Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
1 PublicationSynthesis of 18F-labelled biphenyls via Suzuki cross-coupling with 4-[18F]fluoroiodobenzene
Steiniger, B.; Wüst, F.
Abstract
The SUZUKI reaction of organoboron compounds with 4-[18F]fluoroiodobenzene has been developed as a novel radiolabelling technique in 18F chemistry. The cross-coupling reaction of p-tolylboronic acid with 4-[18F]fluoroiodobenzene was used to screen different palladium complexes, bases and solvents. Optimised reaction conditions (Pd2(dba)3, Cs2CO3, acetonitrile, 60 °C for 5 minutes) were further applied to the synthesis of various 18F-labelled biphenyls bearing different functional groups. The reaction proceeded in excellent radiochemical yields of up to 94 % within 5 min while showing good compatibility to many functional groups.
- Journal of Labelled Compounds and Radiopharmaceuticals 49(2006), 817-827
Permalink: https://www.hzdr.de/publications/Publ-8466