Publications of Institute of Radiopharmaceutical Cancer Research
119 Publications2024
Production of medical radionuclides in the Center for Radiopharmaceutical Tumor Research – a status report
Kreller, M.; Walther, M.; Brühlmann, S. A.; Knieß, T.; Kopka, K.
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Instruments 8(2024)1, 10
DOI: 10.3390/instruments8010010
2023
Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective
Knieß, T.; Zessin, J.; Mäding, P.; Kuchar, M.; Kiß, O.; Kopka, K.
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EJNMMI Radiopharmacy and Chemistry 8(2023)1, 5
DOI: 10.1186/s41181-023-00190-7
Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction
Brühlmann, S. A.; Walther, M.; Kreller, M.; Reissig, F.; Pietzsch, H.-J.; Knieß, T.; Kopka, K.
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Pharmaceuticals 16(2023), 314
DOI: 10.3390/ph16020314
2022
Exploring nitric oxide (NO)- releasing celecoxib derivatives as modulators of radioresponse in pheochromocytoma cells
Brandt, F.; Ullrich, M.; Seifert, V.; Haase-Kohn, C.; Richter, S.; Knieß, T.; Pietzsch, J.; Laube, M.
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Molecules 27(2022), 6587
DOI: 10.3390/molecules27196587
1-(4-Fluorobenzoyl)-9H-carbazole
Laube, M.; König, J.; Köckerling, M.; Knieß, T.
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Molbank (2022)3, M1430
DOI: 10.3390/M1430
2020
Deuteration versus ethylation – strategies to improve the metabolic fate of a 18F-labeled celecoxib derivative
Laube, M.; Gassner, C.; Neuber, C.; Wodtke, R.; Ullrich, M.; Haase-Kohn, C.; Löser, R.; Köckerling, M.; Kopka, K.; Knieß, T.; Hey-Hawkins, E.; Pietzsch, J.
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RSC Advances 10(2020), 38601-38611
DOI: 10.1039/D0RA04494F
2019
Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf
Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; Knieß, T.; Füchtner, F.; Steinbach, J.; Preusche, S.
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Instruments 3(2019)1, 9
DOI: 10.3390/instruments3010009
Synthesis and cyclooxygenase inhibition of sulfonamide-substituted (dihydro)pyrrolo[3,2,1-hi]indoles and their potential prodrugs
Laube, M.; Gassner, C.; Knieß, T.; Pietzsch, J.
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Molecules 24(2019), 3807
DOI: 10.3390/molecules24203807
Nitric oxide-releasing selective estrogen receptor modulators (NO-SERMs): a bifunctional approach to improve the therapeutic index
Bechmann, N.; Knieß, T.; Pietzsch, J.
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Journal of Medicinal Chemistry 62(2019), 6525-6539
DOI: 10.1021/acs.jmedchem.9b00171
ISSN: 0022-2623
Fluorescent Mouse Pheochromocytoma Spheroids Expressing Hypoxia-Inducible Factor 2 alpha: Morphologic and Radiopharmacologic Characterization
Seifert, V.; Liers, J.; Kniess, T.; Richter, S.; Bechmann, N.; Feldmann, A.; Bachmann, M.; Eisenhofer, G.; Pietzsch, J.; Ullrich, M.
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Journal of Cellular Biotechnology 5(2019)2, 135-151
DOI: 10.3233/JCB-199005
ISSN: 2352-3689
Fluorine-18 labeling of S100 proteins for small animal positron emission tomography
Laube, M.; Kniess, T.; Neuber, C.; Haase-Kohn, C.; Pietzsch, J.
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Methods in Molecular Biology 1929(2019), 461-485
DOI: 10.1007/978-1-4939-9030-6_29
ISSN: 1064-3745
Synthesis and preliminary radiopharmacological characterisation of an 11C-labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins
Laube, M.; Frizler, M.; Wodtke, R.; Neuber, C.; Belter, B.; Kniess, T.; Bachmann, M.; Gütschow, M.; Pietzsch, J.; Löser, R.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 448-459
DOI: 10.1002/jlcr.3729
One-pot Cascade Synthesis of Pyrazole-based Isosteres of Valdecoxib by a [3+2] Cycloaddition/[1,5] Sigmatropic Rearrangement Sequence and Evaluation of their COX Inhibitory Activity
Roscales, S.; Bechmann, N.; Pietzsch, J.; Kniess, T.
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Heterocycles 98(2019)3, 416-428
DOI: 10.3987/COM-19-14048
Access to 18F-labelled isoxazoles by Ruthenium-promoted 1,3-dipolar cycloaddition of 4-[18F]fluoro-N-hydroxybenzimidoyl chloride with alkynes.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019), 393-403
DOI: 10.1002/jlcr.3708
2018
Bridging from Brain to Tumor imaging: (S)- and (R)-[18F]Fluspidine for investigation of Sigma-1 Receptors in Tumor-bearing Mice
Kranz, M.; Bergmann, R.; Kniess, T.; Belter, B.; Neuber, C.; Cai, Z.; Deng, G.; Fischer, S.; Steinbach, J.; Zhou, J.; Huang, H.; Brust, P.; Deuther-Conrad, W.; Pietzsch, J.
