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38996 Publications

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Cardinale, J.; Martin, R.; Remde, Y.; Schäfer, M.; Hienzsch, A.; Hübner, S.; Zerges, A.-M.; Marx, H.; Hesse, R.; Weber, K.; Smits, R.; Hoepping, A.; Müller, M.; Neels, O.; Kopka, K.

Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer. In this connection, we recently developed the fluorine-18-labelled PSMA-ligand [18F]PSMA-1007 as the next generation radiofluorinated Glu-ureido PSMA inhibitor after [18F]DCFPyL and [18F]DCFBC. Since radiosynthesis so far has been suffering from rather poor yields, novel procedures for the automated radiosyntheses of [18F]PSMA-1007 have been developed. We herein report on both the two-step and the novel one-step procedures, which have been performed on different commonly-used radiosynthesisers. Using the novel one-step procedure, the [18F]PSMA-1007 was produced in good radiochemical yields ranging from 25 to 80% and synthesis times of less than 55 min. Furthermore, upscaling to product activities up to 50 GBq per batch was successfully conducted. All batches passed quality control according to European Pharmacopoeia standards. Therefore, we were able to disclose a new, simple and, at the same time, high yielding production pathway for the next generation PSMA radioligand [18F]PSMA-1007. Actually, it turned out that the radiosynthesis is as easily realised as the well-known [18F]FDG synthesis and, thus, transferable to all currently-available radiosynthesisers. Using the new procedures, the clinical daily routine can be sustainably supported in-house even in larger hospitals by a single production batch.

Keywords: [18F]PSMA-1007; fluorine-18; PSMA; automation; prostate cancer; PET

Publ.-Id: 31252

Effects of Alloying Elements on Surface Oxides of Hot–Dip Galvanized Steel

Gaderbauer, W.; Truglas, T.; Arndt, M.; Steck, T.; Klingner, N.; Stifter, D.; Faderl, J.; Groiß, H.

Effects of steel alloying agents on the formation of the surface oxide layer of galvanized press hardened steel after austenitization annealing were examined with various advanced microscopy and spectroscopy techniques. The main oxides on top of the original thin Al2O3 layer, originating from the primary galvanizing process, are identified as ZnO and (Mn,Zn)Mn2O4 spinel. For some of the investigated steel alloys, a non-uniform, several nanometer thick Cr-enriched additional film was found at the Al2O3 layer. At a sufficiently high concentration, Cr can act as a substitute for Al during annealing, strengthening and regenerating the original Al2O3 layer with Cr2O3. Further analysis with secondary ion mass spectrometry allowed a reliable distinction between ZnO and Zn(OH)2.

Keywords: Steel; Metal Coatings; Oxidation; AES; SIMS; TEM

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Publ.-Id: 31251

Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas

Glowa, C.; Peschke, P.; Brons, S.; Neels, O.; Kopka, K.; Debus, J.; Karger, C. P.

Background: To summarize the research activities of the “clinical research group heavy ion therapy”, funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypoxia) on local tumor control after carbon (12C-) ion- and photon irradiations. Methods: Three sublines of syngeneic rat prostate tumors (R3327) with various differentiation levels (highly (-H), moderately (-HI) or anaplastic (-AT1), (diameter 10 mm) were irradiated with 1, 2 and 6 fractions of either 12C-ions or 6 MV photons using increasing dose levels. Primary endpoint was local tumor control at 300 days. The relative biological effectiveness (RBE) of 12C-ions was calculated from TCD50-values (dose at 50% tumor control probability) of photons and 12C-ions and correlated with intrinsic tumor parameters. For the HI-subline, larger tumors (diameter 18 mm) were irradiated with either carbon ions, oxygen ions or photons under ambient as well as hypoxic conditions to determine the variability of the RBE under different oxygenation levels. In addition, imaging, histology and molecular analyses were performed to decipher the underlying mechanisms. Results: Experimental results revealed (i) a smaller variation of the TCD50-values between the three tumor sublines for 12C-ions (23.6 - 32.9 Gy) than for photons (38.2 - 75.7 Gy), (ii) steeper dose-response curves for 12C-ions, and (iii) an RBE that increased with tumor grading (1.62 ± 0.11 (H) vs 2.08 ± 0.13 (HI) vs 2.30 ± 0.08 (AT1)). Large HI-tumors resulted in a marked increase of TCD50, which was increased further by 15% under hypoxic relative to oxic conditions. Noninvasive imaging, histology and molecular analyses identified hypoxia as an important radioresistance factor in photon therapy. Conclusions: The dose-response studies revealed a higher efficacy of 12C-ions relative to photon therapy in the investigated syngeneic tumor model. Hypoxia turned out to be at least one important radioresistance factor, which can be partly overridden by high-LET ion beams. This might be used to increase treatment effectiveness also in patients. The results of this project served as a starting point for several ongoing research projects.

Keywords: Carbon ion radiotherapy; relative biological effectiveness (RBE); prostate tumor; hypoxia imaging

Publ.-Id: 31250

Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients

Afshar-Oromieh, A.; Holland-Letz, T.; Giesel, F. L.; Kratochwil, C.; Mier, W.; Haufe, S.; Debus, N.; Eder, M.; Eisenhut, M.; Schäfer, M.; Neels, O.; Hohenfellner, M.; Kopka, K.; Kauczor, H.-U.; Debus, J.; Haberkorn, U.

Purpose Since the clinical introduction of 68Ga-PSMA-11 PET/CT, this imaging method has rapidly spread and is now regarded as a significant step forward in the diagnosis of recurrent prostate cancer (PCa). The aim of this study was to analyse the influence of several variables with possible influence on PSMA ligand uptake in a large cohort. Methods We performed a retrospective analysis of 1007 consecutive patients who were scanned with 68Ga-PSMA-11 PET/CT (1 h after injection) from January 2014 to January 2017 to detect recurrent disease. Patients with untreated primary PCa or patients referred for PSMA radioligand therapy were excluded. The possible effects of different variables including PSA level and PSA doubling time (PSADT), PSA velocity (PSAVel), Gleason score (GSC, including separate analysis of GSC 7a and 7b), ongoing androgen deprivation therapy (ADT), patient age and amount of injected activity were evaluated. Results In 79.5% of patients at least one lesion with characteristics suggestive of recurrent PCa was detected. A pathological (positive) PET/CT scan was associated with PSA level and ADT. GSC, amount of injected activity, patient age, PSADT and PSAVel were not associated with a positive PET/CT scan in multivariate analysis. Conclusion 68Ga-PSMA-11 PET/CT detects tumour lesions in a high percentage of patients with recurrent PCa. Tumour detection is clearly associated with PSA level and ADT. Only a tendency for an association without statistical significance was found between higher GSC and a higher probability of a pathological PET/CT scan. No associations were found between a pathological 68Ga-PSMA-11 PET/CT scan and patient age, amount of injected activity, PSADT or PSAVel.

Keywords: Prostate cancer; PET/CT; positron emission tomography; PSMA; prostate-specific membrane antigen

Publ.-Id: 31249

Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT

Afshar-Oromieh, A.; Sattler, L. P.; Steiger, K.; Holland-Letz, T.; Livorsi Da Cunha, M.; Mier, W.; Neels, O.; Kopka, K.; Weichert, W.; Haberkorn, U.

Purpose Since the introduction of 68Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN. Methods Two patient groups with biphasic 68Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC. SUV of mediastinal/paraaortal LN of group A (n = 100) were compared to SUV of LN metastases of group B (n = 91). Additionally, 22 randomly selected mediastinal and paraaortal LN of patients without PC were immunohistochemically (IHC) analyzed for PSMA expression. Results In group A, 7/38 patients (18.4%) presented with at least one PSMA-positive mediastinal LN at 1 h p.i. and 3/38 (7.9%) positive LN at 3 h p.i. with a SUVmax of 2.3 ± 0.7 at 1 h p.i. (2.0 ± 0.7 at 3 h p.i.). A total of 11 PSMA-positive mediastinal/paraaortal LN were detected in nine patients considering both imaging timing points. SUVmax of LN-metastases was 12.5 ± 13.2 at 1 h p.i. (15.8±17.0 at 3 h p.i.). SUVmax increased clearly (> 10%) between 1 h and 3 h p.i. in 76.9% of the LN metastases, and decreased significantly in 72.7% of the mediastinal/paraaortal LN. By IHC, PSMA-expression was observed in intranodal vascular endothelia of all investigated LN groups and to differing degrees within germinal centers of 15/22 of them (68.1%). Expression was stronger in mediastinal nodes (p = 0.038) and when follicular hyperplasia was present (p = 0.050). Conclusion PSMA-positive mediastinal/paraaortal benign LN were visible in a notable proportion of patients. PSMA-positivity on the histopathological level was associated with the activation state of the LN. However, in contrast to LN metastases of PC, they presented with significantly lower uptake, which, in addition, usually decreased over time.

Keywords: Prostate cancer; PET/CT; Mediastinal; Mediastinal/paraaortal; Lymph nodes; PSMA; Prostate-specific membrane antigen; 68Ga-PSMA-11

Publ.-Id: 31248

Vacancy-Hydrogen Interaction in Niobium during Low-Temperature Baking

Wenskat, M.; Čižek, J.; Liedke, M. O.; Butterling, M.; Bate, C.; Haušild, P.; Hirschmann, E.; Wagner, A.; Weise, H.

A recently discovered modified low-temperature baking leads to reduced surface losses and an increase of the accelerating gradient of superconducting TESLA shape cavities. We will show that the dynamics of vacancy-hydrogen complexes at low-temperature baking lead to a suppression of lossy nanohydrides at 2 K and thus a significant enhancement of accelerator performance. Utilizing Doppler broadening Positron Annihilation Spectroscopy, Positron Annihilation Lifetime Spectroscopy and instrumented nanoindentation, samples made from European XFEL niobium sheets were investigated. We studied the evolution of vacancies in bulk samples and in the sub-surface region and their interaction with hydrogen at different temperature levels during in-situ and ex-situ annealing.

