Publications of Institute of Radiopharmaceutical Cancer Research
216 Publications2024
[¹⁸F]Fluspidine – a PET tracer for imaging of σ1 receptors in the central nervous system
Ludwig, F.-A.; Laurini, E.; Schmidt, J.; Pricl, S.; Deuther-Conrad, W.; Wünsch, B.
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Pharmaceuticals 17(2024)166, 1-21
DOI: 10.3390/ph17020166
2023
Development of a Highly Specific 18F-labeled Radioligand for Imaging of Sigma-2 Receptor in Brain Tumor
Wang, T.; Wang, J.; Chen, L.; Zhang, X.; Mou, T.; An, X.; Zhang, J.; Zhang, X.; Deuther-Conrad, W.; Huang, Y.; Jia, H.
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Journal of Medicinal Chemistry 66(2023)18, 12840-12857
DOI: 10.1021/acs.jmedchem.3c00735
Cited 2 times in Scopus
Radiosynthesis and biological evaluation of [¹⁸F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in gliomas
Lai, T. H.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Arnaud, L.; Maisonial-Besset, A.; Weber, V.; Moldovan, R.-P.; Meister, S.; Pietzsch, J.; Kopka, K.; Juratli, T. A.; Deuther-Conrad, W.; Toussaint, M.
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European Journal of Nuclear Medicine and Molecular Imaging (2023)
Online First (2023) DOI: 10.1007/s00259-023-06515-7
Cited 1 times in Scopus
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
Ueberham, L.; Gündel, D.; Kellert, M.; Deuther-Conrad, W.; Ludwig, F.-A.; Lönnecke, P.; Kazimir, A.; Kopka, K.; Brust, P.; Moldovan, R.-P.; Hey-Hawkins, E.
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Data publication, PET: Development of the High-Affinity Carborane-Based …
ROBIS: 37489 HZDR-primary research data are used by this (Id 36975) publication
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Journal of Medicinal Chemistry 66(2023), 5242-5260
Online First (2023) DOI: 10.1021/acs.jmedchem.3c00195
Cited 4 times in Scopus
Radiofluorination of an anionic, azide-functionalized teroligomer by copper-catalyzed azide-alkyne cycloaddition
Wenzel, B.; Schmid, M.; Teodoro, R.; Moldovan, R.-P.; Lai, T. H.; Mitrach, F.; Kopka, K.; Fischer, B.; Schulz-Siegmund, M.; Brust, P.; Hacker, M. C.
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Nanomaterials 13(2023)14, 2095
DOI: 10.3390/nano13142095
Cited 1 times in Scopus
Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells
Abdelfatah Saleh Hassan, H. A.; Mitwasi, N.; Ullrich, M.; Kubeil, M.; Toussaint, M.; Deuther-Conrad, W.; Neuber, C.; Arndt, C.; Rodrigues Loureiro, L. R.; Kegler, A.; González Soto, K. E.; Belter, B.; Rössig, C.; Pietzsch, J.; Frenz, M.; Bachmann, M.; Feldmann, A.
Involved research facilities
- PET-Center
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Frontiers in Immunology 14(2023), 1166169
DOI: 10.3389/fimmu.2023.1166169
Cited 4 times in Scopus
Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential
Harrington, S.; Pyche, J.; Andrew, R. B.; Spalholz, T.; Ryan, K. T.; Baker, R. J.; Ching, J.; Rufener, L.; Lautens, M.; Kulke, D.; Vernudachi, A.; Zamanian, M.; Deuther-Conrad, W.; Brust, P.; Roy, P. J.
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Nature Communications 14(2023), 1816
DOI: 10.1038/s41467-023-37452-6
Cited 4 times in Scopus
Imaging of Gαq proteins in mouse and human organs and tissues
Voss, J. H.; Al-Hroub, H.; Gedschold, R.; Dietrich, J.; Gaffal, E.; Toma, M.; Kehraus, S.; König, G. M.; Brust, P.; Fleischmann, B. K.; Wenzel, D.; Deuther-Conrad, W.; Müller, C. E.
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Pharmaceutics 15(2023)1, 57
Online First (2022) DOI: 10.3390/pharmaceutics15010057
Cited 1 times in Scopus
Selective a3b4 nicotinic acetylcholine receptor ligand as a potential tracer for drug addiction
Kanasuwan, A.; Deuther-Conrad, W.; Sarasamkan, J.; Chotipanich, C.; Vajragupta, O.; Arunrungvichian, K.
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International Journal of Molecular Sciences 24(2023)4, 3614
DOI: 10.3390/ijms24043614
Cited 2 times in Scopus
Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [18F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET
Teodoro, R.; Gündel, D.; Deuther-Conrad, W.; Toussaint, M.; Wenzel, B.; Bormans, G.; Kopka, K.; Brust, P.; Moldovan, R.-P.
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Data publication: Enantioselective Synthesis, Structure Activity Relationship …
ROBIS: 36778 HZDR-primary research data are used by this (Id 35005) publication
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Journal of Medicinal Chemistry 66(2023)20, 13991–14010
Online First (2023) DOI: 10.1021/acs.jmedchem.3c01035
Cited 2 times in Scopus
2022
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
Keuler, T.; Lemke, C.; Elsinghorst, P. W.; Iriepa, I.; Chioua, M.; Martínez-Grau, M. A.; Beadle, C. D.; Vetman, T.; López-Muñoz, F.; Wille, T.; Bartz, U.; Deuther-Conrad, W.; Marco-Contelles, J.; Gütschow, M.
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ACS Pharmacology & Translational Science 5(2022)11, 1097-1108
DOI: 10.1021/acsptsci.2c00097
Cited 2 times in Scopus
Radiosynthesis and preclinical evaluation of an 18F-labeled tri-azolopyridopyrazine-based inhibitor for neuroimaging of the phosphodiesterase 2A (PDE2A)
Wenzel, B.; Fritzsche, S. R.; Toussaint, M.; Briel, D.; Kopka, K.; Brust, P.; Scheunemann, M.; Deuther-Conrad, W.
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Pharmaceuticals 15(2022)10, 1272
DOI: 10.3390/ph15101272
PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders
Tiepolt, S.; Meyer, P. M.; Patt, M.; Deuther-Conrad, W.; Hesse, S.; Barthel, H.; Sabri, O.
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Journal of Nuclear Medicine 63(2022), 33S-44S
DOI: 10.2967/jnumed.121.263198
Cited 20 times in Scopus
Novel radioiodinated and radiofluorinated analogues of FT-2102 for SPECT or PET imaging of mIDH1 mutant tumours
Weber, V.; Arnaud, L.; Dukic-Stefanovic, S.; Wenzel, B.; Roux, V.; Chezal, J.-M.; Hang Lai, T.; Teodoro, R.; Kopka, K.; Miot-Noirault, E.; Deuther-Conrad, W.; Maisonial-Besset, A.
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Molecules 27(2022)12, 3766
DOI: 10.3390/molecules27123766
Cited 2 times in Scopus
Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP
Wang, T.; Zhang, Y.; Zhang, X.; Chen, L.; Zheng, M.-Q.; Zhang, J.; Brust, P.; Deuther-Conrad, W.; Huang, Y.; Jia, H.
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Chinese Chemical Letters 33(2022)7, 3543-3548
Online First (2022) DOI: 10.1016/j.cclet.2022.03.099
Cited 6 times in Scopus
Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery
Mitrach, F.; Schmid, M.; Toussaint, M.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Franke, H.; Ewe, A.; Aigner, A.; Wölk, C.; Brust, P.; Hacker, M. C.; Schulz-Siegmund, M.
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Pharmaceutics 14(2022)2, 326
DOI: 10.3390/pharmaceutics14020326
Cited 6 times in Scopus
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Bernardes, E.; Caravan, P.; van Dam, M.; Deuther-Conrad, W.; Ellis, B.; Furumoto, S.; Guillet, B.; Huang, Y.-Y.; Jia, H.; Laverman, P.; Li, Z.; Liu, Z.; Lodi, F.; Miao, Y.; Perk, L.; Schirrmacher, R.; Vercoullie, J.; Yang, H.; Yang, M.; Yang, X.; Zhang, J.; Zhang, M.-R.; Zhu, H.
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EJNMMI Radiopharmacy and Chemistry 7(2022)1, 9
DOI: 10.1186/s41181-022-00162-3
Cited 1 times in Scopus
Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain
Clauß, O.; Schäker-Hübner, L.; Wenzel, B.; Toussaint, M.; Deuther-Conrad, W.; Gündel, D.; Teodoro, R.; Dukic-Stefanovic, S.; Ludwig, F.-A.; Kopka, K.; Brust, P.; Hansen, F. K.; Scheunemann, M.
Related publications
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Data publication: Development and Biological Evaluation of the First Highly …
ROBIS: 34366 HZDR-primary research data are used by this (Id 34169) publication
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Pharmaceuticals 15(2022)3, 324
DOI: 10.3390/ph15030324
Structure-Based Design, Optimization and Development of [18F]LU13, a novel radioligand for CB2R Imaging in the Brain with PET
Gündel, D.; Deuther-Conrad, W.; Ueberham, L.; Kaur, S.; Otikova, E.; Teodoro, R.; Lai, T. H.; Clauß, O.; Scheunemann, M.; Bormans, G.; Bachmann, M.; Kopka, K.; Brust, P.; Moldovan, R.-P.
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Data Publication: Structure-Based Design, Optimization and Development of …
ROBIS: 34030 HZDR-primary research data are used by this (Id 33987) publication
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Journal of Medicinal Chemistry 65(2022)13, 9034-9049
Online First (2022) DOI: 10.1021/acs.jmedchem.2c00256
Cited 9 times in Scopus
Automated radiosynthesis of the adenosine A2A receptor-targeting radiotracer [18F]FLUDA
Lai, T. H.; Wenzel, B.; Moldovan, R.-P.; Brust, P.; Kopka, K.; Teodoro, R.
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[18F]FLUDA automation
ROBIS: 33655 HZDR-primary research data are used by this (Id 33558) publication
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Journal of Labelled Compounds and Radiopharmaceuticals 65(2022), 162-166
Online First (2022) DOI: 10.1002/jlcr.3970
Quantitation of the A2A adenosine receptor density in the striatum of mice and pigs with [18F]FLUDA by positron emission tomography
Gündel, D.; Toussaint, M.; Lai, T. H.; Deuther-Conrad, W.; Cumming, P.; Schröder, S.; Teodoro, R.; Moldovan, R.-P.; Pan-Montojo, F.; Sattler, B.
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Pharmaceuticals 15(2022), 516
DOI: 10.3390/ph15050516
Cited 4 times in Scopus
Non-invasive assessment of locally overexpressed human adenosine 2A receptors in the heart of transgenic mice
Gündel, D.; Lai, T. H.; Dukic-Stefanovic, S.; Teodoro, R.; Deuther-Conrad, W.; Toussaint, M.; Moldovan, R.-P.; Kopka, K.; Boknik, P.; Hofmann, B.; Gergs, U.; Neumann, J.; Brust, P.
