 18(2007), 216-230
ISSN: 10.1021/bc0601222
2006
Polyoxometalates a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors
Müller, C. E.; Iqbal, J.; Baqi, Y.; Zimmermann, H.; Röllich, A.; et al. (6 authors)
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Bioorganic & Medicinal Chemistry Letters 16(2006), 5943-5947
DOI: 10.1016/j.bmcl.2006.09.003
Preparation and Biological Characterization of Isomeric 188Re(V) Oxocomplexes with Tetradentate S4 Ligands Derived from DMSA for Labeling of Biomolecules
Seifert, S.; Heinrich, T.; Jentschel, C.; Smuda, C.; Bergmann, R.; et al. (6 authors)
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Bioconjugate Chemistry 17(2006), 1601-1606
DOI: 10.1021/bc0602331
Bromo(tricarbonyl) (15-{[2-(methylthio-S)ethylthio-S} pentadecanoic acid)rhenium(l)
Kraus, W.; Walther, M.; Jung, C. M.; Emmerling, F.; Pietzsch, H.-J.
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Acta Crystallographica Section E 62(2006), m1660-m1662
DOI: 10.1107/S1600536806024081
Tetrabutylammonium bis(2-amidobenzenethiolato-k2S,N)oxorhenate(V)
Gniazdowska, E.; Kraus, W.; Emmerling, F.; Spies, H.; Stephan, H.
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Acta Crystallographica Section E 62(2006), m1197-m1199
DOI: 10.1107/S160053680601511X
Two- and Threefold Intramolecular Bridging p-tert- Butylcalix[8]arene Triphosphates Synthesis, Structure and Stereochemistry
Gloede, J.; Ozegowski, S.; Keitel, I.; Gruner, M.; Costisella, B.; et al. (8 authors)
- Zeitschrift für Anorganische und Allgemeine Chemie (2006)632, 123-132
Chitosan-encapsulated Keggin anion [Ti2W10PO40]7-: Synthesis, characterization and cellular uptake studies
Meißner, T.; Bergmann, R.; Oswald, J.; Rode, K.; Richter, W.; et al. (10 authors)
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Transition Metal Chemistry 31(2006)5, 603-610
DOI: 10.1007/s11243-006-0035-z
ISSN: 0340-4285
Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules
Park, S. H.; Seifert, S.; Pietzsch, H.-J.
- Bioconjugate Chemistry 17(2006), 223-225
A new molecular mechanics force field for the design of oxotechnetium(V) and oxorhenium(V) radiopharmaceuticals
Comba, P.; Daubinet, A.; Martin, B.; Pietzsch, H.-J.; Stephan, H.
- Journal of Organometallic Chemistry 691(2006)11, 2495-2502
Octahedral rhenium cluster complexes with inner organic ligands: synthesis, structure and properties of [Re6Q8(3,5-Me2PzH)6]Br2·2(3,5-Me2PzH) (Q = S, Se)
Mironov, Y.; Bryleva, K.; Shestopalova, M.; Yarovoia, S.; Fedorova, V.; et al. (11 authors)
- Inorganica Chimica Acta (2006)359, 1129-1134
188Re(III)-EDTA - a Multipurpose Starting Material for the Preparation of Relevant 188Re Complexes under Mild Conditions
Seifert, S.; Pietzsch, H.-J.
- Applied Radiation and Isotopes 64(2006), 223-227
2005
[Re6Q7O(3,5-Me2PzH)6]Br2·3,5-Me2PzH (Q = S, Se) new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core
Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, A. S.; Romanenko, G. V.; et al. (12 authors)
- European Journal of Inorganic Chemistry (2005), 657-661
{2-Carboxy-2-{bis[(2-thiolato-_S)ethyl]amino-_N}ethanthiolato-_S} (triphenylphosphin-_P)rhenium(III)
Schiller, E.; Kraus, W.; Reck, G.; Spies, H.; Pietzsch, H.-J.