Keywords: positron annihilation spectroscopy; PALS; Doppler broadening; Nb RF cavities; superconductivity

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Publ.-Id: 31247

Quenched-in Vacancies and Hardening of Fe–Al Intermetallics

Prochazka, I.; Vlasak, T.; Cizek, J.; Lukac, F.; Liedke, M. O.; Anwand, W.; Jiraskova, Y.; Janickovice, D.

The role of vacancies in hardening of Fe–Al intermetallic alloys were studied in the present work for a wide range of Al concentrations from 20 to 50 at%. The alloys quenched from 1000 ◦C as well as those annealed subsequently at 520 ◦C for 1 h were subject to study. Slow-positron beam experiments combined with Vicker’s microhardness tests were utilised. Hardness of Fe–Al alloys exhibited a somewhat complex dependence on Al content which could not be fully explained purely by consideration of intermetallic phases formed. This happens due to additional hardening effect caused by quenched-in vacancies. The concentrations of vacancies were estimated from positron back-diffusion data and found to rise for Al content above 25 at%. Correlation of vacancy concentrations with hardness data for the quenched and annealed alloys has revealed that hardening of alloys with a low Al content (< 30 at%) is originated predominantly by anti-phase boundaries while hardening induced by quenched-in vacancies dominates for alloys with a higher Al content (30–50 at%).

Keywords: positron annihilation spectroscopy; Doppler broadening; FeAl; defetcs; SPONSOR

Publ.-Id: 31246

Investigation of Optical Properties and Defects Structure of Rare Earth (Sm, Gd, Ho) Doped Zinc Oxide Thin Films Prepared by Pulsed Laser Deposition

Novotny, M.; Hruska, P.; Fitl, P.; Maresova, E.; Havlova, S.; Bulir, J.; Fekete, L.; Yatskiv, R.; Vrnata, M.; Cizek, J.; Liedke, M. O.; Lancok, J.

Rare earths (RE = Sm, Gd, Ho) doped ZnO thin films were grown by pulsed laser deposition in oxygen ambient at pressure of 10 Pa on fused silica and Si(100) substrates at room temperature. A good optical quality of the films was confirmed by transmittance measurement in the visible spectral region. Photoluminescence suggested RE3+ oxidation state as confirmed at ZnO:Sm, where local structure was inhomogeneous. ZnO:Sm film exhibited the highest electrical resistivity while ZnO:Ho the lowest. Nanocrystalline structure of the films was observed by atomic force microscopy and X-ray diffraction. Defects structure was examined by variable energy positron annihilation spectroscopy. All ZnO:RE films exhibited significantly higher values of the S parameter as well as shorter positron diffusion lengths compared to ZnO monocrystal reference due to trapping of positrons at open volumes associated with grain boundaries. We observed the impact of the type of RE dopant on optical and electrotransport properties while the defect structure remained unchanged.

Keywords: Doped Zinc Oxide; Sm; positron annihilation spectroscopy; ZnO; Gd; Ho; defects

Publ.-Id: 31245

Tailored fabrication of iridium nanoparticle-sensitized titanium oxynitride nanotubes for solar-driven water splitting: Experimental insights on the photocatalytic-activity-defects relationship

Eid, K.; Soliman, K. A.; Abdulmalik, D.; Mitoraj, D.; Sleim, M. H.; Liedke, M. O.; El-Sayed, H. A.; Aljaber, A. S.; Al-Qaradawi, I. Y.; Mendoza Reyes, O.; Abdullah, A. M.

Understanding the photocatalytic–activity–defects relationship of titanium oxynitride nanotubes (TiON-NTs) is important for tailoring their photocatalytic performance. Herein, we fabricated highly ordered and vertically aligned nanotube arrays of TiON-NT-functionalized with iridium nanoparticles denoted as (Ir/TiON-NTs) for solar-driven water splitting. Positron annihilation lifetime spectroscopy (PALS) and variable-energy positron annihilation spectroscopy (VEPAS) were performed to quantify the vacancy-type defects of Ir/TiON-NTs relative to TiON-NTs and TiO2-NTs. The results display that the Ir/TiON-NTs exhibit abundant defects such as small nitrogen vacancies, larger size vacancy clusters, and small voids. The obtained photocurrent density of the Ir/TiON-NTs (11.3 mA cm−2) is about 3.97, 5, and 11.89 times higher than that of Ir/TiO2-NTs, TiON-NTs, and TiO2-NTs, respectively. The Mott–Schottky analysis revealed the highest significant negative shift in the band potential and the lowest donor density of Ir/TiON-NTs compared to its counterparts. This result is attributed to the unique structural and compositional merits of Ir/TiON-NTs despite the abundant defects, which delay the charge recombination and improve the photocatalytic activity. The presented study may open new frontiers on engineering the defects of metal oxynitrides with metal-based catalysts for photocatalytic applications.

Keywords: titanium oxynitride; PALS; positron annihilation spectroscopy; nanotubes; iridium nanoparticles

Publ.-Id: 31244

Ions and small molecules as radiopharmaceuticals

Neels, O.; Kolenc, P.; Patt, M.

Chapter "Ions and small molecules as radiopharmaceuticals" in the Encyclopedia of Nuclear Medicine and Molecular Imaging, Volume 1: Basic principles and instrumentation

Keywords: PET; SPECT; radiopharmaceutical; small molecules; ions; pharmacopoeia; marketing authorization

  • Book chapter
    Clemens Decristoforo: Elsevier Reference Collection in Biomedical Sciences, Oxford, UK: Elsevier, 2021, 9780128012383
    DOI: 10.1016/B978-0-12-822960-6.00008-9

Publ.-Id: 31243

F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients

Giesel, F. L.; Hadaschik, B.; Cardinale, J.; Radtke, J.; Vinsensia, M.; Lehnert, W.; Kesch, C.; Tolstov, Y.; Singer, S.; Grabe, N.; Duensing, S.; Schäfer, M.; Neels, O.; Mier, W.; Haberkorn, U.; Kopka, K.; Kratochwil, C.

Purpose The prostate-specific membrane antigen (PSMA) targeted positron-emitting-tomography (PET) tracer 68Ga-PSMA-11 shows great promise in the detection of prostate cancer. However, 68Ga has several shortcomings as a radiolabel including short half-life and non-ideal energies, and this has motivated consideration of 18F-labelled analogs. 18F-PSMA-1007 was selected among several 18F-PSMA-ligand candidate compounds because it demonstrated high labelling yields, outstanding tumor uptake and fast, non-urinary background clearance. Here, we describe the properties of 18F-PSMA-1007 in human volunteers and patients. Methods Radiation dosimetry of 18F-PSMA-1007 was determined in three healthy volunteers who underwent whole-body PET-scans and concomitant blood and urine sampling. Following this, ten patients with high-risk prostate cancer underwent 18F-PSMA-1007 PET/CT (1 h and 3 h p.i.) and normal organ biodistribution and tumor uptakes were examined. Eight patients underwent prostatectomy with extended pelvic lymphadenectomy. Uptake in intra-prostatic lesions and lymph node metastases were correlated with final histopathology, including PSMA immunostaining. Results With an effective dose of approximately 4.4–5.5 mSv per 200–250 MBq examination, 18F-PSMA-1007 behaves similar to other PSMA-PET agents as well as to other 18F-labelled PET-tracers. In comparison to other PSMA-targeting PET-tracers, 18F-PSMA-1007 has reduced urinary clearance enabling excellent assessment of the prostate. Similar to 18F-DCFPyL and with slightly slower clearance kinetics than PSMA-11, favorable tumor-to-background ratios are observed 2–3 h after injection. In eight patients, diagnostic findings were successfully validated by histopathology. 18F-PSMA-1007 PET/CT detected 18 of 19 lymph node metastases in the pelvis, including nodes as small as 1 mm in diameter. Conclusion 18F-PSMA-1007 performs at least comparably to 68Ga-PSMA-11, but its longer half-life combined with its superior energy characteristics and non-urinary excretion overcomes some practical limitations of 68Ga-labelled PSMA-targeted tracers.

Keywords: 18F-PSMA; F-18-PSMA; PSMA-1007; PET/CT; Positron emission tomography

Publ.-Id: 31242

Small Crown-Ether Complexes as Molecular Models for Dihydrogen Adsorption in Undercoordinated Extraframework Cations in Zeolites

Wulf, T.; Heine, T.

1:1 metal complexes of small crown ethers are structurally similar to extraframework sites in metal-exchanged zeolites. Using ab initio calculations, we show that adsorbed molecular hydrogen follows the same trends in adsorption energies and vibrational frequencies at both types of metal sites. Unlike zeolites, crown ethers can be characterized in the gas phase, which opens new possibilities for understanding the bonding of dihydrogen at undercoordinated metal sites to help guide the rational design of porous materials for hydrogen isotope separation. Because more strongly binding adsorbates affect the geometry of the hosts, the similarity of crown ethers and zeolites with regard to the vibrational spectra of the adsorbed molecule seems to be limited to H₂.


Publ.-Id: 31241

18F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617

Giesel, F. L.; Cardinale, J.; Schäfer, M.; Neels, O.; Benesova, M.; Mier, W.; Haberkorn, U.; Kopka, K.; Kratochwil, C.

Without Abstract

Publ.-Id: 31240

Radiosynthesis of a Novel PET Fluoronicotinamide for Melanoma Tumour PET Imaging; [18F]MEL050

Greguric, I.; Taylor, S.; Pham, T.; Wyatt, N.; Jiang, C. D.; Bourdier, T.; Loch, C.; Roselt, P.; Neels, O.; Katsifis, A.

[18F]6-Fluoro-N-[2-(diethylamino)ethyl]nicotinamide [18F]MEL050 is a novel nicotinamide-based radiotracer, designed to target random metastatic dissemination of melanoma tumours by targeting melanin. Preclinical studies suggest that [18F]MEL050 has an excellent potential to improve diagnosis and staging of melanoma. Here we report the radiochemical optimization conditions of [18F]MEL050 and its large scale automated synthesis using a GE FXFN automated radiosynthesis module for clinical, phase-1 investigation. [18F]MEL050 was prepared via a one-step synthesis using no-carrier added K[18F]F-Kryptofix® 222 (DMSO, 170° C, 5 min) followed by HPLC purification. Using 6-chloro-N-[2-(diethylamino)ethyl]nicotinamide as precursor, [18F]MEL050 was obtained in 40-46% radiochemical yield (non-decay corrected), in greater than 99.9% radiochemical purity and specific activity ranging from 240 to 325 GBq µmol(-1). Total synthesis time including formulation was 40 min and [18F]MEL050 was stable (99.8%) in PBS for 6 h.