Related publications
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Data publication: Non-invasive assessment of locally overexpressed human …
ROBIS: 34310 HZDR-primary research data are used by this (Id 33505) publication
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International Journal of Molecular Sciences 23(2022)3, 1025
DOI: 10.3390/ijms23031025
Cited 1 times in Scopus
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors
Zhang, Y.; Wang, T.; Zhang, X.; Deuther-Conrad, W.; Fu, H.; Cui, M.; Zhang, J.; Brust, P.; Huang, Y.; Jia, H.
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Acta Pharmaceutica Sinica B 12(2022)3, 1406-1415
Online First (2021) DOI: 10.1016/j.apsb.2021.08.029
Cited 6 times in Scopus
2021
Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels
Weiner, J.; Roth, L.; Kranz, M.; Brust, P.; Boelen, A.; Klöting, N.; Heiker, J. T.; Blüher, M.; Tönjes, A.; Pfluger, P. T.; Stumvoll, M.; Mittag, J.; Krause, K.
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Molecular Metabolism 54(2021), 101348
DOI: 10.1016/j.molmet.2021.101348
Cited 7 times in Scopus
Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease
Schaffernicht, G.; Shang, Q.; Stievenard, A.; Bötzel, K.; Dening, Y.; Kempe, R.; Toussaint, M.; Gündel, D.; Kranz, M.; Reichmann, H.; Vanbesien-Mailliot, C.; Brust, P.; Dieterich, M.; Funk, R. H. W.; Ravens, U.; Pan-Montojo, F.
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Frontiers in Neurology 12(2021), 642604
DOI: 10.3389/fneur.2021.642604
Cited 8 times in Scopus
Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain
Teodoro, R.; Gündel, D.; Ueberham, L.; Toussaint, M.; Bormans, G.; Brust, P.; Deuther-Conrad, W.; Moldovan, R.-P.
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Data Publication: Development of [18F]LU14 for PET Imaging of Cannabinoid …
ROBIS: 33389 HZDR-primary research data are used by this (Id 32557) publication
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International Journal of Molecular Sciences 22(2021)15, 8051
Online First (2021) DOI: 10.3390/ijms22158051
Cited 7 times in Scopus
Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands
Aly, M. W.; Ludwig, F.-A.; Deuther-Conrad, W.; Brust, P.; Abadi, A. H.; Moldovan, R.-P.; Osman, N. A.
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Data publication: Development of fluorinated and methoxylated benzothiazole …
ROBIS: 33347 HZDR-primary research data are used by this (Id 32530) publication
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Bioorganic Chemistry 114(2021), 105191
Online First (2021) DOI: 10.1016/j.bioorg.2021.105191
Cited 4 times in Scopus
Synthesis of novel fluorinated xanthine derivatives with high adenosine A2B receptor binding affinity
Lindemann, M.; Dukic-Stefanovic, S.; Hinz, S.; Deuther-Conrad, W.; Teodoro, R.; Juhl, C.; Steinbach, J.; Brust, P.; Müller, C. E.; Wenzel, B.
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Pharmaceuticals 14(2021), 485
DOI: 10.3390/ph14050485
Cited 1 times in Scopus
Design, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant 18F-labelled σ2 receptor ligand
Moldovan, R.-P.; Gündel, D.; Teodoro, R.; Ludwig, F.-A.; Fischer, S.; Toussaint, M.; Schepmann, D.; Wünsch, B.; Brust, P.; Deuther-Conrad, W.
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Data publication: Design, radiosynthesis and preliminary biological evaluation …
ROBIS: 33346 HZDR-primary research data are used by this (Id 32485) publication
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International Journal of Molecular Sciences 22(2021)11, 5447
DOI: 10.3390/ijms22115447
Cited 6 times in Scopus
Challenges on cyclic nucleotide phosphodiesterases imaging with positron emission tomography: Novel radioligands and (pre-)clinical insights since 2016
Schröder, S.; Scheunemann, M.; Wenzel, B.; Brust, P.
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International Journal of Molecular Sciences 22(2021)8, 3832
DOI: 10.3390/ijms22083832
Cited 3 times in Scopus
Validation of an LC-MS/MS method to quantify the new TRPC6 inhibitor SH045 (larixyl N-methylcarbamate) and its application in an exploratory pharmacokinetic study in mice
Chai, X.-N.; Ludwig, F.-A.; Müglitz, A.; Schaefer, M.; Yin, H.-Y.; Brust, P.; Regenthal, R.; Krügel, U.
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Pharmaceuticals 14(2021), 259
DOI: 10.3390/ph14030259
Cited 3 times in Scopus
Preclinical evaluation of [18F]FACH in healthy mice and piglets: An 18F-labeled ligand for imaging of monocarboxylate transporters with PET
Gündel, D.; Sadeghzadeh, M.; Deuther-Conrad, W.; Wenzel, B.; Cumming, P.; Toussaint, M.; Ludwig, F.-A.; Moldovan, R.-P.; Kranz, M.; Teodoro, R.; Sattler, B.; Sabri, O.; Brust, P.
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International Journal of Molecular Sciences 22(2021)4, 1645
Online First (2021) DOI: 10.3390/ijms22041645
ISSN: 1422-0067
Cited 1 times in Scopus
Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor
Lai, T. H.; Toussaint, M.; Teodoro, R.; Dukic-Stefanovic, S.; Kranz, M.; Deuther-Conrad, W.; Moldovan, R.-P.; Brust, P.
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International Journal of Molecular Sciences 22(2021)3, 1182
DOI: 10.3390/ijms22031182
Cited 10 times in Scopus
Development of 18F-labeled radiotracers for PET imaging of the adenosine A2A receptor: Synthesis, radiolabeling and preliminary biological evaluation
Lai, T. H.; Schröder, S.; Toussaint, M.; Dukic-Stefanovic, S.; Kranz, M.; Ludwig, F.-A.; Fischer, S.; Steinbach, J.; Deuther-Conrad, W.; Brust, P.; Moldovan, R.-P.
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International Journal of Molecular Sciences 22(2021)5, 2285
DOI: 10.3390/ijms22052285
Cited 5 times in Scopus
Improved in vivo PET imaging of the adenosine A2A receptor in the brain using [18F]FLUDA, a deuterated radiotracer with high metabolic stability
Lai, T. H.; Toussaint, M.; Teodoro, R.; Dukic-Stefanovic, S.; Gündel, D.; Ludwig, F.-A.; Wenzel, B.; Schröder, S.; Sattler, B.; Moldovan, R.-P.; Falkenburger, B. H.; Sabri, O.; Deuther-Conrad, W.; Brust, P.
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European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 2727-2736
DOI: 10.1007/s00259-020-05164-4
Cited 15 times in Scopus
In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain
Dukic-Stefanovic, S.; Lai, T. H.; Toussaint, M.; Clauß, O.; Jevtić, I. I.; Penjišević, J. Z.; Andrić, D.; Ludwig, F.-A.; Gündel, D.; Deuther-Conrad, W.; Kostić-Rajačić, S. V.; Brust, P.; Teodoro, R.
Involved research facilities
- PET-Center
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Bioorganic & Medicinal Chemistry Letters 48(2021), 128254
DOI: 10.1016/j.bmcl.2021.128254
Cited 7 times in Scopus
Studies on the affinity of 6-[(: N -(cyclo)aminoalkyl)oxy]-4 H -chromen-4-ones for sigma 1/2 receptors
Deuther-Conrad, W.; Diez-Iriepa, D.; Iriepa, I.; López-Muñoz, F.; Martínez-Grau, A. M.; Gütschow, M.; Marco-Contelles, J.
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RSC Medicinal Chemistry 12(2021)6, 1000-1004
DOI: 10.1039/D1MD00105A
Cited 4 times in Scopus
Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study
Grachev, I.; Meyer, P.; Becker, G.; Bronzel, M.; Marsteller, D.; Pastino, G.; Voges, O.; Rabinovich, L.; Knebel, H.; Zientek, F.; Rullmann, M.; Sattler, B.; Patt, M.; Gerhards, T.; Strauss, M.; Kluge, A.; Brust, P.; Savola, J.; Gordon, M.; Geva, M.; Hesse, S.; Barthel, H.; Hayden, M.; Sabri, O.
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European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 1103-1115
Online First (2020) DOI: 10.1007/s00259-020-05030-3
Cited 25 times in Scopus
(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand – Results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls
Tiepolt, S.; Becker, G.-A.; Wilke, S.; Cecchin, D.; Rullmann, M.; Meyer, P. M.; Barthel, H.; Hesse, S.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Sattler, B.; Deuther-Conrad, W.; Ludwig, F.-A.; Fischer, S.; Gertz, H.-J.; Smits, R.; Hoepping, A.; Steinbach, J.; Brust, P.; Sabri, O.
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European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 731-746
Online First (2020) DOI: 10.1007/s00259-020-05029-w
Cited 9 times in Scopus
2020
In silico finding of key interaction mediated α3β4 and α7 nicotinic acetylcholine receptor ligand selectivity of quinuclidine-triazole chemotype
Arunrungvichian, K.; Chongruchiroj, S.; Sarasamkan, J.; Schüürmann, G.; Brust, P.; Vajragupta, O.
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International Journal of Molecular Sciences 21(2020)17, 6189
DOI: 10.3390/ijms21176189
Cited 5 times in Scopus
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity
Gnad, T.; Navarro, G.; Lahesmaa, M.; Reverte-Salisa, L.; Copperi, F.; Cordomi, A.; Naumann, J.; Hochh€Auser, A.; Haufs-Brusberg, S.; Wenzel, D.; Suhr, F.; Zenius Jespersen, N.; Scheele, C.; Tsvilovskyy, V.; Brinkmann, C.; Rittweger, J.; Dani, C.; Kranz, M.; Deuther-Conrad, W.; Eltzschig, H. K.; Niemi, T.; Taittonen, M.; Brust, P.; Nuutila, P.; Pardo, L.; Fleischmann, B. K.; Bleuher, M.; Franco, R.; Bloch, W.; Virtanen, K. A.; Pfeifer, A.
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Cell Metabolism 32(2020), 56-70
DOI: 10.1016/j.cmet.2020.06.006
Cited 73 times in Scopus
Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S)-(-)-[ 18 F]Fluspidine in Glioblastoma
Toussaint, M.; Deuther-Conrad, W.; Kranz, M.; Fischer, S.; Ludwig, F.-A.; Juratli, T.; Patt, M.; Wünsch, B.; Schackert, G.; Sabri, O.; Brust, P.
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Molecules 25(2020)9, 2170
DOI: 10.3390/molecules25092170
Cited 6 times in Scopus
Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors
Tian, J.; He, Y.; Deuther-Conrad, W.; Fu, H.; Xie, F.; Zhang, Y.; Wang, T.; Zhang, X.; Zhang, J.; Brust, P.; Huang, Y.; Jia, H.
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Bioorganic & Medicinal Chemistry 28(2020)14, 115560
DOI: 10.1016/j.bmc.2020.115560
Cited 6 times in Scopus
Development of a radiofluorinated adenosine A2B receptor antagonist as potential ligand for PET imaging
Lindemann, M.; Moldovan, R.-P.; Hinz, S.; Deuther-Conrad, W.; Gündel, D.; Dukic-Stefanovic, S.; Toussaint, M.; Teodoro, R.; Juhl, C.; Steinbach, J.; Brust, P.; Müller, C. E.; Wenzel, B.
