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Porträt Prof. Dr. Kubeil, Manja; FWOB

Prof. Dr. Manja Kubeil

Head Radiation Research on Biological Systems
Marie Curie Alumna
m.kubeilAthzdr.de
Phone: +49 351 260 2006

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Department of Radiation research on biological systems


Why is research into ionizing radiation and the behavior of radionuclides in the environment still of central importance, even in the age of climate change and the energy transition?

Radionuclides are not only of natural origin but are also continuously released into the environment as a result of human activities. Despite decades of research, significant gaps in knowledge remain regarding the transport of radionuclides in natural systems, their uptake by organisms, and their long-term effects on ecosystems and humans. These questions are becoming increasingly important, particularly in light of the expansion of sustainable energy systems, the safe disposal of radioactive waste, and the sustainable protection of humans.

Against this backdrop, the “Radiation Research on Biological Systems” department investigates the influence of radioactive substances on biological and chemical processes. In doing so, it is important to develop a fundamental and molecular understanding of the transport behavior of radionuclides as well as their bioavailability, which govern the distribution and mobility of radionuclides in the biosphere. This enables a robust assessment of risks to humans and the environment while simultaneously opening up innovative applications. Our research encompasses the deep subsurface in the context of final disposal of high-level radioactive waste, environmental and industrial systems, as well as a wide variety of biological systems.

To this end, we combine modern approaches from molecular biology, microbiology, biochemistry, radioanalytics, spectroscopy, and microscopy. The insights gained contribute to the further development of transport and prediction models that take biological processes into account, support the development of sustainable remediation strategies for contaminated sites, and open up new perspectives for prevention research.

By understanding the complex interactions between biology, chemistry, and physics, we contribute to the safe use of nuclear technologies and the responsible handling of radioactive materials in a changing society.

Interested in working with us?

To support our work, we are always looking for students and interns from the fields of biology, chemistry and environmental sciences who either want to write their thesis with us or simply gain practical experience. Are you interested? Then please get in touch to clarify any questions you may have.


Current research topics

Working fields of the departement of biogeochemistry at the Institute of Resource Ecology (EN) ©Copyright: Dr. Matschiavelli, Nicole
  • Determination of the microbial diversity in water and soil environments contaminated with heavy metals and radionuclides as well as in different host rocks for potential radioactive waste disposals
  • Microbe-radionuclide-interactions with reference strains and isolates
  • Interaction of eukaryotic cells with radionuclides and lanthanides in particular with plants, fungi, sponges and algae
  • Investigation of the interaction of selected bioligands and model compounds with f-elements
  • Characterization of microbial processes affecting the conditions in deep geological repositories for radioactive waste (e.g. transformation of bentonite as barrier material)
  • Calculation and determination of the metal speciation relevant to the environment
  • Verification and validation of transport models
  • Characterization of particles in the environment relevant to the transport of radionuclides
  • Investigation of the transport processes of radionuclides by particles (including microbes) in natural water

Projects

  • PIANOFORTE/EU project, grant number: 101061037, duration: 01.06.2022-31.05.2027
  • EURAD2-InCoManD, EU-EURATOM, grant number: 10 45219 047, duration: 01.10.2024-30.09.2026
  • Vernetzungsdoktoranden über die Helmholtz Forschungsfelder „Energie“ und „Gesundheit“ (zusammen mit dem Institut für Radioonkologie – OncoRay, Abteilung Strahlenbiologie, Prof. Nils Cordes): Alpha-Partikel: Identifizierung von Mechanismen von der Aufnahme bis zum Zelltod, Laufzeit: 01.12.2025 – 30.11.2028
  • ReNATE: Biologische Radionuklidentfernung durch Nutzung natürlicher Assoziationsprozesse: Technische Entwicklung, BMFTR-Projekt, Förderkennzeichen: 15S9454A, Laufzeit: 01.10.2025 - 30.09.2028

An overview of completed projects can be found here.


Latest publication

Characterization of macrocyclic host-guest systems by liquid-liquid extraction

Yoshizuka, K.; Kubeil, M.; Stephan, H.

Abstract

Macrocyclic compounds have advanced the molecular recognition of many organic and inorganic guest molecules, utilizing in particular their high degree of pre-organization. This has led to a number of attractive applications, for example in sensor technology, selective separation processes, and the manufacture of advanced materials, right through to the development of artificial enzymes. Liquid-liquid extraction has accompanied these developments from the outset and has contributed, on the one hand, to a better understanding of the fundamentals of molecular recognition processes and, on the other hand, to the development of practical methods for the effective and selective separation of different guest molecules using macrocyclic compounds. Extraction offers the possibility to investigate host-guest systems where the reaction partners have very different solubility properties. The use of the radiotracer method in particular provides very reliable data with a high degree of accuracy. This approach yields highly accurate separation and selectivity factors, as well as information on the lipophilicity of host compounds and even thermodynamic parameters, which provide insight into the enthalpic and entropic contributions of the molecular recognition process.

Keywords: Extraction; Phase Transfer; Macrocyclic Compounds; Radiotracer Method; Thermodynamics; Lipophilicity

Permalink: https://www.hzdr.de/publications/Publ-43086


More publications


Team


Head

NameBld./Office+49 351 260Email
Prof. Dr. Manja Kubeil801/P1272006
m.kubeilAthzdr.de

Employees

NameBld./Office+49 351 260Email
Nicolas Tim Appel801/P3062860
n.appelAthzdr.de

Deep Biosphere

NameBld./Office+49 351 260Email
Dr. Andrea Cherkouk801/P3562989
a.cherkoukAthzdr.de
Sindy Kluge801/P2193194
s.klugeAthzdr.de
Katrin Lehmann801/P3062860
k.lehmannAthzdr.de

Terrestrial Microbiology

NameBld./Office+49 351 260Email
Dr. Johannes Raff801/P3142951
j.raffAthzdr.de
Rahel Bertheau801/P3543138
Dr. Alix Günther801/P2562433
2522
a.guentherAthzdr.de
Dr. Evelyn Krawczyk-Bärsch801/P2522076
e.krawczyk-baerschAthzdr.de

Plants and Rhizosphere

NameBld./Office+49 351 260Email
Dr. Susanne Sachs801/P2082436
s.sachsAthzdr.de
Julia Marie Mätzkow801/P1533032
j.maetzkowAthzdr.de
Dr. Henry Moll801/P2562433
2549
h.mollAthzdr.de
Jana Seibt801/P2193194
2510
j.seibtAthzdr.de

Spectroscopy and Speciation of f-elements

NameBld./Office+49 351 260Email
Dr. Robin Steudtner801/P3172895
r.steudtnerAthzdr.de
Katrin Flemming801/P3092958
k.flemmingAthzdr.de

Other employees

NameBld./Office+49 351 260Email
Dr. Stephan Hilpmann801/P3182759
s.hilpmannAthzdr.de