Publ.-Id: 31239

Convection Caused Symmetry Breaking of Azimuthal Magnetorotational Instability in a Liquid Metal Taylor Couette Flow

Seilmayer, M.; Ogbonna, J. E.; Stefani, F.

This are the experimental and numerical results for the publication "Convection Caused Symmetry Breaking of Azimuthal Magnetorotational Instability in a Liquid Metal Taylor Couette Flow ". It contains pictures, experimental results, tex files, COMSOL simulation file and PDF.

Keywords: MRI; thermal convection; magnetohydrodynamic; Taylor Couette


Publ.-Id: 31238

Biochemical recurrence of prostate cancer: initial results with 18F-PSMA-1007 PET/CT

Giesel, F. L.; Will, L.; Kesch, C.; Freitag, M.; Kremer, C.; Merkle, J.; Neels, O.; Cardinale, J.; Hadaschik, B.; Hohenfellner, M.; Kopka, K.; Haberkorn, U.; Kratochwil, C.

Biochemical recurrence (BCR) is a concern for prostate cancer patients after local treatment. 68Ga-labeled prostate-specific membrane antigen (PSMA) ligands have significantly improved prostate cancer imaging. However, several 18F-labeled ligands that were developed as fluorinated tracers might present advantages. In this study, we analyzed the potential of 18F-PSMA-1007 in patients with BCR. Methods: Twelve patients with BCR after local treatment underwent PET/CT scans 1 and 3 h after injection of 18F-PSMA-1007. Results: 18F-PSMA-1007 PET/CT detected lesions in 9 of 12 patients (75%). A significant difference was observed when comparing the tracer uptake in 18F-PSMA-1007–positive lesions 1 and 3 h after injection (median SUVmax, 7.00 vs. 11.34; P < 0.001; n = 76). Fortyfour (88%) of 50 18F-PSMA-1007–positive lymph nodes had a shortaxis diameter of less than 8 mm. Conclusion: In this pilot study, 18F-PSMA-1007 PET/CT presented high potential for localization of recurrent disease in prostate cancer patients with BCR.

Keywords: peptides; PET/CT; biochemical recurrence; 18F-PSMA-1007; PSMA-PET; prostate cancer

Publ.-Id: 31237

Intra-individual comparison of 18F-PSMA-1007 and 18F-DCFPyL PET/CT in the prospective evaluation of patients with newly diagnosed prostate carcinoma: A pilot study

Giesel, F. L.; Will, L.; Lawal, I.; Lengana, T.; Kratochwil, C.; Vorster, M.; Neels, O.; Reyneke, F.; Haberkorn, U.; Kopka, K.; Sathekge, M.

The introduction of 18F-labeled prostate-specific membrane antigen (PSMA)–targeted PET/CT tracers, first 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) andmore recently 18F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-18F-fluoronicotinamido)butanamido)butanamido)methyl)phenyl)-3-(naphthalen-2-ylmethyl)-1,4,12-trioxo-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid)), have demonstrated promising results for the diagnostic workup of prostate cancer. This clinical study presents an intraindividual comparison to evaluate tracer-specific characteristics of 18F-DCFPyL versus 18F-PSMA-1007. Methods: Twelve prostate cancer patients, drug-na¨ıve or before surgery, received similar activities of about 250 MBq of 18F-DCFPyL and 18F-PSMA-1007 48 h apart and were imaged 2 h after injection on the same PET/CT scanner using the same reconstruction algorithm. Normal-organ biodistribution and tumor uptake were quantified using SUVmax. Results: PSMA-positive lesions were detected in 12 of 12 prostate cancer patients. Both tracers, 18F-DCFPyL and 18F-PSMA-1007, detected the same lesions. No statistical significance could be observed when comparing the SUVmax of 18F-DCFPyL and 18F-PSMA-1007 for local tumor, lymph node metastases, and bone metastases. With regard to normal organs, 18F-DCFPyL had statistically significant higher uptake in kidneys, urinary bladder, and lacrimal gland. Vice versa, significantly higher uptake of 18F-PSMA-1007 in muscle, submandibular and sublingual gland, spleen, pancreas, liver, and gallbladder was observed. Conclusion: Excellent imaging quality was achieved with both 18F-DCFPyL and 18F-PSMA-1007, resulting in identical clinical findings for the evaluated routine situations. Nonurinary excretion of 18F-PSMA-1007 might present some advantage with regard to delineation of local recurrence or pelvic lymph node metastasis in selected patients; the lower hepatic background might favor 18F-DCFPyL in late stages, when rare cases of liver metastases can occur.

Keywords: 18F-PSMA-1007; 18F-DCFPyL; prostate carcinoma; PET/CT; PSMA

Publ.-Id: 31236

Intra-individual comparison of 18F-PSMA-1007-PET/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer - a retrospective, proof of concept study

Kesch, C.; Vinsensia, M.; Radtke, J. P.; Schlemmer, H. P.; Heller, M.; Ellert, E.; Holland-Letz, T.; Duensing, S.; Grabe, N.; Afshar-Oromieh, A.; Wieczorek, K.; Schäfer, M.; Neels, O.; Cardinale, J.; Kratochwil, C.; Hohenfellner, M.; Kopka, K.; Haberkorn, U.; Hadaschik, B.; Giesel, F. L.

68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of 68Ga the development of alternative tracers is of high interest. The objective of this study was to examine the value of the new PET tracer 18F-PSMA-1007 for the staging of local disease by comparing it with multiparametric MRI (mpMRI) and radical prostatectomy (RP) histopathology. Methods: In 2016, 18F-PSMA-1007 PET/CT was performed in 10 men with biopsy-confirmed high-risk PCa. Nine patients underwent mpMRI in the process of primary diagnosis. Consecutively, RP was performed in all 10 men. Agreement analysis was performed retrospectively. PSMA staining was added for representative sections in RP specimen slices. Localization and agreement analysis of 18F-PSMA-1007 PET/CT, mpMRI, and RP specimens was performed by dividing the prostate into 38 sections as described in the prostate imaging reporting and data system (PI-RADS) (version 2). Sensitivity, specificity, positive predictive values, negative predictive values (NPVs), and accuracy were calculated for total and near-total agreement. Results: 18F-PSMA-1007 PET/CT had an NPV of 68% and an accuracy of 75%, and mpMRI had an NPV of 88% and an accuracy of 73% for total agreement. Near-total agreement analysis resulted in an NPV of 91% and an accuracy of 93% for 18F-PSMA-1007 PET/CT and 91% and 87% for mpMRI, respectively. Retrospective combination of mpMRI and PET/CT had an accuracy of 81% for total and 93% for near-total agreement. Conclusion: Comparison with RP histopathology demonstrates that 18F-PSMA-1007 PET/CT is promising for accurate local staging of PCa.

Keywords: 18F-PSMA; PSMA-1007; prostate cancer; PET/CT; mpMRI

Publ.-Id: 31235

Preclinical Evaluation of 18F-PSMA-1007: A New PSMA-Ligand for Prostate Cancer Imaging

Cardinale, J.; Schäfer, M.; Benesova, M.; Bauder-Wüst, U.; Leotta, K.; Eder, M.; Neels, O.; Haberkorn, U.; Giesel, F. L.; Kopka, K.

In recent years, several radiotracers targeting the prostate-specific membrane antigen (PSMA) have been introduced. Some of them have had a high clinical impact on the treatment of patients with prostate cancer. However, the number of 18F-labeled tracers addressing PSMA is still limited. Therefore, we aimed to develop a radiofluorinated molecule resembling the structure of therapeutic PSMA-617. Methods: The nonradioactive reference compound PSMA-1007 and the precursor were produced by solid-phase chemistry. The radioligand 18F-PSMA-1007 was produced by a 2-step procedure with the prosthetic group 6-18F-fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester. The binding affinity of the ligand for PSMA and its internalization properties were evaluated in vitro with PSMA-positive LNCaP (lymph node carcinoma of the prostate) cells. Further, organ distribution studies were performed with mice bearing LNCaP and PC-3 (prostate cancer cell line; PSMA-negative) tumors. Finally, small-animal PET imaging of an LNCaP tumor–bearing mouse was performed. Results: The identified ligand had a binding affinity of 6.7 ± 1.7 nM for PSMA and an exceptionally high internalization ratio (67% ± 13%) in vitro. In organ distribution studies, high and specific tumor uptake (8.0 ± 2.4 percentage injected dose per gram) in LNCaP tumor–bearing mice was observed. In the small-animal PET experiments, LNCaP tumors were clearly visualized. Conclusion: The radiofluorinated PSMA ligand showed promising characteristics in its preclinical evaluation, and the feasibility of prostate cancer imaging was demonstrated by small-animal PET studies. Therefore, we recommend clinical transfer of the radioligand 18F-PSMA-1007 for use as a diagnostic PET tracer in prestaging and monitoring of prostate cancer.

Keywords: PSMA; 18F; prostate cancer; PET

Publ.-Id: 31234

The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions

Afshar-Oromieh, A.; Hetzheim, H.; Kratochwil, C.; Benesova, M.; Eder, M.; Neels, O.; Eisenhut, M.; Kübler, W.; Holland-Letz, T.; Giesel, F. L.; Mier, W.; Kopka, K.; Haberkorn, U.