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Molecules 23(2018)3, 702
DOI: 10.3390/molecules23030702
Evaluation of fluorine-18-labelled alpha1(I)-N-telopeptide analogues as substrate-based radiotracers for PET imaging of melanoma-associated lysyl oxidase
Kuchar, M.; Neuber, C.; Belter, B.; Bergmann, R.; Lenk, J.; Wodtke, R.; Kniess, T.; Steinbach, J.; Pietzsch, J.; Löser, R.
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Frontiers in Chemistry 6(2018), 121
DOI: 10.3389/fchem.2018.00121
Novel Valdecoxib Derivates by Ruthenium-catalyzed 1,3-Dipolar Cycloaddition of Nitrile Oxides with Alkynes - Synthesis and COX-2 Inhibition Affinity.
Roscales, S.; Bechmann, N.; Weiss, D. H.; Köckerling, M.; Pietzsch, J.; Kniess, T.
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MedChemComm 9(2018), 534-544
DOI: 10.1039/c7md00575j
2017
99mTechnetium-based Small Molecule Radiopharmaceuticals and Radiotracers Targeting Inflammation and Infection
Kniess, T.; Laube, M.; Wüst, F.; Pietzsch, J.
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Dalton Transactions 46(2017), 14435-14451
DOI: 10.1039/c7dt01735a
Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
Moldovan, R.-P.; Els-Heindl, S.; Worm, D. J.; Kniess, T.; Kluge, M.; Beck-Sickinger, A. G.; Deuther-Conrad, W.; Krügel, U.; Brust, P.
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International Journal of Molecular Sciences 18(2017)4, 768
DOI: 10.3390/ijms18040768
Hydrous 18F-fluoroethylation – leaving off the azeotropic drying
Kniess, T.; Laube, M.; Steinbach, J.
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Applied Radiation and Isotopes 127(2017), 260-268
DOI: 10.1016/j.apradiso.2017.06.010
ISSN: 0969-8043
2016
Development of a F-18-labeled Diaryl-Substituted Dihydropyrrolo[3,2,1-hi]indole as Potential Probe for Functional Imaging of Cyclooxygenase-2 with PET
Gassner, C.; Neuber, C.; Laube, M.; Bergmann, R.; Kniess, T.; Pietzsch, J.
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ChemistrySelect 1(2016), 5812-5820
DOI: 10.1002/slct.201601618
ISSN: 2365-6549
Development of antioxidant COX-2 inhibitors as radioprotective agents for radiation therapy – a hypothesis-driven review
Laube, M.; Kniess, T.; Pietzsch, J.
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Antioxidants 5(2016)2, 14
DOI: 10.3390/antiox5020014
5-Chloro-1-phenylpentan-1-one
Bechmann, N.; Kniess, T.; Pietzsch, J.; König, J.; Köckerling, M.
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IUCrData 1(2016), 160055
DOI: 10.1107/S2414314616000559
ISSN: 2414-3146
2015
Protective effects of 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitors on oxidative modification of human low density lipoproteins in vitro
Pietzsch, J.; Laube, M.; Bechmann, N.; Pietzsch, F.-J.; Kniess, T.
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Clinical Hemorheology and Microcirculation 61(2015)4, 615-632
DOI: 10.3233/CH-141923
ISSN: 1386-0291
18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent
Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.
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Journal of Medicinal Chemistry 58(2015), 5395-5407
DOI: 10.1021/acs.jmedchem.5b00593
ISSN: 0022-2623
2-[18F]Fluoroethyl tosylate - a versatile tool for building 18F-based radiotracers for positron emission tomography
Knieß, T.; Laube, M.; Brust, P.; Steinbach, J.
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MedChemComm 6(2015), 1714-1754
DOI: 10.1039/c5md00303b
Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors
Bechmann, N.; Kniess, T.; Köckerling, M.; Pigorsch, A.; Steinbach, J.; Pietzsch, J.
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Bioorganic & Medicinal Chemistry Letters 25(2015), 3295-3300
DOI: 10.1016/j.bmcl.2015.05.059
Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity
Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.
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MedChemComm 6(2015), 1093-1103
DOI: 10.1039/c5md00079c
Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor.
Tondera, C.; Ullm, S.; Laube, M.; Meister, S.; Neuber, C.; Mosch, B.; Kniess, T.; Pietzsch, J.
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Biochemical and Biophysical Research Communications 458(2015), 40-45
DOI: 10.1016/j.bbrc.2015.01.057
Diaryl-substituted (dihydro)pyrrolo[3,2,1-hi]indoles, a class of potent COX-2 inhibitors with tricyclic core structure
Laube, M.; Gassner, C.; Sharma, S. K.; Günther, R.; Pigorsch, A.; König, J.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.
