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Facile synthesis of various nitro-substituted derivatives of semaxinib (SU 5416)

Knieß, T.; Kuchar, M.; Wüst, F.


The synthesis of novel nitro-substituted derivatives of the tyrosine kinase inhibitor SEMAXINIB (SU 5416) is described. The reaction of various substituted oxindoles with 3,5-dimethylpyrrol-2-carbaldehyde derivatives under Knoevenagel conditions gave an array of nitro-substituted derivatives of Semaxinib (SU 5416) in high yields of 72-87%.

Keywords: Nitration; semaxinib; tyrosine kinase


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