PET imaging with the prostate-specific membrane antigen (PSMA)–targeted radioligand 68Ga-PSMA-11 is regarded as a significant step forward in the diagnosis of prostate cancer (PCa). More recently, a PSMA ligand was developed that can be labeled with 68Ga, 111In, 177Lu, and 90Y. This ligand, named PSMA-617, therefore enables both diagnosis and therapy of PCa. The aims of this evaluation were to clinically investigate the distribution of 68Ga-PSMA-617 in normal tissues and in PCa lesions as well as to evaluate the radiation exposure by the radioligand in PET imaging. Methods: Nineteen patients, most of them with recurrent PCa, were referred for 68Ga-PSMA-617 PET/CT. The quantitative assessment of tracer uptake of several organs and of 53 representative tumor lesions was performed in 15 patients at 1 and 3 h after injection. In 4 additional patients, the same procedure was conducted at 5 min, 1 h, 2 h, 3 h, 4 h, and 5 h after injection. On the basis of the data for these 4 patients (mean injected dose, 231 MBq), the radiation exposure of a 68Ga-PSMA-617 PET/CT was identified. Results: Intense tracer uptake was observed in the kidneys and salivary glands. In 14 of 19 patients (73.7%), at least 1 lesion suspected of being a tumor was detected at 3 h after injection. Of 53 representative tumor lesions selected at 3 h after injection, 47 lesions were visible at 1 h after injection. The mean tumor-to-background ratio for maximum standardized uptake value was 20.4 ± 17.3 (range, 2.3–84.0) at 1 h after injection and 38.2 ± 38.6 (range, 3.6–154.3) at 3 h after injection. The average radiation exposure (effective dose) was approximately 0.021 mSv/MBq. Conclusion: Within healthy organs, the kidneys and salivary glands showed the highest 68Ga-PSMA-617 uptake. The radiation exposure was relatively low. 68Ga-PSMA-617 shows PCa lesions with high contrast. Images obtained between 2 and 3 h after injection seem to be the best option with regard to radiotracer uptake and tumor contrast. Later images can help to clarify unclear lesions.

Keywords: prostate cancer; PET/CT; positron emission tomography; PSMA; prostate-specific membrane antigen; dosimetry

Publ.-Id: 31233

Supernova-produced ⁵³Mn on earth

Korschinek, G.; Faestermann, T.; Poutivstev, M.; Arazi, A.; Knie, K.; Rugel, G.; Wallner, A.

For the time period from 1.5 to 4 Myr before present we found in deep ocean ferromanganese crusts a 53Mn excess concentration in terms of 53Mn/Mn of about 4 x 10^-14 over that expected for cosmogenic production. We conclude that this 53Mn is of supernova origin because it is detected in the same time window, about 2.5 Myr ago, where 60Fe has been found earlier. This overabundance confirms the supernova origin of that 60Fe. For the first time supernova-formed 53Mn has been detected and it is the second positively identified radioisotope from the same supernovae. The ratio 53Mn/60Fe of about 14 is consistent with that expected for a SN with a 11 - 25 Mʘ progenitor mass and solar metallicity.


Publ.-Id: 31232

The intermediate filament synemin regulates non-homologous end joining in an ATM-dependent manner

Deville, S.; Vehlow, A.; Förster, S.; Dickreuter, E.; Borgmann, K.; Cordes, N.

Treatment resistance of cancer cells is a multifaceted process in which DNA repair emerged as potential therapeutic target. DNA repair is predominantly conducted by nuclear events; yet, how extra-nuclear cues impact the DNA damage response is largely unknown. Here, using a high-throughput RNAi-based screen in three-dimensionally grown cell cultures of head and neck squamous cell carcinoma (HNSCC), we identified novel focal adhesion proteins controlling DNA repair, including the intermediate filament protein synemin. We demonstrate that synemin critically regulates the DNA damage response by non-homologous end joining repair. Mechanistically, synemin forms a protein complex with DNA-PKcs through its C-terminal tail domain for determining DNA repair processes upstream of this enzyme in an ATM–dependent manner. Our study discovers a critical function of the intermediate filament protein synemin in the DNA damage response fundamentally supporting the concept of cytoarchitectural elements as co-regulators of nuclear events.

Keywords: Synemin; DNA-PKcs; ATM; DNA repair; NHEJ; radiosensitivity; HNSCC

Publ.-Id: 31231

Investigation of Epothilone B-Induced Cell Death Mechanisms in Human Epithelial Cancer Cells –in Consideration of Combined Treatment With Ionizing Radiation

Baumgart, T.; Kriesen, S.; Neels, O.; Hildebrandt, G.; Manda, K.

Epothilone B was shown to have promising chemo- and radiosensitizing effects on cells, but the mechanisms underlying cell death remain ambiguous. The aim of the study was to examine selected cell death pathways on the basis of FaDu and A549 cells. Western blot analyses were used for investigation of specific apoptotic markers. Immunofluorescence imaging and flow cytometry were utilized for examination of cell death mechanisms. DNA-staining was used for studying influence of epothilone B on micronucleus rate. We showed that epothilone B can initiate cell death via apoptosis and mitotic catastrophe, but induction of cell death was cell type specific.

Keywords: Apoptosis; Epothilone B; Irradiation; Micronucleus; Mitotic catastrophe

Publ.-Id: 31230

ExploreASL/ExploreASL: First stable release

Mutsaerts, H.; Petr, J.; Stritt, M.; Vandemaele, P.; Groot, P.

ExploreASL v1.0.0

  • Software in external data repository
    Publication year 2020
    Programming language: Matlab
    System requirements: Windows/Linux/OS X
    License: Other (Open)
    Hosted on
    DOI: 10.5281/zenodo.3905263

Publ.-Id: 31229

Life on a Mesoarchean marine shelf – insights from the world’s oldest known granular iron formation

Smith, A. J. B.; Beukes, N. J.; Gutzmer, J.; Johnson, C. M.; Czaja, A. D.; Nhleko, N.; de Beer, F.; Hoffman, J. W.; Awramik, S. M.

The Nconga Formation of the Mesoarchean (~2.96-2.84 Ga) Mozaan Group of the Pongola Supergroup of southern Africa contains the world’s oldest known granular iron formation. Three dimensional reconstructions of the granules using micro-focus X-ray computed tomography reveal that these granules are microstromatolites coated by magnetite and calcite, and can therefore be classified as oncoids. The reconstructions also show damage to the granule coatings caused by sedimentary transport during formation of the granules and eventual deposition as density currents. The detailed, three dimensional morphology of the granules in conjunction with previously published geochemical and isotope data indicate a biogenic origin for iron precipitation around chert granules on the shallow shelf of one of the oldest supracratonic environments on Earth almost three billion years ago. It broadens our understanding of biologically-mediated iron precipitation during the Archean by illustrating that it took place on the shallow marine shelf coevally with deeper water, below-wave base iron precipitation in micritic iron formations.

Publ.-Id: 31228

P1818 - Verfahren zur gezielten Auswahl eines Sensors zur sensorbasierten Sortierung eines Materialgemisches durch Simulation der sensorbasierten Sortierung des Materialgemisches

Kern, M.; Tusa, L.; Gutzmer, J.; van den Boogaart, K. G.

Es wird Verfahren zur Auswahl eines Sensors (1) aus einer Mehrzahl von Sensoren zur sensorbasierten Sortierung eines Materialgemischs (10) anhand einer Materialeigenschaft zur Konzentration eines Wertstoffes vorgeschlagen, wobei in einem ersten Schritt aus dem Materialgemisch (10) repräsentative Einzelproben gewonnen werden (20), in einem zweiten Schritt Materialeigenschaften der Einzelproben gemessen werden (30), in einem dritten Schritt auf Grundlage der gemessenen Materialeigenschaften eine Mehrzahl von simulierten Sortierungen anhand jeweils unterschiedlicher Materialeigenschaften simuliert wird (40), in einem vierten Schritt eine simulierte Sortierung mit einer hohen Wertstoffkonzentration aus der Mehrzahl von simulierten Sortierungen ausgewählt wird, in einem fünften Schritt ein Sensor (1) zur Messung der Materialeigenschaft ausgewählt wird (50), welcher geeignet ist, mindestens eine der Materialeigenschaften, welche für die ausgewählte simulierte Sortierung genutzt wurde, zu messen.

  • Patent
    DE102018217548 - Offenlegung 16.04.2020; Nachanmeldungen: WO

Publ.-Id: 31227

P1816 - Reaktor und Verfahren zur kontinuierlichen Gewinnung amphiphiler Siderophore aus einer Mikroorganismenkultur

Schrader, S.; Kutschke, S.; Pollmann, K.; Rudolph, M.

Die Erfindung betrifft einen Reaktor, ein Verfahren und die Verwendung dieses Reaktors in dem Verfahren zur Gewinnung amphiphiler Siderophore aus einer Mikroorganismenkultur. Der Reaktor umfasst die Bauteile: (a) Vorrichtung (40) zum Rühren und/oder Begasen, und (b) Ablauf (70) für Schaum, enthaltend die amphiphilen Siderophore, in der Seitenwand des Reaktors, (c) Deckel (90) wobei die Unterkante des Ablaufs (70) für Schaum als Überlauf in einer Höhe liegt, die im Bereich von 40-75% der Gesamthöhe des Reaktors (10), von unten gemessen, liegt, und wobei der Ablauf (70) für Schaum horizontal nach außen oder schräg nach unten außen verläuft oder als Überlauf ausgestaltet ist.

  • Patent
    DE102018122029 - Offenlegung 12.03.2020; Nachanmeldungen: WO

Publ.-Id: 31226

P1814 - Kühlvorrichtung sowie Kühlverfahren basierend auf magnetoelektrischer Kopplung

Hornung, J.; Gottschall, T.

Verschiedene Ausführungsformen betreffen ein Verfahren (700) zum Betreiben einer Kühlvorrichtung (300), das Verfahren (700) aufweisend: ein erstes Verändern eines elektrischen Feldes (304) in einem Feldbereich (306), wobei in dem Feldbereich (306) mindestens ein Magnetsystem mit magnetoelektrischer Kopplung angeordnet ist, und dadurch Erwärmen des mindestens einen Magnetsystems; und, anschließend, ein zweites Verändern des elektrischen Feldes (304) in dem Feldbereich (306) und dadurch Abkühlen des mindestens einen Magnetsystems.