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Journal of Organic Chemistry 80(2015), 5611-5624
DOI: 10.1021/acs.joc.5b00537
Convenient recycling and reuse of bombarded [18O]H2O for the production and the application of [18F]F‒
Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; Fischer, S.; Steinbach, J.
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Applied Radiation and Isotopes 101(2015), 44-52
DOI: 10.1016/j.apradiso.2015.03.009
2014
Organotypical vascular model for characterization of radioprotective compounds: Studies on antioxidant 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitors
Ullm, S.; Laube, M.; Bechmann, N.; Knieß, T.; Pietzsch, J.
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Clinical Hemorheology and Microcirculation 58(2014), 281-295
DOI: 10.3233/CH-141902
2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development
Laube, M.; Tondera, C.; Sharma, S. K.; Bechmann, N.; Pietzsch, F.-J.; Pigorsch, A.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.
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RSC Advances 4(2014), 38726-38742
DOI: 10.1039/c4ra05650g
2013
Radionuclide impurities in [F-18]F- and [F-18]FDG for positron emission tomography
Koehler, M.; Degering, D.; Zessin, J.; Fuechtner, F.; Konheiser, J.
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Applied Radiation and Isotopes 81(2013), 268-271
DOI: 10.1016/j.apradiso.2013.03.044
ISSN: 0969-8043
Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for ß-Amyloid Targeting
Ribeiro Morais, G.; Kniess, T.; Bergmann, R.; Gano, L.; Abrunhosa, A.; Santos, I.; Paulo, A.
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Applied Radiation and Isotopes 82(2013), 100-104
DOI: 10.1016/j.apradiso.2013.07.003
Radiolabeled COX-2 inhibitors for non-invasive visualization of COX-2 expression and activity - a critical update
Laube, M.; Kniess, T.; Pietzsch, J.
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Molecules 18(2013), 6311-6355
DOI: 10.3390/molecules18066311
Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system
Franck, D.; Kniess, T.; Steinbach, J.; Zitzmann-Kolbe, S.; Friebe, M.; Dinkelborg, L. M.; Graham, K.
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Bioorganic & Medicinal Chemistry 21(2013), 643-652
DOI: 10.1016/j.bmc.2012.11.049
Visualization of cyclooxygenase-2 using a 2,3-diarylsubstituted indole-based inhibitor and confocal laser induced cryofluorescence microscopy at 20 K in melanoma cells in vitro
Tondera, C.; Laube, M.; Wimmer, C.; Kniess, T.; Mosch, B.; Großmann, K.; Pietzsch, J.
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Biochemical and Biophysical Research Communications 430(2013), 301-306
Online First (2012) DOI: 10.1016/j.bbrc.2012.10.133
2-Carbaborane-3-phenyl-1H-indoles—Synthesis via McMurry Reaction and Cyclooxygenase (COX) Inhibition Activity
Laube, M.; Neumann, W.; Scholz, M.; Lönnecke, P.; Crews, B.; Marnett, L. J.; Pietzsch, J.; Kniess, T.; Hey-Hawkins, E.
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ChemMedChem 8(2013)2, 329-335
DOI: 10.1002/cmdc.201200455
2012
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
Caballero, J.; Muñoz, C.; Alzate-Morales, J. H.; Cunha, S.; Gano, L.; Bergmann, R.; Steinbach, J.; Kniess, T.
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European Journal of Medicinal Chemistry 58(2012), 272-280
DOI: 10.1016/j.ejmech.2012.10.020
Synthesis and cytotoxicity of pyridine and quinoline oxorhenium(V) complexes with tridentate (NS2, S-3)/monodentate (s) coordination
Segal, I.; Zablotskaya, A.; Kniess, T.; Shestakova, I.
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Chemistry of Heterocyclic Compounds 48(2012), 296-300
DOI: 10.1007/s10593-012-0989-z
ISSN: 0009-3122
Novel 7α-alkoxy-17α-(4’-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumors: synthesis and binding affinity evaluation
Neto, C.; Oliveira, M. C.; Gano Fernanda Marques, M. L.; Yasuda, T.; Thiemann, T.; Kniess, T.; Santos, I.
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Steroids 77(2012), 1123-1132
DOI: 10.1016/j.steroids.2012.05.004
Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis - radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib
Kuchar, M.; Oliveira, M. C.; Gano, L.; Santos, I.; Knieß, T.
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Bioorganic & Medicinal Chemistry Letters 22(2012), 2850-2855
DOI: 10.1016/j.bmcl.2012.02.068
Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents
Neto, C.; Fernandes, C.; Oliveira, M. C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.
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Nuclear Medicine and Biology 39(2012), 247-260
DOI: 10.1016/j.nucmedbio.2011.09.001
Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations
Munoza, C.; Adasmea, F.; Alzate-Morales, J. H.; Vergara-Jaquea, A.; Kniess, T.; Caballero, J.