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Acta Crystallographica Section E 61(2005), M1373-M1375
ISSN: 1600-5368
A novel rhenium chelate system derived from dimercaptosuccinic acid for the selective labeling of biomolecules
Heinrich, T.; Kraus, W.; Pietzsch, H.-J.; Smuda, C.; Spies, H.
- Inorganic Chemistry 44(2005)26, 9930-9937
Disruption of unprecedented B-H...M agostic interactions: An alternative approach for labeling bioactive molecules
Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.; Pietzsch, H.-J.
- Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry 35(2005)1, 35-42
Synthesis and Binding Properties of Dendritic Oxybathophenanthroline Ligands towards Copper(II)
Stephan, H.; Geipel, G.; Bernhard, G.; Comba, P.; Rajaraman, G.; et al. (7 authors)
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European Journal of Inorganic Chemistry 22(2005), 4501-4508
DOI: 10.1002/ejic.200500176
K6H2[TiW11CoO40]×13H2O, with a monotitanoundecatungstocobaltate(II) anion
Kraus, W.; Stephan, H.; Röllich, A.; Matéjka, Z.; Reck, G.
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Acta Crystallographica Section E 61(2005), i35-i37
ISSN: 1600-5368
Mixed-Ligand Rhenium-188 Complexes with Tetradentate/Monodentate NS3/P (4+1) Coordination: Relation of structure with antioxidation stability
Schiller, E.; Seifert, S.; Tisato, F.; Refosco, F.; Bolzati, C.; et al. (8 authors)
- Bioconjugate Chemistry 16(2005), 634-643
[Re6Q7O(3,5-Me2PzH)6]Br2*3,5-Me2PzH (Q = S, Se) - new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core
Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, S. S.; Romanenko, G.; et al. (12 authors)
- European Journal of Inorganic Chemistry (2005)4, 657-661
Pegylation of 1,4,8,11-Tetraazacyclotetradecane (Cyclam) and its Copper(II) Complexation
Stephan, H.; Geipel, G.; Bernhard, G.; Appelhans, D.; Tabuani, D.; et al. (7 authors)
- Tetrahedron Letters 46(2005), 3209-3212
2004
The crucial role of the diphosphine heteroatom X in the stereochemistry and stabilization of the substitution-inert [M(N)(PXP)]2+ metal fragments (M = Tc, Re; PXP = diphosphine ligand)
Tisato, F.; Refosco, F.; Porchia, M.; Bolzati, C.; Bandoli, G.; et al. (11 authors)
- Inorganic Chemistry 43(2004), 8617-8625
Cyclopentadienyl tricarbonyl complexes of 99mTC for the in vivo imaging of the serotonin 5-HT1A receptor in the brain
Saidi, M.; Kretzschmar, M.; Seifert, S.; Bergmann, R.; Pietzsch, H.-J.
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Journal of Organometallic Chemistry 689(2004)25, 4739-4744
DOI: 10.1016/j.jorganchem.2004.09.004
Novel Procedures for Preparing 99mTc(III) Complexes with Tetradentate/Monodentate Coordination of Varying Lipophilicity and Adaptation to 188Re Analogues
Seifert, S.; Künstler, J.-U.; Pietzsch, H.-J.; Pawelke, B.; Bergmann, R.; et al. (6 authors)
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Bioconjugate Chemistry 15(2004)4, 856-863
DOI: 10.1021/bc0300798
Synthesis, Characterization, and Biological Evaluation of Neutral Nitrido Technetium(V) Mixed Ligand Complexes Containing Dithiolates and Aminodiphosphines. A Novel System for Linking Technetium to Biomolecules
Bolzati, C.; Benini, E.; Cazzola, E.; Jung, C.; Tisato, F.; et al. (10 authors)
- Bioconjugate Chemistry 15(2004), 628-637
2003
In vivo Measurement of the Serotonin Transporter with (S)-([18F]fluoromenthyl)-(+)-McN5652
Brust, P.; Hinz, R.; Kuwabara, H.; Hesse, S.; Zessin, J.; et al. (10 authors)
- Neuropsychopharmacology (2003) 28, 2010-2019
Alkyl-Substituted 2,6-Dioxadiazolylpyridines as Selective Extractants for Trivalent Actinides
Weigl, M.; Müllich, U.; Geist, A.; Gompper, K.; Zevaco, T.; et al. (6 authors)
- Journal of Radioanalytical and Nuclear Chemistry, 256/3 (2003) 403-412
Where the anion extraction is going?
