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Application of a Yield Approach for the Prediction of Positron Emitter Distributions Produced During Therapeutic Carbon-Ion Beam Irradiation
Helmbrecht, S.; Priegnitz, M.; Enghardt, W.; Rohling, H.; Fiedler, F.
Positron-Emission-Tomography is a clinically implemented method for in vivo verification of treatment delivery in ion beam therapy. The dose distribution is the relevant measure but PET captures a β+-activity distribution, that is created as a side product during the irradiation.
Therefore, a prediction of the activity distribution is required. We present a simulation code that makes use of measured yields of β+ emitters to perform this task. The yields are available in three reference materials. A conversion from X-ray grey values to a combination of these materials has been set up. The lateral properties of the ion beam are described by means of a formulation of Moliere's scattering theory in thick targets.
A model of the annihilation point density around an emitting nuclide has been implemented in the software to describe the movement of the positrons.
Simulations of phantom experiments as well as of a real patient case were performed. The results are comparable or superior to the results obtained from an established condensed history Monte Carlo code.
We conclude that measured yields can be used as raw data for the calculation of ion beam induced β+-activity distribution instead of nuclear cross sections.
Keywords: PET; simulation; in-beam positron emission tomography; ion beam tumor therapy; hadron therapy; positron emitter distribution; prediction method
IEEE Transactions on Nuclear Science 63(2016)1, 61-69
Online First (2015) DOI: 10.1109/TNS.2015.2481489
Cited 7 times in Scopus
Complex formation of tetravalent actindies with small carboxylate ligands
Hennig, C.; Ikeda-Ohno, A.; Takao, S.; Takao, K.; Kraus, W.; Scheinost, A. C.
Tetravalent actinides form strong complexes with the carboxylic acids. Although there is a number of thermodynamic data reported [1-2] there is no information available on the complex structure in aqueous solution.
We used EXAFS spectroscopy to estimate the complex structure of Th4+, U4+, Np4+ and Ce4+ with different carboxylates (RCOO–; R = H, CH3, C2H2NH2) in aqueous solution [3-6]. The structural information from EXAFS data is limited to radial pair distribution functions. To overcome this limitation we forced single crystals to precipitate in different stability ranges of the solution species. Whether or not a species is preserved in a crystal structure was subsequently investigated by EXAFS spectroscopy. The crystal structure, revealed
by single-crystal diffraction, and combined with EXAFS spectroscopy on liquid and solid samples, provides precise information of coordination and structure of the related solution species. These studies show that in all of the investigated aqueous systems hexanuclear complexes [M6O4(OH)4(RCOO)12] appear, which become predominant with increasing ligand concentration as well as increasing pH, and dominate finally the species distribution.
An example is shown in Figure 1. EXAFS spectra were recorded on samples in aqueous solution with 0.05 M Th(IV), 1 M glycine and pH values ranging from 0.5 to 3.2. The spectrum at pH 0.5 shows a single peak representing mononuclear complexes of Th(OH)n (4n)+ with n 2. With increasing pH, the first peak in the Fourier transform becomes more asymmetric and finally splits. A second peak appears at R+ = 3.75 Å, and its intensity rises with increasing pH. This latter feature represents a Th-Th scattering interaction. The data fit indicate the appearance of a hexanuclear complex. This complex is stable until pH 3.2. At higher pH values precipitates a crystalline material. The EXAFS spectrum of this precipitate is identical with that of the solution at pH 3.2, indicating that the structure of the solution species remains preserved in the crystal structure.
Crystals from the precipitate were used for structure analysis by X-ray diffraction. A drawing of the crystal structure is shown in Figure 2, which is in turn representative for the coordination of the predominating solution species at pH 3.2.
The appearance of hexanuclear complexes in aqueous solution corresponds with both, the onset of the metal hydrolysis at the one hand, and the deprotonation of the carboxylic function at the other hand. This results in a competing reaction between hydrolysis and ligation. The hydrolysis results in a polymerization via oxo and hydroxo bonds, whereas the carboxylic function of the ligand results in the formation of 12 terminating chelate rings providing charge neutrality of the hexanuclear core and preventing further polymerization. Most of the thermodynamic data of actinide(IV) carboxylates are estimated assuming mononuclear solution species.
Our studies indicate that future work on tetravalent actinide carboxylates in aqueous solution need consideration of hexanuclear species.
 G.M. Sergeev, Radiokhimija 22, 536 (1980).
 A. Bismondo, L. Rizzo, G. Tomat, Inorg. Chim. Acta 74, 21 (1983).
 S. Takao, K. Takao, W. Kraus, F. Emmerling, A.C. Scheinost, G. Bernhard, C. Hennig, Eur. J. Inorg. Chem. 4771 (2009).
 K. Takao, S. Takao, A.C. Scheinost, G. Bernhard, C. Hennig, Inorg. Chem. 51, 1336 (2012).
 C. Hennig, S. Takao, K. Takao, S. Weiss, W. Kraus, F. Emmerling, A.C. Scheinost, Dalton Trans. 41, 12818 (2012).
 C. Hennig, A. Ikeda-Ohno, W. Kraus, S. Weiss, P. Pattison, H. Emerich, P.M. Abdala, A.C. Scheinost, Inorg. Chem. 52, 11734 (2013).
Keywords: actinides; xafs; thorium; uranium; neptunium; cerium
- DOI: 10.1107/S1600577520014265 is cited by this (Id 22618) publication
Migration 2015: 15th International Conference on the Chemistry and Migration Behaviour of Actinides and Fission Products in the Geosphere, 13.-18.09.2015, Santa Fe, USA
Artifical neural networks - another view on actinide chemistry
Rossberg, A.; Scheinost, A. C.
Driven by the enormous increase of computing power in the last few years, several theoretical models for biological neural networks have been developed and new modelling concepts are coming up. Close to their biological counterpart, artificial neural networks (ANNs) have been developed, which can be trained by presenting input data along with the desired output . ANNs are used for example to recognize hand-written text, human faces, natural speech or personal interests, all features now commonly used by web-based social networks like Facebook or by search engines like Google. Another step forward was the development of spiking neural networks, a third generation ANN, which counts at the moment as the closest approximation of biological neural networks  and is strongly discussed in the community . In general, ANNs can be considered as a method to infer functional relationships between a cause and the resulting effect. Note that these functional relationships are not inferred from mathematical models; first, the mathematical treatment would be too complex, and second, the required mathematical simplifications by using justified assumptions and constraints would most probably lead to a poor description of the problem. Therefore ANNs are seen as a more efficient and more accurate method to describe complex functional relationships. Here we demonstrate using two examples, that selforganizing maps (SOM) [4,5], a special kind of ANN, are well suited for analysing the complex chemistry of actinides.
The first example shows the relationships between the structure of aliphatic ((di-)hydroxy-)carboxylic acids and their complexation mode towards uranyl (UVI). For this, U LIII-edge EXAFS spectra from 13 aliphatic carboxylic acids (acetic, succinic, tartaric, lactic, 3-hydroxybutyric, citric, formic, malic, maleic, malonic, oxalic, propionic, and tricarballylic acid) at a range of pH, uranium and ligand concentrations were measured, resulting in 60 EXAFS spectra . Based on the known structures of the ligands, SOM was used to determine the dependencies between the structure of the UVI carboxylate complexes and the structure of the interacting ligands, and to derive a predictive classification of the former. SOM revealed, for instance, that acids with an OH-group in α-position cause the formation of monomeric chelates and dimeric and trimeric UVI complexes, while an OH-group in β-position leads only to monomers, where uranyl is bidentately coordinated to the carboxylic group. In the second example, we apply SOM to the U LIII-edge EXAFS spectra of UVI sorption complexes with Al(hydr)oxides in order to determine the dependency of the structure of the formed sorption complexes on relevant physicochemical parameters like pH, pCO2, surface area, and surface loading. SOM here clearly reveals, for example, that polynuclear sorption complexes become predominant the higher the pH and the surface loading, while at low pH mononuclear complexes are present either as binary complexes or – in the presence of carbonate - as ternary complexes.
A properly trained SOM can also be used for the prediction of the spectra and the fractions of the complexes for a given ligand and a set of physicochemical parameters, hence SOM can replace thermodynamic speciation calculations, in case complex formation constants are not available. In turn, for a given spectrum, the corresponding physicochemical parameter can be predicted. SOM is not only restricted to EXAFS, but can use input from any other spectroscopy like NMR, UV-vis, infrared and Raman, or from diffraction/scattering patterns -together with chemical information- in order to derive a reliable multiscale speciation of actinides.
Keywords: Neuronal networks; artifical intelligence
- DOI: 10.1107/S1600577520014265 is cited by this (Id 22617) publication
Migration 2015: 15th International Conference on the Chemistry and Migration Behaviour of Actinides and Fission Products in the Geosphere, 13.-18.09.2015, Santa Fe, USA
Nuclear methods for real-time range verification in proton therapy based on prompt gamma-ray imaging
Accelerated protons are excellent candidates for treating several types of tumours. Such charged particles stop at a defined depth, where their ionisation density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimises the damage to normal tissue compared to photon therapy. Nonetheless, inherent range uncertainties cast doubts on the irradiation of tumours close to organs at risk and lead to the application of conservative safety margins. This constrains significantly the potential benefits of proton over photon therapy and limits its ultimate aspirations. Prompt gamma rays, a by-product of the irradiation that is correlated to the dose deposition, are reliable signatures for the detection of range deviations and even for three-dimensional in vivo dosimetry. In this work, two methods for Prompt Gamma-ray Imaging (PGI) are investigated: the Compton camera (Cc) and the Prompt Gamma-ray Timing (PGT). Their applicability in a clinical scenario is discussed and compared. The first method aspires to reconstruct the prompt gamma ray emission density map based on an iterative imaging algorithm and multiple position sensitive gamma ray detectors. These are arranged in scatterer and absorber plane. The second method has been recently proposed as an alternative to collimated PGI systems and relies on timing spectroscopy with a single monolithic detector. The detection times of prompt gamma rays encode essential information about the depth-dose profile as a consequence of the measurable transit time of ions through matter. At Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and OncoRay, detector components are characterised in realistic radiation environments as a step towards a clinical Cc. Conventional block detectors deployed in commercial Positron Emission Tomography (PET) scanners, made of Cerium-doped lutetium oxyorthosilicate - Lu2SiO5:Ce (LSO) or Bismuth Germanium Oxide - Bi4Ge3O12 (BGO) scintillators, are suitable candidates for the absorber of a Cc due to their high density and absorption efficiency with respect to the prompt gamma ray energy range (several MeV). LSO and BGO block detectors are compared experimentally in clinically relevant radiation fields in terms of energy, spatial and time resolution. On a different note, two BGO block detectors (from PET scanners), arranged as the BGO block Compton camera (BbCc), are deployed for simple imaging tests with high energy prompt gamma rays produced in homogeneous Plexiglas targets by a proton pencil beam. The rationale is to maximise the detection efficiency in the scatterer plane despite a moderate energy resolution. Target shifts, increase of the target thickness and beam energy variation experiments are conducted. Concerning the PGT concept, in a collaboration among OncoRay, HZDR and IBA, the first test at a clinical proton accelerator (Westdeutsches Protonentherapiezentrum Essen) with several detectors and heterogeneous phantoms is performed. The sensitivity of the method to range shifts is investigated, the robustness against background and stability of the beam bunch time profile is explored, and the bunch time spread is characterised for different proton energies. With respect to the material choice for the absorber of the Cc, the BGO scintillator closes the gap with respect to the brighter LSO. The reason behind is the high energies of prompt gamma rays compared to the PET scenario, which increase significantly the energy, spatial and time resolution of BGO. Regarding the BbCc, shifts of a point-like radioactive source are correctly detected, line sources are reconstructed, and one centimetre proton range deviations are identified based on the evident changes of the back projection images. Concerning the PGT experiments, for clinically relevant doses, range differences of five millimetres in defined heterogeneous targets are identified by numerical comparison of the spectrum shape. For higher statistics, range shifts down to two millimetres are detectable. Experimental data are well reproduced by analytical modelling. The Cc and the PGT are ambitious approaches for range verification in proton therapy based on PGI. Intensive detector characterisation and tests in clinical facilities are mandatory for developing robust prototypes, since the energy range of prompt gamma rays spans over the MeV region, not used traditionally in medical applications. Regarding the material choice for the Cc: notwithstanding the overall superiority of LSO, BGO catches up in the field of PGI. It can be considered as a competitive alternative to LSO for the absorber plane due to its lower price, higher photoabsorption efficiency, and the lack of intrinsic radioactivity. The results concerning the BbCc, obtained with relatively simple means, highlight the potential application of Compton cameras for high energy prompt gamma ray imaging. Nevertheless, technical constraints like the low statistics collected per pencil beam spot (if clinical currents are used) question their applicability as a real-time and in vivo range verification method in proton therapy. The PGT is an alternative approach, which may have faster translation into clinical practice due to its lower price and higher efficiency. A proton bunch monitor, higher detector throughput and quantitative range retrieval are the upcoming steps towards a clinically applicable prototype, that may detect significant range deviations for the strongest beam spots. The experimental results emphasise the prospects of this straightforward verification method at a clinical pencil beam and settle this novel approach as a promising alternative in the field of in vivo dosimetry.
Keywords: proton therapy; range verification; in vivo dosimetry; prompt gamma ray imaging; Compton camera; block detector; scintillation; prompt gamma ray timing
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22616) publication
TU Dresden, 2016
Mentor: Prof. Dr. Wolfgang Enghardt
Prompt Gamma Imaging of a Pencil Beam with a High Efficiency Compton Camera at a Clinical Proton Therapy Facility
Hueso-González, F.; Petzoldt, J.; Römer, K. E.; Schöne, S.; Fiedler, F.; Golnik, C.; Kormoll, T.; Pausch, G.; Enghardt, W.
Protons are excellent particles for tumour treatment due to the increased ionization density close to their stopping point. In practice, the uncertainty on the particle range compromises the achievable accuracy. Compton cameras imaging prompt gamma rays, a by-product of the irradiation, have been proposed for indirect range verification years since. At Universitäts Protonen Therapie Dresden, two BGO block detectors (from PET scanners) arranged as Compton camera are deployed for imaging tests with high energy prompt gamma rays produced in PMMA by a proton pencil beam. Target shifts, thickness increase and beam energy variation experiments are conducted. Each measurement lasts about 15 minutes at a low proton beam current. The effect of one centimetre proton range deviations on the backprojected images is analysed. In conclusion, the experimental results highlight the potential application of Compton cameras for high energy prompt gamma ray imaging of pencil beams, as a real-time and in vivo range verification method in proton therapy.
Keywords: proton therapy; prompt gamma ray imaging; range verification; Compton camera; BGO block detector
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22615) publication
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, 31.10.-07.11.2015, San Diego, USA
Contribution to proceedings
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, 31.10.-07.11.2015, San Diego, USA
NCRO-Retreat, 14.-16.04.2016, Dresden, Deutschland
Bioleaching of covellite - A model system for Kupferschiefer
Barthen, R.; Karimzadeh, L.; Gründig, M.; Grenzer, J.; Scholz, A.; Bischoff, L.; Franke, K.; Lippmann-Pipke, J.
Copper is an important base metal with manifold applications. Rising global demand makes low grade copper deposits increasingly attractive. Kupferschiefer represents Europe´s largest copper deposit. However, economic copper extraction from this calciferous, carbon rich ore with finely dispersed copper minerals is difficult. We aim for a deeper understanding of processes of copper (bio-)leaching at neutral pH. We employ synthetic covellite, microbial strains from Johanngeorgenstadt (Germany), model ligands, and geochemical modelling for elucidation of relevant parameters. We differentiate mineral dissolution, complexation, adsorption, and advection.
Keywords: Bioleaching; synthetic covellite; Kupferschiefer; glutamic acid; complexation
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22614) publication
10. PhD-seminar in Altenberg, 02.-04.11.2015, Altenberg, Deutschland
Joint compositional calibration: a geochronological example
Tolosana-Delgado, R.; van den Boogaart, K. G.; Fiserova, E.; Hron, K.; Dunkl, I.
This contribution explores several issues arising in the measurement of a (geo)chemical composition, specially in the case that the quantities of interest are linear functions of (log)-ratios. This is the case of multi-isotopic geochronological analyses, where an age of a geological material is inferred as a function of several logratios in the isotopic system (Hg202, Pb204, Pb206, Pb207, Pb208, Th232, U235, U238), by using several ratios (e.g., Pb208/Pb206, Pb206/Pb204, Hg202/Pb204, U238/U235), quantities that are scaling invariant and subcompositionally coherent, but which in general cannot be estimated without taking into account additive noise effects incompatible with a purely compositional approach. The proposed ways to a solution heavily build upon the multi- Poisson distribution, higlighting the counting nature of the readings delivered by these measuring machines.
Contribution to proceedings
6th International Workshop on Compositional Data Analysis, 01.-05.06.2015, L'Escala, Girona, Espana
Proceedings of the 6th International Workshop on Compositional Data Analysis, 978-84-8458-451-3, 241-257
Biplots for Compositional Regression
Graffelman, J.; Tolosana-Delgado, R.
In the statistical modeling of compositions, the latter can appear as response or explanatory variables, or even in both roles simultaneously. Such modeling is of multivariate nature because compositions consists of vectors of D elements, with potentially large D. Prior to fitting a model, the compositions are typically first transformed by a log-ratio transformation. The transformed compositions remain, however, of multivariate nature. Several techniques from the field of multivariate analysis can be used to analyze the data of which we mention multivariate regression, canonical correlation analysis and redundancy analysis. In multivariate regression the interpretation of the results is complicated by the large number of regression coefficients obtained, and collected in the matrix of regression coefficients B[p,q] with p explanatory and q response variables. Van den Boogaart and Tolosana-Delgado (2013) applied the singular value decomposition of the matrix of regression coefficients in order to find rank two approximations to B so that biplots can be constructed that summarize the relationships between the variables. However, the regression coefficients depend on the scale of the explanatory variables and their variances can be of very different order of magnitude. It is thus more natural to \standardize" the regression coefficient with a Mahanalobis-like transformation prior to biplot construction. Such an approach amounts to a redundancy analysis (also known as reduced-rank regression) of the data, and biplots for this method are discussed in detail by Ter Braak & Looman (1994). In this contribution we develop and apply redundancy analysis in a compositional context, discussing its biplots with empirical geological data and its compositional geometric interpretation.
Keywords: Redundancy analysis; Multivariate regression; Biplot; Conditional biplot; centred log-ratio (clr) transformation
Contribution to proceedings
6th International Workshop on Compositional Data Analysis, 01.-05.06.2015, L'Escala, Girona, Espana
Proceedings of the 6th International Workshop on Compositional Data Analysis, 978-84-8458-451-3, 141-147
Linear models for the conditional distribution
van den Boogaart, K. G.; Lehmann, M.; Tolosana Delgado, R.
