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1 PublicationFluorinated PET tracers for molecular imaging of σ1 receptors in the central nervous system.
Weber, F.; Brust, P.; Laurini, E.; Pricl, S.; Wünsch, B.
Abstract
At first the role of σ1 receptors in various neurological, psychiatric and neurodegenerative disorders is discussed. In the second part, the principle of positron emission tomography (PET) is described and the known fluorinated PET tracers for labeling of σ1 receptors are presented. The third part focuses on fluoroalkyl substituted spirocyclic PET tracers, which represent the most promising class of fluorinated PET tracers reported so far. The homologous fluoroalkyl derivatives 12-15 show high σ
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Book chapter
Smith, S. B.; Su, T.-P.: Sigma Receptors: Their Role in Disease and as Therapeutic Targets, Berlin, Heidelberg: Springer, 2017, 978-3-319-50172-7, 31-48
DOI: 10.1007/978-3-319-50174-1_4
Cited 11 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-22891