Department of Radiation research on biological systems
Why is research into ionizing radiation and the behavior of radionuclides in the environment still of central importance, even in the age of climate change and the energy transition?
Radionuclides are not only of natural origin but are also continuously released into the environment as a result of human activities. Despite decades of research, significant gaps in knowledge remain regarding the transport of radionuclides in natural systems, their uptake by organisms, and their long-term effects on ecosystems and humans. These questions are becoming increasingly important, particularly in light of the expansion of sustainable energy systems, the safe disposal of radioactive waste, and the sustainable protection of humans.
Against this backdrop, the “Radiation Research on Biological Systems” department investigates the influence of radioactive substances on biological and chemical processes. In doing so, it is important to develop a fundamental and molecular understanding of the transport behavior of radionuclides as well as their bioavailability, which govern the distribution and mobility of radionuclides in the biosphere. This enables a robust assessment of risks to humans and the environment while simultaneously opening up innovative applications. Our research encompasses the deep subsurface in the context of final disposal of high-level radioactive waste, environmental and industrial systems, as well as a wide variety of biological systems.
To this end, we combine modern approaches from molecular biology, microbiology, biochemistry, radioanalytics, spectroscopy, and microscopy. The insights gained contribute to the further development of transport and prediction models that take biological processes into account, support the development of sustainable remediation strategies for contaminated sites, and open up new perspectives for prevention research.
By understanding the complex interactions between biology, chemistry, and physics, we contribute to the safe use of nuclear technologies and the responsible handling of radioactive materials in a changing society.
Interested in working with us?
To support our work, we are always looking for students and interns from the fields of biology, chemistry and environmental sciences who either want to write their thesis with us or simply gain practical experience. Are you interested? Then please get in touch to clarify any questions you may have.
Current research topics
- Determination of the microbial diversity in water and soil environments contaminated with heavy metals and radionuclides as well as in different host rocks for potential radioactive waste disposals
- Microbe-radionuclide-interactions with reference strains and isolates
- Interaction of eukaryotic cells with radionuclides and lanthanides in particular with plants, fungi, sponges and algae
- Investigation of the interaction of selected bioligands and model compounds with f-elements
- Characterization of microbial processes affecting the conditions in deep geological repositories for radioactive waste (e.g. transformation of bentonite as barrier material)
- Calculation and determination of the metal speciation relevant to the environment
- Verification and validation of transport models
- Characterization of particles in the environment relevant to the transport of radionuclides
- Investigation of the transport processes of radionuclides by particles (including microbes) in natural water
Projects
- PIANOFORTE/EU project, grant number: 101061037, duration: 01.06.2022-31.05.2027
- EURAD2-InCoManD, EU-EURATOM, grant number: 10 45219 047, duration: 01.10.2024-30.09.2026
- Vernetzungsdoktoranden über die Helmholtz Forschungsfelder „Energie“ und „Gesundheit“ (zusammen mit dem Institut für Radioonkologie – OncoRay, Abteilung Strahlenbiologie, Prof. Nils Cordes): Alpha-Partikel: Identifizierung von Mechanismen von der Aufnahme bis zum Zelltod, Laufzeit: 01.12.2025 – 30.11.2028
- ReNATE: Biologische Radionuklidentfernung durch Nutzung natürlicher Assoziationsprozesse: Technische Entwicklung, BMFTR-Projekt, Förderkennzeichen: 15S9454A, Laufzeit: 01.10.2025 - 30.09.2028
An overview of completed projects can be found here.
Latest publication
Characterization of macrocyclic host-guest systems by liquid-liquid extraction
Yoshizuka, K.; Kubeil, M.; Stephan, H.
Abstract
Macrocyclic compounds have advanced the molecular recognition of many organic and inorganic guest molecules, utilizing in particular their high degree of pre-organization. This has led to a number of attractive applications, for example in sensor technology, selective separation processes, and the manufacture of advanced materials, right through to the development of artificial enzymes. Liquid-liquid extraction has accompanied these developments from the outset and has contributed, on the one hand, to a better understanding of the fundamentals of molecular recognition processes and, on the other hand, to the development of practical methods for the effective and selective separation of different guest molecules using macrocyclic compounds. Extraction offers the possibility to investigate host-guest systems where the reaction partners have very different solubility properties. The use of the radiotracer method in particular provides very reliable data with a high degree of accuracy. This approach yields highly accurate separation and selectivity factors, as well as information on the lipophilicity of host compounds and even thermodynamic parameters, which provide insight into the enthalpic and entropic contributions of the molecular recognition process.
Keywords: Extraction; Phase Transfer; Macrocyclic Compounds; Radiotracer Method; Thermodynamics; Lipophilicity
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Journal of Inclusion Phenomena and Macrocyclic Chemistry 106(2026), 265-278
DOI: 10.1007/s10847-026-01341-4
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-43086
Team
Head | |||||
| Name | Bld./Office | +49 351 260 | |||
|---|---|---|---|---|---|
| Prof. Dr. Manja Kubeil | 801/P127 | 2006 | m.kubeil | ||
Employees | |||||
| Name | Bld./Office | +49 351 260 | |||
| Nicolas Tim Appel | 801/P306 | 2860 | n.appel | ||
Deep Biosphere | |||||
| Name | Bld./Office | +49 351 260 | |||
| Dr. Andrea Cherkouk | 801/P356 | 2989 | a.cherkouk | ||
| Sindy Kluge | 801/P219 | 3194 | s.kluge | ||
| Katrin Lehmann | 801/P306 | 2860 | k.lehmann | ||
Terrestrial Microbiology | |||||
| Name | Bld./Office | +49 351 260 | |||
| Dr. Johannes Raff | 801/P314 | 2951 | j.raff | ||
| Rahel Bertheau | 801/P354 | 3138 | |||
| Dr. Alix Günther | 801/P256 | 2433 2522 | a.guenther | ||
| Dr. Evelyn Krawczyk-Bärsch | 801/P252 | 2076 | e.krawczyk-baersch | ||
Plants and Rhizosphere | |||||
| Name | Bld./Office | +49 351 260 | |||
| Dr. Susanne Sachs | 801/P208 | 2436 | s.sachs | ||
| Julia Marie Mätzkow | 801/P153 | 3032 | j.maetzkow | ||
| Dr. Henry Moll | 801/P256 | 2433 2549 | h.moll | ||
| Jana Seibt | 801/P219 | 3194 2510 | j.seibt | ||
Spectroscopy and Speciation of f-elements | |||||
| Name | Bld./Office | +49 351 260 | |||
| Dr. Robin Steudtner | 801/P317 | 2895 | r.steudtner | ||
| Katrin Flemming | 801/P309 | 2958 | k.flemming | ||
Other employees | |||||
| Name | Bld./Office | +49 351 260 | |||
| Dr. Stephan Hilpmann | 801/P318 | 2759 | s.hilpmann | ||