Our aim is to introduce a regression model for the conditional probablity distributions, of observable random variables as a function of regressors. The approach linear models in Bayes spaces. Bayes spaces are a generalisation of the Aitchison Simplex, which can be seen as the space of all distributions with support 1,...,n to probablity distributions on arbitrary measure spaces. Compositional linear models on the Aitchison simplex turn out to be equivalent to multivariate logistic regression if written in alr representation. Then, likelihood theory for generalized linear models is used to estimate the regression coefficients based on observed realisation of the random variable instead of observed compositions as in compositional regression. This idea is generalized towards Bayes spaces, generating a technique allowing to define and estimate models for the conditional distribution of an observed quantity as a Bayes-space-linear function of regressors.
Keywords: Multinomial Logistic Regression; Bayes Spaces; Compositional Regression
Contribution to proceedings
6th International Workshop on Compositional Data Analysis, 01.-05.06.2015, L'Escala, Girona, Espana
Proceedings of the 6th International Workshop on Compositional Data Analysis, 978-84-8458-451-3, 45-53
Baseline Model for Bubbly Flows in OpenFoam: Current Implementation and Future Needs
Kriebitzsch, S.; Rzehak, R.
Many technical processes in industries such as chemical or energy but also numerous natural phenomena involve multiphase flow. Due to the complex physics and the broad range of relevant length scales involved, it is a formidable task to achieve a better understanding of such flows. A detailed insight into the local flow field can be obtained from multiphase computational fluid dynamics, which therefore is a potentially valuable optimization and design tool. Such simulations are feasible within the framework the so-called multi-fluid modelling, in which the different phases are described as interpenetrating continua. Within this framework closure models are necessary to describe the interaction of the phases and a large body of work using different closure relations of varying degree of sophistication exists, but no complete, reliable, and robust formulation has been achieved so far. Accurate and trustworthy predictions with multiphase CFD are only possible if a fixed set of closures is available that has been validated for a wide range of flow conditions and can therefore reliably be used also for unknown flow problems.
In this work a set of closure relations has been implemented into OpenFOAM, which represents the best available knowledge and is applicable for monodisperse turbulent adiabatic bubbly flow. Specifically we select closures for the exchange of momentum, i.e. drag and non-drag forces, and the effect of the disperse phase on the carrier-phase turbulence, the so-called bubble-induced turbulence. This set of closure models may serve as a baseline for further improvements and extensions to more general situations.
Experimental data for bubbly air-water flows, available from literature and from in-house experiments, are used to validate the model. Overall all three experimental data sets are reasonably well reproduced by the simulation results, in particular in the bulk of the flow. Larger discrepancies show up especially in the near-wall region and for the turbulent quantities. Also for bubble sizes around 4.5 to 5 mm, the reproduction of the experimental data with a monodisperse model becomes challenging. From the validation cases the following needs for further developments are identified:
- improved modelling of the near-wall region
- refined description of the bubble-induced turbulence
- modelling of the bubble-size distribution coupled with multiple momentum equations for the disperse phase.
Keywords: OpenFOAM; Bubbly Flow; Modelling; CFD
The 3rd OpenFOAM User Conference 2015, 19.-20.10.2015, Stuttgart, Deutschland
PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
Hillmer, A. T.; Zheng, M.-Q.; Li, S.; Scheunemann, M.; Lin, S.-F.; Holden, D.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Carson, R. E.; Brust, P.; Huang, Y.
Purpose Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer’s disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7 -nAChR-spe c i f i c radioligand, 7-( 1 ,4-diazabicyclo[3.2.2]nonan-4-yl)-2-[18F]-fluorodibenzo[b,d]thiophene 5,5-dioxide ([18F]DBT-10), in nonhuman primates.
Methods [18F]DBT-10 was produced via nucleophilic substitution of the nitro-precursor. Four Macaca mulatta subjects were imaged with [18F]DBT-10 PET, with measurement of [18F]DBT-10 parent concentrations and metabolism in arterial plasma. Baseline PET scans were acquired for all subjects.
Following one scan, ex vivo analysis of brain tissue was performed to inspect for radiolabeled metabolites in brain. Three blocking scans with 0.69 and 1.24 mg/kg of the α7-nAChRspecific ligand ASEM were also acquired to assess dosedependent blockade of [18F]DBT-10 binding. Kinetic analysis of PET data was performed using the metabolite-corrected input function to calculate the parent fraction corrected total distribution volume (VT/fP).
Results [18F]DBT-10 was produced within 90 min at high specific activities of 428±436 GBq/μmol at end of synthesis.
Metabolism of [18F]DBT-10 varied across subjects, stabilizing by 120 min post-injection at parent fractions of 15–55 %. Uptake of [18F]DBT-10 in brain occurred rapidly, reaching peak standardized uptake values (SUVs) of 2.9–3.7 within 30 min. The plasma-free fraction was 18.8±3.4 %. No evidence for radiolabeled [18F]DBT-10 metabolites was found in ex vivo brain tissue samples. Kinetic analysis of PET data was best described by the two-tissue compartment model. Estimated VT/fP values were 193–376 ml/cm3 across regions, with regional rank order of thalamus>frontal cortex>striatum>hippocampus>occipital cortex>cerebellum>pons. Dosedependent blockade of [18F]DBT-10 binding by structural analog ASEMwas observed throughout the brain, and occupancy plots yielded a VND/fP estimate of 20±16 ml/cm3.
Conclusion These results demonstrate suitable kinetic properties of [18F]DBT-10 for in vivo quantification of α7-nAChR binding in nonhuman primates.
Keywords: Nicotine; Nicotinic acetylcholine receptor; Alpha 7; PET
European Journal of Nuclear Medicine and Molecular Imaging 43(2016)3, 537-547
Online First (2015) DOI: 10.1007/s00259-015-3209-0
Cited 15 times in Scopus
Effects of ionic strength and fulvic acid on the adsorption of Tb3+ and Eu3+ onto clay
Poetsch, M.; Lippold, H.
High salinity and natural organic matter are both known to facilitate migration of toxic or radioactive metals in geochemical systems, but little is known on their combined effect.
We investigated complexation of Tb3+ and Eu3+ (as analogues for trivalent actinides) with fulvic acid and their adsorption onto clay in the presence of NaCl, CaCl2 and MgCl2 at ionic strengths up to saturation. 160Tb, 152Eu and 14C were employed as radiotracers, allowing invesitigations at very low concentrations according to probable conditions in far-field scenarios of nuclear waste repositories.
A composite approach (linear additive model) was tested for suitability in the prediction of Kd values for solid-liquid distribution of Tb(III) and Eu(III) in the ternary system of metal ion, clay and fulvic acid based on the constituent binary subsystems. The model was found suitable in reproducing the influence of fulvic acid as a function of ionic strength for bivalent electrolyte cations. In this analysis, it could be shown that high ionic strength does not further enhance the mobilizing potential of humic matter.
Keywords: fulvic acid; metal binding; linear additive model; adsorption; ionic strength
Journal of Contaminant Hydrology 192(2016), 146-151
Cited 8 times in Scopus
- Final Draft PDF 562 kB Secondary publication
Characterization of scintillator crystals for usage as prompt gamma monitors in particle therapy
Roemer, K.; Pausch, G.; Bemmerer, D.; Berthel, M.; Dreyer, A.; Golnik, C.; Hueso-González, F.; Kormoll, T.; Petzoldt, J.; Rohling, H.; Thirolf, P.; Wagner, A.; Wagner, L.; Weinberger, D.; Fiedler, F.
Particle therapy in oncology is advantageous compared to classical radiotherapy due to its well-defined penetration depth. In the so-called Bragg peak, the highest dose is deposited; the tissue behind the cancerous area is not exposed. Different factors influence the range of the particle and thus the target area, e.g. organ motion, mispositioning of the patient or anatomical changes. In order to avoid over-exposure of healthy tissue and under-dosage of cancerous regions, the penetration depth of the particle has to be monitored, preferably already during the ongoing therapy session. The verification of the ion range can be performed using prompt gamma emissions, which are produced by interactions between projectile and tissue, and originate from the same location and time of the nuclear reaction. The prompt gamma emission profile and the clinically relevant penetration depth are correlated. Various imaging concepts based on the detection of prompt gamma rays are currently discussed: collimated systems with counting detectors, Compton cameras with (at least) two detector planes, or the prompt gamma timing method, utilizing the particle time-of-flight within the body. For each concept, the detection system must meet special requirements regarding energy, time, and spatial resolution. Nonetheless, the prerequisites remain the same: the gamma energy region (2 to 10 MeV), high counting rates and the stability in strong background radiation fields. The aim of this work is the comparison of different scintillation crystals regarding energy and time resolution for optimized prompt gamma detection.
Keywords: Instrumentation for hadron therapy; Scintillators; scintillation and light emission processes (solid and gas and liquid scintillators)
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22604) publication
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22604) publication
Journal of Instrumentation 10(2015), P10033
Cited 12 times in Scopus
On the hydrodynamics of airlift reactors, Part I: Experiments
Ziegenhein, T.; Zalucky, J.; Rzehak, R.; Lucas, D.
It is more and more possible to design bubbly flow reactors with methods of the computational fluid dynamics (CFD). However, measurements that can be used for model validation are often missing, especially for complex setups like airlift reactors. Such measurements include locally resolved information about the dispersed and continuous phase, particularly the flow field and interface structure. In the present work Reynolds stresses, liquid velocity and gas void fraction profiles as well as bubble size distributions are provided at several positions in the riser and the downcomer in a rectangular airlift reactor for this purpose. In addition, the hydrodynamics inside this airlift reactor are in detail described by the measured values.
Keywords: dispersed gas-liquid multiphase flow; airlift reactor; model validation; particle tracking velocimetry; turbulence; videography; bubble size distribution
Chemical Engineering Science 150(2016), 54-65
Cited 36 times in Scopus
Particle tracking using micro bubbles in bubbly flows
Ziegenhein, T.; Garcon, M.; Lucas, D.
Micro bubbles do not contaminate multiphase flows like conventional tracer particles so that the velocity in such can be determined completely non-intrusive by tracking them. Micro bubbles, however, are often larger as conventional tracer particles and have a significantly different density than the surrounding fluid. The ability of micro bubbles to follow the flow is investigated in this work. For this purpose, the particle tracking velocimetry results that are obtained with naturally occurring micro bubbles are compared to particle image velocimetry measurements using PMMA tracer particles. In combination with the used volume illumination, a simple, robust and reliable measuring technique is presented, which is deployable for complex problems from biological to oceanic engineering.
Averaged liquid velocities as well as basic turbulence parameters are determined in a rectangular bubble column for different gas volume flow rates. High flow rats are good manageable due to the volume illumination whereas the PIV measurements using a light sheet are approaching their limits. The general sampling bias in multiphase flows found recently for PIV measurements is also present for particle tracking methods; a hold processor that waits a time depending on the distribution of the particle information over the measuring area gives reasonable results.
Keywords: Velocity measurement; sampling bias; multiphase flow; particle tracking velocimetry; particle image velocimetry; bubble tracking velocimetry; volume illumination
Chemical Engineering Science 153(2016), 155-164
Cited 31 times in Scopus
- Final Draft PDF 3,8 MB Secondary publication
Towards a unified approach for modelling uniform and non‐uniform bubbly flows
Ziegenhein, T.; Rzehak, R.; Ma, T.; Lucas, D.
An important ingredient of closure relations for the Euler-Euler two-fluid model is the description of turbulent fluctuations. Models proposed in the literature disagree concerning the treatment of such on all scales. The large scale fluctuation structures as well as the bubble induced turbulence might be neglected or resolved and/or modeled respectively in different ways. Each treatment has been demonstrated to work for a certain application but a unifying perspective is lacking so far.
To this end a set of closure relations for the fluid dynamics of bubbly flow has been collected that represents the best available knowledge and may serve as a baseline for further improvements and extensions. This model comprises a set of bubble forces as well as a turbulence model including turbulence modification due to the bubbles and has been successfully validated for bubbly flows in pipes and bubble columns. Here it is applied to two sets of data representing non-uniform and uniform flows in bubble columns which are dominated by large scale fluctuations and bubble induced turbulence respectively.
Keywords: dispersed gas-liquid multiphase flow; Euler-Euler two-fluid model; CFD simulation; bubble column; bubble-induced turbulence
Canadian Journal of Chemical Engeneering 95(2017)1, 170-179
Cited 41 times in Scopus
Visualising the molecular alteration of the calcite (104) – water interface by sodium nitrate
Hofmann, S.; Voitchovsky, K.; Spijker, P.; Schmidt, M.; Stumpf, T.
The reactivity of calcite, one of the most abundant minerals in the earth’s crust, is determined by the molecular details of its interface with the contacting solution. Recently, it has been found that trace concentrations of NaNO3 severely affect calcite’s (104) surface and its reactivity. Here we combine molecular dynamics (MD) simulations, X-ray reflectivity (XR) and in situ atomic force microscopy (AFM) to probe the calcite (104)-water interface in the presence of NaNO3. Simulations reveal density profiles of different ions near calcite’s surface, with NO3- able to reach closer to the surface than CO32- and in higher concentrations. Reflectivity measurements show a structural destabilisation of the (104) surfaces’ topmost atomic layers in NaNO3 bearing solution, with distorted rotation angles of the carbonate groups and substantial displacement of the lattice ions. Nanoscale AFM results confirm the alteration of crystallographic characteristics and the ability of dissolved NaNO3 to alter the structure of interfacial water was observed by AFM force spectroscopy. Our experiments and simulations consistently evidence a dramatic deterioration of the crystals’ surface, with potentially important implications for geological and industrial processes.
Keywords: Calcite; lanthanides; surface; AFM; Molecular dynamics; Surface X-ray Diffraction; nitrate
Defect-induced magnetism in SiC: The new opportunity in spintronics
The charge and spin are two intrinsic properties of electron. Electronic devices mainly utilize the charge of electrons, while mass storage devices are based on the spin of electrons. Diluted magnetic semiconductors provide the opportunity to use the charge and spin of electrons simultaneously, which may bring revolutionary changes in the information technology. Progresses have been achieved in the preparation of magnetic wide band-gap semiconductors with Curie temperatures at around room temperature by dopings. However, limited solubility of transition metals often leads to the precipitation of second phases, thwarting the attempts to get the unambiguous experimental results. Recently, there has been increasing evidence that traditional magnetic elements are not the sole source in inducing intrinsic magnetism. The effect of defects on magnetism formation is gradually being realized.
Our work has been focusing on the origin of magnetism in SiC for many years. Early research demonstrated that Mn is not the only source to determine the magnetic ordering in Mn doped SiC. Subsequently, ferromagnetism was induced in SiC by non-TM element Al dopings. Based on the results mentioned above, we carefully investigated the magnetism of neutron irradiated / noble gas ion implanted SiC single crystals in a series of work. The results unambiguously verified that defects can induce magnetism. The intentionally created defects dominated by divacancies (VSiVC) are responsible for the observed magnetism. The long-range ferromagnetic coupling can be attributed to the p electrons of the nearest-neighbor carbon atoms around VSiVC. Besides, the concentration of VSiVC has an optimal value and excess defects will depress the magnetism.
Keywords: Defect-induced magnetism; semiconductor; spintronics; SiC
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22598) publication
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22598) publication
Seminar in the State University of New York at Buffalo, 13.10.2015, Buffalo, United States of America
Seminar in Shanghai Institute of Ceramics, Chinese Academy of Sciences, 25.01.2016, Shanghai, China
LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells.
Zienert, E.; Eke, I.; Aust, D.; Cordes, N.
Numerous factors determine the current poor prognosis of pancreatic ductal adenocarcinoma (PDAC). One of the greatest challenges to overcome is treatment resistance. Among a large repertoire of intrinsic resistance mechanisms, integrin-mediated cell adhesion to extracellular matrix (ECM) has been identified to be fundamental. Coalesced in focal adhesion complexes, integrins, receptor tyrosine kinases, protein kinases and adapter proteins mediate prosurvival signaling. Four and a half LIM domains protein 2 (FHL2) is one of these adapter proteins, which operates through protein-protein interactions and shows tumor-specific expression. Based on this, we investigated FHL2 expression in PDAC specimens and three-dimensionally grown cell lines and how FHL2 mechanistically contributes to cell survival, cell cycling and radiation resistance. PDAC exhibited a significantly increased and heterogeneous FHL2 expression. Upon FHL2 depletion, pancreatic cancer cell lines showed significantly decreased cell survival, proliferation and radioresistance as well as enhanced apoptosis and MEK/ERK signaling and cyclin D1, E, A and B1 expression were strongly induced. Targeting of FHL2 and MEK1 was similarly effective than FHL2 depletion alone, suggesting MEK1 as a downstream signaling mediator of FHL2. Taken together, our results provide evidence for the importance of the focal adhesion protein FHL2 in pancreatic cancer cell survival, proliferation and radiosensitivity.
DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.
Willers, H.; Gheorghiu, L.; Liu, Q.; Efstathiou, J. A.; Wirth, L. J.; Krause, M.; von Neubeck, C.
Predictive biomarkers are urgently needed for individualization of radiation therapy and treatment with radiosensitizing anticancer agents. Genomic profiling of human cancers provides us with unprecedented insight into the mutational landscape of genes directly or indirectly involved in the response to radiation-induced DNA damage. However, to what extent this wealth of structural information about the cancer genome produces biomarkers of sensitivity to radiation remains to be seen. Investigators are increasingly studying the subnuclear accumulation (ie, foci) of proteins in the DNA damage response (DDR), such as gamma-H2AX, 53BP1, or RAD51, as a surrogate of treatment sensitivity. Recent findings from preclinical studies have demonstrated the predictive potential of DDR foci by correlating foci with clinically relevant end points such as tumor control probability. Therefore, preclinical investigations of DDR foci responses are increasingly moving into cells and tissues from patients, which is the major focus of this review. The advantage of using DDR foci as functional biomarkers is that they can detect alterations in DNA repair due to various mechanisms. Moreover, they provide a global measurement of DDR network function without needing to know the identities of all the components, many of which remain unknown. Foci assays are thus expected to yield functional insight that may complement or supersede genomic information, thereby giving radiation oncologists unique opportunities to individualize cancer treatments in the near future.
Seminars in Radiation Oncology 25(2015)4, 237-250
Cited 54 times in Scopus
Implementation of a software for REmote COMparison of PARticlE and photon treatment plans: ReCompare.
Löck, S.; Roth, K.; Skripcak, T.; Worbs, M.; Helmbrecht, S.; Jakobi, A.; Just, U.; Krause, M.; Baumann, M.; Enghardt, W.; Lühr, A.
To guarantee equal access to optimal radiotherapy, a concept of patient assignment to photon or particle radiotherapy using remote treatment plan exchange and comparison - ReCompare - was proposed. We demonstrate the implementation of this concept and present its clinical applicability.
MATERIALS AND METHODS:
The ReCompare concept was implemented using a client-server based software solution. A clinical workflow for the remote treatment plan exchange and comparison was defined. The steps required by the user and performed by the software for a complete plan transfer were described and an additional module for dose-response modeling was added.
The ReCompare software was successfully tested in cooperation with three external partner clinics and worked meeting all required specifications. It was compatible with several standard treatment planning systems, ensured patient data protection, and integrated in the clinical workflow.
The ReCompare software can be applied to support non-particle radiotherapy institutions with the patient-specific treatment decision on the optimal irradiation modality by remote treatment plan exchange and comparison.