Gloe, K.; Stephan, H.; Grotjahn, M.
- Chem. Eng. Technol. 26 (2003) 1107-1117
Towards promising oxoanion extractants: azacages and open-chain counterparts
Farrell, D.; Gloe, K.; Gloe, K.; Goretzki, G.; Mckee, V.; et al. (11 authors)
- J. Chem. Soc., Dalton Trans. (2003) 1961-1968
A new Cryptophane Receptor Featuring Three endo-Carboxylic Acid Groups: Synthesis, Host Behavior and Structural Study
Roesky, C. E. O.; Weber, E.; Rambusch, T.; Stephan, H.; Gloe, K.; et al. (6 authors)
- Chemistry, A European Journal 9/5 (2003) 1104-1112
Aqueous synthesis of derivatized cyclopentadienyl complexes of technetium and rhenium directed towards radiopharmaceutical application
Bernard, J.; Ortner, K.; Spingler, B.; Pietzsch, H.-J.; Alberto, R.
- Inorganic Chemistry 42 (2003) 1014-1022
Synthesis, characterization and biological evaluation of technetium(III) complexes with tridendate/bidendate S,E,S/P,S coordination (E = O, N(CH3), S): A novel approach to robust technetium chelates suitable for linking the metal to biomolecules
Pietzsch, H.-J.; Seifert, S.; Syhre, R.; Tisato, F.; Refosco, F.; et al. (7 authors)
- Bioconjugate Chemistry 14 (2003) 136-143
2002
Quo vadis Anionenextraktion?
Gloe, K.; Stephan, H.; Grotjahn, M.
- Chemie Ingenieur Technik 74 (2002) 767-777
A novel technetium-99m radioligand for the 5-HT1A receptor derived from desmethyl-WAY-100635 (DWAY)
Heimbold, I.; Drews, A.; Syhre, R.; Kretzschmar, M.; Pietzsch, H.-J.; et al. (6 authors)
- European Journal of Nuclear Medicine 29 (2002) 82-87
Syntheses and first crystal structures of rhenium complexes derived from omega-functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging
Jung, C. M.; Kraus, W.; Leibnitz, P.; Pietzsch, H.-J.; Kropp, J.; et al. (6 authors)
- European Journal of Inorganic Chemistry (2002) 1219-1225
Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha1-adrenergic receptor
Drews, A.; Pietzsch, H.-J.; Syhre, R.; Seifert, S.; Varnäs, K.; et al. (12 authors)
- Nuclear Medicine and Biology 29 (2002) 389-398
Development of technetium-99m-based CNS receptor ligands: have there been any advances?
Johannsen, B.; Pietzsch, H.-J.
- Eur. J. Nucl. Med. 29 (2002) 263-275
Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor
Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; et al. (12 authors)
- Nuclear Medicine and Biology 29 (2002) 375-387
2001
Synthesis and properties of triethyl(triphenyl)siloxyalkyl(aryl)thiolato(3-thiapentane-1,5-dithialato)oxorhenium(V)- potential brain seeking agents
Abedin, M. Z.; Spies, H.; Pietzsch, H.-J.; Zablotskaya, A.
- Bangladesh Journal of Nuclear Medicine (2001) 1-6.
Synthesis and host-guest properties of multi-crown-dendrimers towards sodium pertechnetate and mercury(II) chloride
Stephan, H.; Spies, H.; Johannsen, B.; Gloe, K.; Gorka, M.; et al. (6 authors)
- Eur. J. Inorg. Chem. (2001) 2957-2963
Reactivity of Technetium(I) Thioether Carbonyl Complexes towards Histidine - An EXAFS Study in Solution
Seifert, S.; Künstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; et al. (8 authors)
- Inorganica Chimica Acta 322 (2001) 79-86
Mixed-ligand technetium(III) complexes with tetra-dendate/monodendate NS3/isocyanide coordination: A new nonpolar Technetium chelate system for the design of neutral and lipophilic complexes stable in vivo
Pietzsch, H.-J.; Gupta, A.; Syhre, R.; Leibnitz, P.; Spies, H.