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Journal of Molecular Graphics and Modelling 32(2012), 39-48
DOI: 10.1016/j.jmgm.2011.10.005
Radiolabeled small molecule inhibitors of VEGFR – recent advances
Kniess, T.
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Current Pharmaceutical Design 18(2012), 2867-2874
DOI: 10.2174/138161212800672796
ISSN: 1873-4286
Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; Patt, M.; Sorger, D.; Zessin, J.; Sacher, J.; Lobsien, D.; Habermann, B.; Meyer, P. M.; Füchtner, F.; Luthardt, J.; Bresch, A.; Steinbach, J.; Sabri, O.
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European Journal of Nuclear Medicine and Molecular Imaging 39(2012)6, 1001-1011
DOI: 10.1007/s00259-012-2078-z
Site-selective radiolabeling of peptides by 18F-fluorobenzoylation with [18F]SFB in solution and on solid phase - a comparative study
Kuchar, M.; Pretze, M.; Knieß, T.; Steinbach, J.; Pietzsch, J.; Löser, R.
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Amino Acids 43(2012), 1431-1443
DOI: 10.1007/s00726-012-1216-z
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
Kniess, T.; Laube, M.; Bergmann, R.; Graf, F.; Steinbach, J.; Wuest, F.; Pietzsch, J.
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Bioorganic & Medicinal Chemistry 20(2012), 3410-3421
DOI: 10.1016/j.bmc.2012.04.022
2011
Synthesis of an 18F-labeled cyclin-dependent kinase-2 inhibitor
Svensson, F.; Kniess, T.; Bergmann, R.; Pietzsch, J.; Wuest, F.
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Journal of Labelled Compounds and Radiopharmaceuticals 54(2011), 769-774
DOI: 10.1002/jlcr.1922
Radiolabeling of phosphatidylserine-binding peptides with prosthetic groups N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM) and N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
Kapty, J.; Kniess, T.; Wuest, F.; Mercer, J. R.
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Applied Radiation and Isotopes 69(2011), 1218-1225
DOI: 10.1016/j.apradiso.2011.05.012
ISSN: 0969-8043
Visualization of the focus in congenital hyperinsulinism by intraoperative sonography
von Rohden, L.; Mohnike, K.; Mau, H.; Eberhard, T.; Mohnike, W.; Blankenstein, O.; Empting, S.; Koch, M.; Fuechtner, F.; Barthlen, W.
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Seminars in Pediatric Surgery 20(2011)1, 28-31
DOI: 10.1053/j.sempedsurg.2010.10.011
ISSN: 1055-8586
Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors
Al-Hourani, B. J.; Sharma, S. K.; Mane, J. Y.; Tuszynski, J.; Baracos, V.; Kniess, T.; Suresh, M.; Pietzsch, J.; Wuest, F.
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Bioorganic & Medicinal Chemistry Letters 21(2011), 1823-1826
DOI: 10.1016/j.bmcl.2011.01.057
ISSN: 0960-894X
Intraoperative Sonography: A Technique for Localizing Focal Forms of Congenital Hyperinsulinism in the Pancreas
von Rohden, L.; Mohnike, K.; Mau, H.; Eberhard, T.; Mohnike, W.; Blankenstein, O.; Empting, S.; Koch, M.; Füchtner, F.; Barthlen, W.
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Ultraschall in der Medizin 32(2011), 74-80
DOI: 10.1055/s-0029-1245598
Automated radiosynthesis of the thiol-reactive labeling agent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM)
Knieß, T.; Kuchar, M.; Pietzsch, J.
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Applied Radiation and Isotopes 69(2011), 1226-1230
DOI: 10.1016/j.apradiso.2011.03.043
2010
Synthesis of neurotensin(8-13)-phosphopeptide heterodimers via click chemistry
Richter, S.; Ramenda, T.; Bergmann, R.; Knieß, T.; Steinbach, J.; Pietzsch, J.; Wuest, F.
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Bioorganic & Medicinal Chemistry Letters 20(2010), 3306-3309
DOI: 10.1016/j.bmcl.2010.04.038
ISSN: 0960-894X
2009
Radiolabelling of proteins with fluorine-18 via click chemistry
Ramenda, T.; Knieß, T.; Bergmann, R.; Steinbach, J.; Wüst, F.
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Chemical Communications 48(2009), 7521-7523
DOI: 10.1039/b916075b
ISSN: 1359-7345
PET-Tracer für die onkologische Diagnostik: Welche radiomarkierten Substanzen sind relevant?
Knieß, T.; Steinbach, J.
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Onkologische Pharmazie 11(2009)4, 4-5
ISSN: 1437-8825
Synthesis and radiopharmacological investigation of 3-[4-[18F]fluorobenzylidenyl]-indolin-2-one as possible tyrosine kinase inhibitor
Knieß, T.; Bergmann, R.; Kuchar, M.; Steinbach, J.; Wüst, F.