Keywords: Bestrahlungsplanvergleich; Entscheidungsunterstützung; Partikeltherapie; Patientenauswahl; Radiotherapy; Strahlentherapie; decision support; particle therapy; patient selection; treatment plan comparison
Zeitschrift für Medizinische Physik 25(2015)3, 287-294
Cited 8 times in Scopus
Exploring the joint compositional variability of major components and trace elements in the TELLUS soil geochemistry campaign (Northern Ireland)
Tolosana-Delgado, R.; Mckinley, J.
Geochemical datasets are growing in both their number of samples and components, including elements which typical values cover the ranges of magnitude from % to ppm or even ppb. Moreover, the sources of variability increase as well. It is becoming thus increasingly necessary to have appropriate tools to explore this geochemical variability. An example of such framework is provided by any modern regional geochemistry campaign, typically having thousands of samples analysed for several tens of elements covering diverse geological units in non-homogeneous climate-landscape environments. Using the TELLUS soil geochemical survey of Northern Ireland, this paper primarily aims to present one such exploratory case study.
The typical tools to use in this context are all based on principal component analysis (PCA) and variants. Several different alternatives are considered: raw data, standardized data and log-ratio transformed data; classical PCA vs robust PCA; only major components vs. a mixture of major and trace elements. Using the 12 resulting analyses, insights into the nature of the dominant factors of geochemical variability are extracted, and the advantages of a log-ratio approach highlighted.
From a methodological point of view, we show: (i) that raw data should seldom be considered; (ii) standardised data do not show any difference relevant between robust and classical PCA; and (iii) that standardised data and log-ratio data deliver a roughly similar picture, but (iv) logratio data offer much more insights, especially when comparing robust and classical PCA using all variables available.
From the perspective of the case study presented, we conclude that the first two sources of soil geochemical variation are related to the background geology and the presence/absence of blanket peat (a major feature of the landscape of Northern Ireland). Which of the two factors is the dominant one depends on whether robust or classical PCA was used. Besides this (rather expected) result, the analysis showed in addition striking positive correlations between the logratios Se/LOI, MnO/CaO and I/Br; between Br/Ni, Cl/Cr, Sb/TiO2 and Cd/MnO; or between Cs/I, Rb/Zn and Cr/Ni. Also null correlations are detected between the ratios of the second and third groups. Taking into account information on the major lithologies present in Northern Ireland, the third group of ratios appears to describe lithological changes, while the second group of ratios is strongly related. to peat building processes, which not only enrich in LOI (as expected) but in Br, Cl, Cd and Sb as well.
Applied Geochemistry 75(2016), 263-276
Cited 35 times in Scopus
Lorentz TEM Imaging of Stripe Structures Embedded in a Soft Magnetic Matrix
Néel walls in soft magnetic NiFe/NiFeGa hybrid stripe structures surrounded by a NiFe film are investigated by high-resolution Lorentz transmission-electron-microscopic imaging. An antiparallel orientation of magnetization in 1000-nm-wide neighboring unirradiated-irradiated stripes is observed by forming high-angle domain walls during magnetization reversal. Upon downscaling the stripe structure size from 1000 to 200 nm, a transition from a discrete domain pattern to an effective magnetic medium is observed for external magnetic-field reversal. This transition is associated with the vanishing ability of hosting high-angle domain walls between adjacent stripes.
Keywords: magnetism; domains; imaging; ion irradiation
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22592) publication
Physical Review Applied 4(2015), 034012
Cited 2 times in Scopus
Study of solar wind ions implantation effects in optical coatings in view of Solar Orbiter space mission operation
Bacco, D.; Corso, A. J.; Zuppella, P.; Böttger, R.; Gerlin, F.; Napolitani, E.; Tessarolo, E.; Nardello, M.; Pelizzo, M. G.
Low energy ions coming from the quite solar wind are considered among the causes of potential damage of the optical instrumentation and components on board of ESA Solar Orbiter. Predictions of space radiation parameters are available for instruments on board of such mission. Accelerators are commonly used to reproduce the particle irradiation on a spacecraft during its lifetime at the ground level. By selecting energies and equivalent doses it is possible to replicate the damage induced on space components. Implantation of Helium ions has been carried out on different single layer thin films at LEI facility at Forschungszentrum Dresden-Rossendorf varying the total dose. Profile of the implanted samples has been experimentally recovered by SIMS measurements. The change in reflectance performances of such coatings has been experimentally evaluated and modelled. The outcomes have been used to verify the potential impact on the METIS instrument and to drive the optimization of the M0 mirror coating..
Keywords: Ions; Optical coatings; Equipment and services; Helium; Mirrors; Particles; Radiation; Reflectivity; Thin films; Coating
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22590) publication
Proceedings of SPIE 9604(2015), 960407
Ferromagnetism induced by vacancy clusters in Silicon
Liu, Y.; Zhang, X. H.; Yuan, Q.; Han, J. C.; Zhou, S. Q.; Song, B.
Defect-induced ferromagnetism provides an alternative for organic and semiconductor spintronics. Though it is weak, it can be stable above room temperature. Till now it has been confirmed at least in oxides [1, 2] and carbon based materials [3, 4]. Interestingly, the relation between magnetism and defects in Silicon was demonstrated decades ago . Since then, some progresses were made [6-9] and push forward the research of magnetic Mn doped Si a lot but it is drawn little attention itself. Here, with the latest growth purifying technique and sensitive measurements, we investigated the magnetism in Silicon after neutron irradiation and try to correlate the observed magnetism to particular defects in Si.
Keywords: defect-induced ferromagnetism; silicon; neutron irradiation; semiconductors
ALS User Meeting, 05.-07.10.2015, Berkeley, United States of America
Discrepancy between fluvial incision and denudation rates at the western Pamir margin
Fuchs, M.; Gloaguen, R.; Pohl, E.; Merchel, S.; Andermann, C.; Krbetschek, M.; Rugel, G.
Surface process rates provide keys to unravel controls of tectonics and climate on mountain evolution. In the Pamir, significant discrepancies exist between fluvial incision and denudation rates. Optically stimulated luminescence (OSL)-based fluvial incision outpaces cosmogenic nuclide (Be-10)-based denudation by up to 10 times at the western Pamir margin.
Differences in averaging times of determined rates cannot explain the contrast. The millennial denudation rates are highest (1.0 – 1.5 mm/yr) where long-term (104years) fluvial incision is moderate (2 – 5 mm/yr). In contrast, denudation is lower (~0.8 mm/yr) where incision is highest (7 – 10 mm/yr).
Process rates across the Pamir reveal differing control factors. The longitudinal profile and valley profiles of the Panj highlight links between fluvial incision and tectonic structures. Convex river reaches across the Pamir domes correspond to intense incision, whereas graded river segments coincide with southern dome boundaries. The indicated river captures induce intense incision and base level lowering for basins at the Pamir margins. Both, rapid incision and base level changes, maintain the steep slopes (0.75 quartiles) that are the predominant driver (R2 of ~0.8) for high denudation rates at the Pamir margins (0.5 – 1.5 mm/yr). However, highest denudation and lowest discrepancy to fluvial incision (~2 - 3 times) coincides with the areas receiving the highest annual precipitation. Multiple linear regression of denudation rates with the 0.75 quartiles of basin slopes and precipitation shows an R2 of 0.93. We propose that river captures are responsible for driving the intense incision along the Panj and consequently, provide the conditions for hillslope adjustment that contributes to the high denudation at the Pamir margins. Winter precipitation, and related concentrated discharge during the melting season, may act as limiting factor to hillslope adjustment and consequently, to denudation processes.
Keywords: accelerator mass spectrometry
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22588) publication
AGU Fall Meeting, 14.-18.12.2015, San Francisco, USA
Tailoring dynamic magnetic characteristics of Fe60Al40 films through ion irradiation
Magnetization dynamics in Fe60Al40 thin films possessing depth-varying saturation magnetization (Ms) has been studied experimentally and theoretically. Variation in Ms was achieved by irradiation of 40 nm thick, chemically ordered (B2) Fe60Al40 films with Ne+ ions with energies between 0 – 30 keV. The initial B2 phase is paramagnetic and as the penetrating ions cause chemical disordering, the ion-affected region transforms to the ferromagnetic A2 phase. The effective ferromagnetic thickness and the depth of the A2/B2 phase boundary depend on the ion-energy (E); the effective thicknesses are 8.5 and 40 nm respectively for E = 2.5 and 30 keV. Thermally excited spin-waves in films with varying effective ferromagnetic thicknesses were analyzed by employing Brillouin light scattering and vector network analyzer ferromagnetic resonance spectroscopy. The analytical calculations are in good agreement with the experimental values, and show that the observed spin-wave modes are directly related to the effective ferromagnetic thickness; films irradiated with E < 5 keV only show the Damon-Eshbach mode, whereas for 15 < E < 20 keV an additional lower frequency standing spin-wave mode is observed. In films irradiated with E > 20 keV the Damon- Eshbach mode is observed to lie between two standing spin-wave modes. Furthermore, the A2/B2 phase boundary can be shown to act as an asymmetric pinning site. Controlling the depth of the phase boundary by varying the ion-energy can be a path to manipulate spin-wave propagation in materials displaying the phenomenon of disorder induced ferromagnetism.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22587) publication
Evolution of magnetic domain structure formed by ion-irradiation of B2-Fe0.6Al0.4
Magnetic domains and magnetization reversal in 40 nm thick films of Fe0.6Al0.4, have been studied by longitudinal magneto-optical Kerr effect. By varying the Ne+ ion-energy E between 2 and 30 keV (keeping a constant fluence), we varied the depth-penetration of the ions, and thereby influenced the homogeneity of the induced saturation magnetization Ms. The dependence of coercivity on ion energy shows maximum for 5 keV Ne+. Considerable differences in the magnetic domain formation and magnetization reversal processes were observed: at low E (≤ 5keV), the reversal process is dominated by domain nucleation mechanism (high density of domain nucleation sites), consistent with the occurrence of an inhomogeneous Ms. Films irradiated with E > 5keV ions exhibit significantly low domain nucleation density, and the reversal is dominated by domain propagation mechanism, suggesting homogeneity in induced Ms. These results demonstrate the tunability of magnetization reversal behavior in materials possessing disorder induced magnetic phase transitions.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22586) publication
Prompt gamma imaging of passively shaped proton fields with a knife-edge slit camera
Priegnitz, M.; Barczyk, S.; Keitz, I.; Mein, S.; Vander Stappen, F.; Janssens, G.; Hotoiu, L.; Smeets, J.; Fiedler, F.; Prieels, D.; Enghardt, W.; Pausch, G.; Richter, C.
Range verification in proton therapy is highly desirable to fully exploit the advantageous properties of proton beams for tumor therapy. In this context, prompt gamma imaging (PGI) is of growing interest and different technical concepts for realization are currently under investigation. The feasibility of range shift detection with a slit camera has previously been shown for different targets irradiated with protons in pencil beam scanning mode. In preparation of the clinical application of the slit camera within a patient study, we report on the first application of the slit camera to passively shaped proton beams.
Keywords: prompt gamma imaging; slit camera; proton range verification
ICTR-PHE 2016, International Conference on Translational Research in Radio-Oncology | Physics for Health in Europe, 15.-19.02.2016, Geneva, Switzerland
2. Heidelberg Symposium on Novel Techniques in Ion Beam Radiotherapy, 09.-11.03.2016, Heidelberg, Deutschland
Abstract in refereed journal
Radiotherapy and Oncology 118(2016)Suppl. 1, S86-S87
LiPON Thin Films with High Nitrogen Content for Application in Lithium Batteries and Electrochromic Devices Prepared by RF Magnetron Sputtering
Su, Y.; Falgenhauer, J.; Polity, A.; Leichtweiß, T.; Kronenberger, A.; Obel, J.; Zhou, S.; Schlettwein, D.; Janek, J.; Meyer, B. K.
Transparent amorphous lithium phosphorus oxynitride (LiPON) thin films with different thickness have been prepared by RF magnetron sputtering at a growth rate of 14 nm/min. The mean ionic conductivity of as-deposited LiPON films determined by impedance spectroscopy was 4.9 μS/cm at 22 °C with the activation energy of 0.55 eV. The electronic partial conductivity was measured to be 1.6 × 10− 6 μS/cm by recording the current–time curves at a constant voltage. The optical transmission of LiPON films were measured by UV–Vis/IR spectroscopy. The prepared LiPON films on silica glass substrate showed transmission higher than 80% in the visible light range. The complex refractive index and bandgap (~ 2.94 eV) were estimated by fitting the transmission data with the Tauc–Lorentz dielectric function model. The local structure of the film was investigated by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. Both methods confirmed the incorporation of nitrogen in the matrix. Nitrogen is present in two different chemical environments, corresponding to P − N < PP and Psingle bondNdouble bond; length as m-dashP. Inductively coupled plasma-optical emission spectrometry (ICP-OES) and Rutherford backscattering spectrometry (RBS) measurements showed that the composition of the LiPON film was Li3.13PO1.69N1.39. The high nitrogen content and low oxygen content appears to be responsible for the specific electrical and optical properties of the LiPON films.
Keywords: LiPON; Lithium solid electrolyte; Solid state battery; Electrochromic device
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22584) publication
Interaction of Selected Actinides and Lanthanides with Degradation Products of Organic Low and Intermediate Level Waste
Brinkmann, H.; Moll, H.; Arnold, T.; Stumpf, T.
Organic compounds present in LILW in a deep geological disposal are exposed to different conditions affecting their structure and chemical properties. Ionizing radiation, high pH, and microbial activity may lead to the generation of small water soluble organic compounds. These degradation products can probably enhance the mobility of radionuclides due to complex formation. Therefore the interaction of selected degradation products with certain actinides/lanthanides has to be investigated. This is necessary to predict the safety and long term evolution of a nuclear waste repository. This poster presents the objectives of the doctoral thesis and first results.
Keywords: actinides; lanthanides; organic radioactive waste; degradation; complexation
10th HZDR PhD-Seminar, 02.-04.11.2015, Altenberg, Deutschland
Direct Depth- and Lateral- Imaging of Nanoscale Magnets Generated by Ion Impact
Nanomagnets form the building blocks for a variety of spin-transport, spin-wave and data storage devices. In this work we generated nanoscale magnets by exploiting the phenomenon of disorder-induced ferromagnetism; disorder was induced locally on a chemically ordered, initially non-ferromagnetic, Fe60Al40 precursor film using a ∼ 2 nm diameter beam of Ne+ ions at 25 keV. The beam of energetic ions randomized the atomic arrangement locally, leading to the formation of ferromagnetism in the ion-affected regime. The interaction of a penetrating ion with host atoms is known to be spatially inhomogeneous, raising questions on the magnetic homogeneity of nanostructures caused by ion-induced collision cascades. Direct holographic observations of the flux-lines emergent from the disorder-induced magnetic nanostructures were made in order to measure the depth- and lateral- magnetization variation at ferromagnetic/non-ferromagnetic interfaces. Our results suggest that high-resolution nanomagnets of practically any desired 2-dimensional geometry can be directly written onto selected alloy thin films using a nanofocussed ion-beam stylus, thus enabling the rapid prototyping of novel magnetization configurations and testing for their magneto-coupling and spin-wave phenomena.
Keywords: phase transitions; chemical disorder; electron holography; magnetic imaging; nanomagnets
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22582) publication
Spin wave eigenmodes in transversely magnetized thin film ferromagnetic wires
Duan, Z.; Krivorotov, I.; Arias, R.; Reckers, N.; Stienen, S.; Lindner, J.
We report experimental and theoretical studies of spin wave eigenmodes in transversely magnetized thin film Permalloy wires. Using broadband ferromagnetic resonance technique, we measure the spectrum of spin wave eigenmodes in individual wires as a function of magnetic field and wire width. Comparison of the experimental data to our analytical model and micromagnetic simulations shows that the intrinsic dipolar edge pinning of spin waves is negligible in transversely magnetized wires. Our data also quantify the degree of extrinsic edge pinning in Permalloy wires. This work establishes the boundary conditions for dynamic magnetization in transversely magnetized thin film wires for the range of wire widths and thicknesses studied, and provides a quantitative description of the spin wave eigenmode frequencies and spatial profiles in this system as a function of the wire width.
Physical Review B 92(2015), 104424
Online First (2015) DOI: 10.1103/PhysRevB.92.104424
Cited 16 times in Scopus
Correction of quantification errors in pelvic and spinal lesions caused by ignoring higher photon attenuation of bone in [18F]NaF PET/MR
Schramm, G.; Maus, J.; Hofheinz, F.; Petr, J.; Lougovski, A.; Beuthien-Baumann, B.; Oehme, L.; Platzek, I.; van den Hoff, J.
MR-based attenuation correction (MRAC) in routine clinical whole-body positron emission tomography and magnetic resonance imaging (PET/MRI) is based on tissue type segmentation. Due to lack of MR signal in cortical bone and the varying signal of spongeous bone, standard whole-body segmentation-based MRAC ignores the higher attenuation of bone compared to the one of soft tissue (MRACnobone). The authors aim to quantify and reduce the bias introduced by MRACnobone in the standard uptake value (SUV) of spinal and pelvic lesions in 20 PET/MRI examinations with [18F]NaF.
The authors reconstructed 20 PET/MR [18F]NaF patient data sets acquired with a Philips Ingenuity TF PET/MRI. The PET raw data were reconstructed with two different attenuation images. First, the authors used the vendor-provided MRAC algorithm that ignores the higher attenuation of bone to reconstruct PETnobone. Second, the authors used a threshold-based algorithm developed in their group to automatically segment bone structures in the [18F]NaF PET images. Subsequently, an attenuation coefficient of 0.11 cm−1 was assigned to the segmented bone regions in the MRI-based attenuation image (MRACbone) which was used to reconstruct PETbone. The automatic bone segmentation algorithm was validated in six PET/CT [18F]NaF examinations. Relative SUVmean and SUVmax differences between PETbone and PETnobone of 8 pelvic and 41 spinal lesions, and of other regions such as lung, liver, and bladder, were calculated. By varying the assigned bone attenuation coefficient from 0.11 to 0.13 cm−1, the authors investigated its influence on the reconstructed SUVs of the lesions.
The comparison of [18F]NaF-based and CT-based bone segmentation in the six PET/CT patients showed a Dice similarity of 0.7 with a true positive rate of 0.72 and a false discovery rate of 0.33. The [18F]NaF-based bone segmentation worked well in the pelvis and spine. However, it showed artifacts in the skull and in the extremities. The analysis of the 20 [18F]NaF PET/MRI examinations revealed relative SUVmax differences between PETnobone and PETbone of (−8.8% ± 2.7%, p = 0.01) and (−8.1% ± 1.9%, p = 2.4×10−8) in pelvic and spinal lesions, respectively. A maximum SUVmax underestimation of −13.7% was found in lesion in the third cervical spine. The averaged SUVmean differences in volumes of interests in lung, liver, and bladder were below 3%. The average SUVmax differences in pelvic and spinal lesions increased from −9% to −18% and −8% to −17%, respectively, when increasing the assigned bone attenuation coefficient from 0.11 to 0.13 cm−1.
The developed automatic [18F]NaF PET-based bone segmentation allows to include higher bone attenuation in whole-body MRAC and thus improves quantification accuracy for pelvic and spinal lesions in [18F]NaF PET/MRI examinations. In nonbone structures (e.g., lung, liver, and bladder), MRACnobone yields clinically acceptable accuracy.