  • Patent
    DE102018118813 - Erteilung 21.11.2019

Publ.-Id: 31225

P1813 - Schichtabfolge zur Erzeugung von Elektrolumineszenz und deren Verwendung

Bogusz, A.; Rayapati, V. R.; Skorupa, I.; Schmidt, H.; Bürger, D.; Krüger, S.; Rebohle, L.

Die Erfindung betrifft eine Schichtabfolge zur Erzeugung von Elektrolumineszenz und deren Verwendung, beispielsweise in einem Pixelarray oder in textilen Materialien. Die Aufgabe eine Schichtstruktur anzugeben, die einfach realisierbar bzw. herstellbar sowie einfach aufgebaut ist, mit der Elektrolumineszenz einfach erzeugt werden kann und langzeitstabil einsetzbar ist, wird durch eine Schichtabfolge zur Erzeugung von Elektrolumineszenz gelöst, die mindestens eine polykristalline Seltene-Erd-Manganat-Schicht sowie einen ersten Kontakt, der auf einer Seite der Seltene-Erd-Manganat-Schicht angeordnet ist sowie einen zweiten Kontakt, der auf der gegenüberliegenden Seite des ersten Kontaktes oder auf der gleichen Seite wie der erste Kontakt angeordnet ist, aufweist, wobei in der Seltene-Erd-Manganat-Schicht zwischen dem ersten Kontakt und dem zweiten Kontakt ein Widerstand größer als 100 Ohm ausgebildet ist und wobei die Seltene-Erd-Manganat-Schicht geeignet ist, bei Anlegen einer elektrischen Gleichspannung, lokal im Bereich des sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes in der Seltene-Erd-Manganat-Schicht eine Elektrolumineszenz aufgrund von Stoßionisation auszubilden.

  • Patent
    DE102018117210 - Offenlegung 20.02.2020

Publ.-Id: 31224

P1812 - Fluidik-Detektionssystem

Illing, R.; Makarov, D.

Die Erfindung betrifft ein Fluidik-Detektionssystem zur magnetisch-elektrischen Messung einer fluiden Probe, wobei das System jeweils mindestens ein Probenmodul, einen Magnetfeldsensor und einen Magneten umfasst, welche voneinander beabstandet angeordnet sind. Dabei weist das Probenmodul mindestens einen Kanal auf, der zum Befördern einer fluiden Probe entlang einer Fließrichtung ausgebildet ist. Der Magnet erzeugt ein Magnetfeld in einem Mess- und Anregungsbereich des Kanals. Dabei entspricht der Detektionsbereich des Magnetfeldsensors dem Mess- und Anregungsbereich des Kanals. Beim Befördern der fluiden Probe im Mess- und Anregungsbereich des Kanals wird das Magnetfeld von der zu untersuchenden fluiden Probe modifiziert, wobei der Magnetfeldsensor das modifizierte Magnetfeld erfasst. Die Erfindung betrifft weiterhin ein Verfahren zum Betrieb des erfindungsgemäßen Fluidik-Detektionssystems zur magnetisch-elektrischen Messung einer fluiden Probe.

  • Patent
    DE102018116918 - Offenlegung 16.01.2020; Nachanmeldungen: WO

Publ.-Id: 31223

P1810 - 2-Phenoxypyridin-3-amin-Derivate und deren Verwendung

Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Brust, P.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I worin R¹ aus der Gruppe ausgewählt ist, die aus einer C₁-C₁₂-Alkylgruppe, einer C₃-C₁₂-Cycloalkylgruppe und einer Hetrocycloalkylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, besteht; R² Wasserstoff oder Fluor ist, R³ eine Gruppe der Formel II oder eine Gruppe der Formel III ist: X¹ aus der Gruppe ausgewählt ist, die aus -(CR⁵R⁶)ₘ-, -(CR⁵R⁶)ₙC(O)-(CR⁵R⁶)ₚ- und -(CR⁵R⁶)q-X2-(CR⁵R⁶)ᵣ- besteht, wobei m, n, p, q und r unabhängig voneinander jeweils 0 oder eine Ganzzahl von 1 bis 6 sind; R⁴ aus der Gruppe ausgewählt ist, die aus einer Arylgruppe, einer Heteroarylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, einer C₃-C₁₂-Cycloalkylgruppe und einer Heterocycloalkylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, besteht; Ring A eine Arylgruppe oder eine Heteroarylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, ist.

  • Patent
    DE102018113646 - Offenlegung 12.12.2019

Publ.-Id: 31222

P1809 - Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltenen-Erd-Manganat, ein nichtflüchtiger Impedanzschalter und dessen Verwendung

Bogusz, A.; Krüger, S.; Skorupa, I.; Schmidt, H.; Du, N.

Die Erfindung beschreibt ein Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltene-Erd-Manganat sowie einen nichtflüchtigen Impedanzschalter mit rekonfigurierbarer Impedanz. Die Aufgabe ein Verfahren anzugeben, mittels dem in speziellen Materialien deren Impedanz in Abhängigkeit von einer Vortex-Dichte ohne großen Aufwand beeinflusst und eingestellte werden kann, wird durch ein Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltene-Erd-Manganat gelöst, wobei ein einmaliges Spannungs-Zeit-Profil zwischen einem ersten und einem zweiten, an das Seltene-Erd-Manganat angebrachten elektrisch leitenden Kontakt angelegt wird, so dass das Seltene-Erd-Manganat in einem Bereich eines sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes während eines Abkühlvorganges während und nach Anlegen des Spannungspulses oder der Spannungsrampe eine Ordnungstemperatur durchläuft und damit die Vortex-Dichte lokal im Bereich des sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes beeinflusst und eingestellt wird.

  • Patent
    DE102018112605 - Offenlegung 28.11.2019; Nachanmeldungen: WO

Publ.-Id: 31221

P1808 - Festbettreaktor

Schubert, M.

Die Erfindung betrifft einen Festbettreaktor (1) mit einem rohrförmigen Reaktionsbehälter (2), der einen Rohrmantel (7), der einen Innenraum (14) begrenzt, und eine Längsachse (B) aufweist, die gegen die Horizontale geneigt ist und um die der Reaktionsbehälter (2) drehbar ist. Dabei ist vorgesehen, dass in dem Innenraum (14) ein Verdrängungskörper (15) unter Ausbildung eines umlaufenden Spaltes (20) zwischen dem Verdrängungskörper (15) und dem Rohrmantel (7) angeordnet ist, wobei im Betriebszustand des Festbettreaktors (1) ein Festbett (13) aus einem Katalysatormaterial in dem Spalt (20) fixiert ist, das von zumindest einer Flüssigkeit (51) und zumindest einem Gas (52) durchströmt ist.

  • Patent
    DE102018110091 - Offenlegung 31.10.2019

Publ.-Id: 31220

P1807 - Multisensorisches therapeutisch-diagnostisches System zum Monitoring des orthopädischen Trainings und der sportlichen Leistung

Canon Bermudez, G. S.; Voitsekhivska, T.; Makarov, D.; Fuchs, H.; Tsvyakh, A.; Hospodarskyy, A.; Shevchuk, O.

Die Erfindung betrifft ein multisensorisches therapeutisch-diagnostisches System zum Monitoring des orthopädischen Trainings und der sportlichen Leistung mit voneinander beabstandeten elektrischen Komponenten, welche eine Datenverarbeitungseinrichtung, einen Energiespeicher, ein Sensorsystem zur Erfassung von Daten sowie eine Trageeinrichtung aufweisen, wobei die elektrischen Komponenten zumindest teilweise in oder an der Trageeinrichtung angeordnet sind. Weiterhin betrifft die Erfindung ein Verfahren zum Monitoring des orthopädischen Trainings und der sportlichen Leistung sowie ein Computerprogrammprodukt zur Durchführung des Verfahrens.

  • Patent
    DE102018109913 - Offenlegung 31.10.2019; Nachanmeldungen: WO

Publ.-Id: 31219

P1806 - Rückgewinnung von Metallen aus Industrieabwässern geringer Metall-Konzentration

Jain, R.; Pollmann, K.; Lehmann, F.

Die Erfindung stellt ein mehrstufiges Verfahren bereit, zur selektiven, umweltfreundlichen und kostengünstigen Rückgewinnung von Nichteisenmetallen aus Industrieabwässern. Das Verfahren basiert auf dem Prinzip der Komplexierung der Nichteisenmetalle, Abtrennung der Komplexe und anschließender Dekomplexierung der Nichteisenmetalle. Zur Anwendung kommen als Komplexbildner Siderophore, die innerhalb des Prozesses zurückgewonnen werden. Das Verfahren ist insbesondere auch bei geringen Nichteisenmetall-Konzentrationen anwendbar. Es ist effizient, umweltfreundlich und kostengünstig.

  • Patent
    DE102018107923 - Offenlegung 10.10.2019; Nachanmeldungen: WO, EP, JP, KR, US

Publ.-Id: 31218

P1805 - Transparenter Objektträger

Rebohle, L.; Wiesenhütter, K.; Skorupa, I.; Schmidt, H.

Die Erfindung betrifft einen transparenten Objektträger. Die Aufgabe der Erfindung einen Objektträger anzugeben, an dem die Reichweite sowie die Stärke der oberflächennahen, elektrostatischen Kräfte, während eines Herstellungsprozesses des Objektträgers zu beeinflussen und einzustellen sind, wird durch einen transparenten Objektträger gelöst, welcher eine aufnahmeseitige Oberfläche und eine von der Aufnahmeseite abgewandte, also rückseitige Oberfläche ausweist und mindestens drei Schichten umfasst: eine elektrisch isolierende erste Schicht, eine auf der ersten Schicht angeordnete siliziumhaltige zweite Schicht sowie eine auf der zweiten Schicht angeordnete elektrisch isolierende dritte Schicht, wobei sich jeweils eine Grenzfläche zwischen der ersten und zweiten Schicht sowie zwischen der zweiten und dritten Schicht ausbildet, wobei die Grenzfläche zwischen der ersten und zweiten Schicht eine erste Flächenladungsdichte aufweist und die Grenzfläche zwischen der zweiten und dritten Schicht eine zweite Flächenladungsdichte aufweist, wobei die erste und zweite Flächenladungsdichte gleiche oder unterschiedliche Vorzeichen aufweisen und der Objektträger oberflächennahe, elektrostatischen Kräfte auf beiden Oberflächenseiten aufweist, deren Reichweite sowie Stärke während des Herstellungsprozesses zu beeinflussen und einzustellen sind.