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International Journal of Molecular Sciences 21(2020), 3197
DOI: 10.3390/ijms21093197
Cited 3 times in Scopus
Development of novel analogs of the monocarboxylate transporter ligand FACH and biological validation of one potential radiotracer for PET imaging
Sadeghzadeh, M.; Wenzel, B.; Gündel, D.; Deuther-Conrad, W.; Toussaint, M.; Moldovan, R.-P.; Fischer, S.; Teodoro, R.; Jonnalagadda, S.; Jonnalagadda, S. K.; Mereddy, V. R.; Drewes, L. R.; Brust, P.
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Molecules 25(2020)10, 2309
DOI: 10.3390/molecules25102309
Cited 4 times in Scopus
Preclinical incorporation dosimetry of [18F]FACH - a novel 18F-labeled MCT1/MCT4 lactate transporter inhibitor for imaging cancer metabolism with PET
Sattler, B.; Kranz, M.; Wenzel, B.; Thachaantara Jain, N.; Moldovan, R.-P.; Toussaint, M.; Deuther-Conrad, W.; Ludwig, F.-A.; Teodoro, R.; Sattler, T.; Sadeghzadeh, M.; Sabri, O.; Brust, P.
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Molecules 25(2020)9, 2024
DOI: 10.3390/molecules25092024
Cited 2 times in Scopus
The sigma-1 receptor: potential role in the modulation of cellular radiation sensitivity
Belter, B.; Deuther-Conrad, W.; Hofheinz, F.; Bachmann, M.; Brust, P.; Pietzsch, J.
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Journal of Cellular Biotechnology 6(2020), 13-21
DOI: 10.3233/JCB-209007
Newly synthesized fluorinated cinnamylpiperazines possessing low in vitro MAO-B binding
Jevtić, I. I.; Lai, T. H.; Penjišević, J. Z.; Dukic-Stefanovic, S.; Andrić, D. B.; Brust, P.; Kostić-Rajačić, S. V.; Teodoro, R.
Involved research facilities
- PET-Center
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Molecules 25(2020)21, 4941
Online First (2020) DOI: 10.3390/molecules25214941
Cited 4 times in Scopus
PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy
Schröder, S.; Lai, T. H.; Toussaint, M.; Kranz, M.; Chovsepian, A.; Shang, Q.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Teodoro, R.; Wenzel, B.; Moldovan, R.-P.; Pan-Montojo, F.; Brust, P.
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Molecules 25(2020)7, 1633
DOI: 10.3390/molecules25071633
Cited 14 times in Scopus
2019
Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- based Radioligand for Imaging of Phosphodiesterase 2A with Positron Emission Tomography
Ritawidya, R.; Wenzel, B.; Teodoro, R.; Toussaint, M.; Kranz, M.; Deuther-Conrad, W.; Dukic-Stefanovic, S.; Ludwig, F.-A.; Scheunemann, M.; Brust, P.
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Molecules 24(2019)22, 4149
DOI: 10.3390/molecules24224149
Cited 5 times in Scopus
One-step radiosynthesis of the MCTs imaging agent [18F]FACH by aliphatic 18F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group
Sadeghzadeh, M.; Moldovan, R.-P.; Teodoro, R.; Brust, P.; Wenzel, B.
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Scientific Reports 9(2019), 18890
DOI: 10.1038/s41598-019-55354-w
Cited 6 times in Scopus
Structure–Affinity Relationships of Fluorinated Spirocyclic Sigma2 Receptor Ligands with an Exocyclic Benzylamino Moiety
Bergkemper, M.; Kronenberg, E.; Schepmann, D.; Ludwig, F.-A.; Brust, P.; Wünsch, B.
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ChemMedChem 14(2019), 1392-1402
Online First (2019) DOI: 10.1002/cmdc.201900284
Cited 2 times in Scopus
¹⁸F-Labeled benzylpiperazine derivatives as highly selective ligands for imaging σ1 receptor with positron emission tomography
Ye, J.; Wang, L.; Deuther-Conrad, W.; Chen, Y.; Zhang, X.; Zhang, J.; Huang, Y.; Brust, P.; Jia, H.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 425-437
DOI: 10.1002/jlcr.3738
Cited 2 times in Scopus
Synthesis and in vitro evaluation of 8-pyridinyl substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A (PDE2A) inhibitors
Ritawidya, R.; Ludwig, F.-A.; Briel, D.; Brust, P.; Scheunemann, M.
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Molecules 24(2019)15, 2791
DOI: 10.3390/molecules24152791
Cited 9 times in Scopus
SPECT-Untersuchungen mit dem 123 I-markierten Dopamintransporter-Liganden FP-CIT (DaTSCAN):DGN-Handlungsempfehlung (S1-Leitlinie)
Tatsch, K.; Buchert, R.; Bartenstein, P.; Barthel, H.; Boecker, H.; Brust, P.; Drzezga, A.; La Fougère, C.; Gründer, G.; Grünwald, F.; Krause, B.-J.; Kuwert, T.; Langen, K.-J.; Rominger, A.; Sabri, O.; Schreckenberger, M.; Meyer, P. T.
- Nuklearmedizin 58(2019)1, 5-16
In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – a Radioligand for Imaging σ1 Receptors with Positron Emission Tomography (PET)
Ludwig, F.-A.; Fischer, S.; Houska, R.; Hoepping, A.; Deuther-Conrad, W.; Schepmann, D.; Patt, M.; Meyer, P.; Hesse, S.; Becker, G.-A.; Zientek, F. R.; Steinbach, J.; Wünsch, B.; Sabri, O.; Brust, P.
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Frontiers in Pharmacology 10(2019), 534
DOI: 10.3389/fphar.2019.00534
Cited 9 times in Scopus
Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)
Sadeghzadeh, M.; Moldovan, R.-P.; Fischer, S.; Wenzel, B.; Ludwig, F.-A.; Teodoro, R.; Deuther-Conrad, W.; Jonnalagadda, S.; K. Jonnalagadda, S.; Gudelis, E.; Šačkus, A.; R. Mereddy, V.; R. Drewes, L.; Brust, P.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 411-424
DOI: 10.1002/jlcr.3739
Cited 6 times in Scopus
Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18
Wenzel, B.; Liu, J.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Teodoro, R.; Ludwig, F.-A.; Chezal, J.-M.; Moreau, E.; Brust, P.; Maisonial-Besset, A.
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Bioorganic Chemistry 86(2019), 346-362
DOI: 10.1016/j.bioorg.2019.01.037
Cited 14 times in Scopus
Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation
Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Neumann, W.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Hey-Hawkins, E.; Krügel, U.; Brust, P.
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European Journal of Medicinal Chemistry (2019), 142-159
Online First (2019) DOI: 10.1016/j.ejmech.2019.01.006
Cited 13 times in Scopus
2018
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety
Bergkemper, M.; Kronenberg, E.; Thum, S.; Börgel, F.; Daniliuc, C.; Schepmann, D.; Nieto, F. R.; Brust, P.; Reinoso, R. F.; Alvarez, I.; Wünsch, B.
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Journal of Medicinal Chemistry 61(2018), 9666-9690
DOI: 10.1021/acs.jmedchem.8b01183
Cited 10 times in Scopus
Fourier Analysis of Cerebral Metabolism of Glucose: Gender Differences in Mechanisms of Color Processing in the Ventral and Dorsal Streams in Mice
Njemanze, P. C.; Kranz, M.; Brust, P.
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Forecasting 1(2018), 135-156
DOI: 10.3390/forecast1010010
ISSN: 2571-9394
Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition and H3R Antagonism with Sigma 1R Agonism Profile
Bautista-Aguilera, O. M.; Budni, J.; Mina, F.; Medeiros, E. B.; Deuther-Conrad, W.; Entrena, J. M.; Moraleda, I.; Iriepa, I.; López-Muñoz, F.; Marco-Contelles, J.
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Journal of Medicinal Chemistry 61(2018), 6937-6943
DOI: 10.1021/acs.jmedchem.8b00848
Cited 41 times in Scopus
Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia
Sabri, O.; Meyer, P. M.; Gräf, S.; Hesse, S.; Wilke, S.; Becker, G.-A.; Rullmann, M.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Tiepolt, S.; Fischer, S.; Deuther-Conrad, W.; Hegerl, U.; Barthel, H.; Schönknecht, P.; Brust, P.
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Brain 141(2018)6, 1840-1854
DOI: 10.1093/brain/awy099
Cited 54 times in Scopus
Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor
Lindemann, M.; Hinz, S.; Deuther-Conrad, W.; Namasivayam, V.; Dukic-Stefanovic, S.; Teodoro, R.; Toussaint, M.; Kranz, M.; Juhl, C.; Steinbach, J.; Brust, P.; Müller, C. E.; Wenzel, B.
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Bioorganic & Medicinal Chemistry 26(2018), 4650-4663
DOI: 10.1016/j.bmc.2018.07.045
Cited 17 times in Scopus
Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET
Teodoro, R.; Scheunemann, M.; Wenzel, B.; Peters, D.; Deuther-Conrad, W.; Brust, P.
Involved research facilities
- PET-Center
-
Bioorganic & Medicinal Chemistry Letters 28(2018), 1471-1475
DOI: 10.1016/j.bmcl.2018.03.081
Cited 6 times in Scopus
Exploring the Metabolism of (+)-[18F]Flubatine in vitro and in vivo: LC-MS/MS aided Identification of Radiometabolites in a Clinical PET Study
Ludwig, F.-A.; Fischer, S.; Smits, R.; Deuther-Conrad, W.; Hoepping, A.; Tiepolt, S.; Patt, M.; Sabri, O.; Brust, P.
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Molecules 23(2018)1, 464
DOI: 10.3390/molecules23020464
Cited 8 times in Scopus
Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Kranz, M.; Scheunemann, M.; Egerland, U.; Höfgen, N.; Briel, D.; Steinbach, J.; Brust, P.
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Molecules 23(2018)3, 556
DOI: 10.3390/molecules23030556
Cited 8 times in Scopus
Bridging from Brain to Tumor imaging: (S)- and (R)-[18F]Fluspidine for investigation of Sigma-1 Receptors in Tumor-bearing Mice
Kranz, M.; Bergmann, R.; Kniess, T.; Belter, B.; Neuber, C.; Cai, Z.; Deng, G.; Fischer, S.; Steinbach, J.; Zhou, J.; Huang, H.; Brust, P.; Deuther-Conrad, W.; Pietzsch, J.
Involved research facilities
- PET-Center
-
Molecules 23(2018)3, 702
DOI: 10.3390/molecules23030702
Cited 7 times in Scopus
2017
Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment
Mattei, D.; Ivanov, A.; Ferrai, C.; Jordan, P.; Guneykaya, D.; Buonfiglioli, A.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Patt, M.; Sabri, O.; Ross, T. L.; Eggen, B. J. L.; Bodecke, E. W. G. M.; Kaminska, B.; Beule, D.; Pombo, A.; Kettenmann, H.; Wolf, S. A.