Keywords: PET/MRI; attenuation correction; quantification
Sensitivity analysis and implications for surface processes from a hydrological modelling approach in the Gunt catchment, high Pamir Mountains
Pohl, E.; Knoche, M.; Gloaguen, R.; Andermann, C.; Krause, P.
A clear understanding of the hydrology is required to capture surface processes and potential inherent hazards in orogens. Complex climatic interactions control hydrological processes in high mountains that in their turn regulate the erosive forces shaping the relief. To unravel the hydrological cycle of a glaciated watershed (Gunt River) considered representative of the Pamir Mountains' hydrologic regime, we developed a remote-sensing-based approach. At the boundary between two distinct climatic zones dominated by the Westerlies and Indian summer monsoon, the Pamir Mountains are poorly instrumented and only a few in situ meteorological and hydrological data are available. We adapted a suitable conceptual distributed hydrological model (J2000g). Interpolations of the few available in situ data are inadequate due to strong, relief-induced, spatial heterogeneities. Instead of these we use raster data, preferably from remote sensing sources depending on availability and validation. We evaluate remote-sensing-based precipitation and temperature products. MODIS MOD11 surface temperatures show good agreement with in situ data, perform better than other products, and represent a good proxy for air temperatures. For precipitation we tested remote sensing products as well as the HAR10 climate model data and the interpolation-based APHRODITE data set. All products show substantial differences both in intensity and seasonal distribution with in situ data. Despite low resolutions, the data sets are able to sustain high model efficiencies (NSE ≥ 0.85). In contrast to neighbouring regions in the Himalayas or the Hindu Kush, discharge is dominantly the product of snow and glacier melt, and thus temperature is the essential controlling factor. Eighty percent of annual precipitation is provided as snow in winter and spring contrasting peak discharges during summer. Hence, precipitation and discharge are negatively correlated and display complex hysteresis effects that allow for the effect of interannual climatic variability on river flow to be inferred. We infer the existence of two subsurface reservoirs. The groundwater reservoir (providing 40 % of annual discharge) recharges in spring and summer and releases slowly during autumn and winter, when it provides the only source for river discharge. A not fully constrained shallow reservoir with very rapid retention times buffers meltwaters during spring and summer. The negative glacier mass balance (-0.6 m w.e. yr-1) indicates glacier retreat, which will ultimately affect the currently 30 % contribution of glacier melt to annual stream flow. The spatiotemporal dependence of water release from snow and ice during the annual cycle likewise implies spatiotemporally restricted surface processes, which are essentially confined to glaciated catchments in late summer, when glacier runoff is the only source of surface runoff. Only this precise constraint of the hydrologic cycle in this complex region allows for unravelling of the surface processes and natural hazards such as floods and landslides as well as water availability in the downstream areas. The proposed conceptual model has a tremendous importance for the understanding of the denudation processes in the region. In the Pamirs, large releases of running water that control erosion intensity are primarily controlled by temperature and the availability of snow and glaciers, thus making the region particularly sensitive to climatic variations.
Keywords: hydrological modelling; sensitivity Analysis; Pamir Mountains
Earth Surface Dynamics 3(2015)3, 333-362
Cited 22 times in Scopus
Clinical applicability of the Compton camera for Prompt y-ray Imaging during proton therapy
Rohling, H.; Priegnitz, M.; Schöne, S.; Schumann, A.; Enghardt, W.; Golnik, C.; Hueso-Gonzalez, F.; Kormoll, T.; Pausch, G.; Petzoldt, J.; Römer, K.; Fiedler, F.
In order to guarantee the best outcome of a therapeutic irradiation with protons and other light ions a non-invasive in-vivo range verification is desired. One approach in this field is Prompt y-ray Imaging (PGI). A possible detection system for the prompt y-rays is the Compton camera. Several groups have been working on the construction of Compton camera prototypes (Kormoll et al., 2011; Llosá et al., 2013; Thirolf et al., 2014; Hueso-González et al., 2014). Up to now, Compton cameras have not been used in clinical practice for the monitoring of particle therapy. Therefore, by means of Geant4 simulations, we performed an end-to-end test to evaluate the clinical applicability of a Compton camera detection system and to determine the requirements regarding hardware and image reconstruction.
First, a treatment plan for a therapeutic proton irradiation for the head-neck region was prepared using XiO (Electa AB, Sweden). Based on this treatment plan, the y-ray emissions from the patient's tissue were simulated with Geant4. As a next step, the detector response was modelled, also with Geant4, for two large Compton cameras arranged around the patient in an angle of 90 degrees. Large-area detectors were already recommended (McCleskey et al., 2015). Each camera was built up from a scatter layer (CdZnTe) of dimension 10 × 10 × 0.5 cm3 and an absorber layer (LuSiO) of size 20 × 20 × 2 cm3. In practice, these cameras would be replaced by several smaller camera modules. For the simulation of the detector response a total number of previously simulated y-ray emissions were used as input corresponding to an applied dose of 1 Gy, i.e. a common dose of one field of one treatment session. After extracting the resulting coincident events, the image was reconstructed using a 3D MLEM algorithm (Schoene et al., 2015). The impact of the number of events as well as background on the image quality was also studied.
Figure 1 shows the images for the planned dose, the distribution of the y-ray emissions and the reconstructed image obtained with 128 iterations of the MLEM algorithm. For the considered number of events and the chosen voxels of 5 mm3 the runtime of the reconstruction was about two days on a cluster.
For the considered large camera system and the realistic patient scenario with a dose of 1 Gy adequate images are obtained, which certainly could be applied to detect range deviations in the range of centimeters. Thus, this study demonstrates in principle the clinical applicability. The reconstruction algorithm still has potential for improvements with respect to performance. Furthermore, in practice, the costs of this complex detection system could lead to the preference of simpler methods of PGI.
Keywords: Compton camera; Geant4 simulations; image reconstruction
ICTR-PHE 2016 - International Conference on Translational Research in Radio-Oncology | Physics for Health in Europe, 15.-19.02.2016, Geneve, Schweiz
Abstract in refereed journal
Radiotherapy and Oncology 118(2016)S1, S90-S91
Characterization of defects in thick semiconducting amorphous YMnO3
Bogusz, A.; Anwand, W.; Blaschke, D.; Scholz, A.; Cornelius, S.; Bürger, D.; Skorupa, I.; Schmidt, O. G.; Schmidt, H.
In recent years amorphous semiconducting oxides have gained a lot of attention both from science and industry . The rapid development in this field can be illustrated with the example of amorphous oxide semiconductor thin film transistors. Although invented only approximately one decade ago, they are already commercialized for active-matrix liquid crystal display backplane applications. Comparing to single-crystalline and polycrystalline materials, processing of amorphous oxides benefits from the easiness of production on the large, both plastic and glass areas (e.g. for solar cells) at low temperatures. In addition, thanks to amorphous nature, the problem of scattering (e.g. of light or carriers) and trapping at the defects of crystal structure and/or grain boundaries is avoided. “Amorphous”, however, does not mean “defect free” and as in the case of crystals, defects significantly influence the electronic, vibrational, optical and transport properties of the material. In this work, we present an attempt to identify and characterize defects in amorphous YMnO3, a well-known multiferroic when in crystalline form , deposited on sapphire by multiple techniques. We use X-ray diffractometry, Rutherford backscattering spectroscopy, scanning electron and atomic force microscopy to define composition, structural and surface properties of the oxides. Optical properties in the range between 210 and 1000 nm are measured and modelled by variable angle spectroscopic ellipsometry. Open volume defects are probed by positron annihilation spectroscopy (PAS). Comparison of results obtained on as-grown films and films annealed at T= 400°C for 5 and 10 hours in air allows for qualitative description of defects formed in YMnO3. According to the results of PAS presented in Figure 1, we consider following scenarios: (1) two types of negatively charged, vacancy-type defects are formed during the growth of which one was annealed out and (2) one type of negatively charged, vacancy-type defect is formed during the growth which agglomerates to bigger and stable form during annealing. Our research enables qualitative description of the defects in the amorphous semiconducting films. Obtained results might be used for (1) further optimization of film processing in order to reduce amount of defects, or for (2) defect engineering in order to prepare a film with tuned properties.
 T. Kamiya, H. Hosono, NPG Asia Mater. 2 (2010) 15-22
 B. B. Van Aken, T. T. M. Palstra, A. Filippetti, N. A. Spaldin, Nat. Mater. 3 (2004) 164-170
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22576) publication
The 16th conference on defects-recognition, imaging and physics in semiconductors, 06.-10.09.2015, Suzhou, China
Comparison of Consolidation Routes for Mo-Si-B Materials Prepared by Using Nitride Containing Powders
Wiltner, A.; Klöden, B.; Hilger, I.; Weißgärber, T.; Kieback, B.
Pressureless sintering is a well-established powder metallurgical route for processing and consolidation of mixed materials. Especially materials exhibiting a high melting point could be densified without tool abrasion by this sintering technique. As the sintering temperatures are often higher compared to pressure-assisted techniques care must be taken by means of grain growth. In our studies we used a ternary compound mixture to obtain Mo-based alloys. Consolidation applying pressure-assisted methods (hot pressing, spark plasma sintering) and pressureless sintering were used, respectively. The densities reached and the microstructures obtained were compared. These Mo-Si-B alloys were processed using a nitride-powder-based route offering lower impurity contents due to short processing times by avoiding time consuming mixing / milling steps. The sintering conditions depending on the powder particle size as well as the sample shape will be presented in detail. The composition investigated in this article offered a continuous α-Mo matrix with intermetallic islands consisting of Mo3Si and Mo5SiB2 (T2) phases. The combination of a ductile α-Mo matrix and intermetallic phases embedded within offered an enhanced mechanical behavior at room temperature compared to MoSi2 or other intermetallic alloys. Moreover, the intermetallic compounds as well as Mo are candidates for high-temperature applications. As the high-temperature behavior could be strongly influenced by the respective microstructure we present here the processing and the microstructure obtained.
Keywords: Grain growth; High temperature applications; Hot pressing; Intermetallics; Metallurgy; Microstructure; Nitrides; Particle size; Silicon; Silicon alloys; Sintering; Spark plasma sintering; Ternary alloys; High temperature behavior; Intermetallic alloys; Intermetallic phasis; Mechanical behavior; Powder metallurgical; Pressure-less sintering; Sintering condition; Sintering temperatures
Journal of the American Ceramic Society 98(2015)11, 3569-3575
Online First (2015) DOI: 10.1111/jace.13764
Solarenergie und Photovoltaik - Nanostrukturen für mehr Leistungsfähigkeit
Der Vortrag führt in die verschiedenen Methoden zur Stromerzeugung aus Sonnenlicht ein. Nach einer Motivation über die Rahmenbedingungen werden die verschiedenen Konzepte und Funktionsweisen der Solarthermie und der Photovoltaik vorgestellt. In einer engen Partnerschaft mit industriellen Partnern arbeitet die Gruppe Nanokompositmaterialien des Instituts für Ionenstrahlphysik und Materialforschung an neuartigen Nanostrukturen. Diese können in unterschiedlichsten Komponenten von solarthermischen Kraftwerken und Solarzellen, ähnlich der von Dünnschichtsilizium, zur Anwendung kommen.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22574) publication
Invited lecture (Conferences)
Lehrerfortbildung 2015, 13.02.2015, Dresden, Deutschland
Spectroscopic Ellipsometry - short course
Schumann, E.; Lungwitz, F.
A short introduction into spectroscopic ellipsometry. Covering topics starting with the nature and description of polarized light. The optical constants and dielectric function is introduced and the interaction from light with bulk matter and multiple thin films is discussed. The first part concludes with the explanation of what an ellipsometer measures.
The second half of the course comprises basic analysis procedures, model building with oscillator models, fitting and walk through steps of some examples.
Workshop, 15.10.2015, Sevilla, Espana
Investigation of mass transfer in milli-channels using high-resolution microfocus X-ray imaging
Haghnegahdar, M.; Boden, S.; Hampel, U.
In this work, the absorption rate of a single Taylor bubble of carbon dioxide in water was investigated within vertical capillaries using high resolution X-ray imaging. The liquid side mass transfer coefficient was calculated from the changes in the size of the bubble at constant pressure obtained from the high-resolution X-ray images by image processing. The bubbles were continuously monitored by holding the bubble stationary in a downward flow of liquid. The processed images, which give the volume of the bubble with high accuracy as a function of time, were processed to evaluate the liquid side mass transfer coefficient between bubble and liquid using the mass conservation equation.
The experiments covered a large range of initial Taylor bubble length varying from 5 to 22 mm. The results show that the measured Sherwood numbers depend strongly on the bubble length and also equivalent diameter, which is the same trend as in previously reported results for larger pipe sizes. However the values of measured Sherwood numbers could not be predicted by available correlations. As a result a new mass transfer coefficient in the form of Sherwood number and as a function of Peclet number as well as the ratio of bubble equivalent diameter to capillary diameter (deq/D) is presented. The proposed correlation is applicable for a large range of the ratio deq/D that varies from 0.8 to 1.6. The average relative error between measured Sherwood number and the one calculated with the new correlation is less than 9.6%.
Keywords: mass transfer; Taylor bubble; carbon dioxide; X-ray imaging; milli-channels
International Journal of Heat and Mass Transfer 93(2016), 653-664
Cited 9 times in Scopus
Leitwertkontrolle einzelner elektrisch kontaktierter Moleküle
Die molekulare Elektronik setzt sich zum Ziel, passive und aktive Bausteine in integrierten Schaltkreisen auf molekularer Ebene zu realisieren. Dabei ist entscheidend, dass sich der elektrische Leitwert der molekularen Bauelemente hinreichend regulieren lässt. Um zu belegen, dass dies möglich ist, wird in dieser Dissertation die gezielte Leitwertkontrolle einzelner über Nanoelektroden kontaktierter Moleküle nachgewiesen. Die erzielten Ergebnisse ergänzen dabei nahtlos aktuellste Studien.
Zum einen werden kontaktierte molekulare Schalter durch Bestrahlung mit Licht einer bestimmten Wellenlänge in-situ von einem nicht-leitenden in einen leitenden Zustand geschaltet, wobei der Einfluss unterschiedlicher Seitengruppen für eine zusätzliche Modifikation des Leitwerts sorgt. Ausschlaggebend ist hierbei die elektronische Anbindung des Moleküls an die Elektroden. Zum anderen werden Molekül-Metall-Komplexe durch die Einbindung eines Übergangsmetallions von einem isolierenden in einen leitenden Zustand versetzt. In diesem Fall lässt sich der leitende Zustand durch die Wahl des Ions innerhalb einer Größenordnung variieren, was eine völlig neue Möglichkeit der Leitwertkontrolle in molekularen Bausteinen darstellt. Das Ion bestimmt dabei sowohl die mechanische Stabilität als auch die elektronische Struktur des Moleküls.
Für die Kontaktierung einzelner Moleküle kommt die Technik des mechanisch kontrollierten Bruchkontakts zum Einsatz. So lassen sich feine Goldnanoelektroden herstellen, an die Moleküle anbinden. Um eine präzise Analyse durchzuführen, werden über zwei unabhängige Messstrategien Informationen über das elektrische Transportverhalten sowie über die elektronische Struktur der Moleküle erworben.
In dieser Arbeit sind echte Neuentwicklungen auf dem Gebiet der molekularen Elektronik gelungen, die einen wesentlichen Beitrag für die Umsetzung integrierter molekularer Schaltkreise leisten.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22570) publication
TU Dresden, 2015
Induced Conductance in Single-Molecule Junctions
Sendler, T.; Luka-Guth, K.; Wieser, M.; Lokamani, J. W.; Mortensen, M.; Gothelf, K.; Helm, M.; Gemming, S.; Kerbusch, J.; Scheer, E.; Huhn, T.; Erbe, A.
The goal of molecular electronics is the realization of integrated molecular circuits. For this purpose reliable contacts to single molecules have to be built and the characteristics of those junctions need to be investigated. We have demonstrated that the mechanically controllable break junction (MCBJ) technique is a suitable tool to study the electrical transport through molecular junctions and to analyze the electronic structure of the molecules. Furthermore, based on the use of complex molecules, we are able to control the conductance of single molecular junctions. On the one hand, molecular switches are transformed in-situ from a non-conductive “off”- to a conductive ”on”-state via light-irradiation of a well-defined wavelength. On the other hand molecule-metal complexes are turned from an isolating to a conductive state by introducing metal centers into the molecular structures. The findings provide a significant contribution to the development of functional molecular junctions.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22569) publication
Annual Workshop IHRS NanoNet 2015, 30.09.-02.10.2015, Lohmen, Deutschland
Zellbasierte Sensor- und Aktormaterialien für strategisch relevante Metalle
Vogel, M.; Matys, S.; Raff, J.
Unter dem Leitmotiv „Lebende Zellen auf Oberflächen – hochempfindlich, trotzdem stabil“ soll die BioSAM-Technologieplattform für eine breite wirtschaftliche Nutzung von zellbasierten Sensor-Aktor-Systemen in den Bereichen Bioverfahrenstechnik, Wasser- und Umwelttechnologie sowie Klimatechnik erschlossen werden. Im Rahmen des Teilprojektes BioNEWS geht es um Langzeitstabile Zellen zum Aufbau und zur Regenerierung von Sensor- und Aktorsystemen für den Nachweis und die Bindung strategisch relevanter Metalle (insbesondere Seltene Erden). Hier werden die Detektions- und Sorptionskonzepte sowie erste Ergebnisse zu den entsprechnden zellbasierten Sensor- und Aktormaterialien vorgestellt.
Keywords: Sensor; Aktor; Seltene Erden; S-Layer; Zellen
"Wachstumskern BioSAM - Themenworkshop" - Biologische Sensor-Aktor-Systeme auf der Basis von funktionalisierten Mikroorganismen (BioSAM), 04.11.2015, Dresden, Deutschland
Single-Layer ReS2: Two-Dimensional Semiconductor with Tunable In-Plane Anisotropy
Lin, Y.-C.; Komsa, H.-P.; Yeh, C.-H.; Björkman, T.; Liang, Z.-Y.; Ho, C.-H.; Huang, Y.-S.; Chiu, P.-W.; Krasheninnikov, A. V.; Suenaga, K.
Rhenium disulfide (ReS2) and diselenide (ReSe2), the group 7 transition metal dichalcogenides (TMDs), are known to have a layered atomic structure showing an in-plane motif of diamond-shaped-chains (DS-chains) arranged in parallel. Using a combination of transmission electron microscopy and transport measurements, we demonstrate here the direct correlation of electron transport anisotropy in single-layered ReS2 with the atomic orientation of the DS-chains, as also supported by our density functional theory calculations. We further show that the direction of conducting channels in ReS2 and ReSe2 can be controlled by electron beam irradiation at elevated temperatures and follows the strain induced to the sample. Furthermore, high chalcogen deficiency can induce a structural transformation to a nonstoichiometric phase, which is again strongly direction-dependent. This tunable in-plane transport behavior opens up great avenues for creating nanoelectronic circuits in 2D materials.