- Bioconjugate Chem. Vol.12 Nr. 4 (2001) 538-544
Synthesis and characterization of novel trigonal-bipyramidal technetium(III) mixed-ligand complexes with SES/S/P coordination (E = O, N(CH3), S)
Pietzsch, H.-J.; Tisato, F.; Refosco, F.; Leibnitz, P.; Drews, A.; et al. (7 authors)
- Inorg. Chem. 40 (2001), 40, 59-64
2000
pH-controlled inclusion and release of oxyanions by denrimers bearing methyl orange moieties
Stephan, H.; Spies, H.; Johannsen, B.; Kaufmann, C.; Vögtle, F.
- Organic Letters 2 (15) (2000) 2343-2346
Glutathione interaction with SNS/S mixed ligand complexes of oxorhenium(V): Kinetic aspects and characterization of the products
Nock, B.; Maina, T.; Tsortos, A.; Pelecanou, M.; Raptopoulou, C. P.; et al. (12 authors)
- Inorganic Chemistry 39 (2000) 4433-4441
EXAFS Analyses of Technetium(I) Carbonyl Complexes - Stability Studies in Solutions
Seifert, S.; Kuenstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; et al. (10 authors)
- Radiochim. Acta 88 (2000) 239-245
Chemical and biological characterization of technetium(I) and rhenium(I) tricarbonyl complexes with dithioether ligands serving as linkers for coupling the Tc(CO)3 and Re(CO)3 moieties to biologically active molecules
Pietzsch, H.-J.; Gupta, A.; Reisgys, M.; Drews, A.; Seifert, S.; et al. (10 authors)
- Bioconjugate Chem. 11 (2000) 414-424
Oxorhenium mixed-ligand complexes with the 2,6-dimercaptomethylpyridine ligand. Crystal structure of [2,6-dimercaptomethylpyridinato][p-methoxybenzenethiolato]oxorhenium(V)
Nock, B.; Pietzsch, H.-J.; Tisato, F.; Maina, T.; Leibnitz, P.; et al. (7 authors)
- Inorg. Chim. Acta 304 (2000) 26-32
Stability Studies on 99mTechnetium(III) Complexes with Tridentate/Monodentate Thiol Ligands and Phosphine ("3+1+1" Complexes)
Seifert, S.; Drews, A.; Gupta, A.; Pietzsch, H.-J.; Spies, H.; et al. (6 authors)
- Appl. Radiat. Isot. 53 (2000) 431-438
Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.
Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; et al. (7 authors)
- Nucl. Med. Biol. 27 (2000) 135-141
1999
Study on the formation of mixed ligand oxorhenium and oxotechnetium complexes (SNS/S combination)
Papadopoulos, M.; Pirmettis, I.; Tsoukalas, C.; Nock, B.; Maina, T.; et al. (12 authors)
- Inorg. Chim. Acta 295 (1999) 1-8
Lipophilic urea-functionalized dendrimers as efficient carriers for oxyanions
Stephan, H.; Spies, H.; Johannsen, B.; Klein, L.; Vögtle, F.
- Chem. Commun., 1999, 1875-1876
First Application of fac-[99mTc(OH2)3(CO)3]+ in Bioorganometallic Chemistry: Design, Structure, and in Vitro Affinity of a 5-HT1A Receptor Ligand Labeled with 99mTc
Alberto, R.; Schibli, R.; Schubiger, P. A.; Abram, U.; Pietzsch, H.-J.; et al. (6 authors)
- J. Am. Chem. Soc. 121, 25, 1999, 6076-6077
Efficient phase transfer of pertechnetate with bicyclic guanidinium compounds
Stephan, H.; Berger, R.; Spies, H.; Johannsen, B.; Schmidtchen, F.-P.