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Translational Psychiatry 7(2017)e1120, 1-13
DOI: 10.1038/tp.2017.80
Cited 148 times in Scopus
PET Imaging Evaluation of Four sigma1 Radiotracers in Nonhuman Primates
Baum, E.; Cai, Z.; Bois, F.; Holden, D.; Lin, S.-F.; Lara-Jaime, T.; Kapinos, M.; Chen, Y.; Deuther-Conrad, W.; Fischer, S.; Dukic-Stefanovic, S.; Bunse, P.; Wünsch, B.; Brust, P.; Jia, H.; Huang, Y.
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Journal of Nuclear Medicine 58(2017)6, 982
DOI: 10.2967/jnumed.116.188052
Cited 21 times in Scopus
1‑(4‑[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ1 Receptors in the Brain
He, Y.; Xie, F.; Ye, J.; Deuther-Conrad, W.; Cui, B.; Wang, L.; Lu, J.; Steinbach, J.; Brust, P.; Huang, Y.; Lu, J.; Jia, H.
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Journal of Medicinal Chemistry 60(2017), 4161-4172
DOI: 10.1021/acs.jmedchem.6b01723
Cited 24 times in Scopus
18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain
Wang, L.; Ye, J.; He, Y.; Deuther-Conrad, W.; Zhang, J.; Zhang, X.; Cui, M.; Steinbach, J.; Huang, Y.; Brust, P.; Jia, H.
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Bioorganic & Medicinal Chemistry 25(2017), 3792-3802
DOI: 10.1016/j.bmc.2017.05.019
Cited 16 times in Scopus
Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter
Roslin, S.; de Rosa, M.; Deuther-Conrad, W.; Eriksson, J.; Odell, L. R.; Antoni, G.; Brust, P.; Larhed, M.
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Bioorganic & Medicinal Chemistry 25(2017)19, 5095-5106
DOI: 10.1016/j.bmc.2017.01.041
Cited 5 times in Scopus
Radiosynthesis of (S)-[18F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors
Sarasamkan, J.; Fischer, S.; Deuther-Conrad, W.; Ludwig, F.-A.; Scheunemann, M.; Arunrungvichian, K.; Vajragupta, O.; Brust, P.
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Applied Radiation and Isotopes 124(2017), 106-113
DOI: 10.1016/j.apradiso.2017.03.015
Cited 5 times in Scopus
Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
Lindemann, M.; Deuther-Conrad, W.; Moldovan, R.; Sekhar, K. V. G. C.; Brust, P.; Wenzel, B.
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Bioorganic & Medicinal Chemistry 25(2017)19, 5107-5113
Online First (2017) DOI: 10.1016/j.bmc.2017.03.028
Cited 7 times in Scopus
Development of highly affine and selective fluorinated cannabinoid receptor type 2 ligands
Moldovan, R.-P.; Hausmann, K.; Deuther-Conrad, W.; Brust, P.
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ACS Medicinal Chemistry Letters (2017), 566-571
DOI: 10.1021/acsmedchemlett.7b00129
Cited 10 times in Scopus
Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
Moldovan, R.-P.; Els-Heindl, S.; Worm, D. J.; Kniess, T.; Kluge, M.; Beck-Sickinger, A. G.; Deuther-Conrad, W.; Krügel, U.; Brust, P.
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International Journal of Molecular Sciences 18(2017)4, 768
Online First (2017) DOI: 10.3390/ijms18040768
Cited 9 times in Scopus
PET Imaging of α7 Nicotinic Acetylcholine Receptors: A comparative study of [18F]ASEM and [18F]DBT-10 in non-human primates, and further evaluation of [18F]ASEM in humans
Hillmer, A. T.; Li, S.; Zheng, M.-Q.; Scheunemann, M.; Lin, S.-F.; Nabulsi, N.; Holden, D.; Pracitto, R.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Esterlis, I.; Cosgrove, K. P.; Carson, R. E.; Brust, P.; Huang, Y.
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European Journal of Nuclear Medicine and Molecular Imaging 44(2017)6, 1042-1050
DOI: 10.1007/s00259-017-3621-8
Cited 42 times in Scopus
Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain µ-opioid Receptor Availability in Diet-Induced Obese Male Rats
Hankir, M.; Patt, M.; Patt, J.; Becker, G.; Rullmann, M.; Kranz, M.; Deuther-Conrad, W.; Schichke, K.; Seyfried, F.; Brust, P.; Hesse, S.; Sabri, O.; Krügel, U.; Fenske, W.
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Frontiers in Neuroscience 10(2017), 620
Online First (2016) DOI: 10.3389/fnins.2016.00620
Cited 16 times in Scopus
Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes
Liu, J.; Maisonial-Besset, A.; Wenzel, B.; Canitrot, D.; Baufond, A.; Chezal, J. M.; Brust, P.; Moreau, E.
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European Journal of Medicinal Chemistry 136(2017), 548-560
DOI: 10.1016/j.ejmech.2017.03.091
Cited 21 times in Scopus
Gender Differences in Neural Networks for Color Processing in Mice: A PET/MR Study
Njemanze, P. C.; Kranz, M.; Amend, M.; Wehrl, H.; Brust, P.
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PLOS ONE 12(2017)7, e0179919.
DOI: 10.1371/journal.pone.0179919
Cited 3 times in Scopus
Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein deficient mice
Hankir, M. K.; Kranz, M.; Keipert, S.; Andreasen, S.; Kern, M.; Patt, M.; Klöting, N.; Hesse, S.; Brust, P.; Jastroch, M.; Fenske, W. K.
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Journal of Nuclear Medicine 58(2017)7, 1100-1103
Online First (2017) DOI: 10.2967/jnumed.116.186460
Cited 69 times in Scopus
Synthesis and Preliminary Biological Evaluation of Indol-3-yl-oxoacetamides as Potent Cannabinoid Receptor Type 2 Ligands
Moldovan, R.-P.; Deuther-Conrad, W.; Horti, A. G.; Brust, P.
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Molecules 22(2017)1, 77
DOI: 10.3390/molecules22010077
Cited 3 times in Scopus
Gastric Bypass Surgery Recruits a Gut – Striatal Dopamine Pathway to Reduce Fat Appetite in Obese Rats
Hankir, M. K.; Seyfried, F.; Hintschich, C. A.; Diep, T. A.; Kleberg, K.; Kranz, M.; Deuther-Conrad, W.; Tellez, L. A.; Rullmann, M.; Patt, M.; Teichert, S.; Sabri, O.; Brust, P.; Hansen, H. S.; de Araujo, I. E.; Krügel, U.; Fenske, W. K.
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Cell Metabolism 25(2017)2, 335-344
Online First (2016) DOI: 10.1016/j.cmet.2016.12.006
Cited 99 times in Scopus
Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A
Wagner, S.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Scheunemann, M.; Fischer, S.; Wenzel, B.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)1, 36-48
Online First (2016) DOI: 10.1002/jlcr.3471
Cited 12 times in Scopus
2016
Targetting microglia activation in schizophrenia by minocycline treatment
Mattei, D.; Ivanov, A.; Ferrai, G.; Jordan, P.; Guneykaya, D.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Eggen, B.; Bodekke, E.; Kaminska, B.; Pombo, A.; Kettenmann, H.; Wolf, S. A.
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Lecture (Conference)
29th ECNP Congress, 17.-20.09.2016, Vienna, Österreich - European Neuropsychopharmacology 26(2016), 134
Evaluation of the enantiomer specific biokinetics and radiation doses of [18-F]-fluspidine – a new tracer in clinical translation for imaging of σ1 receptors
Kranz, M.; Sattler, B.; Wüst, N.; Deuther-Conrad, W.; Patt, M.; Meyer, P. M.; Fischer, S.; Donat, C. K.; Wünsch, B.; Hesse, S.; Steinbach, J.; Brust, P.; Sabri, O.
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Molecules 21(2016), 1164
DOI: 10.3390/molecules21091164
Cited 30 times in Scopus
Synthesis and evaluation of a 18F-labeled 4-phenylpiperidine-4-carbonitrile radioligand for σ1 receptor imaging
Ye, J.; Wang, X.; Deuther-Conrad, W.; Zhang, J.; Li, J.; Zhang, X.; Wang, L.; Steinbach, J.; Brust, P.; Jia, H.
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Journal of Labelled Compounds and Radiopharmaceuticals (2016), 332-339
Online First (2016) DOI: 10.1002/jlcr.3408
Cited 7 times in Scopus
Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [18F]NS14490
Rötering, S.; Scheunemann, M.; Günther, R.; Löser, R.; Hiller, A.; Peters, D.; Brust, P.; Fischer, S.; Steinbach, J.
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Applied Radiation and Isotopes 114(2016), 57-62
Online First (2016) DOI: 10.1016/j.apradiso.2016.04.028
Cited 4 times in Scopus
Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]Flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results
Kranz, M.; Sattler, B.; Tiepolt, S.; Wilke, S.; Deuther-Conrad, W.; Donat, C.; Fischer, S.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Steinbach, J.; Sabri, O.; Brust, P.
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EJNMMI Physics (2016), 3-25
Online First (2016) DOI: 10.1186/s40658-016-0160-5
Cited 16 times in Scopus
Novel radioligands for cyclic nucleotide phosphodiesterase imaging with positron emission tomography: An update on developments since 2012
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.
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Molecules 21(2016)5, 650
DOI: 10.3390/molecules21050650
Cited 18 times in Scopus
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds
Sarasamkan, J.; Scheunemann, M.; Apaijai, N.; Palee, S.; Parichatikanond, W.; Arunrungvichian, K.; Fischer, S.; Chattipakorn, S.; Deuther-Conrad, W.; Schüürmann, G.; Brust, P.; Vajragupta, O.
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ACS Medicinal Chemistry Letters 7(2016)10, 890-895
DOI: 10.1021/acsmedchemlett.6b00146
Cited 11 times in Scopus
Comparison of in silico, electrochemical, in vitro and in vivo metabolism of a homologous series of (radio)fluorinated sigma1 receptor ligands designed for positron emission tomography
Wiese, C.; Große Maestrup, E.; Galla, F.; Schepmann, D.; Hiller, A.; Fischer, S.; Ludwig, F. A.; Deuther-Conrad, W.; Donat, C. K.; Brust, P.; Büter, L.; Karst, U.; Wünsch, B.
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ChemMedChem 11(2016), 2445-2458
Online First (2016) DOI: 10.1002/cmdc.201600366
Cited 11 times in Scopus
Beta-Amyloid-PET-Bildgebung des Gehirns - DGN-Handlungsempfehlung
Barthel, H.; Meyer, P. T.; Drzezga, A.; Bartenstein, P.; Boecker, H.; Brust, P.; Buchert, R.; Coenen, H. H.; Fougère, C. L.; Gründer, G.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Schreckenberger, M.; Tatsch, K.; Langen, K. J.; Sabri, O.