Keywords: transition metal dichalcogenides; 2D materials; defects
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22567) publication
ACS Nano 9(2015)11, 11249-11257
Online First (2015) DOI: 10.1021/acsnano.5b04851
Cited 307 times in Scopus
Xe irradiation of graphene on Ir(111): From trapping to blistering
Herbig, C.; Åhlgren, E. H.; Schröder, U. A.; Martínez-Galera, A. J.; Arman, M. A.; Kotakoski, J.; Knudsen, J.; Krasheninnikov, A. V.; Michely, T.
Using x-ray photoelectron spectroscopy, thermal desorption spectroscopy, and scanning tunneling microscopy, we show that upon keV Xe+ irradiation of graphene on Ir(111), Xe atoms are trapped under the graphene. Upon annealing, aggregation of Xe leads to graphene bulges and blisters. The efficient trapping is an unexpected and remarkable phenomenon given the absence of chemical binding of Xe to Ir and to graphene, the weak interaction of a perfect graphene layer with Ir(111), as well as the substantial damage to graphene due to irradiation. By combining molecular dynamics simulations and density functional theory calculations with our experiments, we uncover the mechanism of trapping. We describe ways to avoid blister formation during graphene growth, and also demonstrate how ion implantation can be used to intentionally create blisters without introducing damage to the graphene layer. Our approach may provide a pathway to synthesize new materials at a substrate—2D material interface or to enable confined reactions at high pressures and temperatures.
Keywords: Graphene; irradiation; defects
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22566) publication
Anwendungen der Röntgenfarbkamera SLcam® in der Geologie und Resourcentechnologie
Scharf, O.; Arkadiev, V.; Buchriegler, J.; Dressler, S.; Kühn, A.; Renno, A.; Ziegenrücker, R.
Die Messung von mikro-Röntgenfluoreszenzspektren über einer Fläche, ein Vollfeld Röntgenfluoreszenzdatensatz, ermöglicht die Verteilung von Elementen und deren Konzentrationen in einer Probe zu bestimmen. Diese Informationen sind wichtig für die Analyse von Gesteinsproben und die (Rück-)Gewinnung von Wertstoffen, da sich der Aufschluss und die Aufbereitung neben der chemischen Zusammensetzung auch nach den umgebenden Stoffen und der Größen- und Formverteilung richten. Diese Daten werden vor allem durch die Mineral Liberation Analyse am Rasterelektronenmikroskop gewonnen und durch gezielte Messungen an ausgewählten Punkten verfeinert.
In jüngster Zeit wurden zwei Forschungsprojekte gestartet, die den Vollfeld Röntgenfluoreszenzdatensatz mit Hilfe der Röntgenfarbkamera gewinnen. Im Helmholtz-Zentrum Dresden-Rossendorf wurde die High-Speed PIXE Anlage in Betrieb genommen, die einen Vollfeld Röntgenfluoreszenzdatensatz über eine 1,44 cm2 große Fläche mit Hilfe der protoneninduzierten Röntgenfluoreszenz aufnimmt. In der gleichen Geometrie wurde ein Auftischgerät entwickelt (MEGA), das zur Anregung eine 1.2 kW Röntgenröhre nutzt. Zusätzlich wurde ein Polarisationsmikroskop integriert. Beide Geräte arbeiten im Vakuum und können mit unterschiedlichen Optiken verwendet werden.
Die Projekte werden vorgestellt und erste Ergebnisse werden präsentiert.
MEGA - Methodische und gerätetechnische F&E für die schnelle Vorort-Analyse der feinkörnigen und inhomogenen Verteilung von Hochtechnologiemetallen in Lagerstätten
This work has been supported by Marie Curie Actions - Initial Training Networks (ITN) as an Integrating Activity Supporting Postgraduate Research with Internships in Industry and Training Excellence (SPRITE) under EC contract no. 317169.
Keywords: SLcam; X-ray; PIXE; XRF
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22565) publication
PRORA 2015 - Prozessnahe Röntgenanalytik, 12.-13.11.2015, Berlin, Deutschland
My Interpretation of DREsden AMS – Status, Developments, Ideas
DREAMS, the DREsden AMS-facility at the Helmholtz-Zentrum Dresden-Rossendorf is performing routine accelerator mass spectrometry of 10Be, 26Al, 36Cl, 41Ca, and 129I for a wide range of applications . I will give an overview of the facility with its 6 MV HVEE tandetron and also its performance the last four years. Recent technical developments such as a low-memory ion source for 36Cl and 129I will be shown. Some of the applications will be highlighted. I will also briefly report the status of the Super-SIMS project, which will connect a CAMECA SIMS (SIMS = Secondary Ion Mass Spectrometry) to the tandem accelerator aiming for lower detection limits for analysing geological samples within our focus of resource technology. Ref.:  www.dresden-ams.de
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22564) publication
Vera-Seminar, 15.10.2015, Wien, Österreich
Strengths of the resonances at 436, 479, 639, 661, and 1279 keV in the 22Ne(p,γ)23Na reaction
Depalo, R.; Cavanna, F.; Ferraro, F.; Slemer, A.; Al-Abdullah, T.; Akhmadaliev, S.; Anders, M.; Bemmerer, D.; Elekes, Z.; Mattei, G.; Reinicke, S.; Schmidt, K.; Scian, C.; Wagner, L.
The 22Ne(p,γ)23Na reaction is included in the neon-sodium cycle of hydrogen burning. A number of narrow resonances in the Gamow window dominates the thermonuclear reaction rate. Several resonance strengths are only poorly known. As a result, the 22Ne(p,γ)23Na thermonuclear reaction rate is the most uncertain rate of the cycle. Here, a new experimental study of the strengths of the resonances at 436, 479, 639, 661, and 1279 keV proton beam energy is reported. The data have been obtained using a tantalum target implanted with 22Ne. The strengths ωγ of the resonances at 436, 639, and 661 keV have been determined with a relative approach, using the 479 and 1279 keV resonances for normalization. Subsequently, the ratio of resonance strengths of the 479 and 1279 keV resonances was determined, improving the precision of these two standards. The new data are consistent with, but more precise than, the literature with the exception of the resonance at 661 keV, which is found to be less intense by one order of magnitude. In addition, improved branching ratios have been determined for the gamma decay of the resonances at 436, 479, and 639 keV.
Keywords: Nuclear Astrophysics; Radiative Capture; Underground Nuclear Astrophysics; Nova nucleosynthesis; Explosive hydrogen burning
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22563) publication
Contribution to WWW
arXiv Preprint-Server: http://arxiv.org/abs/1507.03893
Physical Review C 92(2015), 045807
Cited 26 times in Scopus
Diffusive magnetohydrodynamic instabilities beyond the Chandrasekhar theorem
Rüdiger, G.; Schultz, M.; Stefani, F.; Mond, M.
We consider the stability of axially unbounded cylindrical flows that contain a toroidal magnetic background field with the same radial profile as their azimuthal velocity. For ideal fluids, Chandrasekhar had shown the stability of this configuration if the Alfven velocity of the field equals the velocity of the background flow, i.e., if the magnetic Mach number Mm = 1. We demonstrate that magnetized Taylor–Couette flows with such profiles become unstable against non-axisymmetric perturbations if at least one of the diffusivities is finite. We also find that for small magnetic Prandtl numbers Pm the lines of marginal instability scale with the Reynolds number and the Hartmann number. In the limit Pm -> 0 the lines of marginal instability completely lie below the line for Mm = 1 and for Pm -> infinity they completely lie above this line. For any finite value of Pm, however, the lines of marginal instability cross the line Mm = 1, which separates slow from fast rotation. The minimum values of the field strength and the rotation rate that are needed for the instability (slightly) grow if the rotation law becomes flat. In this case, the electric current of the background field becomes so strong that the current-driven Tayler instability (which also exists without rotation) appears in the bifurcation map at low Hartmann numbers.
Transient eddy current flow metering
Forbriger, J.; Stefani, F.
Measuring local velocities or entire flow rates in liquid metals or semiconductor melts is a notorious problem in many industrial applications, including metal casting and silicon crystal growth. We present a new variant of an old technique which relies on the continuous tracking of a flow-advected transient eddy current that is induced by a pulsed external magnetic field. This calibration-free method is validated by applying it to the velocity of a spinning disk made of aluminum. First tests at a rig with a flow of liquid GaInSn are also presented.
Measurement Science and Technology 26(2015)10, 105303
Cited 11 times in Scopus
Collinear order in the frustrated three-dimensional spin-1/2 antiferromagnet Li2CuW2O8
Ranjith, K. M.; Nath, R.; Skoulatos, M.; Keller, L.; Kasinathan, D.; Skourski, Y.; Tsirlin, A. A.
Magnetic frustration in three dimensions (3D) manifests itself in the spin-1/2 insulator Li2CuW2O8. Density-functional band-structure calculations reveal a peculiar spin lattice built of triangular planes with frustrated interplane couplings. The saturation field of 29 T contrasts with the susceptibility maximum at 8.5 K and a relatively low Néel temperature TN similar or equal to 3.9 K. Magnetic order below TN is collinear with the propagation vector (0, 1/2,0) and an ordered moment of 0.65(4) µB according to neutron diffraction data. This reduced ordered moment together with the low maximum of the magnetic specific heat (Cmax/R similar or equal to 0.35) pinpoint strong magnetic frustration in 3D. Collinear magnetic order suggests that quantum fluctuations play a crucial role in this system, where a noncollinear spiral state would be stabilized classically.
High-field magnetization study of a HoFe6Al6 single crystal
Gorbunov, D. I.; Andreev, A. V.; Skourski, Y.; Tereshina, E. A.
Magnetization measurements have been performed in static (up to 14 T) and pulsed (up to 60 T) magnetic fields on a HoFe6Al6 single crystal with a tetragonal crystal structure of ThMn type. HoFe6Al6 is a ferrimagnet with exact compensation of the Ho and Fe sublattices at low temperatures, the spontaneous magnetic moment is Ms = 0 at 4.2 K. At elevated temperatures, Ms passes through a wide maximum (4.2 µB at 200 K) and vanishes at the Curie temperature, TC = 315 K. The compound displays a high magnetic anisotropy of the easy-plane type, a noticeable anisotropy exists also within the easy plane with the  axis as the easy magnetization direction. HoFe6Al6 exhibits two field-induced magnetic phase transitions along the easy  axis and two more along the  axis, the hard direction in the basal plane. The critical fields of the lower-and higher-field transitions display qualitatively different temperature dependencies. A T-H magnetic phase diagram has been constructed for the  and  directions. The Ho-Fe inter-sublattice exchange constant has been determined to be nHoFe = 3.8 T/µB.
Journal of Alloys and Compounds 648(2015), 488-493
Cited 4 times in Scopus
MLA-based partition curves for magnetic separation
Leißner, T.; Bachmann, K.; Gutzmer, J.; Peuker, U. A.
Mineral liberation analysis (MLA) allows access to detailed information on the composition of a sample as well as of single particles visible on the cross-sectioned surface of a grain mount. This information can be used to evaluate processing related to the liberation distribution of valuables or to the distribution of a feature used for separation of valuables from barren particles. When separation processes are studied, the separation feature has to be added to the particle population data. In case of density separation (particle size and particle density) this is already been done by MLA software. For magnetic separation the MLA data has to be combined with mineral susceptibilities using additional software.
This article describes the calculation of partition curves for magnetic separation based on the liberation analysis of the feed and the products. Magnetic susceptibility data from measurements of pure minerals and from literature are is and combined with the particle composition data from the liberation analysis. Using sieved fractions in the magnetic separation experiments the evolution of cut susceptibility and separation efficiency with particle size is studied. The effects of a stereological correction and of the width of susceptibility classes as well as of the mineral susceptibilities used in calculation are discussed.
Keywords: partition curves; magnetic separation; mineral liberation analysis
Minerals Engineering 94(2016), 94-103
Online First (2016) DOI: 10.1016/j.mineng.2016.05.015
Cited 28 times in Scopus
Spectroscopic screening for the speciation of europium and curium in the gastrointestinal tract
Wilke, C.; Barkleit, A.; Stumpf, T.
Lanthanide and actinide elements are exogenous metals, which have no essential role in normal biochemistry. Through different processes these heavy metals could be potentially released into the environment where they could be further incorporated into the food chain. Because of their potential chemical- and radiotoxicity, it is important to understand their chemical and biological behavior in the human body. This study focuses particularly on the biochemical behavior of Ln(III) and An(III) in the human gastrointestinal tract. To this end, a spectroscopic screening was performed for Eu(III), as a representative of Ln(III) and An(III), by time-resolved laser-induced fluorescence spectroscopy (TRLFS) to identify their possible binding partners in the human gastrointestinal system simulated by using an in vitro digestion model.
Keywords: body fluids; digestive system; lanthanides; actinides; europium; curium; TRLFS
RANC-International Conference on Radioanalytical and Nuclear Chemistry, 10.-15.04.2016, Budapest, Ungarn
Using quasi-DNS to investigate the deposition of elongated aerosol particles in a wavy channel flow
Lecrivain, G.; Rayan, R.; Hurtado, A.; Hampel, U.
In gas-cooled high temperature reactors, the diffusion of the fission products into the graphite matrix causes a radioactive contamination of the carbonaceous dust. The contaminated graphite aerosol particles often exhibit large aspect ratios and deposit in complex geometries, which hinders a detailed experimental investigation. The use of quasi Direct Numerical Simulation (quasi-DNS) to simulate the turbulent flow in nuclear reactors has seen an increased interest over the last few years. The capabilities of a quasi-DNS to simulate the transport and the deposition of elongated particles in an wavy channel flow are presently tested. It is shown that quasi-DNS effectively predicts deposition and that, unlike the deposition in a plane channel flow, the particle aspect ratio has no significant effect on the overall deposition rate in a wavy channel. It is suggested that in numerical studies of particle deposition on a significantly roughened channel, the particle can be assumed to be spherical without affecting the results of the deposition study.
Keywords: Graphite dust deposition; high temperature reactor; quasi-DNS; deposition of elongated particles; wavy channel flow
Gravitational settling of glass fibers on an air bubble
Lecrivain, G.; Petrucci, G.; Hampel, U.; Yamamoto, R.
Froth flotation is a separation process in which air bubbles are introduced in a water tank to separate the valuable commodities from the valueless material. Based on their relative affinity to water the valuable particles attach to the bubble surface and are carried to the top of the flotation tank to form the froth layer. The resulting froth layer is eventually collected to produce the concentrate. Froth flotation has been used for more than a century in mining operations to separate valuable materials such as rare earth metals from excavated ores. More recently, froth flotation has been employed for the treatment of contaminated water. In the present study, the effect of the particle elongation on the attachment mechanism is investigated in great detail. Using an in-house optical micro-bubble sensor the attachment of micron glass fibres on the surface of a stationary air bubble immersed in stagnant water is investigated. The attachment mechanism is here defined as three successive events: the approach of the particle near the bubble upstream pole, the collision of the solid particle with the gas-liquid interface and the particle sliding on the gas bubble surface. The translational particle velocities together with the particle orientation during entire attachment process are measured and compared with a theoretical model. For the first time the existence of two types of attachment is shown. Upon collision near the upstream pole of the gas bubble the major axis of the fibre aligns with the local bubble surface. If collision occurs at least 30° further downstream the contact is likely to take a punctual form, i.e. the head of the fibre is in contact with the gas-liquid interface.
Keywords: Froth flotation; particle attachment; gas bubble; micro-bubble sensor
Contribution to proceedings
ASME-JSME-KSME Joint Fluids Engineering Conference, 26.-31.07.2015, Seoul, South Korea
Proceedings of the ASME-JSME-KSME Joint Fluids Engineering Conference
Universal ultrafast detector for short optical pulses based on graphene
Mittendorff, M.; Kamann, J.; Eroms, J.; Weiss, D.; Drexler, C.; Ganichev, S. D.; Kerbusch, J.; Erbe, A.; Suess, R. J.; Murphy, T. E.; Chatterjee, S.; Kolata, K.; Ohser, J.; König-Otto, J. C.; Schneider, H.; Helm, M.; Winnerl, S.
Graphene has unique optical and electronic properties that make it attractive as an active material for broadband ultrafast detection. We present here a graphene-based detector that shows 40-picosecond electrical rise time over a spectral range that spans nearly three orders of magnitude, from the visible to the far-infrared. The detector employs a large area graphene active region with interdigitated electrodes that are connected to a log-periodic antenna to improve the long-wavelength collection efficiency, and a silicon carbide substrate that is transparent throughout the visible regime. The detector exhibits a noise-equivalent power of approximately 100 μW·Hz–½ and is characterized at wavelengths from 780 nm to 500 μm.
Keywords: detector; broadband detector; fast detector; graphene
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22554) publication
THz Autocorrelators for ps Pulse Characterization Based on Schottky Diodes and Rectifying Field-Effect Transistors
Preu, S.; Mittendorff, M.; Winnerl, S.; Cojocari, O.; Penirschke, A.
When operating Schottky diodes andr ectifying field-effect transistors in the saturation regime, where they show a sub-
linear response to incident THz power, they can be used as fast autorcorrelators yielding information on the pulse envelope. We report on autocorrelation measurements at 3.41 THz of high-power THz pulses for determination of the pulse duration and pulse structure. By fringe resolved measurements, the THz frequency of the pulse is also obtained. We develop a theoretical model for the rectification process and compare the performance of anantenna-coupled Schottky diode to a large-area field-effecttransistorrectifier. While the Schottky diode saturates earlier and can therefore be used for autocorrelation measurements at lower input power, antenna-less large-area field-effect transistors can be used for highest power levels - even at free electron lasers - and turn out to be very robust.
Keywords: autocorrelator; detector; Schottky diode; field-effect transistor
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22553) publication
IEEE Transactions on Terahertz Science and Technology 5(2015), 922-929
Cited 15 times in Scopus
Schlussbericht: Apparatus for in-situ defect Analysis (AIDA)
Ziel des Antrages ist die Entwicklung eines Systems (Apparatus for in-situ defect analysis, AIDA) zur Untersuchung und zur experimentellen Simulation der Defektentstehung in neuartigen, für die Energiewende relevanten Materialien. Das Besondere am AIDA-System ist, dass diese Untersuchungen/Simulationen im oberflächennahen Bereich bereits auf der atomaren Skala, d.h. in einem frühen Stadium der Defektentstehung erfolgen, sowie in-situ („live“-Messungen) und somit ein grundlegendes Verständnis der Defektentstehung erlauben.
Keywords: Materialien für die Energiewende; Defekte; Positronenannihilationsspektroskopie; Ionenstrahlanalytik
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22552) publication
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22552) publication
Dresden: Eigenverlag, 2015
Investigation of the release of zinc in the reactor sump and the behavior of dissolved zinc at hotspots in the reactor core after a loss of coolant accident
Renger, S.; Alt, S.; Kästner, W.; Seeliger, A.; Kryk, H.
Generic experimental and methodical investigations were carried out aiming at the systematical elucidation of physico-chemical mechanisms and their influence on thermo-hydraulic processes, which can occur during the sump circulation operation after loss-of-coolant accidents in PWR. In such cases, boric acid containing coolant with dissolved zinc, which is formed by corrosion of zinc-coated containment internals, may reach core regions with higher temperature (hot-spots).
