Research interests

Dr. Kristof Zarschler ©Copyright: Oliver Killig

Our research focus is on the in-depth biological characterization and pharmacological evaluation of novel radiopharmaceuticals based on small molecules, peptides and antibody derivatives. Hereby, the individual building blocks (e.g. radiometals, chelators) as well as the conjugates as a whole are analyzed in depth regarding their in vitro stability, their effects on cell signaling and health as well as their multifaceted interactions with biomolecules and cells. Our fundamental aim is to understand the biology of such materials and to shed light on involved molecular mechanisms and use the knowledge gained for rationally improving their design in that respect. Building up on these studies, we are also working on precise engineering and tailoring of different kinds of bioconjugates for their application as diagnostic tools and therapeutic agents.

Interested in our research activities? For collaborations, internships, theses (Bachelor / Master / Diploma) contact:

Foto: Nanoteilchen für die Krebsforschung ©Copyright: HZDR/Frank Bierstedt

Curriculum vitae

Kristof completed his university studies in Biology at the Technische Universität Dresden (TUD) Germany in 2005 and received his PhD with distinction from the Department of Nanobiotechnology at the University of Natural Resources and Life Science Vienna (BOKU), Austria in 2009. Before joining the Nanoscalic Systems group of Dr. Holger Stephan at the Institute of Radiopharmaceutical Cancer Research of the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) as a research associate in 2011, Kristof was a postdoctoral research associate at the Institute for Genetics of the TUD (2010-2011).

In recognition of the quality of his research results, Kristof receives many invites to speak at international conferences, overseas universities and research organizations including:

  • Annual congress of the European Association of Nuclear Medicine (EANM)
  • Internacional Caparica Christmas Congress on Translational Chemistry (IC3TC)
  • International Symposium on Radiopharmaceutical Sciences (ISRS)
  • International Chemical Congress of Pacific Basin Societies (Pacifichem)
Kristof Zarschler at IC3TC2017 ©Copyright: Dr. Zarschler, Kristof

Contact & Details

Range of methods (excerpt)

  • Heterologous protein expression
    Kristof Zarschler Research ©Copyright: Frank Bierstedt
  • Protein purification (Affinity chromatography, Size exclusion chromatography)
  • Protein characterization (SDS-PAGE, Western Blot, MALDI-TOF MS)
  • Protein modification and functionalization (site-specific & classic)
  • Radiolabeling of small molecules, peptides and protein derivatives (radio-thin layer chromatography, autoradiography, stability assessment, ligand challenge studies)
  • Analysis of cell binding, uptake, localization, signaling, toxicity (flow cytometry, fluorescence microscopy, saturation and competitive binding, internalization, etc.)
  • Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry (MALDI-TOF-MS)

Past and present students

  • Marie-Charlotte Ludik, M. Sc, 2021
  • Charlice Hill, B. Sc., 2021
  • Alisa Maier, internship, 2021
  • Michelle Erkenberg, practical semester, 2019
  • Eva Schlein, M. Sc., 2018
  • Kenny Rabe, M. Sc., 2015
  • Ines Dünnbier, B. Sc., 2015
  • Franz Kapplusch, M. Sc., 2013
  • Stefanie Witecy, M. Sc., 2013