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Nuklearmedizin 55(2016)4, 129-137
DOI: 10.3413/Nukmed-0816-16-04
Cited 6 times in Scopus
99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma‑2 Receptor Ligands for Tumor Imaging
Li, D.; Chen, Y.; Wang, X.; Deuther-Conrad, W.; Chen, X.; Jia, B.; Dong, C.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.
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Journal of Medicinal Chemistry 59(2016)3, 934-946
DOI: 10.1021/acs.jmedchem.5b01378
Cited 18 times in Scopus
LC-MS supported Studies on the in vitro Metabolism of both Enantiomers of Flubatine and the in vivo Metabolism of (+)-[18F]Flubatine – a Positron Emission Tomography Radioligand for Imaging α4β2-Nicotinic Acetylcholine Receptors
Ludwig, F.-A.; Smits, R.; Fischer, S.; Donat, C. K.; Hoepping, A.; Brust, P.; Steinbach, J.
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Molecules 21(2016)9, 1200
DOI: 10.3390/molecules21091200
Cited 9 times in Scopus
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
Weiner, J.; Kranz, M.; Klöting, N.; Kunath, A.; Steinhoff, K.; Rijntjes, E.; Köhrle, J.; Zeisig, V.; Hankir, M.; Gebhardt, C.; Deuther-Conrad, W.; Heiker, J.; Kralisch, S.; Stumvoll, M.; Bluher, M.; Sabri, O.; Hesse, S.; Brust, P.; Tönjes, A.; Krause, K.
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Scientific Reports 6(2016), 38124
DOI: 10.1038/srep38124
Cited 64 times in Scopus
Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury
Donat, C. K.; Gaber, K.; Meixensberger, J.; Brust, P.; Pinborg, L. H.; Hansen, H. H.; Mikkelsen, J. D.
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Neuromolecular Medicine 18(2016)2, 158-169
Online First (2016) DOI: 10.1007/s12017-016-8385-y
Cited 21 times in Scopus
Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor
Moldovan, R.-P.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Wang, Y.; Nakano, M.; Valentine, H.; Fischer, S.; Pomper, M.; Wong, D. F.; Dannals, R. F.; Brust, P.; Horti, A. G.
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Journal of Medicinal Chemistry 59(2016)17, 7840-7855
DOI: 10.1021/acs.jmedchem.6b00554
Cited 48 times in Scopus
Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain.
Liu, J.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Ludwig, F.-A.; Deuther-Conrad, W.; Schröder, S.; Chezal, J.-M.; Moreau, E.; Brust, P.; Maisonial-Besset, A.
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Pharmaceuticals 9(2016)2, 22
Online First (2016) DOI: 10.3390/ph9020022
ISSN: 1424-8247
Cited 14 times in Scopus
PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
Hillmer, A. T.; Zheng, M.-Q.; Li, S.; Scheunemann, M.; Lin, S.-F.; Holden, D.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Carson, R. E.; Brust, P.; Huang, Y.
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European Journal of Nuclear Medicine and Molecular Imaging 43(2016)3, 537-547
Online First (2015) DOI: 10.1007/s00259-015-3209-0
Cited 18 times in Scopus
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
Hankir, M.; Kranz, M.; Gnad, T.; Wagner, S.; Deuther-Conrad, W.; Bronisch, F.; Steinhoff, K.; Luthardt, J.; Klöting, N.; Hesse, S.; Seibyl, J.; Blüher, M.; Sabri, O.; Pfeifer, A.; Brust, P.; Fenske, W.
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EMBO Molecular Medicine 8(2016), 796-812
Online First (2016) DOI: 10.15252/emmm.201506085
ISSN: 0021-9738
Cited 32 times in Scopus
Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridyl- and 1-pyridinol-substituted imidazo[1,5-a]quinoxalines
Wagner, S.; Scheunemann, M.; Dipper, K.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.
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European Journal of Medicinal Chemistry 107(2016), 97-108
DOI: 10.1016/j.ejmech.2015.10.028
Cited 10 times in Scopus
On the development of a novel non-peptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography
Wenzel, B.; Mollitor, J.; Deuther-Conrad, W.; Kranz, M.; Dukic-Stefanovic, S.; Günther, R.; Teodoro, R.; Ludwig, F.-A.; Fischer, S.; Smits, R.; Steinbach, J.; Hoepping, A.; Brust, P.
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Poster
ISRS2015 - 21st International Symposium on Radiopharmaceutical Sciences, 26.-31.05.2015, Columbia, Missouri, USA -
Abstract in refereed journal
Journal of Labelled Compounds and Radiopharmaceuticals 58(2015)1, 173
DOI: 10.1002/jlcr.3302_2
ISSN: 1099-1344 -
Journal of Medicinal Chemistry 59(2016)5, 1800-1817
Online First (2016) DOI: 10.1021/acs.jmedchem.5b01080
ISSN: 0022-2623
Cited 16 times in Scopus
2015
18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent
Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.
Involved research facilities
- PET-Center
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Journal of Medicinal Chemistry 58(2015), 5395-5407
DOI: 10.1021/acs.jmedchem.5b00593
ISSN: 0022-2623
Cited 23 times in Scopus
2-[18F]Fluoroethyl tosylate - a versatile tool for building 18F-based radiotracers for positron emission tomography
Knieß, T.; Laube, M.; Brust, P.; Steinbach, J.
Involved research facilities
- PET-Center
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MedChemComm 6(2015), 1714-1754
Online First (2015) DOI: 10.1039/c5md00303b
Cited 35 times in Scopus
Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity
Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.
Involved research facilities
- PET-Center
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MedChemComm 6(2015), 1093-1103
DOI: 10.1039/c5md00079c
Cited 15 times in Scopus
First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F]Flubatine
Sabri, O.; Becker, G.-A.; Meyer, P. M.; Hesse, S.; Wilke, S.; Graef, S.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Habermann, B.; Neuhaus, P.; Fischer, S.; Tiepolt, S.; Deuther-Conrad, W.; Barthel, H.; Schönknecht, P.; Brust, P.
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NeuroImage 118(2015), 199-208
DOI: 10.1016/j.neuroimage.2015.05.065
Cited 47 times in Scopus
A promising PET tracer for imaging of α7 nicotinic acetylcholine receptors in the brain: Design, synthesis, and in vivo evaluation of a dibenzothiophene-based radioligand
Teodoro, R.; Scheunemann, M.; Deuther-Conrad, W.; Wenzel, B.; Colombo, S.; Gotti, C.; Kranz, M.; Donat, C.; Patt, M.; Hillmer, A.; Zheng, M.; Peters, D.; Steinbach, J.; Sabri, O.; Huang, Y.; Brust, P.
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Molecules 20(2015), 18387-18421
DOI: 10.3390/molecules201018387
ISSN: 1420-3049
Cited 11 times in Scopus
Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Egerland, U.; Kranz, M.; Scheunemann, M.; Höfgen, N.; Steinbach, J.; Brust, P.
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Molecules 20(2015), 9591-9615
DOI: 10.3390/molecules20069591
ISSN: 1420-3049
Cited 14 times in Scopus
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter – A critical examination of the lead structure.
Barthel, C.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Schweiger, S.; Jäckel, P.; Roghani, A.; Steinbach, J.; Schüürmann, G.; Sabri, O.; Brust, P.; Wenzel, B.
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European Journal of Medicinal Chemistry 100(2015), 50-67
DOI: 10.1016/j.ejmech.2015.05.033
Cited 11 times in Scopus
A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743
Teodoro, R.; Wenzel, B.; Oh-Nishi, A.; Fischer, S.; Peters, D.; Suhara, T.; Deuther-Conrad, W.; Brust, P.
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Applied Radiation and Isotopes 95(2015), 76-84
DOI: 10.1016/j.apradiso.2014.09.016
Cited 10 times in Scopus
Convenient recycling and reuse of bombarded [18O]H2O for the production and the application of [18F]F‒
Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; Fischer, S.; Steinbach, J.
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Applied Radiation and Isotopes 101(2015), 44-52
Online First (2015) DOI: 10.1016/j.apradiso.2015.03.009
Cited 10 times in Scopus
2014
Internal Dose Assessment of (-)-18F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results
Sattler, B.; Kranz, M.; Starke, A.; Wilke, S.; Donat, C. K.; Deuther-Conrad, W.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Schoenknecht, P.; Steinbach, J.; Brust, P.; Sabri, O.
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Journal of Nuclear Medicine 55(2014)11, 1885-1892
Online First (2014) DOI: 10.2967/jnumed.114.137059
ISSN: 2159-662X
Cited 15 times in Scopus
Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent
Chen, Y.-Y.; Wang, X.; Zhang, J.-M.; Deuther-Conrad, W.; Zhang, X.-J.; Huang, Y.; Li, Y.; Ye, J.-J.; Cui, M.-C.; Steinbach, J.; Brust, P.; Liu, B.-L.
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Bioorganic & Medicinal Chemistry 22(2014), 5270-5278
DOI: 10.1016/j.bmc.2014.08.003
Cited 16 times in Scopus
Novel Cyclopentadienyl Tricarbonyl 99mTc Complexes Containing 1‑Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma‑1 Receptors
Wang, X.; Li, D.; Deuther-Conrad, W.; Lu, J.; Xie, Y.; Jia, B.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.
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Journal of Medicinal Chemistry 57(2014), 7113-7125
DOI: 10.1021/jm5009488
Cited 24 times in Scopus
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
Gnad, T.; Scheibler, S.; von Kügelgen, I.; Scheele, C.; Kilic, A.; Glöde, A.; Hoffmann, L.; Reverte, L.; Horn, P.; Mutlu, S.; El-Tayeb, A.; Kranz, M.; Deuther-Conrad, W.; Brust, P.; Lidell, M.; Betz, M.; Enerbäck, S.; Schrader, J.; Yegutkin, G.; Mueller, C.; Pfeifer, A.
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Nature 516(2014), 395-399
Online First (2014) DOI: 10.1038/nature13816
Cited 300 times in Scopus
Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18 F]Flubatine in humans
Patt, M.; Becker, G. A.; Grossmann, U.; Habermann, B.; Schildan, A.; Wilke, S.; Deuther-Conrad, W.; Graefe, S.; Fischer, S.; Smits, R.; Wagenknecht, G.; Steinbach, J.; Gertze, H.-J.; Hesse, S.; Schönknecht, P.; Brust, P.; Sabri, O.
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Nuclear Medicine and Biology 41(2014), 489-494
DOI: 10.1016/j.nucmedbio.2014.03.018
Cited 17 times in Scopus
Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490
Rötering, S.; Deuther-Conrad, W.; Cumming, P.; Donat, C. K.; Scheunemann, M.; Fischer, S.; Xiong, G.; Steinbach, J.; Peters, D.; Sabri, O.; Bucerius, J.; Brust, P.
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EJNMMI Research 4(2014), 1-11
Online First (2014) DOI: 10.1186/s13550-014-0043-5
Cited 17 times in Scopus
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
Donat, C. K.; Fischer, F.; Walter, B.; Deuther-Conrad, W.; Brodhun, M.; Bauer, R.; Brust, P.