The experimental studies done at semi-technical scale were focused on the influence of such zinc containing coolants on thermo-hydraulics at heating configurations similar to those inside the core of PWR. The impact of physico-chemical mechanisms on thermo-fluid-dynamical behavior of the coolant inside a 3×3 heating rod configuration with spacer segments was determined. As an initial condition, boric coolant with dissolved zinc was used at a fluid temperature in the range of 45...50°C.
During the heating of zinc-containing coolant, an increasing turbidity of the fluid caused by formed colloids was observed first, followed by the formation of several solid corrosion products consisting of zinc borates. In dependence of the temperatures of fluid and heatable surfaces, the solids showed a different behavior concerning their mobilization potential, density and ability to layer formation. Deposits occurred at the rod surfaces as well as at the spacer segments. They effected a hindered heat transfer from the rod surfaces to the fluid, an increasing head loss at the spacers and some changes of the flow distribution. In addition, quantifications of the formed solid corrosion products including a characterization of the released particles were done. Subsequently, investigations were expanded considering original zinc sources (zinc-coated gratings) and a 16×16 fuel rod dummy with a centered 8×8 heating rod configuration.
Summing up, achieved experimental results allow conclusions about the solubility behavior of zinc corrosion products in boric coolant as well as about the formation of solids and the effects thereof. Beside processes of deposit layer formation and particle release, effects like outgassing of air dissolved in the coolant and local subcooled boiling phenomena were observed, which can contribute to the remobilization of formed solids and may strengthen the mentioned mechanisms.
Keywords: reactor safety research; loss of coolant accident; particle formation; corrosion; zinc release; zinc borate; experiment
NURETH-16, 16th International Topical Meeting on Nuclear Reactor Thermal Hydraulics, 30.08.-04.09.2015, Chicago, USA
Contribution to proceedings
NURETH-16, 16th International Topical Meeting on Nuclear Reactor Thermal Hydraulics, 30.08.-04.09.2015, Chicago, USA
Proceedings of NURETH-16
Kerntechnische Ausbildung und Forschung in Deutschland – Quo vadis?
Der Vortrag widmet sich der Fragestellung, mit welchen Themen und in welcher Tiefe und Breite kerntechnische Ausbildung und Forschung derzeit in Deutschland stattfindet und wie die aktuellen Entwicklungsprognosen dazu sind. Im Zentrum stehen die Fragen: Welche Kompetenzen braucht Deutschland in Zukunft im Bereich nukleare Sicherheit, wie ist die kerntechnische Ausbildung an den Universitäten und Helmholtz-Einrichtungen zu sehen und welche Rolle spielt der Kompetenzverbund Kerntechnik?
Keywords: Kompetenzerhalt Kerntechnik
Invited lecture (Conferences)
Kompetenznetzwerk Forschung und Lehre „Perspektive Kerntechnik“, 07.-08.09.2015, Mannheim, Deutschland
Melting behavior of americium-doped uranium dioxide
Prieur, D.; Lebreton, F.; Caisso, M.; Martin, P.; Scheinost, A. C.; Somers, J.; Delahaye, T.; Manara, D.
Uranium-americium mixed oxides are considered as potential blankets for americium transmutation in fast neutron reactors. Their thermophysical properties and notably their melting behavior have not been properly assessed although required in order to evaluate the safety of these compounds under irradiation. In this study, we measured via laser heating the melting points under inert atmosphere (Ar) of U1 xAmxO2±δ samples with Am/(U+Am) contents equal to 10, 15 and 20 mol.%. The experimental atmosphere was chosen in order to maintain, as much as possible throughout the heating/cooling cycles, the oxygen-to-metal ratio, initially set very close to 2.00. Structural characterizations of the samples carried out before and after melting confirm that this goal was satisfactorily attained. The obtained melting/solidification temperatures, measured here for the first time, indicate that under the current experimental conditions and as far as the investigated AmO2 contents, the solidus line of the UO2-AmO2 system follows with very good approximation the ideal solution behavior. Accordingly, the observed liquidus formation temperature decreases from 3130 ± 20 K for pure UO2 to 3051 ± 30 K for U0.8Am0.2O2±δ.
Keywords: uranium; americium; XAFS; transmutation
- DOI: 10.1107/S1600577520014265 is cited by this (Id 22549) publication
The Journal of Chemical Thermodynamics 97(2016), 244-252
Cited 14 times in Scopus
Entstehung und Vermeidung von Gasmitriss bei Notkühlung – numerische und experimentelle Analysen
Kreiselpumpen kommen im Kraftwerksbereich in vielfältiger Weise zum Einsatz. Sie werden unter anderem als Speisepumpen oder als Umwälzpumpen in Kühlkreisläufen genutzt. Neben hoher Effizienz bei geringem Energieverbrauch bieten sie ein Reihe weiterer Vorteile, wie zum Beispiel ruhiger und kontinuierlicher Förderstrom und hohe Haltbarkeit und Beständigkeit. Erfolgt der Einsatz auch in sicherheitsrelevanten Bereichen, wie z. B. in der Reaktornotkühlung von Kernkraftwerken, muss unbedingt ein störungsfreier und zuverlässiger Betrieb gewährleistet werden. Dies kann nicht mehr sichergestellt werden, wenn es bei der Förderung des Notkühlmittels zu einem Gaseintrag durch Hohlwirbelbildung im Kühlmittelreservoir kommt.
Die vorgestellte Arbeit erläutert zunächst das Problem des Gasmitrisses durch Hohlwirbelbildung. Anschließend werden experimentelle Untersuchungen von Hohlwirbeln und Einlaufgeometrien beschrieben und Maßnahmen zur Vermeidung von Hohlwirbeln vorgeschlagen. Es werden Möglichkeiten der numerische Modellierung von Hohlwirbeln beschrieben und mit den experiementellen Untersuchungen verglichen. Weiterhin werden ausgewählte Tests an nuklearen Armaturen erläutert. Darüber hinaus werden die Auswirkungen des Gaseintrages in sicherheitsrelevante Systemkomponenten, wie Kreiselpumpen und Armaturen mittels tomographischen Untersuchungen aufgeschlossen und analysiert und es werden vorbeugende Maßnahmen vorgeschlagen. Auf den gewonnenen Ergebnissen basierend, können Betriebshinweise für Anlagenbetreiber optimiert werden. Darüber hinaus können verbesserte Design- und Auslegungsempfehlungen für sicherheitsrelevante Systemkomponenten erarbeitet und validiert werden.
Keywords: Notkühlung; Hohlwirbelbildung; Gaseintrag; Kreiselpumpe; Armaturen; Experimente; numerische Modellierung; Computertomographie; emergency cooling; hollow vortex formation; gas entrainment; centrifugal pump; valves; experiments; numeric modelling; computed tomography
Invited lecture (Conferences)
47. Kraftwerkstechnisches Kolloquium, 13.-14.10.2015, Dresden, Deutschland
Synthesis and Structural/Physical Properties of U3Fe2Ge7: A Single-Crystal Study
Henriques, M. S.; Gorbunov, D. I.; Waerenborgh, J. C.; Pasturel, M.; Andreev, A. V.; Dusek, M.; Skourski, Y.; Havela, L.; Goncalves, A. P.
A single crystal of U3Fe2Ge7 was synthesized by the tin-flux method, and its structural and electronic properties were studied. The compound crystallizes in the orthorhombic crystal structure of La3Co2Sn7 type with two Wyckoff sites for the U atoms. U3Fe2Ge7 displays a ferromagnetic order below TC = 62 K. Magnetization measurements in static (up to 14 T) and pulsed (up to 60 T) magnetic fields revealed a strong two-ion uniaxial magnetic anisotropy. The easy magnetization direction is along the c axis and the spontaneous magnetic moment is 3.3 μB per formula unit at 2 K. The moment per Fe atom is 0.2 μB, as follows from Mössbauer spectroscopy. The magnetic moments are oriented perpendicular to the shortest inter-uranium distances that occur within the zigzag chains in the ab plane, contrary to other U-based isostructural compounds. The magnetization along the a axis reveals a first-order magnetization process that allows for a quantitative description of the magnetic anisotropy in spite of its enormous energetic strength. The strong anisotropy is reflected in the specific heat and electrical resistivity that are affected by a gap in magnon spectrum.
Inorganic Chemistry 54(2015), 9646-9655
Cited 5 times in Scopus
Giant low field magnetocaloric effect and field-induced metamagnetic transition in TmZn
Li, L.; Yuan, Y.; Zhang, Y.; Namiki, T.; Nishimura, K.; Pöttgen, R.; Zhou, S.
The magnetic properties and the magnetocaloric effect (MCE) in TmZn have been studied by magnetization and heat capacity measurements. The TmZn compound exhibits a ferromagnetic state below a Curie temperature of TC=8.4K and processes a field-induced metamagnetic phase transition around and above TC. A giant reversible MCE was observed in TmZn. For a field change of 0-5T, the maximum values of magnetic entropy change (-ΔSMmax) and adiabatic temperature change (ΔTadmax) are 26.9J/kg K and 8.6K, the corresponding values of relative cooling power and refrigerant capacity are 269 and 214J/kg, respectively. Particularly, the values of -ΔSMmax reach 11.8 and 19.6J/kg K for a low field change of 0-1 and 0-2T, respectively. The present results indicate that TmZn could be a promising candidate for low temperature and low field magnetic refrigeration.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22546) publication
Detection of mixed-range proton pencil beams with a prompt gamma slit camera
Priegnitz, M.; Helmbrecht, S.; Janssens, G.; Perali, I.; Smeets, J.; Vander Stappen, F.; Sterpin, E.; Fiedler, F.
With increasing availability of proton and particle therapy centers for tumor treatment, the need for in-vivo range verification methods comes more into the focus. Imaging of prompt gamma rays emitted during the treatment is one of the possibilities currently under investigation. A knife-edge shaped slit camera was recently proposed for this task and measurements proved the feasibility of range deviation detection in homogeneous and inhomogeneous targets. In the present paper, we concentrate on laterally inhomogeneous materials, which lead to range mixing situations when crossed by one pencil beam: different sections of the beam have different ranges.
We chose exemplative cases from clinical irradiation and assembled idealized tissue equivalent targets. One-dimensional emission profiles were obtained by measuring the prompt gamma emission with the slit camera. It could be shown that the resulting range deviations can be detected by evaluation of the measured data with a previously developed range deviation detection algorithm. The retrieved value, however, strongly depends on the target composition, and is not necessarily in direct relation to the ranges of both parts of the beam. By combining the range deviation detection with an analysis of the slope of the distal edge of the measured prompt gamma profile, the origin of the detected range deviation, i.e.\ the mixed range of the beam, is also identified. It could be demonstrated that range mixed prompt gamma profiles exhibit less steep distal slopes than profiles from beams traversing laterally homogeneous material. For future application of the slit camera to patient irradiation with double scattered proton beams, situations similar to the range mixing cases are present and results could possibly apply.
Physics in Medicine and Biology 61(2016)2, 855-871
Cited 18 times in Scopus
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
Hankir, M.; Kranz, M.; Gnad, T.; Wagner, S.; Deuther-Conrad, W.; Bronisch, F.; Steinhoff, K.; Luthardt, J.; Klöting, N.; Hesse, S.; Seibyl, J.; Blüher, M.; Sabri, O.; Pfeifer, A.; Brust, P.; Fenske, W.
Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and a novel drug target for several psychiatric and neurodegenerative diseases. PDE10A has additionally been implicated in the regulation of energy homeostasis, but the mechanisms remain unclear. Here, we showed marked levels of PDE10A in interscapular brown adipose tissue (BAT) of mice by utilizing small animal PET/MRI and the novel radioligand [18F]-AQ28A. In addition to BAT, Pde10a mRNA is also expressed in perigonadal visceral white adipose tissue (VAT). Pharmacological targeting of PDE10A with the selective inhibitor MP-10 increased [18F]-FDG uptake by BAT and enhanced thermogenesis in vivo. Moreover, acute MP-10 treatment of mouse brown adipocytes stimulated lipolysis and chronic treatment induced browning of primary human white adipocytes. Functional studies on diet induced obese mice further demonstrated that MP-10 produces weight loss independent of changes in food intake associated with increased energy expenditure and browning of VAT. Finally, human PET imaging with the radioligand [18F]-MNI-659 revealed marked levels of PDE10A in the supraclavicular region where brown/beige adipocytes are clustered in adults. Collectively, our findings highlight a novel thermoregulatory role for PDE10A in mouse and human adipocytes and promote PDE10A inhibitors as promising candidates for the treatment of obesity.
EMBO Molecular Medicine 8(2016), 796-812
Online First (2016) DOI: 10.15252/emmm.201506085
Cited 27 times in Scopus
Synthese von substituierten Benzo[4,5]thienopyridinen für die Entwicklung von α7-nAChR-Liganden für die Positronen-Emissions-Tomographie (PET)
Es ist kein Abstract vorhanden.
Universität Leipzig, Fakultät für Chemie und Mineralogie, 2015
Mentor: Prof. Dr. Dr. Athanassios Giannis, Prof. Dr. Peter Brust
A hybrid electron cyclotron resonance metal ion source with integrated sputter magnetron for the production of an intense Al+ ion beam
Weichsel, T.; Hartung, U.; Kopte, T.; Zschornack, G.; Kreller, M.; Philipp, A.
A metal ion source prototype has been developed: a combination of magnetron sputter technology with 2.45 GHz electron cyclotron resonance (ECR) ion source technology—a so called magnetron ECR ion source (MECRIS). An integrated ring-shaped sputter magnetron with an Al target is acting as a powerful metal atom supply in order to produce an intense current of singly charged metal ions. Preliminary experiments show that an Al+ ion current with a density of 167 μA/cm2 is extracted from the source at an acceleration voltage of 27 kV. Spatially resolved double Langmuir probe measurements and optical emission spectroscopy were used to study the plasma states of the ion source: sputter magnetron, ECR, and MECRIS plasma. Electron density and temperature as well as Al atom density were determined as a function of microwave and sputter magnetron power. The effect of ECR heating is strongly pronounced in the center of the source. There the electron density is increased by one order of magnitude from 6 × 109 cm−3 to 6 × 1010 cm−3 and the electron temperature is enhanced from about 5 eV to 12 eV, when the ECR plasma is ignited to the magnetron plasma. Operating the magnetron at constant power, it was observed that its discharge current is raised from 1.8 A to 4.8 A, when the ECR discharge was superimposed with a microwave power of 2 kW. At the same time, the discharge voltage decreased from about 560 V to 210 V, clearly indicating a higher plasma density of the MECRIS mode. The optical emission spectrum of the MECRIS plasma is dominated by lines of excited Al atoms and shows a significant contribution of lines arising from singly ionized Al. Plasma emission photography with a CCD camera was used to prove probe measurements and to identify separated plasma emission zones originating from the ECR and magnetron discharge.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22542) publication
Gallium-Recycling aus Prozessabwässern mit Dialyseverfahren
Reinhold, T.; Zeidler, O.
Der Vortrag zeigt die Entwicklung eines Recycling-Projektes für Gallium vom Labor- bis in den Pilotmaßstab und zeigt technologische, sowie ökonomische Aspekte. Das erfolgreiche Projekt der Freiberger Compound Materials GmbH mit den Forschungseinrichtungen TU Bergakademie Freiberg und Helmholtz-Institut Freiberg wurde 2014 mit dem Deutschen Rohstoff-Effizienzpreis ausgezeichnet.
Invited lecture (Conferences)
Vortragsreihe Materialeffizienz - ein Gewinn für Unternehmen, 13.04.2015, Hannover, Deutschland
Chiral symmetry aspects in the open charm sector
Buchheim, T.; Hilger, T.; Kämpfer, B.
QCD sum rules serve as tools to investigate changing hadronic properties in a hot and/or dense nuclear medium. The role of chiral symmetry breaking and restoration effects in a medium can be addressed also in the heavy-light meson sector. Thus, we consider Weinberg sum rules which refer to chiral partner mesons composed of a light and a heavy quark.
Contribution to WWW
Journal of Physics: Conference Series 668(2016), 012047
Cited 7 times in Scopus
Non-equilibrium thermal processing towards p-n junction formation in TCOs
Prucnal, S.; Wu, J.; Gago, R.; Gao, K.; Liu, F.; Zhou, S.; Cai, H.; Zahn, D. R. T.; Gordan, O. D.; Skorupa, W.
Wide band gap semiconductors (> 3.0 eV) like ZnO and TiO2 are widely investigated in the field of optoelectronics for ultraviolet lasers, heterojunction solar cells, thin film transistors and light emitting diodes. Nowadays, the transparent conductive oxides (TCO) like Al- or F-doped ZnO (AZO or FZO) are basic materials for the front contact in thin-film photovoltaics. A highly doped n-type ZnO thin layer is an attractive candidate to replace the much more expensive indium-tin-oxide layer in the microelectronics industry. The optoelectronic properties of TCOs are determined by the type of doping and carrier concentration. The n-type conductivity of ZnO is easily achieved by substitution of Zn by group III elements (Al, Ga, In), or by doping with halogen elements (F, Cl or I) substituting oxygen in the lattice site. In the case of TiO2 the n-type material can be achieved by doping with Nb, Ta or F ions while p-type TiO2 can be realized by e.g. Cr doping. Here, we will present the utilization of highly non-equilibrium thermal processing of TCO/Si heterojunctions using millisecond (ms) range flash lamp annealing (FLA) techniques for the structural modification and dopant activation to form highly doped p- and n-type TCOs films on silicon substrate. The n- and p-type doping in ZnO was made by incorporation of Al and F or N and P into ZnO, respectively. While the conductivity of TiO2 films was controlled by efficient incorporation of Ta and Cr into the lattice side of titania. It will be presented that via millisecond range FLA treatment not only the optoelectronic properties but also the crystallographic orientation and phase formation of TCOs can be modified. The optical properties of fabricated TCOs were investigated using temperature dependent photoluminescence, Raman and transmission spectroscopy. X-Ray diffraction (XRD) and cross-sectional transmission electron microscopy (TEM) were utilized to study the microstructural properties while the electrical properties of the TCO layers and heterojunctions were measured using Hall Effect and current-voltage characterization, respectively. Moreover, it is shown that the annealing atmosphere, even during ms range annealing, can efficiently passivates the surface state and bulk defects in the TCOs significantly improving the near band gap emission. - See more at: http://www.european-mrs.com/2015-fall-symposium-g-european-materials-research-society#sthash.tu4VYSCO.dpuf
Keywords: TCOs; FLA; doping; ZnO
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22539) publication
2015 E-MRS Fall Meeting, 15.-18.09.2015, Warsaw, Poland
Lateral growth of Ge nanowires and GeOI via millisecond range explosive recrystallization: solid vs. liquid case
Prucnal, S.; Pezoldt, J.; Tiagulskyi, S.; Kerbusch, J.; Bischoff, L.; Rebohle, L.; Voelskow, M.; Wutzler, R.; Pyszniak, K.; Skorupa, W.