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Bioorganic & Medicinal Chemistry 17(2009), 7732-7742
DOI: 10.1016/j.bmc.2009.09.038
Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives
Wuest, F.; Tang, X.; Knieß, T.; Pietzsch, J.; Suresh, M.
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Bioorganic & Medicinal Chemistry 17(2009), 1146-1151
DOI: 10.1016/j.bmc.2008.12.032
Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer
Wüst, F.; Knieß, T.; Henry, B.; Peeters, B. W. M. M.; Wiegerinck, P. H. G.; Pietzsch, J.; Bergmann, R.
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Applied Radiation and Isotopes 67(2009), 308-312
DOI: 10.1016/j.apradiso.2008.10.014
Cell cycle regulating kinase Cdk4 as a potential target for tumor cell treatment and tumor imaging
Graf, F.; Köhler, L.; Knieß, T.; Wüst, F.; Mosch, B.; Pietzsch, J.
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Journal of Oncology 2009(2009), 106378
DOI: 10.1155/2009/106378
2008
Radiation treatment planning in brain tumours Potential impact of 3-O-methyl-6-[18F]fluoro-L-DOPA and PET
Alheit, H.; Oehme, L.; Winkler, C.; Füchtner, F.; Hoepping, A.; Grabowski, J.; Kotzerke, J.; Beuthien-Baumann, B.
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Nuklearmedizin 47(2008)5, 200-204
DOI: 10.3413/nukmed-0171
Congenital hyperinsulinism: [18F]DOPA PET/CT scan of a focal lesion in the head of the pancreas
Kapoor, R. R.; Gilbert, C.; Mohnike, K.; Blankenstein, O.; Füchtner, F.; Hussain, K.
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Archives of Disease in Childhood 93(2008)2, 166
DOI: 10.1136/adc.2007.121178
Factors affecting the specific activity of [18F]fluoride from a [18O]water target
Füchtner, F.; Preusche, S.; Mäding, P.; Zessin, J.; Steinbach, J.
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Nuklearmedizin 47(2008), 116-119
DOI: 10.3413/nukmed-0133
Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor
Wüst, F.; Knieß, T.; Bergmann, R.; Pietzsch, J.
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Bioorganic & Medicinal Chemistry 16(2008), 7662-7670
DOI: 10.1016/j.bmc.2008.07.016
Facile synthesis of various nitro-substituted derivatives of semaxinib (SU 5416)
Knieß, T.; Kuchar, M.; Wüst, F.
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Synthetic Communications 38(2008), 3017-3022
DOI: 10.1080/00397910802044256
ISSN: 0039-7911 print/1532
Radiolabeled glucocorticoids as molecular probes for imaging brain glucocorticoid receptors by means of positron-emission-tomography (PET)
Steiniger, B.; Knieß, T.; Bergmann, R.; Pietzsch, J.; Wüst, F.
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Mini-Reviews in Medicinal Chemistry 8(2008)7, 728-739
ISSN: 1389-5575
Evaluation of 18F- L-DOPA PET-CT for surgery in focal congenital hyperinsulinism
Barthlen, W.; Mau, H.; Koch, M.; Höhne, C.; Blankenstein, O.; Mohnike, W.; Eberhard, T.; Füchtner, F.; Lorenz-Depiereux, B.; Mohnike, K.
- Journal of Clinical Endocrinology and Metabolism 93(2008)3, 869-875
18F-DOPA Positron Emission Tomography for Preoperative Localization in Congenital Hyperinsulinism
Mohnike, K.; Blankenstein, O.; Minn, H.; Mohnike, W.; Füchtner, F.; Otonovski, T.
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Hormone Research 70(2008)2, 65-72
DOI: 10.1159/000137655
Aspects of 6-[18F]fluoro-L-DOPA preparation: Deuterochloroform as a substitute solvent for Freon 11
Füchtner, F.; Zessin, J.; Mäding, P.; Wüst, F.
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Nuklearmedizin 47(2008), 62-64
DOI: 10.3413/nukmed-0112
Practical experiences with the synthesis of [11C]CH3 trough gas phase iodination reaction using a TRACERlabFXC synthesis module
Knieß, T.; Rode, K.; Wüst, F.
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Applied Radiation and Isotopes 66(2008), 482-488
DOI: 10.1016/j.apradiso.2007.06.005
2007
L-Type Amino Acid Transporters LAT1 and LAT4 in Cancer: Uptake of 3-O- Methyl-6-18F-Fluoro-L-Dopa (18F-OMFD) in Human Adenocarcinoma and Squamous Cell Carcinoma in vitro and in vivo
Haase, C.; Bergmann, R.; Füchtner, F.; Hoepping, A.; Pietzsch, J.
