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1 Publication

Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C-H activation

Tsushima, S.; Kretzschmar, J.; Doi, H.; Okuwaki, K.; Kaneko, M.; Mochizuki, Y.; Takao, K.

Abstract

Bovine serum albumin (BSA) has a uranyl(VI) binding hotspot where uranium is tightly bound by three carboxylates. Uranyl oxygen is “soaked” into the hydrophobic core of BSA. Isopropyl hydrogen of Val is trapped near UO22+ and upon photoexcitation, C–H bond cleavage is initiated. A unique hydrophobic contact with “yl”-oxygen, as observed here, can be used to induce C-H activation.

Permalink: https://www.hzdr.de/publications/Publ-38885