The incorporation of different functional optoelectronic elements on a single chip enables performance progress, which can overcome the downsizing limit in silicon technology. For example, the use of Ge instead of silicon as a basic material in nanoelectronics would enable faster chips containing smaller transistors. In order to improve the device performance and fully exploit the unique properties of germanium, the germanium on insulator (GeOI) structure using the ultrathin body (UTB) GeOI architecture with an active doping concentration above 6×1019 cm-3 has to be explored. Here we present a new concept for the development, optimisation and fabrication of high-mobility channel materials based on Ge using plasma enhanced chemical vapour deposition of Ge and its recrystallization via millisecond range lateral explosive epitaxy. It is shown that the mechanism of explosive recrystallization (solid vs liquid) can be controlled by Sn co-doping and/or varying the annealing time. An influence of the explosive recrystallization and co-doping of Sn on the dopant activation efficiency and the carrier distribution in the ultra-thin GeOI and Ge NWs after millisecond range flash lamp annealing is discussed. Finally, the nanowire FETs will be presented. - See more at: http://www.european-mrs.com/2015-spring-symposium-z-european-materials-research-society#sthash.fI9UKy1b.dpuf
Keywords: Ge; explosive recrystallization; FLA; GeOI
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22538) publication
2015 E-MRS Spring Meeting, 11.-15.05.2015, Lille, France
Optical and electrical properties of ZnO/Si heterostructures after plasma treatment and millisecond annealing
Prucnal, S.; Gao, K.; Zhou, S.; Wu, J.; Cai, H.; Gordan, O. D.; Skorupa, W.
Nowadays, the transparent and conductive ZnO layer is a basic material for the front contact in thin-film photovoltaics. A highly doped n-type ZnO thin layer is an attractive candidate to replace the much more expensive indium-tin-oxide layer in the microelectronic industry. The optoelectronic properties of the ZnO are determined by the type of doping and carrier concentration. The n-type conductivity of ZnO is easily achieved by substitution of Zn by group III elements (Al, Ga, In), or by doping with halogen elements (F, Cl or I) substituting into the oxygen lattice site. Here we will present the utilisation of plasma immersion ion implantation (PIII) and millisecond range flash lamp annealing (FLA) techniques for the formation of highly p- and n-type ZnO films on silicon substrate. Whereas the n-type doping is made by incorporation of F into ZnO, the p-type ZnO films are obtained due to the PIII of N and P. Both p- and n-type dopants are activated using post-implantation millisecond range FLA process. The microstructural and opto-electrical investigations confirm the formation of a high-quality, highly-doped ZnO layer. Moreover the current-voltage characteristics show a heterojunction between ZnO and Si. It is shown that the SF6 plasma treatment efficiently passivates the surface state and bulk defects in the ZnO film significantly improving the near band gap emission from ZnO.
Keywords: ZnO; doping; FLA
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22537) publication
2015 E-MRS Spring Meeting, 11.-15.05.2015, Lille, France
Millisecond range liquid phase processing of nanowire structures
A key milestone for the next generation of high-performance microelectronic devices is the monolithic integration of germanium or III-V compound semiconductors with silicon technology. The incorporation of different functional optoelectronic elements on a single chip enables performance progress, which can overcome the downsizing limit in silicon technology. For example, the use of Ge or III-V compound semiconductors instead of silicon as a basic material in nanoelectronic would enable faster chips containing smaller transistors. Conventionally, the integration of III-V semiconductors or Ge with silicon is based on the heteroepitaxial growth of multi-layered structures on silicon or a variety of wafer bonding techniques . Devices based on such structures combine the high carrier mobility and high luminescence efficiency of III-V semiconductors with the advantages of the well-developed silicon technology. On the other hand, the nearly 1D nanostructure of semiconductor nanowires offers a great potential for the future nanoelectronics. Silicon heteronanowires with integrated III-V segments are one of the most promising candidates for nanophotonic devices operating in the single-electron or single-photon regime . Here we present the fundamental research on the physics of Ge micro- and nanostructures and III-V/Si hetero-nanowires to enable the integration of innovative Ge and III-V based devices for the main stream of Si CMOS technology. The proposed concept for the development, optimisation and fabrication of high-mobility channel materials is based on millisecond range explosive epitaxy performed with the flash lamp annealing (FLA) process.
Keywords: FLA; III-V; silicon
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22536) publication
Invited lecture (Conferences)
NATO Advanced Workshop “Functional Nanomaterials and Devices for Electronics, Sensors, Energy Harvesting”, 13.-16.04.2015, Lviv, Ukraine
Cladding-like waveguide structure in Nd:YAG crystal fabricated by multiple ion irradiation for enhanced waveguide lasing
Shang, Z.; Tan, Y.; Akhmadaliev, S.; Zhou, S.; Chen, F.
We report on a cladding-like waveguide structure in Nd:YAG crystal fabricated by the multiple carbon ion beam irradiation. After the designed multiple irradiation process, the cladding-like waveguide with triple refractive-index layers were constructed in the region near the surface of the crystal. With such a structure, the waveguiding core was compressed and refractive index profile was modified, resulting in a higher light intensity than that of the single ion-beam-irradiated monolayer waveguide. The waveguide lasing at wavelength of 1064 nm was achieved with enhanced performance in the cladding-like structures with both planar and ridge configurations by the optical pump at 810 nm.
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22535) publication
N and Cr (co-)doping of TiO2 Thin Films Prepared by Reactive Magnetron Sputtering
Gago-Fernandez, R.; Prucnal, S.; Palomares, F. J.; Caretti, I.; Redondo-Cubero, A.; Vinnichenko, M.
The photoactivity of TiO2 has been exploited in many applications ranging from photocatalysis, hydrogen production, pigments or solar cells . However, optical absorption in TiO2 is mostly limited to the ultraviolet region of the solar spectrum (band-gap > 3 eV), triggering strong efforts to achieve visible-light (VISL) response by band-gap narrowing . Non-metal (anion) doping seems to be a promising approach, as shown for the case of nitrogen (N) doped films . However, it is unclear if the effective optical absorption of N-doped TiO2 is based on real band-gap narrowing or the formation of intragap localized states . Recently, it has been argued that narrow-gap TiO2 would require heavy doping, relating VISL absorption to oxygen vacancies and color centers . Another obstacle is the low thermodynamic solubility of dopants at substitutional sites . This situation does not only compromise the effectiveness of band-gap narrowing but also provide recombination centers that are responsible for the loss of photogenerated electron-hole pairs . A recent concept relies on N and Cr co-doping  to increase the solubility limit by non-compensated dopants where the opposite charge state of p- and n-type sites substantially enhances the thermodynamic kinetics of dopant pairs. In any case, a critical aspect of cation (co)doping relies in the introduction of large structural distortions in the host TiO2 matrix , needing processing or post-processing thermal treatments at moderate temperatures (~500ºC). In this work, we address the production and characterization of TiO2 (co)doped films by magnetron sputtering. We also compare different thermal annealing methods for further dopant activation and enhancement/design of the structural order, with special attention to the influence of as-grown films. The potential of novel rapid thermal processing such as flash-lamp annealing is also explored. The electronic structure of as-grown and modified films is assessed by means of X-ray absorption fine-structure and photoelectron spectroscopy, which permits the analysis of either (nano)crystalline or disordered structures. The optical response is derived from spectroscopic ellipsometry and transmission measurements. Finally, the structural, optical and electronic properties are correlated with the photocatalytic response of the samples. REFS:  M.A. Henderson, Surf. Sci. Rep. 66, 185 (2011);  R. Asahi et al. Science 293, 269 (2001) ;  M. Batzill et al. Phys. Rev. Lett. 96, 026103 (2006);  N. Serpone et al., J. Phys. Chem. B 110, 24287 (2006);  W. Zhu et al., Phys. Rev. Lett. 103, 226401 (2009)
Keywords: TiO2; nitrogen; band-gap narrowing
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 22534) publication
2015 MRS Spring Meeting & Exhibit, 06.-10.04.2015, San Francisco, California, USA
Analysis Methods of Magnesium Chips
Ohmann, S.; Ditze, A.; Scharf, C.
The quality of recycled magnesium from chips depends strongly on their exposure to inorg. and org. impurities that are added during the prodn. processes. Different kinds of magnesium chips from these processes were analyzed by several methods. In addn., the accuracy and effectiveness of the methods are discussed. The results show that the chips belong either to the AZ91, AZ31, AM50/60, or AJ62 alloy. Some kinds of chips show deviations from the above-mentioned normations. Different impurities result mainly from transition metals and lime. The water and oil content does not exceed 25%, and the chip size is not more than 4 mm in the diam. The sieve anal. shows good results for oily and wet chips. The detn. of oil and water shows better results for the application of a Soxhlet compared with the addn. of lime and vacuum distn. The most accurate values for the detn. of water and oil are obtained by drying at 110°C (for water) and washing with acetone (for oil) by hand.
JOM: The Journal of the Minerals, Metals & Materials Society 67(2015)11, 2747-2753
Online First (2015) DOI: 10.1007/s11837-015-1630-2
Cited 1 times in Scopus
Oxyhydroxy silicate colloids: A new type of waterborne actinide(IV) colloids
Zänker, H.; Weiss, S.; Hennig, C.; Brendler, V.; Ikeda-Ohno, A.
At the near-neutral and reducing aquatic conditions expected in undisturbed ore deposits or in closed nuclear waste repositories, the actinides Th, U, Np and Pu are primarily tetravalent. These tetravalent actinides (An(IV)) are sparingly soluble in aquatic systems and, hence, are often assumed to be immobile. However, An(IV) could become mobile if they occur as colloids. This mini-review focuses on a new type of An(IV) colloids, oxyhydroxy silicate colloids. We herein discuss the chemical characteristics of these colloids and the potential implication for their environmental behavior. The binary oxyhydroxy silicate colloids of An(IV) could be potentially more mobile as a waterborne species than the well-known mono-component oxyhydrox-ide colloids.
Keywords: Tetravalent actinides; thorium(IV); uranium(IV); neptunium(IV); silica; colloids; colloid stability; nuclear waste repositories
- DOI: 10.1107/S1600577520014265 is cited by this (Id 22532) publication
All-optical free electron lasers with Traveling-wave Thomson-scattering -- Realizable with existing machines
Debus, A.; Steiniger, K.; Pausch, R.; Irman, A.; Jochmann, A.; Schramm, U.; Cowan, T.; Bussmann, M.
Optical free-electron lasers (OFEL) based on the Traveling-wave Thomson scattering (TWTS) geometry [*] are realizable using existing petawatt class laser systems and electron beams from either conventional or Laser-wakefield accelerators. Such OFELs operate in the EUV to x-ray range, while at the same time remaining compact with centimeter to sub-meter total length.
Based on results from our analytical 1.5D-theory, as well as numerical investigations, we show using example scenarios that TWTS OFELs can be realized in SASE mode with existing RF sources such as ELBE at HZDR as well as Laser-wakefield accelerated electrons. We detail the necessary equipment for a TWTS OFEL experiment and discuss how current experimental limitations affect the design.
Keywords: Thomson-scattering; X-ray; FEL; PIConGPU; OFEL; optical free-electron laser; EUV; Traveling-wave; TWTS
37th International Free Electron Laser Conference - FEL2015, 23.-28.08.2015, Daejeon, Südkorea
All-optical free-electron lasers with Traveling-wave Thomson-scattering -- Theory and scaling
Debus, A.; Steiniger, K.; Pausch, R.; Irman, A.; Jochmann, A.; Schramm, U.; Cowan, T.; Bussmann, M.
In Traveling-Wave Thomson-Scattering (TWTS) an optical, high-power laser pulse is scattered off a relativistic electron pulse to realize optical ree-electron lasers (OFELs) with a wavelength ranging from ultraviolet to Angstrom [*].
Such TWTS-OFELs optimally exploit the high spectral photon density in high-power laser pulses by spatially stretching the laser pulse and overlapping it with the electrons in a side scattering setup. The introduction of a laser pulse-front tilt provides for interaction lengths appropriate for FEL operation, so that beam electrons witness an undulator field of near-constant strength and wavelength over hundreds to thousands of undulator periods, thus giving enough time for self-amplified spontaneous emission (SASE) to seed the FEL instability and the realization of large laser gains.
In contrast to head-on OFEL schemes, TWTS-OFEL operates at sub-mm to mm effective undulator wavelength. Thus previous show-stoppers to OFELs due to small transverse coherence, large space charge or significant quantum effects are avoided. One of the key advantages of this approach is its scalability to x-ray wavelengths with existing lasers. We present the complete analytical description of the TWTS field and a self-consistent 1.5D theory of TWTS OFELs. We discuss the main scalings of resulting
TWTS OFELs with respect to electron and laser beam properties.
Keywords: Traveling-wave; Thomson scattering; X-ray; EUV; OFEL; FEL; optical free-electron laser
37th International Free Electron Laser Conference - FEL2015, 23.-28.08.2015, Daejeon, Südkorea
Realizing All-Optical Free-Electron Lasers with Traveling-Wave Thomson-Scattering
Debus, A.; Steiniger, K.; Pausch, R.; Bussmann, M.; Irman, A.; Jochmann, A.; Röser, F.; Schramm, U.; Sauerbrey, R.
We show how all-optical free-electron lasers (OFELs) from EUV to the X-ray range can be realized using existing high-power lasers and electron accelerators.
Keywords: Traveling-wave; Thomson scattering; OFEL; FEL; optical free-electron laser; X-ray; EUV
3rd ARD ST3 Workshop, 15.-17.07.2015, Karlsruhe, Deutschland
Radiation from laser-plasma interactions - From diagnostics to all-optical free-electron lasers
Debus, A.; Steiniger, K.; Pausch, R.; Bussmann, M.; Irman, A.; Jochmann, A.; Röser, F.; Schramm, U.; Sauerbrey, R.
Radiation spectra from Laser-Plasma interactions are straightforward to obtain in experiment, but due to the large number of simulated particles these are challenging to model ab-initio. Since the emitted spectra include the complete phase-space dynamics, they are a key to both designing and optimizing brilliant plasma-driven x-ray sources for applications such as ultra-short pump-probe experiments. We present angularly-resolved em-radiation spectra from all billions of particles in a laser-plasma simulation, including the full coherence properties from plasma structure and dynamics. These spectra range from far IR to X-rays. We show recent results from the multi-GPU, open-source code PIConGPU.
We use very similar methods, when designing optical free-electron lasers (OFELs) driven by Laser-wakefield accelerated (LWFA) electrons using both existing LWFA beams and OFEL driver lasers. Such optical FELs (OFELs) based on Traveling-wave Thomson scattering (TWTS) optimally exploit the high spectral photon density in high-power laser pulses by spatially stretching the laser pulse and overlapping it with the electrons in a side scattering setup. The introduction of a laser pulse-front tilt provides for interaction lengths appropriate for FEL operation. With careful dispersion control, electrons witness an undulator field of almost constant strength and wavelength over hundreds to thousands of undulator periods, thus giving enough time for self-amplified spontaneous emission (SASE) to seed the FEL instability and the realization of large laser gains.
Keywords: Traveling-Wave; Thomson scattering; X-ray; FEL; OFEL; optical free-electron laser
Novel Light Sources from Laser-Plasma Interactions, 20.-24.04.2015, Dresden, Deutschland
Optical free-electron lasers on table-top with Traveling-wave Thomson scattering
Debus, A.; Steiniger, K.; Bussmann, M.; Pausch, R.; Cowan, T.; Irman, A.; Jochmann, A.; Sauerbrey, R.; Schramm, U.
Optical FELs (OFELs) based on Traveling-wave Thomson scattering (TWTS) optimally exploit the high spectral photon density in high-power laser pulses by spatially stretching the laser pulse and overlapping it with the electrons in a side scattering setup. The introduction of a laser pulse-front tilt provides for interaction lengths appropriate for FEL operation. With careful dispersion control, electrons witness an undulator field of almost constant strength and wavelength over hundreds to thousands of undulator periods, thus giving enough time for self-amplified spontaneous emission (SASE) to seed the FEL instability and the realization of large laser gains.
We provide an overview on the differences between TWTS OFELs, head-on OFEL designs and magnetic undulator FELs. In this dicussion we emphasize the respective impact on transverse coherence, quantum recoil and space-charge.
Keywords: Optical free-electron laser; OFEL; Traveling-wave; Thomson scattering; TWTS; FEL; X-ray
DPG Frühjahrstagung Wuppertal 2015, 09.-13.03.2015, Wuppertal, Deutschland
Reduction of selenite to red elemental selenium by methane-oxidizing bacteria
Eswayah, A. S.; Hondow, N.; Scheinost, A. C.; Smith, T. J.; Gardiner, P. H. E.
Selenium (Se) is an essential element that is required for biosynthesis of selenocysteine, the 21st proteinogenic amino acid in prokaryotes and eukaryotes. Se is toxic at high concentrations for most living organisms.1 Toxic high levels of Se, particularly in the form of selenite (SeO32-) in the environment, may be of natural or anthropogenic origin. In the natural environments, Se is subject to various microbial transformations which are important for bioremediation of Se species.2
For example, microbial reduction of toxic SeO32- to insoluble elemental selenium (Se0) results in its removal from water. Also, the reduction and methylation of SeO42- and SeO32- is considered an effective detoxification process, since the products (dimethylselenide [DMSe] or dimethyldiselenide [DMDSe]) are 500 to 700 times less toxic than SeO42- or SeO32-.3
Although a wide range of microorganisms have been investigated for their ability to transform selenium species, to our knowledge, aerobic methane-oxidising bacteria (which are ubiquitous in the environment and have numerous potential applications in remediation of organic and inorganic pollutants) have not previously been investigated for their ability to transform Se compounds.
Keywords: methanotrophs; selenium
- DOI: 10.1107/S1600577520014265 is cited by this (Id 22526) publication
VI International Conference on Environmental, Industrial and Applied Microbiology - BioMicroWorld 2015, 28.-30.10.2015, Barcelona, Spain
Bibliothekskonzeption als eine Möglichkeit, Konflikte zu vermeiden
Bis zum Jahr 2009 gab es immer wieder Diskussionen, ob es mit der Bibliothek am Helmholtz-Zentrum Dresen-Rossendorf weitergehen soll und wenn ja wie, insbesondere hinsichtlich der Personalstärke und des Raumbedarfs (Bibliothek als Ort in einer Forschungseinrichtung).
Daraufhin habe ich eine Bibliothekskonzeption für die Jahre 2010-2014 entwickelt, die zur Entscheidungsgrundlage wurde. Die Konzeption wurde von unserer Bibliothekskommission als richtungsweisend eingeschätzt und gegenüber dem Vorstand des Forschungszentrums zur Umsetzung empfohlen. Jetzt, 2015, können wir die vollständige Umsetzung der Konzeption berichten. Es gibt z.Z. keine Diskussionen um Bestand und Aufgaben der Bibliothek. Zwischen dem Vorstand, der Bibliothekskommission, unserem Zentralabteilungsleiter und der Bibliothek besteht Einvernehmen, dass sich zwar die Aufgaben der Bibliothek in ihrer Wichtung ändern, aber an der Notwendigkeit der Bibliothek vor Ort wird aktuell nicht gezweifelt.
Unterm Strich: Mit der gemeinsame Umsetzung der Konzeption wurde der Konflikt "Bibliothek brauchen wir-brauchen wir nicht" gelöst. Es entstand Planungssicherheit, die natürlich über den Zeitraum der Konzeptionsplanung hinaus weiter verteidigt/erkämpft werden muss.