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Journal of Nuclear Medicine 48(2007)12, 2063-2071
DOI: 10.2967/jnumed.107.043620
Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors
Wüst, F.; Knieß, T.; Bergmann, R.; Henry, B.; Pietzsch, J.
- Bioorganic & Medicinal Chemistry Letters 17(2007), 4035-4039
2006
Synthesis of a 11C-labelled taxane derivative by [1-11C]acetylation
Mäding, P.; Zessin, J.; Pleiß, U.; Füchtner, F.; Wüst, F.
-
Journal of Labelled Compounds and Radiopharmaceuticals 49(2006), 357-365
DOI: 10.1002/jlcr.1059
18F-Labelling of a potent nonpeptide CCR1 antagonist: Synthesis of 1-(5-chloro-2-{2-[(2R)-4-(4-[18F]fluorobenzyl)-2methylpiperazin-1-yl]-2-oxoethoxy}phenyl)urea in an automated module
Mäding, P.; Füchtner, F.; Johannsen, B.; Steinbach, J.; Hilger, C. S.; Friebe, M.; Halks-Miller, M.; Horuk, R.; Mohan, R.
- Journal of Labelled Compounds and Radiopharmaceuticals 49 (2006) 253-262
2005
Effect of Moderate Hypercapnic Hypoxia on Cerebral Dopaminergic Activity and Brain O2 Uptake in Intrauterine GrowthRestricted Newborn Piglets
Bauer, R.; Walter, B.; Vorwieger, G.; Fritz, A.; Füchtner, F.; Zwiener, U.; Brust, P.
-
Pediatric Research 57(2005)3, 363-370
DOI: 10.1203/01.PDR.0000150800.19956.F0
Module-assisted synthesis of the bifunctional labelling agent N-succinimidy 4-[18F]fluorobenzoate ([18F]SFB)
Mäding, P.; Füchtner, F.; Wüst, F.
- Applied Radiation and Isotopes 63(2005), 329-332
Synthesis and radiopharmacological evaluation of 2´-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET)
Wüst, F.; Knieß, T.; Kretzschmar, M.; Bergmann, R.
- Bioorganic & Medicinal Chemistry Letters 15(2005), 1303-1306
Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazolde piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)
Garcia, R.; Xavier, C.; Paulo, A.; Santos, I.; Knieß, T.; Bergmann, R.; Wüst, F.
- Journal of Labelled Compounds and Radiopharmaceuticals 48(2005), 301-315
N-Arylation of indoles with 4-[18F]fluoroiodobenzene: synthesis of 18F-labelled σ2 receptor ligands for positron emission tomography (PET)
Wüst, F.; Knieß, T.
-
Journal of Labelled Compounds and Radiopharmaceuticals 48(2005), 31-43
DOI: 10.1002/jlcr.893
2004
The Influx of Neutral Amino Acids into the Porcine Brain During Development: A Positron Emission Tomography Study
Brust, P.; Vorwieger, G.; Walter, B.; Füchtner, F.; Stark, H.; Kuwabara, H.; Steinbach, J.; Bauer, R.
- Developmental Brain Research 152(2004), 241-253
3-O-Methyl-6-18F-Fluoro-L-Dopa, a New Tumor Imaging Agent: Investigation of Transport Mechanism In Vitro
Bergmann, R.; Pietzsch, J.; Füchtner, F.; Pawelke, B.; Beuthien-Baumann, B.; Johannsen, B.; Kotzerke, J.
- Journal of Nuclear Medicine 45(2004), 2116-2122
Synthesis and biological evaluation of silylated mixed-ligand 99mTc complexes with the [PNS/S] donor atom set
Fernandes, C.; Knieß, T.; Gano, L.; Seifert, S.; Spies, H.; Santos, I.
-
Nuclear Medicine and Biology 31(2004), 785-793
DOI: 10.1016/j.nucmedbio.2004.03.011
No-carrier added synthesis of 18F-labelled nucleosides using Stille cross-coupling reactions with 4-[18F]fluoroiodobenzene
Wüst, F.; Knieß, T.
-
Journal of Labelled Compounds and Radiopharmaceuticals 47(2004), 457-468
DOI: 10.1002/jlcr.834
Developmental changes in the activity of aromatic amino acid decarboxylase and catechol-O-methyl transferase in pigs: a positron emission tomography study
Brust, P.; Walter, B.; Hinz, R.; Füchtner, F.; Müller, M.; Steinbach, J.; Bauer, R.
- Neuroscience Letters, 364(2004)3, 159-163
Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs
Walter, B.; Brust, P.; Füchtner, F.; Müller, M.; Hinz, R.; Kuwabara, H.; Fritz, H.; Zwiener, U.; Bauer, R.
- Journal of Neurotrauma 21(2004)8, 1076-1089
Changes in brain metabolism associated with remission in unipolar major depression
Holthoff, V.; Beuthien-Baumann, B.; Zündorf, G.; Triemer, A.; Lüdecke, S.; Winiecki, P.; Koch, R.; Füchtner, F.; Herholz, K.