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Acta Neurobiologiae Experimentalis 74(2014), 197-210
ISSN: 0365-0820
Distinctive In Vivo Kinetics of the New Sigma1 Receptor Ligands (R)-(+) and (S)-(-)- 18F-Fluspidine in Porcine Brain
Brust, P.; Deuther-Conrad, W.; Becker, G.; Patt, M.; Dont, C. K.; Stittsworth, S.; Fischer, S.; Hiller, A.; Wenzel, B.; Dukic-Stefanovic, S.; Hesse, S.; Steinbach, J.; Wünsch, B.; Lever, S. Z.; Sabri, O.
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Journal of Nuclear Medicine 55(2014)10, 1730-1736
DOI: 10.2967/jnumed.114.137562
ISSN: 0161-5505
Cited 24 times in Scopus
Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain
Holl, K.; Schepmann, D.; Fischer, S.; Ludwig, F. A.; Hiller, A.; Donat, C. K.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.
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Pharmaceuticals 7(2014), 78-112
DOI: 10.3390/ph7010078
ISSN: 1424-8247
Cited 2 times in Scopus
Synthesis and biological evaluation of both enantiomers of [18F]flubatine, promising radiotracers with fas kinetics for the imaging of α4β2-nicotinic acetylcholine receptors
Smits, R.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wenzel, B.; Patt, M.; Cumming, P.; Steinbach, J.; Sabri, O.; Brust, P.; Hoepping, A.
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Bioorganic & Medicinal Chemistry 22(2014), 804-812
DOI: 10.1016/j.bmc.2013.12.011
Cited 26 times in Scopus
Development of 18F-labeled radiotracers for neuroreceptor imaging with positron emission tomography
Brust, P.; van den Hoff, J.; Steinbach, J.
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Neuroscience Bulletin 30(2014)5, 777-811
Online First (2014) DOI: 10.1007/s12264-014-1460-6
ISSN: 1995-8218
Cited 44 times in Scopus
Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity
Lueg, C.; Galla, F.; Frehland, B.; Schepmann, D.; Daniliuc, C. G.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.
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Archiv der Pharmazie 347(2014), 21-31
DOI: 10.1002/ardp.201300255
Cited 7 times in Scopus
Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ1 receptors in brain.
Maisonial-Besset, A.; Funke, U.; Wenzel, B.; Fischer, S.; Holl, K.; Wünsch, B.; Steinbach, J.; Brust, P.
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Applied Radiation and Isotopes 84(2014), 1-7
DOI: 10.1016/j.apradiso.2013.10.015
Cited 16 times in Scopus
Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives
Brust, P.; Deuther-Conrad, W.; Lehmkuhl, K.; Jia, H.; Wünsch, B.
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Current Medicinal Chemistry 21(2014)1, 35-69
DOI: 10.2174/09298673113209990214
Cited 36 times in Scopus
Fluorine containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10A: Synthesis and in vitro evaluation of inhibition potency, selectivity and metabolism
Schwan, G.; Asskar, G. B.; Höfgen, N.; Kubicova, L.; Funke, U.; Egerland, U.; Zahn, M.; Nieber, K.; Scheunemann, M.; Sträter, N.; Brust, P.; Briel, D.
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ChemMedChem 9(2014)7, 1476-1487
DOI: 10.1002/cmdc.201300522
ISSN: 1860-7187
Cited 14 times in Scopus
2013
Development of fluorinated CB2 receptor agonists for PET studies
Lueg, C.; Schepmann, D.; Günther, R.; Brust, P.; Wünsch, B.
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Bioorganic & Medicinal Chemistry 21(2013), 7481-7498
DOI: 10.1016/j.bmc.2013.09.040
Cited 22 times in Scopus
Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers
Holl, K.; Falck, E.; Köhler, J.; Schepmann, D.; Humpf, H.-U.; Brust, P.; Wünsch, B.
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ChemMedChem 8(2013)12, 2047-2056
DOI: 10.1002/cmdc.201300322
Cited 27 times in Scopus
Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors
Teodoro, R.; Moldovan, R.-P.; Lueg, C.; Günther, R.; Donat, C. K.; Ludwig, F.-A.; Fischer, S.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.
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Organic and Medicinal Chemistry Letters 3(2013)11
Online First (2013) DOI: 10.1186/2191-2858-3-11
Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Patt, M.; Schildan, A.; Habermann, B.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wilke, S.; Smits, R.; Hoepping, A.; Wagenknecht, G.; Steinbach, J.; Brust, P.; Sabri, O.
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Applied Radiation and Isotopes 80(2013), 7-11
Online First (2013) DOI: 10.1016/j.apradiso.2013.05.009
ISSN: 0969-8043
Cited 19 times in Scopus
Use of 3-[18F]fluoropropanesulfonyl chloride as prosthetic agent for the radiolabelling of amines: Investigation of precursor molecules, labelling conditions and enzymatic stability of the corresponding sulfonamides
Löser, R.; Fischer, S.; Hiller, A.; Köckerling, M.; Funke, U.; Maisonial, A.; Brust, P.; Steinbach, J.
Involved research facilities
- PET-Center
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Beilstein Journal of Organic Chemistry 9(2013), 1002-1011
DOI: 10.3762/bjoc.9.115
Cited 8 times in Scopus
Synthesis and Evaluation of Novel 18F-Labeled Spirocyclic Piperidine Derivatives as σ1 Receptor Ligands for Positron Emission Tomography Imaging
Li, Y.; Wang, X.; Zhang, J.; Deuther-Conrad, W.; Xie, F.; Zhang, X.; Liu, J.; Qiao, J.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.
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Journal of Medicinal Chemistry 56(2013), 3478-3491
DOI: 10.1021/jm301734g
ISSN: 0022-2623
Cited 22 times in Scopus
A fluoro versus a nitro derivative - a high-performance liquid chromatography study of two basic analytes with different RP and silica phases as basis for the separation of a positron emission tomography radiotracer
Wenzel, B.; Günther, R.; Brust, P.; Steinbach, J.
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Journal of Chromatography A 1311(2013), 98-105
DOI: 10.1016/j.chroma.2013.08.068
Cited 5 times in Scopus
Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets
Bernd, W.; Eiselt, M.; Cumming, P.; Xiong, G.; Hinz, R.; Uthe, S.; Brust, P.; Bauer, R.
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International Journal of Developmental Neuroscience 31(2013), 157-164
DOI: 10.1016/j.ijdevneu.2012.12.008
ISSN: 0736-5748
Cited 3 times in Scopus
Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors
Rötering, S.; Scheunemann, M.; Fischer, S.; Hiller, A.; Peters, D.; Deuther-Conrad, W.; Brust, P.
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Bioorganic & Medicinal Chemistry 21(2013), 2635-2642
Online First (2013) DOI: 10.1016/j.bmc.2013.02.018
Cited 28 times in Scopus
Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging
Wang, X.; Li, Y.; Deuther-Conrad, W.; Xie, F.; Chen, X.; Cui, M.-C.; Zhang, X.-J.; Zhang, J.-M.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.
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Bioorganic & Medicinal Chemistry 21(2013)1, 215-222
Online First (2012) DOI: 10.1016/j.bmc.2012.10.038
Cited 18 times in Scopus
Leitlinie für die Hirnperfusions-SPECT mit Tc-99m Radiopharmaka / Hirnperfusions-SPECT with 99mTc-labelled Radiopharmaceuticals DGN-Guidance (S1 Guideline)
Kranert, T.; Menzel, C.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Krause, B. J.; Kuwert, T.; Sabri, O.; Schreckenberger, M.; Tatsch, K.; Grünwald, F.
- Nuklearmedizin 5(2013)52, 157-162
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Contribution to WWW
AWMF online - Das Portal der wissenschaftlichen Medizin: http://www.awmf.org/leitlinien/detail/ll/031-016.html
Radiosynthesis of racemic and enantiomerically pure (–)-[18F]flubatine – A promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors
Fischer, S.; Hiller, A.; Smits, R.; Hoepping, A.; Funke, U.; Wenzel, B.; Cumming, P.; Sabri, O.; Steinbach, J.; Brust, P.
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Applied Radiation and Isotopes 74(2013), 128-136
DOI: 10.1016/j.apradiso.2013.01.002
ISSN: 0969-8043
Cited 22 times in Scopus -
Contribution to WWW
Global Medical Discovery [ISSN 1929-8536]: http://globalmedicaldiscovery.com/?s=Radiosynthesis+of+racemic
Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Sridhar, D.; Nagesh, H. N.; Kumar, V. S.; Brust, P.; Kumar, M. M. K.
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Medicinal Chemistry Research 22(2013)4, 1660-1673
Online First (2012) DOI: 10.1007/s00044-012-0164-1
Cited 11 times in Scopus
2012
Synthesis and biological evaluation of a novel Tc-99m cyclopentadienyl tricarbonyl complex ([(Cp-R)Tc-99m(CO)(3)]) for sigma-2 receptor tumor imaging
Chen, X.; Cui, M. C.; Deuther-Conrad, W.; Tu, Y. F.; Ma, T.; Xie, Y.; Jia, B.; Li, Y.; Xie, F.; Wang, X.; Steinbach, J.; Brust, P.; Liu, B. L.; Jia, H. M.
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Bioorganic & Medicinal Chemistry Letters 22(2012)20, 6352-6357
DOI: 10.1016/j.bmcl.2012.08.083
ISSN: 0960-894X
Cited 24 times in Scopus
Cannabinoid Receptor Type 2 (CB2) Selective N-Aryl-oxadiazolyl-propionamides: Synthesis, Radiolabeling, Molekular Modelling and Biological Evaluation
Rühl, T.; Deuther-Conrad, W.; Fischer, S.; Günther, R.; Hennig, L.; Krautscheid, P.; Brust, P.
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Organic and Medicinal Chemistry Letters 2(2012), 32
Online First (2012) DOI: 10.1186/2191-2858-2-32
Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Wenzel, B.; Li, Y.; Kraus, W.; Sorger, D.; Sabri, O.; Brust, P.; Steinbach, J.
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Bioorganic & Medicinal Chemistry Letters 22(2012), 2163-2166
DOI: 10.1016/j.bmcl.2012.01.127
Cited 8 times in Scopus
Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; Patt, M.; Sorger, D.; Zessin, J.; Sacher, J.; Lobsien, D.; Habermann, B.; Meyer, P. M.; Füchtner, F.; Luthardt, J.; Bresch, A.; Steinbach, J.; Sabri, O.
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European Journal of Nuclear Medicine and Molecular Imaging 39(2012)6, 1001-1011
Online First (2012) DOI: 10.1007/s00259-012-2078-z
Cited 29 times in Scopus
Development of radioligands for α7-nAChR imaging with positron emission tomography
Brust, P.; Peters, D.; Deuther-Conrad, W.
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Current Drug Targets 13(2012)5, 594-601
DOI: 10.2174/138945012800398955
ISSN: 1389-4501
Cited 28 times in Scopus
Synthesis, radiofluorination and pharmacological evaluation of fluoromethyl substituted spirocyclic PET tracers for labeling of σ1 receptors in the central nervous system and comparison with longer homologues
Maisonial, A.; Grosse Maestrup, E.; Wiese, C.; Hiller, A.; Schepmann, D.; Deuther-Conrad, W.; Fischer, S.; Brust, P.; Wünsch, B.
