Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

1 Publication

Nodal recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: incidence and proposed risk factors

Wink, K. C. J.; van Baardwijk, A.; Troost, E. G. C.; de Ruysscher, D.


Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with EBUS, and undergo intra-operative lymph node dissection or sampling. Occult nodal metastases (ONM) detected by lymph node dissection have been shown to increase the incidence of regional recurrence (RR) after surgery, which is associated with poor outcome. In patients undergoing SBRT, however, definite pathological nodal staging is lacking. Therefore, other ways to identify patients at high risk for ONM and RR might be thought for.
The aim of this systematic review is to summarize the incidence of and risk factors for RR after SBRT and compare these to those after surgery.

Keywords: SBRT; SABR; NSCLC; regional recurrence; lymph node; early stage


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