- Acta Psychiatrica Scandinavica 110(2004), 184-194
2003
Impact of asymmetric intrauterine growth restriction on organ function in newborn piglets
Bauer, R.; Walter, B.; Brust, P.; Füchtner, F.; Zwiener, U.
- European Journal of Obstetrics and Gynecology and Reproductive Biology 110 (2003) S40-S49
3-O-Methyl-6-[18F]Fluoro-L-DOPA and its Evaluation in Brain Tumour Imaging
Beuthien-Baumann, B.; Bredow, J.; Burchert, W.; Füchtner, F.; Bergmann, R.; Alheit, H.-D.; Reiss, G.; Hliscs, R.; Steinmeier, R.; Franke, W.-G.; Johannsen, B.; Kotzerke, J.
- European Journal of Nuclear Medicine and Molecular Imaging (2003) 30: 1004-1008
Synthesis and Enzymatic Evaluation of Nucleosides Derived from 5-Iodo-2'-deoxyuridines
Knieß, T.; Grote, M.; Noll, B.; Johannsen, B.
- Z. Naturforsch. 58b, 226-230 (2003)
Silylated mixed-ligand rhenium complexes with the [PNS/S] donor atom set
Knieß, T.; Fernandes, C.; Santos, I.; Kraus, W.; Spies, H.
- Inorganica Chimica Acta 348 (2003) 237-241
Synthesis of 4-[18F]fluoroiodobenzene and its application in Sonogashira cross-coupling reactions
Wüst, F.; Knieß, T.
- Journal of Labelled Compounds and Radiopharmaceuticals 2003, 46: 699-713
Efficient synthesis of the 18F-labelled amino acid 3-O-methyl-6-[18F]fluoro-L-DOPA
Füchtner, F.; Steinbach, J.
- Applied Radiation and Isotopes 58 (2003) 575-578
2002
Synthesis and biological activity of 3+1' mixed ligand (3-thiapentane-1,5-dithiolato)oxorhenium(V) complexes bearing 1,2,3,4-tetrahydro(iso)quinoline and quinoline
Zablotskaya, A.; Segal, I.; Germane, S.; Shestakova, I.; Lukevics, E.; Knieß, T.; Spies, H.
- Applied Organometallic Chemistry 16 (2002) 550-555
Synthesis of hydroxyl silylated rhenium and (99mTc)technetium 3+1'mixed ligand complexes
Knieß, T.; Spies, H.; Santos, I.; Zablotskaya, A.
- J Label Compd Radiopharm 45 (2002) 629-636
Effect of hypoxia/hypercapnia on metabolism of 6-[18F]fluoro-L-DOPA in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Elhalag, E.; Fritz, A.; Steinbach, J.; Füchtner, F.; Hinz, R.; Zwiener, U.; Johannsen, B.
- Brain Research 934 (2002) 22-33
Distribution of estrone sulfatase in rat brain determined by in vitro autoradiography with 16alpha-[18F]fluoroestradiol-3,17beta-disulfamate
Rodig, H.; Brust, P.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Johannsen, B.
- Applied Radiation and Isotopes 56 (2002) 773-780
Aspects of 6-[18F]fluoro-L-DOPA preparation: Precursor synthesis, preparative HPLC purification and determination of radiochemical purity
Füchtner, F.; Angelberger, P.; Kvaternik, H.; Hammerschmidt, F.; Peric Simovc, B.; Steinbach, J.
- Nuclear Medicine and Biology, 29 (2002) 477-481
Distribution of 16alpha-[18F]fluoro-estradiol-3,17beta-disulfamate (FESDS) in rats, tumour-bearing mice and piglets
Brust, P.; Rodig, H.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Zips, D.; Baumann, M.; Steinbach, J.; Johannsen, B.
- Applied Radiation and Isotopes 57 (2002) 687-695
2001
Synthesis and physico-chemical characterization of triorganylsiloxyalkyl monodentate ligands with free mercapto group.
Zablotskaya, A.; Segal, I.; Lukevics, E.; Knieß, T.; Spies, H.
- Latv. Kim. Z. N4 (2001) 339-342
Simultaneous preparation of 16alpha-[18F]fluoroestradiol-sulphamates in an automated module. A high-yield procedure for 16alpha-[18F]fluoroestradiol-17beta-sulphamate
Römer, J.; Füchtner, F.; Steinbach, J.; Kasch, H.
- Journal of Labelled Compounds and Radiopharmaceuticals 44 (2001) 689-700
Intrauterine growth restriction induces up-regulation of cerebral aromatic amino acid decarboxylase activity in newborn piglets: [18F]fluorodopa positron-emission-tomographic study
Bauer, R.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Brust, P.
- Pediatric Research 49 (2001) 474-480
Automated Synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate
Römer, J.; Füchtner, F.; Steinbach, J.; Kasch, H.