  • Patent
    DE102018107810 - Offenlegung 10.10.2019; Nachanmeldungen: WO

Publ.-Id: 31217

P1804 - Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten

Kosub, T.

Die Erfindung betrifft ein Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten, wie Dünnschichtwiderständen und Dünnschichtsensoren aller Art. Durch die Erfindung soll ein Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten, wie Dünnschichtwiderständen und Dünnschichtsensoren aller Art, geschaffen werden, bei dem mit einer minimierten Anzahl von Kontakten eine kontinuierliche Bestimmung aller Komponenten des Widerstandstensors ohne Umschalten der Kontaktpunkte ermöglicht wird. Erreicht wird das dadurch, dass ein beliebig geformtes homogenes Teilstück (T) der Dünnschicht mit mindestens drei in Abständen zueinander angeordneten Kontaktpunkten (K₁ bis K₃) versehen wird, wobei an jedem der Kontaktpunkte (K₁ bis K₃) eine Eingangsspannung Uᵢ(t) angelegt wird, dass die die Kontaktpunkte (K₁ bis K₃) durchfließenden Ströme Iᵢ(t) erfasst werden und dass aus den Spannungs- und Stromwerten der vollständige Widerstandstensor p des Teilstücks (T) der Dünnschicht bestimmt wird.

  • Patent
    DE102018106466 - Erteilung 25.04.2019; Nachanmeldungen: WO

Publ.-Id: 31216

P1803 - Teilchenspektrometer und Teilchenspektrometrieverfahren

Klingner, N.; Wilhelm, R. A.

Die Erfindung betrifft ein Teilchenspektrometer und Teilchenspektrometrieverfahren zum Analysieren eines entlang eines Teilchenpfades verlaufenden Teilchenpulses, wobei der Teilchenpuls an einer Kreuzungsposition zur Überlagerung mit einem Photonenpuls gebracht wird, sodass ein Teil der Teilchen des Teilchenpulses mittels des Photonenpulses elektrisch umgeladen wird, und wobei anschließend mittels eines Analysators die umgeladenen Teilchen separiert und die umgeladenen oder die nicht umgeladenen Teilchen separat mittels eines Teilchendetektors detektiert werden.

  • Patent
    DE102018106412 - Offenlegung 26.09.2019

Publ.-Id: 31215

Magnetic phase diagram and magnetoelastic coupling of NiTiO3

Dey, K.; Sauerland, S.; Werner, J.; Scurschii, I.; Abdel-Hafiez, M.; Bag, R.; Singh, S.; Klingeler, R.

We report high-resolution dilatometry on high-quality single crystals of NiTiO3 grown by means of the optical floating-zone technique. The anisotropic magnetic phase diagram is constructed from thermal expansion and magnetostriction studies up toB=15 T and magnetization studies in static (15-T) and pulsed (60-T) magnetic fields. Our data allow us to quantitatively study magnetoelastic coupling and to determine uniaxial pressure dependencies. While the entropy changes are found to be of magnetic nature, Grüneisen analysis implies only one relevant energy scale in the whole low-temperature regime. Thereby, our data suggest that the observed structural changes due to magnetoelastic coupling and previously reported magnetodielectric coupling [L. Balhorn, J. Hazi, M. C. Kemei, and R. Seshadri, Phys. Rev. B93, 104404(2016)] are driven by the same magnetic degrees of freedom that lead to long-range magnetic order in NiTiO3.


Publ.-Id: 31214

Extremely slow nonequilibrium monopole dynamics in classical spin ice

Stöter, T.; Doerr, M.; Granovsky, S.; Rotter, M.; Goennenwein, S. T. B.; Zherlitsyn, S.; Petrenko, O. A.; Balakrishnan, G.; Zhou, H. D.; Wosnitza, J.

We report on the nonequilibrium monopole dynamics in the classical spin ice Dy2Ti2O7 detected by means of high-resolution magnetostriction measurements. Significant lattice changes occur at the transition from the kagome-ice to the saturated-ice phase, visible in the longitudinal and transverse magnetostriction. A hysteresis opening at temperatures below 0.6 K suggests a first-order transition between the kagome and saturated state. Extremely slow lattice relaxations, triggered by changes of the magnetic field, were observed. These latticerelaxation effects result from nonequilibrium monopole formation or annihilation processes. The relaxation times extracted from our experiment are in good agreement with theoretical predictions with decay constants of the order of 104 s at 0.3K.


Publ.-Id: 31213

Splitting of the magnetic monopole pair-creation energy in spin ice

Hornung, J.; Gottschall, T.; Opherden, L.; Antlauf, M.; Schwarz, M.; Kroke, E.; Herrmannsdörfer, T.; Wosnitza, J.

The thermodynamics in spin-ice systems are governed by emergent magnetic monopole excitations and, until now, the creation of a pair of these topological defects was associated with one specific pair-creation energy. Here, we show that the electric dipole moments inherent to the magnetic monopoles lift the degeneracy of their creation process and lead to a splitting of the pair-creation energy. We consider this finding to extend the model of magnetic relaxation in spin-ice systems and show that an electric dipole interaction in the theoretically estimated order of magnitude leads to a splitting which can explain the controversially discussed discrepancies between the measured temperature dependence of the magnetic relaxation times and previous theory. By applying our extended model to experimental data of, various spin-ice systems, we show its universal applicability and determine a dependence of the electric dipole interaction on the systemparameters, which is in accordance with the theoretical model of electric dipole formation.

Publ.-Id: 31212

Resource Model Updating For Compositional Geometallurgical Variables

Prior-Arce, A.; Tolosana Delgado, R.; van den Boogaart, K. G.; Benndorf, J.

In the field of mineral resources extraction, one main challenge is to meet production targets in terms of geometallurgical properties. These properties influence the processing of the ore and are often represented in resource modeling by coregionalized variables with a complex relationship between them. Valuable data are available about geometalurgical properties and their interaction with the beneficiation process given sensor technologies during production monitoring. The aim of this research is to update resource models as new observations become available. A popular method for updating is the ensemble Kalman filter. This method relies on Gaussian assumptions and uses a set of realizations of the simulated models to derive sample covariances that can propagate the uncertainty between real observations and simulated ones. Hence, the relationship among variables has a compositional nature, such that updating these models while keeping the compositional constraints is a practical requirement in order to improve the accuracy of the updated models. This paper presents an updating framework for compositional data based on ensemble Kalman filter which allows us to work with compositions that are transformed into a multivariate Gaussian space by log-ratio transformation and flow anamorphosis. This flow anamorphosis, transforms the distribution of the variables to joint normality while reasonably keeping the dependencies between components. Furthermore, the positiveness of those variables, after updating the simulated models, is satisfied. The method is implemented in a bauxite deposit, demonstrating the performance of the proposed approach.

Keywords: Geostatistics; Compositional Data; Data Assimilation; Flow Anamorphosis; Multivariate Modelling; Kalman Filter

Publ.-Id: 31211

CFD simulation of bubbly flow around an obstacle in a vertical pipe with a focus on breakup and coalescence modelling

Tas-Köhler, S.; Neumann-Kipping, M.; Liao, Y.; Krepper, E.; Hampel, U.

In the present study, we assessed the capabilities of Eulerian-Eulerian CFD two-phase flow simulation with the homogeneous Multiple Size Group Model (MUSIG) and consideration of breakup and coalescence under transient three-dimensional flow conditions. We compared void fraction, bubble size and bubble velocity distributions against experimental data from vertical gas-disperse two-phase flow in a pipe with a flow obstruction. The simulation results generally agree well upstream the obstacle, where we have a typically developed pipe flow. Downstream of the obstacle void fraction is overpredicted while bubble velocity is underpredicted. The bubble size distribution has no clear trend. With higher liquid velocities, the deviations increase. As a conclusion, the simulation has difficulties to balance the gas fraction in the strong vortex in the shadow of the obstacle. Here further model improvement is needed.

Keywords: CFD; bubbly flow; model validation; bubble breakup; bubble coalescence


Publ.-Id: 31210

A Dual Radiologic Contrast Agent Protocol for 18F-FDG and 18F-FLT PET/CT Imaging of Mice Bearing Abdominal Tumors

Aide, N.; Kinross, K.; Beauregard, J.-M.; Neels, O.; Potdevin, T.; Roselt, P.; Dorow, D.; Cullinane, C.; Hicks, R. J.

Purpose: The aim of the study was to improve abdominal tumor detection by use of a dual radiologic contrast protocol. Procedures: eXia160® (Benitio international) was mixed with 2-deoxy-2-[18F]fluoro-D-glucose or 3′-[18F]fluoro-3′-deoxythymidine for intravenous (IV) injections. Omnipaque® 300 (GE healthcare) was used for intraperitoneal (IP) injections. Positron emission tomography/computed tomography (PET/CT) scans were acquired on a Siemens Biograph® equipped with point spread function reconstruction. The optimal concentration and injection schedule of IP contrast agent was studied in 12 mice. The impact of IP contrast media on PET quantitative accuracy was investigated by phantom studies and by imaging six mice before and after IP injection of Omnipaque®. The impact of a dual contrast media protocol on tumor delineation and quantitation was evaluated in 15 tumor-bearing mice using ex vivo counting as the reference. Results: The optimal sequence was a mixture of tracer plus IV contrast agent followed by 1 mL of IP contrast agent (20 mg iodine/mL) administered 10 min before PET/CT acquisition. Phantom studies showed that the use of a 20-mg iodine/mL concentration of Omnipaque® led to a 4.8% overestimation of radioactivity concentration, as compared to saline. This was confirmed by animal studies that demonstrated a 4.3% overestimation. Tumor detection was excellent and correlation between PET/CT quantitative data and ex vivo counting was good (r2=0.91, slope=0.7). Conclusions: A dual radiologic contrast protocol is useful in PET/CT scanning of mice bearing abdominal tumors. Contrast agents used in this manner lead to a small but acceptable overestimation of quantitative PET data.