Keywords: Strategisches Bibliotheksmanagement; Bibliothekskonzeption
Invited lecture (Conferences)
35. Arbeitstagung der Arbeitsgemeinschaft der Spezialbibliotheken (ASpB), 23.-25.09.2015, Bonn, Deutschland
Die Bibliothek: das Publikations- und Open Access Kompetenzzentrum am HZDR
Die Publikationsdatenbank im Helmholtz-Zentrum Dresden-Rossendorf wird seit 1992 geführt. Anfangs wurden nur bibliographische Daten erfasst. Mit den Jahren entstanden Bedürfnisse, mit diesen Daten mehr zu machen als Publikationslisten und es sollte keine doppelte Datenerfassung und Datenvorhaltung geben. Dafür mussten weitere Daten und Parameter in der einen Publikationsdatenbank erfasst werden. Der Genehmigungsworkflow wurde eingebaut, Controllingabfragen mussten möglich gemacht werden, wachsendes Berichtswesen erforderte zunehmende Flexibilität in den Abfragemöglichkeiten, Open Access Finanzierung, Verlinkung zur Datenarchivierung und weiteres. Ergebnis ist eine proprietäre Datenbankanwendung, basierend auf Oracle, die durch ihre Komplexität den Anforderungen aller beteiligten Akteure: Wissenschaftler, Bibliothek, wissenschaftliches Controlling, Institutsdirektoren und Vorstand, gerecht werden kann. Im Vortrag werden die verschiedenen Funktionen und die Organisation der Publikationsdatenbank vorgestellt.
Keywords: Library; Open Access; Publication database; Bibliothek; Publikationsdatenbank
Invited lecture (Conferences)
Fraunhofer Arbeitstagung Bibliotheks- und Informationswesen 2015, 19.-22.10.2015, Fulda, Deutschland
Verification of Master Curve testing on mini-0.16T-C(T) specimens
Viehrig, H.-W.; Houska, M.; Yamamoto, M.
Fracture toughness evaluation by the Master Curve method using 4-mm-thick miniature compact tension (mini-C(T)) specimens has been proposed. There were round robin exercises to validate the reference temperature, T0, determined on mini-C(T) of RPV base and weld metal. The HZDR has contributed to these round robin exercises. In addition to the mandatory testing, the distribution of the cleavage initiation sites over the crack front was determined. The mini-C(T) testing was also verified on RPV base metal 22 NiMoCr 3-7 from the lower ring of the non-commissioned Biblis C RPV. The fracture toughness values and therewith evaluated reference temperatures, T0, measured on 1T-, 0.5T-, 0.25T and 0.16T-C(T) specimens are compared. The results show that the T0 values determined with C(T) specimens of different size scatter within one standard deviation according to ASTM E1921. The testing of mini-C(T) specimens machined from the broken halves of Charpy specimens is a promising option to determine fracture toughness values of already tested surveillance specimens. The advantage of using mini-C(T) specimens is that material from the weld region can be investigated directly.
Keywords: compact tension specimen; Master Curve approach; fracture toughness; reference temperature
International workshop “RPV Embrittlement and Surveillance Programmes”, 13.-15.10.2015, Prag, Tschechische Republik
Immobilisierung von Tc(VII)/Tc(IV) an Eisenphasen
Die Immobilisierung von Tc(VII)/Tc(IV) an den Eisenphasen Magnetit und Siderit wurde mittels Batch-Sorptionsversuchen, ATR FT-IR-Spektroskopie und Röntgenabsorptionsspektroskopie untersucht.
Keywords: Technetium; Magnetite; Siderite
TU Dresden, 2015
Mentor: Dr. Katja Schmeide / Prof. Dr. Thorsten Stumpf
Speciation Studies of Metals in Trace Concentrations: The Mononuclear Uranyl(VI) Hydroxo Complexes
Drobot, B.; Bauer, A.; Steudtner, R.; Tsushima, S.; Bok, F.; Patzschke, M.; Raff, J.; Brendler, V.
A direct luminescence spectroscopic experimental setup for the determination of complex stability constants of mononuclear uranyl(VI) hydrolysis species is presented. The occurrence of polynuclear species is prevented using a low uranyl(VI) concentration of 10-8M (2.4 ppb). Time-resolved laser-induced fluorescence spectra were recorded in a pH range from 3 to 10.5. Deconvolution with parallel factor analysis (PARAFAC) resulted in three hydrolysis complexes. A tentative assignment was based on thermodynamic calculations: UO2+2 - 1:0 (aquo ion), UO2(OH)+ - 1:1, UO2(OH)2 - 1:2, UO2(OH)-3 - 1:3. An implementation of a Newton-Raphson algorithm into PARAFAC allowed a direct extraction of complex stability constants during deconvolution yielding log(ß1 M, 1 °C)1:1 =-4.4, log(ß1 M, 1 °C)1:2 =-11.7, log(ß1 M, 1 °C)1:3 =-21.6. Extrapolation to standard conditions gave: log(ß0)1:1 =-3.7, log(ß0)1:2 =-10.4 and log(ß0)1:3 =-20.1. Luminescence characteristics (band position, lifetime) of the individual mononuclear hydroxo species were derived to serve as reference data set for further investigations. A correlation of luminescence spectroscopic features with Raman frequencies was demonstrated for the mononuclear uranyl(VI) hydroxo complexes for the first time. Thereby a signal-to-structure correlation was achieved and the complex assignment validated.
Analytical Chemistry 88(2016)7, 3548-3555
Cited 27 times in Scopus
All-optical free electron lasers -- realizable with Traveling-wave Thomson scattering
Debus, A.; Steiniger, K.; Bussmann, M.; Irman, A.; Jochmann, A.; Pausch, R.; Roeser, F.; Schramm, U.; Sauerbrey, R.
Optical free-electron lasers (OFEL) based on the Traveling-wave Thomson scattering (TWTS) geometry are realizable using existing petawatt class laser systems and electron beams from either conventional or Laser-wakefield accelerators. Such OFELs operate in the EUV to x-ray range, while at the same time remaining compact.
Such TWTS OFELs optimally exploit the high spectral photon density in high-power laser pulses by spatially stretching the laser pulse and overlapping it with the electrons in a side scattering setup. The introduction of a laser pulse-front tilt provides for interaction lengths appropriate for FEL operation, so that beam electrons witness an undulator field of near-constant strength and wavelength over hundreds to thousands of undulator periods, thus giving enough time for self-amplified spontaneous emission (SASE) to seed the FEL instability and the realization of large laser gains.
Based on results from our analytical 1.5D-theory and numerical investigations, we discuss scaling laws and show using example scenarios that TWTS OFELs can be realized with existing RF sources such as ELBE at HZDR as well as LWFA electrons. We detail the necessary equipment for a TWTS OFEL experiment and discuss how current experimental limitations affect the design.
Keywords: optical FEL; X-ray; free-electron laser; TWTS; Traveling-wave Thomson scattering
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22520) publication
2nd European Advanced Accelerator Concepts Workshop (EAAC 2015), 13.-19.09.2015, La Biodola, Isola d'Elba, Italien
Ultra-compact all-optical FELs and Compton sources
Debus, A.; Steiniger, K.; Pausch, R.; Bussmann, M.; Krämer, J.; Jochmann, A.; Irman, A.; Schramm, U.
The interaction of an electron beam emerging from laser wakefield accelerators with an optical undulator allows for the realization of ultra-compact all-optical FELs and Compton sources using existing high-power lasers.
This presentation will review the various schemes considered to date with emphasis on both expected performance of the emitted radiation and challenges to face in terms of electron beam and laser pulse parameters.
Keywords: optical free-electron laser; OFEL; Compton source; Thomson source; FEL; free-electron laser; X-ray FEL
- DOI: 10.17815/jlsrf-2-58 is cited by this (Id 22519) publication
Invited lecture (Conferences)
2nd European Advanced Accelerator Concepts Workshop 2015 (EAAC 2015), 13.09.-19.10.2015, La Biodola, Isola d'Elba, Italien
Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer.
Eke, I.; Zscheppang, K.; Dickreuter, E.; Hickmann, L.; Mazzeo, E.; Unger, K.; Krause, M.; Cordes, N.
Signaling from integrins and receptor tyrosine kinases (RTKs) contributes substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 integrin-epidermal growth factor receptor (EGFR) targeting plus radiotherapy in human head and neck squamous cell carcinomas (HNSCCs).
Ten HNSCC cell lines were grown in three-dimensional laminin-rich extracellular matrix cell cultures and two of them as tumor xenografts in nude mice (n = 12-16 per group). Targeting of β1 integrin and EGFR with monoclonal inhibitory antibodies (AIIB2 and cetuximab, respectively) was combined with x-ray irradiation. Clonogenic survival, tumor growth, and tumor control (evaluated by Kaplan-Meier analysis), apoptosis, phosphoproteome (interactome, network betweeness centrality analysis), receptor expression (immunohistochemistry), and downstream signaling (western blotting) were assessed. Various mutants of the integrin signaling mediator focal adhesion kinase (FAK) were employed for mechanistic studies. All statistical tests were two-sided.
Compared with β1 integrin or EGFR single inhibition, combined β1 integrin-EGFR targeting resulted in enhanced cytotoxicity and radiosensitization in eight out of 10 tested HNSCC cell lines, which responded with an FAK dephosphorylation after β1 integrin inhibition. In vivo, simultaneous anti-β1 integrin/anti-EGFR treatment and radiotherapy of UTSCC15 responder xenografts enabled better tumor control compared with anti-EGFR monotherapy and irradiation (hazard ratio [HR] = 6.9, 95% confidence interval [CI] = 1.6 to 30.9, P = .01), in contrast to the SAS nonresponder tumor model (HR = 0.9, 95% CI = 0.4 to 2.3, P = .83). Mechanistically, a protein complex consisting of FAK- and Erk1-mediated prosurvival signals for radiation resistance, which was effectively compromised by β1 integrin and EGFR blocking.
Concomitant targeting of β1 integrin and EGFR seems a powerful and promising approach to overcome radioresistance of HNSCCs.
JNCI-Journal of the National Cancer Institute 107(2015)2, dju419
Cited 71 times in Scopus
Radiation-induced lung damage - Clinical risk profiles and predictive imaging on their way to risk-adapted individualized treatment planning?
Ebert, N.; Baumann, M.; Troost, E. G.
there ist no abstract
Radiotherapy and Oncology 117(2015)1, 1-3
Online First (2015) DOI: 10.1016/j.radonc.2015.09.001
Cited 16 times in Scopus
Complex formation of europium and curium with the digestive enzyme alpha-amylase
Barkleit, A.; Heller, A.; Bernhard, G.
In case of the incorporation of radioactive heavy metal ions, they would represent a serious health risk to humans due to their chemo- and/or radiotoxicity. Trivalent actinides (An(III)) like Am(III) or Cm(III) are man-made radioactive elements exclusively generated in nuclear reactors, whilst non-radioactive lanthanides (Ln(III)) are naturally occurring elements having wide technological and medical applications. These heavy metals have a potential risk of intake into humans with different pathways. Since Ln(III) and An(III) are considered to have no significant essential function in the human body, little is known about their biochemical behaviour from the uptake, in-vivo transport to the final accumulation or excretion.
Our recent studies on the speciation of U(VI) and Cm(III) in body fluids (e.g., saliva) suggested α-amylase as a potential binding partner of these actinides, which would finally affect the biochemical behaviour of these elements in-vivo. The enzyme α-amylase is one of the major enzymes in salivary and pancreatic secretions of mammals and catalyses the hydrolysis of polysaccharides like starch or glycogen. In order to further understand the potential role of α-amylase in the in-vivo speciation and complexation of Ln(III) and An(III), we investigated the complexation of Eu(III) and Cm(III) with α-amylase over a wide pH range by using time-resolved laser-induced fluorescence spectroscopy (TRLFS). Based on the obtained spectroscopic results, stability constants were determined at ambient and physiological temperature. The data were further extrapolated to infinite dilution to make the obtained data compatible with the existing thermodynamic database. The speciation of Eu(III) and Cm(III) in the saliva studied were determined based on these new data and will be presented.
International Conference on Radioanalytical and Nuclear Chemistry (RANC-2016), 10.-15.04.2016, Budapest, Hungary
Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells
Herwig, N.; Belter, B.; Wolf, S.; Haase-Kohn, C.; Pietzsch, J.
S100A4, a member of the S100 protein family of EF-hand calcium-binding proteins, is overexpressed in various tumour entities, including melanoma, and plays an important role in tumour progression. Several studies in epithelial and mesenchymal tumours revealed a correlation between extracellular S100A4 and metastasis. However, exact mechanisms how S100A4 stimulates metastasis in melanoma are still unknown. From a pilot experiment on baseline synthesis and secretion of S100A4 in human melanoma cell lines, which are in broad laboratory use, A375 wild-type cells and, additionally, newly generated A375 cell lines stably transfected with human S100A4 (A375-hS100A4) or human receptor for advanced glycation endproducts (A375-hRAGE), were selected to investigate the influence of extracellular S100A4 on cell motility, adhesion, migration and invasion in more detail. We demonstrated that A375 cells actively secrete S100A4 in the extracellular space via an endoplasmic reticulum-Golgi-dependent pathway. S100A4 overexpression and secretion resulted in prometastatic activation of A375 cells. Moreover, we determined the influence of S100A4-RAGE interaction and its blockade on A375, A375-hS100A4, A375-hRAGE cells, and showed that interaction of RAGE with extracellular S100A4 contributes to the observed activation of A375 cells. This investigation reveals additional molecular targets for therapeutic approaches aiming at blockade of ligand binding to RAGE or RAGE signalling to inhibit melanoma metastasis.
Keywords: Calcium-binding proteins; Cancer metastasis; ER-Golgi-dependent secretion pathway; S100 protein secretion; Soluble receptor for advanced glycation endproducts
Journal of Cellular and Molecular Medicine 20(2016)5, 825-835
Online First (2016) DOI: 10.1111/jcmm.12808
Cited 28 times in Scopus
Physical modelling of temperature fluctuations in a high aspect ratio model of the Czochralski crystal growth
Pal, J.; Cramer, A.; Grants, I.; Eckert, S.; Gerbeth, G.
A low temperature liquid metal model of the Czochralski (CZ) crystal growth process is considered experimentally for a high aspect ratio. Temperature fluctuations close to the edge of the model crystal are studied under the action of a rotating magnetic field (RMF) and/or rotation of the model crystal. A rotation of thermal structures is observed which loses its periodicity at sufficiently high strengths of the RMF. This finding is in qualitative agreement with previous findings in Rayleigh-Bénard (RB) cells. Opposing to that more generic case, the remaining amplitude of the temperature fluctuations stays significantly higher. I.e., the suppression of the fluctuations, which are detrimental to the growth of a mono-crystal, is weaker in the model under investigation.
Keywords: Rayleigh-Bénard convection; Large-scale temperature oscillation; Magnetohydrodynamics; Electromagnetic stirring; Czochralski crystal growth; Model Experiment
Journal of Crystal Growth 432(2015), 69-77
Online First (2015) DOI: 10.1016/j.jcrysgro.2015.09.009
Cited 16 times in Scopus
Physical model of Czochralski crystal growth in a horizontal magnetic field
Pal, J.; Grants, I.; Eckert, S.; Gerbeth, G.
A low temperature liquid metal model of the Czochralski crystal growth process is considered experimentally under conditions of high aspect ratio. In this paper we focus on the influence of a horizontal magnetic field (HMF) on the radial flow field and present first results from related model experiments. The flow is measured by means of the ultra-sound Doppler velocimetry (UDV).
Keywords: Czochralski Crystal Growth; Horizontal Magnetic Field; Flow Measurements
Contribution to proceedings
8th International Conference on Electromagnetic Processing of Materials, EPM 2015, 12.10.-16.12.2015, Cannes, France
Proceedings of the 8th International Conference on Electromagnetic Processing of Materials, EPM 2015, 978-2-9553861-0-1, 41-44
8th International Conference on Electromagnetic Processing of Materials, EPM 2015, 12.-16.10.2015, Cannes, France
Pages: [1.] [2.] [3.] [4.] [5.] [6.] [7.] [8.] [9.] [10.] [11.] [12.] [13.] [14.] [15.] [16.] [17.] [18.] [19.] [20.] [21.] [22.] [23.] [24.] [25.] [26.] [27.] [28.] [29.] [30.] [31.] [32.] [33.] [34.] [35.] [36.] [37.] [38.] [39.] [40.] [41.] [42.] [43.] [44.] [45.] [46.] [47.] [48.] [49.] [50.] [51.] [52.] [53.] [54.] [55.] [56.] [57.] [58.] [59.] [60.] [61.] [62.] [63.] [64.] [65.] [66.] [67.] [68.] [69.] [70.] [71.] [72.] [73.] [74.] [75.] [76.] [77.] [78.] [79.] [80.] [81.] [82.] [83.] [84.] [85.] [86.] [87.] [88.] [89.] [90.] [91.] [92.] [93.] [94.] [95.] [96.] [97.] [98.] [99.] [100.] [101.] [102.] [103.] [104.] [105.] [106.] [107.] [108.] [109.] [110.] [111.] [112.] [113.] [114.] [115.] [116.] [117.] [118.] [119.] [120.] [121.] [122.] [123.] [124.] [125.] [126.] [127.] [128.] [129.] [130.] [131.] [132.] [133.] [134.] [135.] [136.] [137.] [138.] [139.] [140.] [141.] [142.] [143.] [144.] [145.] [146.] [147.] [148.] [149.] [150.] [151.] [152.] [153.] [154.] [155.] [156.] [157.] [158.] [159.] [160.] [161.] [162.] [163.] [164.] [165.] [166.] [167.] [168.] [169.] [170.] [171.] [172.] [173.] [174.] [175.] [176.] [177.] [178.] [179.] [180.] [181.] [182.] [183.] [184.] [185.] [186.] [187.] [188.] [189.] [190.] [191.] [192.] [193.] [194.] [195.] [196.] [197.] [198.] [199.] [200.] [201.] [202.] [203.] [204.] [205.] [206.] [207.] [208.] [209.] [210.] [211.] [212.] [213.] [214.] [215.] [216.] [217.] [218.] [219.] [220.] [221.] [222.] [223.] [224.] [225.] [226.] [227.] [228.] [229.] [230.] [231.] [232.] [233.] [234.] [235.] [236.] [237.] [238.] [239.] [240.] [241.] [242.] [243.] [244.] [245.] [246.] [247.] [248.] [249.] [250.] [251.] [252.] [253.] [254.] [255.] [256.] [257.] [258.] [259.] [260.] [261.] [262.] [263.] [264.] [265.] [266.] [267.] [268.] [269.] [270.] [271.] [272.] [273.] [274.] [275.] [276.] [277.] [278.] [279.] [280.] [281.] [282.] [283.] [284.] [285.] [286.] [287.] [288.] [289.] [290.] [291.] [292.] [293.] [294.] [295.] [296.] [297.] [298.] [299.] [300.] [301.] [302.] [303.] [304.] [305.] [306.] [307.] [308.] [309.] [310.] [311.] [312.] [313.] [314.] [315.] [316.] [317.] [318.] [319.] [320.] [321.] [322.] [323.] [324.] [325.] [326.] [327.]