Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
1 PublicationHexadentate bispidine radiocopper complexes: emerging opportunities for the application in nuclear medicine
Stephan, H.; Juran, S.; Walther, M.; Bergmann, R.; Steinbach, J.; Comba, P.
Abstract
The advantageous properties of numerous 3,7-diazabicyclo[3.3.1]nonane (bispidine) derivatives have attracted much attention and caused intensive research efforts in different directions. An attractive goal represents the development of target-specific radiopharmaceuticals. For this purpose, bifunctional chelating agents are needed which have to show fast metal complexation kinetics, form complexes with high in vitro and in vivo stability and contain a group that can be linked to biomolecules. In this regard, hexadentate bispidines 1 3 containing pyridine units in C2, C4, N3, and N7 position have been shown to rapidly form stable radiocopper (such as 64Cu and 67Cu) complexes. Furthermore, the carboxylic groups of ligand 3 provide the possibility for coupling bio-molecules.
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Lecture (Conference)
2nd EuCheMS Chemistry Congress, 16.-20.09.2008, Torino, Italy
Permalink: https://www.hzdr.de/publications/Publ-11630