- Journal of Radioanalytical and Nuclear Chemistry 242 (2) (1999) 399-403
Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT2A Receptor
Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; et al. (10 authors)
- Nuclear Medicine and Biology, 26 (1999) 865-875
1998
No Carrier Added Preparations of '3+1' Mixed-Ligand 99mTc Complexes
Seifert, S.; Pietzsch, H.-J.; Scheunemann, M.; Spies, H.; Syhre, R.; et al. (6 authors)
-
Appl. Radiat. Isot. Vol. 49, Nos 1-2, pp. 5-11, 1998
DOI: 10.1016/S0969-8043(97)00221-2
1997
Technetium and rhenium complexes with thioether ligands. VI. Synthesis and structural characterization of mixed-ligand oxorhenium(V) complexes containing bidentate dithioethers and monothiolato ligands.
Reisgys, M.; Spies, H.; Johannsen, B.; Leibnitz, P.; Pietzsch, H.-J.
- Chem. Ber. 130 (1997) 1343-1347
Synthesis of Rhenium(I) and Technetium(I) Carbonyl/Dithioether Ligand Complexes Bearing 3,17-BETA-Estradiol
Reisgys, M.; Wüst, F.; Alberto, R.; Schibli, R.; Schubiger, P. A.; et al. (8 authors)
-
Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 17, pp 2243-2246, 1997
DOI: 10.1016/S0960-894X(97)00396-X
Synthesis and Structural Characterization of Neutral Oxorhenium(V) Complexes with Tridentate Dithioethers
Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.
- Chemische Berichte 130 (1997) pp. 357-361
Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake
Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; et al. (8 authors)
- European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319
Technetium and Rhenium Complexes with Thioether Ligands, 5 Synthesis and Structural Characterization of Neutral Oxorhenium (V) Complexes with Tridentate Dithioethers
Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.
- Chemische Berichte, Recueil 1997, 130, 357-361
1996
Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations
Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; et al. (7 authors)
-
Journal of Nuclear Medicine and Biology 23 (1996) 429-438
DOI: 10.1016/0969-8051(96)00015-7
1995
Synthesis and reactions of trigonal-bipyramidal rhenium and technetium complexes with a tripodal, tetradentate NS3 ligand*
Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Lügger, T.
- Inorganica Chimica Acta 240 (1995) pp. 465-478
Neutral Oxorhenium(V) Complexes with Tridentate Dithiolates and Monodentate Alkane- or Arene-thiolate Coligands
Spies, H.; Fietz, T.; Pietzsch, H.-J.; Johannsen, B.; Leibnitz, P.; et al. (8 authors)
-
Journal of the Chemical Society Dalton Transactions (1995) 13 pp. 2277-2280
DOI: 10.1039/dt9950002277
Technetium- and Rhenium Complexes with Thioether Ligands-IV. Synthesis and Structural Characterization of Binuclear Oxorhenium (V) Complexes with Bidentate Thioether Coordination
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.
-
Polyhedron 14 (1995) 13-14 pp.1849-1853
DOI: 10.1016/0277-5387(94)00470-Y
Synthesis and molecular structure of chlore(3-thiapentane-1.5-dithiolato)oxorhenium(V)
Fietz, T.; Spies, H.; Pietzsch, H.-J.; Leibnitz, P.
-
Inorganica Chimica Acta 231 (1995) pp. 233-236
DOI: 10.1016/0020-1693(94)04351-U
1994
Trigonal-bipyramidale Technetium- und Rhenium-Komplexe mit vierzähnigen tripodalen NS3-Liganden
Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Kintzel, O.; et al. (6 authors)
- Angewandte Chemie 106 (1994) 13 pp. 1416-1419
1993
Technetium Complexes with Thioether Ligands
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.; Johannsen, B.
-
Radiochimica Acta 63 (1993) pp. 163-166
DOI: 10.1524/ract.1993.63.special-issue.163
Technetium Complexes with Thioether Ligands - III. Synthesis and Structural Characterization of Cationic Nitridotechnetium(V) Complexes with Thiacrown ethers
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.
- Polyhedron 12 (1993) 24 pp. 2995-3002