Keywords: PET/CT; Preclinical studies; Abdominal tumors; Contrast media

Publ.-Id: 31209

18F-FLT PET as a Surrogate Marker of Drug Efficacy During mTOR Inhibition by Everolimus in a Preclinical Cisplatin-Resistant Ovarian Tumor Model

Aide, N.; Kinross, K.; Cullinane, C.; Roselt, P.; Waldeck, K.; Neels, O.; Dorow, D.; Mcarthur, G.; Hicks, R. J.

Targeting the mammalian target of rapamycin (mTOR) pathway is a potential means of overcoming cisplatin resistance in ovarian cancer patients. Because mTOR inhibition affects cell proliferation, we aimed to study whether 39-deoxy-39-18F-fluorothymidine (18F-FLT) PET could be useful for monitoring early response to treatment with mTOR inhibitors in an animal model of cisplatin-resistant ovarian tumor. Methods: BALB/c nude mice bearing subcutaneous human SKOV3 ovarian cancer xenografts were treated with either the mTOR inhibitor everolimus (5 mg/kg) or vehicle, and 18F-FLT PET was performed at baseline, day 2, and day 7 of treatment. 18F-FLT uptake was evaluated by calculation of mean standardized uptake value (SUVmean) corrected for partial-volume effect. Ex vivo immunohistochemistry studies were performed on separate cohorts of mice treated as above and sacrificed at the same time points as for the PET studies. The ex vivo analysis included bromodeoxyuridine incorporation as a marker of cell proliferation, and phosphorylation of ribosomal protein S6 as a downstream marker of mTOR activation. Results: During the treatment period, no significant change in tumor 18F-FLT uptake was observed in the vehicle group, whereas in everolimus-treated mice, 18F-FLT SUVmean decreased by 33% (P = 0.003) at day 2 and 66% (P < 0.001) at day 7, compared with baseline. Notably, the reduction of 18F-FLT uptake observed at day 2 in the everolimus group preceded changes in tumor volume, and a significant difference in 18F-FLT uptake was observed between vehicle and drug-treated tumors at both day 2 (P = 0.0008) and day 7 (P = 0.01). In ex vivo studies, everolimus treatment resulted in a 98% reduction in phosphorylated ribosomal protein S6 immunostaining at day 2 (P = 0.02) and 91% reduction at day 7 (P = 0.003), compared with the vehicle group. Bromodeoxyuridine incorporation was reduced by 65% at day 2 (not significant) and by 41% at day 7 (P = 0.02) in drug versus vehicle groups. Conclusion: Reduction in 18F-FLT uptake correlates well with the level of mTOR inhibition by everolimus in the SKOV3 ovarian tumor model. These data suggest that early treatment monitoring by 18F-FLT PET may be of use in future preclinical or clinical trials evaluating treatment of cisplatinresistant ovarian tumors by mTOR inhibitors.

Keywords: animal imaging; oncology; PET; FLT; mTOR inhibition; ovarian cancer; small-animal PET

Publ.-Id: 31208

Improved Detection of Regional Melanoma Metastasis Using 18F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration

Denoyer, D.; Potdevin, T.; Roselt, P.; Neels, O.; Kirby, L.; Greguric, I.; Katsifis, A.; Dorow, D. S.; Hicks, R. J.

The efficacy of differing routes of administration of 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050), a new benzamide-based PET radiotracer for imaging regional lymph node metastasis in melanoma, was assessed. Methods: B16-Black/6 metastatic melanoma cells harboring an mCherry transgene were implanted into the left-upper-foot surface of 49 C57 Black/6 mice as a model of popliteal lymph node (PLN) metastasis. Ultrasound scanning of the left PLN was performed at baseline and in combination with 18F-MEL050 PET on days 5, 9, and 14. Mice were divided into 2 groups to compare the results of tracer administration either subcutaneously at the tumor site (local) or in the lateral tail vein (systemic). After PET on each imaging day, 5 mice per group—including any with evidence of metastasis—were sacrificed for ex vivo validation studies including assessment of retained radioactivity and presence of the mCherry transgene as a surrogate of nodal tumor burden. Results: Nine mice were judged as positive for PLN metastasis by ultrasound at day 5, and 8 PLNs were positive on 18F-MEL050 PET, 3 after systemic and 5 after local administration. Ex vivo analysis showed that ultrasound correctly identified 90% of positive PLNs, with 1 false-positive. 18F-MEL050 PET correctly identified 60% of positive PLNs after systemic administration and 100% after local administration with no false-positive results by either route. The average node-to-background ratio for positive PLNs was 6.8 in the systemic-administration group and correlated with disease burden. In the local-administration group, the mean uptake ratio was 48, without clear relation to metastatic burden. Additional sites of metastatic disease were also correctly identified by 18F-MEL050 PET. Conclusion: In addition to its potential for systemic staging, perilesional administration of 18FMEL050 may allow sensitive and specific, noninvasive identification of regional lymph node metastasis in pigmented malignant melanomas.

Keywords: MEL050; benzamide; melanoma imaging; lymphoscintigraphy; small-animal PET; fluoro-nicotinamide analog

Publ.-Id: 31207

68Ga PET/CT Ventilation–Perfusion Imaging for Pulmonary Embolism: A Pilot Study with Comparison to Conventional Scintigraphy

Hofman, M. S.; Beauregard, J.-M.; Barber, T. W.; Neels, O.; Eu, P.; Hicks, R. J.

Ventilation–perfusion (V/Q) scintigraphy is established for regional assessment of lung function in a variety of diseases, including pulmonary embolism (PE). PET/CT may further improve the accuracy and utility of V/Q imaging because of its superior technical characteristics. This pilot study assessed the feasibility of performing V/Q PET/CT and compared diagnostic utility with conventional V/Q imaging in patients with clinical suspicion of PE. Methods: Ten patients undergoing conventional V/Q imaging were prospectively recruited. PET/CT V/Q imaging was performed after inhalation of 68Ga-carbon nanoparticles (“Galligas”) and administration of 68Ga-macroaggregated albumin. Blinded to the results of the other study, SPECT/CT (n = 9) or SPECT (n = 1) images and PET/CT images were graded by a predefined scoring system for scan quality. The number of matched or unmatched defects and diagnosis were also measured and compared with a final diagnosis. Results: PET image quality was equivalent or superior to SPECT in all patients, with more homogeneous radiotracer distribution for both ventilation and perfusion studies (P < 0.01). Based on conventional V/Q imaging, the diagnosis was acute PE in 2 patients and no PE in 7 patients, and the imaging results were nondiagnostic in 1 patient. The PET/CT diagnosis was concordant in 8 patients, and these studies demonstrated a similar number and distribution of matched and unmatched defects. In 1 discordant case, a patient with a SPECT/CT study that was nondiagnostic because of severe airway disease showed no PE on PET/CT. In another, the diagnosis of PE established on SPECT/CT was not reported on PET/CT 2 d later, possibly because of interval clot lysis or migration. Conclusion: This intraindividual comparative study demonstrated that V/Q PET/CT with 68Ga-labeled radiotracers can be performed in clinical practice. Compared with conventional V/Q imaging, advantages include higher-resolution, fully tomographic images with potentially better regional quantitation of lung function. The short half-life of 68Ga also enables more flexible acquisition protocols with the option of performing ventilation studies selectively on patients with abnormal perfusion. On the basis of our results, further studies are indicated to assess whether V/Q PET/CT can improve diagnostic algorithms for patients with suspected PE.

Keywords: PET/CT; ventilation; perfusion; V/Q; 68Ga; pulmonary embolism

Publ.-Id: 31206

Design and high temperature behavior of novel heat resistant steels strengthened by high density of stable nanoprecipitates

Vivas, J.; De-Castro, D.; Altstadt, E.; Houska, M.; San-Martin, D.; Capdevila, C.

International efforts have been focused on the development of new 9Cr Ferritic/Martensitic steels capable of operating at temperatures above 700 ºC to improve thermal efficiency of new power plants. The distribution and size of the MX nanoprecipitates present in these steels have been reported to be the key factor for improving the thermal stability of the microstructure during creep. Bearing in mind these findings, three different heat resistant steels were designed to have a higher number density of MX nanoprecipitates than commercial 9Cr ferritic/martensitic steels. The manufacturing and subsequent microstructural characterization carried out showed that this goal was achieved. Preliminary high temperature strength results performed by means of Small Punch Creep Tests (SPCT) demonstrated that these new steels improve significantly the high temperature strength without an important loss of ductility as compared to a current commercial 9Cr Ferritic/Martensitic steel.

Keywords: nanoprecipitates; alloy design; small punch creep test; high temperature strength; heat resistant steels

Publ.-Id: 31205

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

Feldmann, A.; Hoffmann, A.; Bergmann, R.; Koristka, S.; Berndt, N.; Arndt, C.; Rodrigues Loureiro, L. R.; Kittel-Boselli, E.; Metwasi, N.; Kegler, A.; Lamprecht, C.; González Soto, K. E.; Bachmann, M.

Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize off-target and on-target/off-tumor reactions, improve safety, enable controllability, provide high flexibility, and increase tumor specificity, we established a novel humanized artificial receptor platform termed RevCARs. RevCAR genes encode for small surface receptors lacking any antigen-binding moiety. Steering of RevCAR T cells occurs via bispecific targeting molecules (TMs). The small size of RevCAR-encoding genes allows the construction of polycistronic vectors. Here, we demonstrate that RevCAR T cells efficiently kill tumor cells, can be steered by TMs, flexibly redirected against multiple targets and used for combinatorial targeting following the “OR” and “AND” gate logic.

Keywords: Chimeric antigen receptor (CAR); T cell therapy; tumor immunotherapy; adaptor CAR platform; combinatorial gated targeting

Publ.-Id: 31204

Fermi surface investigation of the noncentrosymmetric superconductor α-PdBi

Klotz, J.; Butcher, T.; Förster, T.; Hornung, J.; Sheikin, I.; Wisniewski, P.; Jesche, A.; Wosnitza, J.; Kaczorowski, D.