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Bioorganic & Medicinal Chemistry 20(2012), 257-269
DOI: 10.1016/j.bmc.2011.11.002
Cited 21 times in Scopus
Radiosynthesis and Radiotracer Properties of a 7-(2-[F-18]Fluoroethoxy)-6-methoxy-pyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET
Funke, U.; Deuther-Conrad, W.; Schwan, G.; Maisonial, A.; Scheunemann, M.; Fischer, S.; Hiller, A.; Briel, D.; Brust, P.
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Pharmaceuticals 5(2012)2, 169-188
Online First (2012) DOI: 10.3390/ph5020169
ISSN: 1424-8247
Cited 16 times in Scopus
2011
Leitlinie für PET und SPECT–Untersuchungen von Hirntumoren mit radioaktiv markierten Aminosäuren
Langen, K.-J.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Drzezga, A.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Sabri, O.; Tatsch, K.; Weber, W. A.; Schreckenberger, M.
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Nuklearmedizin 50(2011)4, 167-173
DOI: 10.3413/nuk-2011041
Cited 87 times in Scopus
A 18F-labeled Fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET imaging of sigma1 receptors
Maisonial, A.; Große Maestrup, E.; Fischer, S.; Hiller, A.; Scheunemann, M.; Wiese, C.; Schepmann, D.; Steinbach, J.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.
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ChemMedChem 6(2011), 1401-1410
DOI: 10.1002/cmdc.201100108
Cited 21 times in Scopus
Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging
Li, Z.-J.; Ren, H.-Y.; Cui, M.-C.; Deuther-Conrad, W.; Tang, R.-K.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.
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Bioorganic & Medicinal Chemistry 19(2011)9, 2911-2917
DOI: 10.1016/j.bmc.2011.03.037
Cited 13 times in Scopus
In vitro binding profile and radiosynthesis of a novel 18F-labeled azaspirovesamicol analog as potential ligand for imaging of the vesicular acetylcholine transporter
Wenzel, B.; Hiller, A.; Fischer, S.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.; Sabri, O.; Steinbach, J.
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Journal of Labelled Compounds and Radiopharmaceuticals 54(2011), 426-432
DOI: 10.1002/jlcr.1891
Cited 8 times in Scopus
Assessment of alpha 7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743
Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Becker, G.; Cumming, P.; Xiong, G.; Funke, U.; Sabri, O.; Peters, D.; Brust, P.
- European Journal of Nuclear Medicine and Molecular Imaging 38(2011)8, 1541-1549
Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position
Große Maestrup, E.; Wiese, C.; Schepmann, D.; Brust, P.; Wünsch, B.
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Bioorganic & Medicinal Chemistry 19(2011), 393-405
DOI: 10.1016/j.bmc.2010.11.013
Cited 40 times in Scopus
The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
Hesse, S.; Stengler, K.; Regenthal, R.; Patt, M.; Becker, G.-A.; Franke, A.; Knüpfer, H.; Meyer, P. M.; Luthardt, J.; Jahn, I.; Lobsien, D.; Heinke, W.; Brust, P.; Hegerl, U.; Sabri, O.
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International Journal of Neuropsychopharmacology 14(2011), 1-12
DOI: 10.1017/S1461145710001604
Cited 53 times in Scopus
Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine
Fischer, S.; Wiese, C.; Grosse Maestrup, E.; Hiller, A.; Deuther-Conrad, W.; Scheunemann, M.; Schepmann, D.; Steinbach, J.; Wünsch, B.; Brust, P.
- European Journal of Nuclear Medicine and Molecular Imaging 38(2011)3, 540-551
Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models
Hoffmeister, P.-G.; Donat, C. K.; Schuhmann, M. U.; Voigt, C.; Walter, B.; Nieber, K.; Meixensberger, J.; Bauer, R.; Brust, P.
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Neuromolecular Medicine 13(2011)1, 44-53
DOI: 10.1007/s12017-010-8136-4
ISSN: 1535-1084
Cited 30 times in Scopus
Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1’-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4’-piperidine]
Wiese, C.; Große Maestrup, E.; Schepmann, D.; Grimme, S.; Humpf, H.-U.; Brust, P.; Wünsch, B.
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Chirality 23(2011), 148-154
DOI: 10.1002/chir.20893
Cited 11 times in Scopus
Design, Synthesis and Preliminary in vitro and in vivo Pharmacological Evaluation of 2-{4-[4-(2,5-disubstituted thiazolyl)phenylethyl] piperazin-1-yl}-1,8-naphthyridine-3- carbonitriles as Atypical Antipsychotic Agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Reddy, A. S.; Brust, P.; Kumara, M. M. K.
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Journal of Enzyme Inhibition And Medicinal Chemistry 26(2011)4, 561-568
DOI: 10.3109/14756366.2010.537658
Cited 4 times in Scopus
2010
Accessible silanol sites - beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.
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Journal of Chromatography A 1217(2010), 7884-7890
DOI: 10.1016/j.chroma.2010.10.061
Cited 9 times in Scopus
3D QSAR study, synthesis and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the Vesicular AcetylCholine Transporter (VAChT)
Kovac, M.; Mavel, S.; Deuther-Conrad, W.; Méheux, N.; Glöckner, J.; Wenzel, B.; Anderluh, M.; Brust, P.; Guilloteau, D.; Emond, P.
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Bioorganic & Medicinal Chemistry 18(2010), 7659-7667
DOI: 10.1016/j.bmc.2010.08.028
Cited 24 times in Scopus
Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent
Chen, R.-Q.; Li, Y.; Zhang, Q.-Y.; Jia, H.-M.; Deuther-Conrad, W.; Schepmann, D.; Steinbach, J.; Brust, P.; Wuensch, B.; Liu, B.-L.
-
Journal of Labelled Compounds and Radiopharmaceuticals 53(2010), 569-574
DOI: 10.1002/jlcr.1777
Cited 11 times in Scopus
Design, Synthesis and in Vitro Biological Evaluation of Reference Compounds of 123I and 99Tcm Labeled Indole Radiotracers for σ2 Receptor Imaging
Li, Y.; Jia, H.-M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; Liu, B.-L.
- Journal of Nuclear and Radiochemistry 32(2010)2, 132-138
Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain
Donat, C. K.; Walter, B.; Kayser, T.; Deuther-Conrad, W.; Schliebs, R.; Nieber, K.; Bauer, R.; Haertig, W.; Brust, P.
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International Journal of Developmental Neuroscience 28(2010), 31-38
DOI: 10.1016/j.ijdevneu.2009.10.001
Cited 12 times in Scopus
Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets
Donat, C. K.; Walter, B.; Deuther-Conrad, W.; Nieber, K.; Brust, R.; Bauer, P.
-
Neuropathology and Applied Neurobiology 36(2010), 225-236
DOI: 10.1111/j.1365-2990.2009.01050.x
Cited 13 times in Scopus
Novel Indole Derivatives as Potential Imaging Agents for Alzheimers Disease
Yu, L.; Scheunemann, M.; Deuther-Conrad, W.; Hiller, A.; Fischer, S.; Sorger, D.; Sabri, O.; Jia, H.; Steinbach, J.; Brust, P.; Liu, B.
-
Bulletin of the Korean Chemical Society 31(2010)1, 177-180
DOI: 10.5012/bkcs.2010.31.01.177
Cited 1 times in Scopus
Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.
-
Journal of Chromatography A 1217(2010), 3855-3862
DOI: 10.1016/j.chroma.2010.04.018
Cited 15 times in Scopus
2009
Molecular imaging of α7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743
Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Ostergaard Nielsen, E.; Brunicardi Timmermann, D.; Steinbach, J.; Sabri, O.; Peters, D.; Brust, P.
-
European Journal of Nuclear Medicine and Molecular Imaging 36(2009), 791-800
DOI: 10.1007/s00259-008-1031-7
Cited 36 times in Scopus
2008
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination
Funke, U.; Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.
-
Bioorganic & Medicinal Chemistry Letters 18(2008), 4727-4730
DOI: 10.1016/j.bmcl.2008.06.077
Cited 12 times in Scopus
Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands
Guo, Y.; Chen, X.; Jia, H.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; Vercouillie, J.; Liu, B.
-
Science in China Series B: Chemistry 51(2008)5, 457-463
DOI: 10.1007/s11426-008-0007-6
Radiosynthesis of novel 18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET
Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; Hoepping, A.; Diekers, M.; Wegner, F.; Brust, P.; Steinbach, J.
-
Journal of Labelled Compounds and Radiopharmaceuticals 51(2008), 123-131
DOI: 10.1002/jlcr.1473
Cited 8 times in Scopus
2006
[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: Synthesis, pharmacological characterization and microPET studies in rats
Zessin, J.; Deuther-Conrad, W.; Kretzschmar, M.; Wüst, F.; Pawelke, B.; Brust, P.; Steinbach, J.; Bergmann, R.
- Nuclear Medicine and Biology 33(2006)1, 53-63
2005
Effect of Moderate Hypercapnic Hypoxia on Cerebral Dopaminergic Activity and Brain O2 Uptake in Intrauterine GrowthRestricted Newborn Piglets
Bauer, R.; Walter, B.; Vorwieger, G.; Fritz, A.; Füchtner, F.; Zwiener, U.; Brust, P.
-
Pediatric Research 57(2005)3, 363-370
DOI: 10.1203/01.PDR.0000150800.19956.F0
Cited 1 times in Scopus
2004
The Influx of Neutral Amino Acids into the Porcine Brain During Development: A Positron Emission Tomography Study
Brust, P.; Vorwieger, G.; Walter, B.; Füchtner, F.; Stark, H.; Kuwabara, H.; Steinbach, J.; Bauer, R.
- Developmental Brain Research 152(2004), 241-253
Developmental changes in the activity of aromatic amino acid decarboxylase and catechol-O-methyl transferase in pigs: a positron emission tomography study
Brust, P.; Walter, B.; Hinz, R.; Füchtner, F.; Müller, M.; Steinbach, J.; Bauer, R.
- Neuroscience Letters, 364(2004)3, 159-163
Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs
Walter, B.; Brust, P.; Füchtner, F.; Müller, M.; Hinz, R.; Kuwabara, H.; Fritz, H.; Zwiener, U.; Bauer, R.
- Journal of Neurotrauma 21(2004)8, 1076-1089
2003
Impact of asymmetric intrauterine growth restriction on organ function in newborn piglets
Bauer, R.; Walter, B.; Brust, P.; Füchtner, F.; Zwiener, U.
- European Journal of Obstetrics and Gynecology and Reproductive Biology 110 (2003) S40-S49
S-[18F]fluoromethyl-(+)-McN5652, a PET Tracer for the Serotonin Transporter: Evaluation in Rats
Marjamäki, P.; Zessin, J.; Eskola, O.; Grönroos, T.; Haaparanta, M.; Bergman, J.; Lehikoinen, P.; Forsback, S.; Brust, P.; Steinbach, J.; Solin, O.