- Applied Radiation and Isotopes 55 (2001) 631-639.
2000
Synthesis of 16alpha-[18F]fluorestradiol-3,17beta-disulphamate
Römer, J.; Füchtner, F.; Steinbach, J.
- J. Labelled Cpd. Radiopharm. 43 (2000) 425-436
Relation between brain tissue pO2 and dopamine synthesis of basal ganglia - A 18FDOPA-PET study in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Steinbach, J.; El-Hallag, E.; Fritz, A.; Johannsen, B.; Zwiener, U.
- J. Perinat. Med. 28 (2000) 54-60
1999
Nicotinamide-substituted complexes as redox markers. 2. Synthesis of a 99Tc-dihydropyridine mixed-ligand complex and investigation of the stability in tissue homogenates
Rother, A.; Kniess, T.; Pütz, M.; Jungclas, H.; Spies, H.; Johannsen, B.
- Journal of Labelled Compounds and Radiopharmaceuticals 42, 673-681(1999)
The stability of 2-[18F]fluoro-deoxy-D-glucose towards epimerisation under alkaline conditions
Meyer, G. J.; Matzke, K. H.; Hamacher, K.; Füchtner, F.; Steinbach, J.; Notohamiprodjo, G.; Zijlstra, S.
- Applied Radiation and Isotopes 51 (1999) 37-41
Effective coupling of Re/Tc-MAG3 complexes with amines and nucleobases in aprotic solvents.
Kniess, T.; Noll, S.; Noll, B.; Spies, H.; Johannsen, B.
-
Journal of Radioanalytical and Nuclear Chemistry, 240, No. 2 (1999), 657-660
DOI: 10.1007/BF02349428
Upregulation of the Aromatic Amino Acid Decarboxylase under Neonatal Asphyxia
Brust, P.; Bauer, R.; Vorieger, G.; Walter, B.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Zwiener, U.; Johannsen, B.
-
Neurobiology of Disease 6, (1999) 131-139
DOI: 10.1006/nbdi.1998.0232
Long-distance transport of radionuclides between PET cyclotron and PET radiochemistry
Preusche, S.; Füchtner, F.; Steinbach, J.; Zessin, J.; Krug, H.; Neumann, W.
- Appl. Rad. Isot. 51 (1999) 625-630
Nicotinamide-substituted complexes as redox markers 2. Synthesis of a 99Tc dihydropyridine mixed-ligand complex and investigation of the stability in tissue homogenates
Rother, A.; Knieß, T.; Pütz, M.; Jungclas, H.; Spies, H.; Johannsen, B.
- J. Labelled Cpd. Radiopharm. 42 (1999) 673-681
Automated Production of the PET Tracer 16 alpha-[18F] Fluoroestradiol for Breast Cancer Imaging
Römer, J.; Füchtner, F.; Steinbach, J.; Johannsen, B.
- Nucl. Med. Biol. 26 (1999) 473-479
1998
Nicotinamide-Substituted Complexes as Redox Marker
Knieß, T.; Spies, H.; Brandau, W.; Johannsen, B.
-
Journ. Labelled Comp. and Radiopharm. XLI, 605-614 (1998)
DOI: 10.1002/(SICI)1099-1344(199807)41:7<605::AID-JLCR112>3.0.CO;2-P
Simultaneous Measurement of 18F-FDOPA Metabolism and Cerebral Blood Flow in Newborn Piglets
Brust, P.; Bauer, R.; Walter, B.; Bergmann, R.; Füchtner, F.; Vorwieger, G.; Steinbach, J.; Johannsen, B.; Zwiener, U.
-
Int. J. Devl. Neuroscience, Vol. 16, No. 5, pp 353-364, 1998
DOI: 10.1016/S0736-5748(98)00017-3
1996
Rhenium(V) gluconate, a suitable precursor for the preparation of rhenium(V) complexes
Noll, B.; Knieß, T.; Friebe, M.; Spies, H.; Johannsen, B.
-
Isotopes Environmental Health Studies 32 (1996) pp. 21-29
DOI: 10.1080/10256019608036290
Basic Hydrolysis of 2-(18F)Fluoro-1,3,4,6-tetra-0-acetyl-D-glucose in the Preparation of 2-(18F)Fluoro-2-deoxy-D-glucose
Füchtner, F.; Steinbach, J.; Mäding, P.; Johannsen, B.
-
Applied Radiation and Isotopes 47 (1996) 1 pp. 61-66
DOI: 10.1016/0969-8043(95)00258-8
1994
N.C.A. 11C-labelling of aromatic compounds in the ring-position: synthesis of nitro-[1-11C]benzene and [1-11C]aniline
Steinbach, J.; Mäding, P.; Füchtner, F.; Johannsen, B.
-
Journal of Labelled Compounds and Radiopharmaceuticals 36 (1994) 1 pp. 33
DOI: 10.1002/jlcr.2580360104