- Synapse (2003) 47: 45-53
In vivo Measurement of the Serotonin Transporter with (S)-([18F]fluoromenthyl)-(+)-McN5652
Brust, P.; Hinz, R.; Kuwabara, H.; Hesse, S.; Zessin, J.; Pawelke, B.; Stephan, H.; Bergmann, R.; Steinbach, J.; Sabri, O.
- Neuropsychopharmacology (2003) 28, 2010-2019
Positron Emission Tomography Imaging of the Serotonin Transporter in the Pig Brain Using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652
Brust, P.; Zessin, J.; Kuwabara, H.; Pawelke, B.; Kretzschmar, M.; Hinz, R.; Bergman, J.; Eskola, O.; Solin, O.; Steinbach, J.; Johannsen, B.
- Synapse (2003) 47: 143-151
Autoradiographic analyses of 5-HT1A and 5-HT2A receptors after social isolation in mice
Schiller, L.; Jähkel, M.; Kretzschmar, M.; Brust, P.; Oehler, J.
- Brain Research 980 (2003) 169-178
Autoradiographic imaging of the serotonin ransporter in the brain of rats and pigs using S-([18F]Fluoromethyl)-(+)-McN5652
Kretzschmar, M.; Brust, P.; Zessin, J.; Cumming, P.; Bergmann, R.; Johannsen, B.
- European Neuropsychopharmacology 13 (2003) 387-397
2002
Effect of hypoxia/hypercapnia on metabolism of 6-[18F]fluoro-L-DOPA in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Elhalag, E.; Fritz, A.; Steinbach, J.; Füchtner, F.; Hinz, R.; Zwiener, U.; Johannsen, B.
- Brain Research 934 (2002) 22-33
Tc and Re chelates of 8alpha-amino-6-methyl-ergoline: synthesis and affinity to the dopamine D2 receptor
Spies, H.; Noll, B.; Noll, S.; Findeisen, M.; Brust, P.; Syhre, R.; Berger, R.
- Bioorganic and Medicinal Chemistry 10 (2002) 3523-3528
Distribution of estrone sulfatase in rat brain determined by in vitro autoradiography with 16alpha-[18F]fluoroestradiol-3,17beta-disulfamate
Rodig, H.; Brust, P.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Johannsen, B.
- Applied Radiation and Isotopes 56 (2002) 773-780
Distribution of 16alpha-[18F]fluoro-estradiol-3,17beta-disulfamate (FESDS) in rats, tumour-bearing mice and piglets
Brust, P.; Rodig, H.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Zips, D.; Baumann, M.; Steinbach, J.; Johannsen, B.
- Applied Radiation and Isotopes 57 (2002) 687-695
Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor
Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; Halldin, C.; Syhre, R.; Kraus, W.; Pietzsch, H.-J.; Seifert, S.; Brust, P.; Johannsen, B.
- Nuclear Medicine and Biology 29 (2002) 375-387
2001
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 tymidine kinase gene expression
Brust, P.; Haubner, R.; Friedrich, A.; Scheunemann, M.; Anton, M.; Koufaki, O.-N.; Hauses, M.; Noll, S.; Noll, B.; Haberkorn, U.; Schackert, G.; Schackert, H. K.; Avril, N.; Johannsen, B.
- European Journal of Nuclear Medicine Vol.28, No. 6, (2001) 721-729
Synthesis of S-([18F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter
Zessin, J.; Eskola, O.; Brust, P.; Bergman, J.; Steinbach, J.; Lehikoinen, P.; Solin, O.; Johannsen, B.
- Nuclear Medicine and Biology 28 (2001) 857-863
Quantitative Radioluminography of Serotonin Uptake Sites in the Porcine Brain
Cumming, P.; Kretzschmar, M.; Brust, P.; Smith, D. F.
- Synapse 39 (2001) 351-355
Intrauterine growth restriction induces up-regulation of cerebral aromatic amino acid decarboxylase activity in newborn piglets: [18F]fluorodopa positron-emission-tomographic study
Bauer, R.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Brust, P.
- Pediatric Research 49 (2001) 474-480
Reactivity of 99mTc(V) "3+1" mixed-ligand complexes towards glutathione
Gupta, A.; Seifert, S.; Syhre, R.; Scheunemann, M.; Brust, P.; Johannsen, B.
- Radiochimica Acta 89 (2001) 43-49
2000
Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.
Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; Roux, F.; Johannsen, B.
- Nucl. Med. Biol. 27 (2000) 135-141
Relation between brain tissue pO2 and dopamine synthesis of basal ganglia - A 18FDOPA-PET study in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Steinbach, J.; El-Hallag, E.; Fritz, A.; Johannsen, B.; Zwiener, U.
- J. Perinat. Med. 28 (2000) 54-60
Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells
Brust, P.; Friedrich, A.; Krizbai, I. A.; Bergmann, R.; Roux, F.; Ganapathy, V.; Johannsen, B.
- J.Neurochem. 74, (2000) 1241-1248
-
Journal of Cerebral Blood Flow and Metabolism, Vol. 19 (Suppl.1), 245
DOI: 10.1046/j.1471-4159.2000.741241.x
Cited 50 times in Scopus
1999
Upregulation of the Aromatic Amino Acid Decarboxylase under Neonatal Asphyxia
Brust, P.; Bauer, R.; Vorieger, G.; Walter, B.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Zwiener, U.; Johannsen, B.
-
Neurobiology of Disease 6, (1999) 131-139
DOI: 10.1006/nbdi.1998.0232
Cited 6 times in Scopus
Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets - effect of hypoxia / hypercapnia
Bauer, R.; Bergmann, R.; Walter, B.; Brust, P.; Zwiener, U.; Johannsen, B.
-
Developmental Brain Research 112 (1999) 89-98
DOI: 10.1016/S0165-3806(98)00167-9
Cited 18 times in Scopus
Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice
Srinivas, P.; Subramanian, A. R.; Brust, P.; Raghavan, S. A. V.; Rangisetty, J. B.; Gupta, C. N. V. H. B.; Sridhar, N.; Veeranjaneyulu, A.; Parimoo, P.
- IL FARMACO 54 (1999) 567-572
Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT2A Receptor
Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; Seifert, S.; Brust, P.; Spies, H.; Syhre, R.; Johannsen, B.
- Nuclear Medicine and Biology, 26 (1999) 865-875
Synthesis and preliminary binding affinities of 1(1,2-dihydro-2-acenaphthylenyl)piperazine - a new arylpiperazine
Srinivas, P.; Brust, P.; Subramanian, A. R.; Raghavan, S. A. V.; Rangisetty, J. B.; Gupta, C. N. V. H. B.; Parimoo, P.
- Pharmaceutica Acta Helvetiae 74 (1999) 73-73
Efficient Synthesis of Enantiomerically Pure Thioester Precursors of [11C] MCN-5652 from Racemic MCN-5652
Zessin, J.; Gucker, P.; Ametamey, S. M.; Steinbach, J.; Brust, P.; Vollenweider, T. X.; Johannsen, B.; Schubiger, P. A.
- J. Labelled Cpd. Radiopharm. 42 (1999) 1301-1312
Radioligands for the Study of the 5-HT Transporter in Vivo
Brust, P.; Scheffel, U.; Szabo, Z.
- IDrugs 1999 Vol 2 No 2 , Review Radioligands 129-145
1998
TROTEC-1 a new high affinity ligand for Labeling of the dopamine transporter
Hoepping, A.; Reisgys, M.; Brust, P.; Seifert, S.; Spies, H.; Alberto, R.; Johannsen, B.
- Journal of Medicinal Chemistry, 41(23) (1998) 4429-4432
Differentiation Between Specific and Nonspecific Effects Related to P-Glycoprotein Inhibition in Immortalized Rat Brain Endothelial Cells
Bergmann, R.; Brust, P.; Johannsen, B.
- International Journal of Clinical Pharmacology and Therapeutics, Vol. 36, No. 1, 1998 (46-49)
Simultaneous Measurement of 18F-FDOPA Metabolism and Cerebral Blood Flow in Newborn Piglets
Brust, P.; Bauer, R.; Walter, B.; Bergmann, R.; Füchtner, F.; Vorwieger, G.; Steinbach, J.; Johannsen, B.; Zwiener, U.
-
Int. J. Devl. Neuroscience, Vol. 16, No. 5, pp 353-364, 1998
DOI: 10.1016/S0736-5748(98)00017-3
Cited 13 times in Scopus
Novel Rhenium Complexes Derived from ALPHA-Tropanol as Potential Ligands for the Dopamin Transporter
Hoepping, A.; Brust, P.; Berger, R.; Leibnitz, P.; Spies, H.; Machill, S.; Scheller, D.; Johannsen, B.
-
Bioorganic & Medicinal Chemistry 6 (1998) 1663-1672
DOI: 10.1016/S0968-0896(98)00144-8
Cited 11 times in Scopus
1997
Different response of cerebral and non-cerebral endothelial cells to cytotoxic hypoxia
Ahlemeyer, B.; Brust, P.; Johannsen, B.
- Neurochem. Int. 31 (1997) 39-44
Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake
Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; Seifert, S.; Spies, H.; Syhre, R.
- European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319
1996
High-affinity binding of [3H]paroxetine to caudate nucleus and microvessels from porcine brain
Brust, P.; Bergmann, R.; Johannsen, B.
-
NeuroReport 7 (1996) pp. 1405-1408
DOI: 10.1097/00001756-199605310-00016
Cited 9 times in Scopus
Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations
Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; Syhre, R.; Pietzsch, H.-J.
-
Journal of Nuclear Medicine and Biology 23 (1996) 429-438
DOI: 10.1016/0969-8051(96)00015-7
Cited 61 times in Scopus
1995
Specific binding of (3H)imipramine indicates the presence of a specific serotonin transport system on endothelial cells of porcine brain
Brust, P.; Bergmann, R.; Johannsen, B.
-
Neuroscience Letters 194 (1995) 21-24
DOI: 10.1016/0304-3940(95)11709-6
Cited 10 times in Scopus
Evaluation of Radioselenium Labeled Selenomethionine, a Potential Tracer for Brain Protein Synthesis by PET
Bergmann, R.; Brust, P.; Kampf, G.; Coenen, H. H.; Stöcklin, G.
-
J. Nucl. Med. Biol. 22 (1995) 475-481
DOI: 10.1016/0969-8051(94)00123-2
Cited 17 times in Scopus
1994
Characterization of serotonin uptake sites on the blood brain barrier
Brust, P.; Bergmann, R.
- Journal of Neurochemistry 63 (1994) (Suppl. 1) S13C
Compartmental analysis of blood brain transfer and protein incorporation of L-[75Se]seleno methionine in rat brain
Bergmann, R.; Brust, P.; Coenen, H. H.; Stöcklin, G.
- Journal of Neurochemistry 63 (1994) (Suppl. 1) S78C
Developmental changes of enzymes involved in peptide degradation in isolated rat brain microvessels
Brust, P.; Bech, A.; Kretzschmar, R.; Bergmann, R.
-
Peptides 15 (1994) 6 pp. 1085-1088
DOI: 10.1016/0196-9781(94)90074-4
Cited 16 times in Scopus