The noncentrosymmetric superconductor α-PdBi is a candidate material for the realization of topological superconductivity. Here, we present a detailed de Haas–van Alphen (dHvA) study together with band-structure calculations within the framework of density functional theory. The rich dHvA spectra are a manifestation of the 13 bands that cross the Fermi energy EF . We find excellent agreement between calculated and experimentally observed dHvA frequencies with moderately enhanced effective masses. One of the bands crossing EF, the so-called α band, exhibits topological character with Weyl nodes lying 43 meV below EF .


Publ.-Id: 31203

High-field magnetization study of (Nd,Dy)2Fe14B: Intrinsic properties and promising compositions

Kostychenko, N. V.; Tereshina, I. S.; Gorbunov, D.; Tereshina-Chitrova, E. A.; Rogacki, K.; Andreev, A. V.; Doerr, M.; Politova, G. A.; Zvezdin, A. K.

The crystal-electric field and exchange parameters are determined for the (Nd0.5Dy0.5)2Fe14B compound by analyzing experimental magnetization curves obtained in high magnetic fields up to 58 T. The series (NdxDy1-x)2Fe14B compounds were analyzed theoretically to achieve a temperature stability while maintaining a large maximum energy product (BH)max. We demonstrate that computational simulations is an important tool in the materials design.

Publ.-Id: 31202

Direct measurements of the magnetocaloric effect of Fe49Rh51 using the mirage effect

Amirov, A. A.; Cugini, F.; Kamantsev, A. P.; Gottschall, T.; Solzi, M.; Aliev, A. M.; Spichkin, Y. I.; Koledov, V. V.; Shavrov, V. G.

The magnetocaloric effect in the Fe49Rh51 alloy was systematically studied using three different approaches: in-field differential scanning calorimetry, standard direct measurement of the adiabatic temperature change, and a non-contact method based on a thermo-optical phenomenon, the mirage effect, which was able to directly test the magnetocaloric response induced by a fast magnetic field variation. The metamagnetic phase transition of Fe49Rh51 was studied in the temperature range of 290–330 K at magnetic fields up to 1.8 T through magnetic and calorimetric measurements. The estimated parameters of phase transition were comparable with the literature data. The values of adiabatic temperature change obtained with the three methods (calorimetry, standard direct measurement, and mirage-based technique), which explore three different time scales of the field variation (static field, 1 T s−1, 770 T s−1), were consistent, proving the absence of dynamic constraints in the first-order magnetostructural transition at the maximum field sweep rate.

Publ.-Id: 31201

Detection Efficacy of 18F-PSMA-1007 PET/CT in 251 Patients with Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy

Giesel, F. L.; Knorr, K.; Spohn, F.; Will, L.; Maurer, T.; Flechsig, P.; Neels, O.; Schiller, K.; Amaral, H.; Weber, W.; Haberkorn, U.; Schwaiger, M.; Kratochwil, C.; Choyke, P.; Kramer, V.; Kopka, K.; Eiber, M.

Prostate-specific membrane antigen (PSMA)–targeted PET imaging recently emerged as a new method for the staging and restaging of prostate cancer. Most published studies investigated the diagnostic potential of 68Ga-labeled PSMA agents that are excreted renally 18F-PSMA-1007 is a novel PSMA ligand that has excellent preclinical characteristics and that is only minimally excreted by the urinary tract, a potential advantage for pelvic imaging. The aim of this study was to investigate the diagnostic efficacy of 18F-PSMA-1007 for biochemical recurrence (BCR) after radical prostatectomy. Methods: From 3 academic centers, 251 patients with BCR after radical prostatectomy were evaluated in a retrospective analysis. Patients who had received second-line androgen deprivation therapy (ADT) or chemotherapy were excluded, but prior first-line ADT exposure was allowed. The median prostate-specific antigen (PSA) level was 1.2 ng/mL (range, 0.2–228 ng/mL). All patients underwent PSMA PET/CT at 92 ± 26 min after injection of 301 ± 46 MBq of 18FPSMA-1007. The rate of detection of presumed recurrence sites was correlated with the PSA level and original primary Gleason score. A comparison to a subset of patients treated previously with ADT was undertaken. Results: Of the 251 patients, 204 (81.3%) had evidence of recurrence on 18F-PSMA-1007 PET/CT. The detection rates were 94.0% (79/84), 90.9% (50/55), 74.5% (35/47), and 61.5% (40/65) for PSA levels of greater than or equal to 2, 1 to less than 2, 0.5 to less than 1, and 0.2 to less than 0.5 ng/mL, respectively. 18FPSMA-1007 PET/CT revealed local recurrence in 24.7% of patients (n = 62). Lymph node metastases were present in the pelvis in 40.6% of patients (n = 102), in the retroperitoneum in 19.5% of patients (n = 49), and in supradiaphragmatic locations in 12.0% of patients (n = 30). Bone and visceral metastases were detected in 40.2% of patients (n = 101) and in 3.6% of patients (n = 9), respectively. In tumors with higher Gleason scores (≤7 vs. ≥8), detection efficacy trended higher (76.3% vs. 86.7%) but was not statistically significant (P = 0.32). However, detection efficacy was higher in patients who had received ADT (91.7% vs. 78.0%) within 6 mo before imaging (P = 0.0179). Conclusion: 18F-PSMA-1007 PET/CT offers high detection rates for BCR after radical prostatectomy that are comparable to or better than those published for 68Ga-labeled PSMA ligands.

Keywords: 18F-PSMA-1007; PET/CT; hybrid imaging; prostate cancer; biochemical recurrence

Publ.-Id: 31200

High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours

Hofman, M. S.; Kong, G.; Neels, O.; Eu, P.; Hong, E.; Hicks, R. J.

Introduction: Ga-68 DOTATATE (Ga-octreotate, GaTate) positron emission tomography (PET)/CT has multiple advantages compared with conventional and In-111 octreotide imaging for neuroendocrine tumours and other somatostatin-receptor expressing tumours. This study assesses the management impact of incremental diagnostic information obtained from this technique compared with conventional staging. Methods: Fifty-nine GaTate PET/CT studies were performed over an 18-month period (52 proven or suspected gastro-entero-pancreatic or bronchial neuroendocrine tumours and seven neural crest/mesenchymal tumours). A retrospective blinded review was performed on the number of abnormalities (1, 2–5 or >5) within defined regions with comparison to conventional imaging to assess incremental diagnostic information. Subsequent management impact (high, moderate or low) was determined by clinical review and follow up to assess pre-PET stage, treatment intent and post-PET management change. Results: Eighty-eight percent of GaTate studies were abnormal. Compared with conventional and In-111 octreotide imaging, additional information was provided by GaTate PET/CT in 68 and 83% of patients, respectively. Management impact was high (inter-modality change) in 47%, moderate (intra-modality change) in 10% and low in 41% (not assessable in 2%). High management impact included directing patients to curative surgery by identifying a primary site and directing patients with multiple metastases to systemic therapy. Conclusion: GaTate PET/CT imaging provides additional diagnostic information in a high proportion of patients with consequent high management impact. GaTate PET/CT could replace 1In-111 octreotide scintigraphy at centres where it is available given its superior accuracy, faster acquisition and lower radiation exposure. Rapid implementation could be achieved by allowing substitutional funding in the Medicare Benefit Schedule.

Keywords: DOTATATE; Ga-68; octreoscan; octreotate; PET/CT; somatostatin-receptor imaging

Publ.-Id: 31199

Laboratory Study of Bilateral Supernova Remnants and Continuous MHD Shocks

Mabey, P.; Albertazzi, B.; Rigon, G.; Marquès, J. R.; Palmer, C. A. J.; Topp-Mugglestone, J.; Perez-Martin, P.; Kroll, F.; Brack, F.-E.; Cowan, T.; Schramm, U.; Falk, K.; Gregori, G.; Falize, E.; Koenig, M.

Many supernova remnants (SNRs), such as G296.5+10.0, exhibit an axisymmetric or barrel shape. Such morphologies have previously been linked to the direction of the Galactic magnetic field, although this remains uncertain. These SNRs generate magnetohydrodynamic shocks in the interstellar medium, modifying its physical and chemical properties. The ability to study these shocks through observations is difficult due to the small spatial scales involved. In order to answer these questions, we perform a scaled laboratory experiment in which a lasergenerated blast wave expands under the influence of a uniform magnetic field. The blast wave exhibits a spheroidal shape, whose major axis is aligned with the magnetic field, in addition to a more continuous shock front. The implications of our results are discussed in the context of astrophysical systems.

Keywords: Supernova remnants (1667); Shocks (2086); Magnetic fields (994); Astrophysical magnetism (102); Magnetohydrodynamics (1964); Galaxy magnetic fields (604); Interstellar magnetic fields (845)


Publ.-Id: 31198

Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer

Denoyer, D.; Kirby, L.; Waldeck, K.; Roselt, P.; Neels, O.; Bourdier, T.; Shepherd, R.; Katsifis, A.; Hicks, R. J.

Purpose The imaging potential of a new 18F-labelled methionine derivative, S-(3-[18F]fluoropropyl)-D-homocysteine (18F-D-FPHCys), and its selectivity for amino acid transporter subtypes were investigated in vitro and by imaging of human tumour xenografts. Methods Expression of members of the system L (LAT isoforms 1–4 and 4F2hc) and ASCT (ASCT isoforms 1 and 2) amino acid transporter subclasses were assessed by quantitative real-time PCR in four human tumour models, including A431 squamous cell carcinoma, PC3 prostate cancer, and Colo 205 and HT-29 colorectal cancer lines. The first investigations for the characterization of 18F-D-FPHCys were in vitro uptake studies by comparing it with [1-14C]-L-methionine (14C-MET) and in vivo by PET imaging. In addition, the specific involvement of LAT1 transporters in 18F-DFPHCys accumulation was tested by silencing LAT1 mRNA transcription with siRNAs. To determine the proliferative activity in tumour xenografts ex vivo, Ki-67 staining was used as a biomarker. Results A431 cells showed the highest 18F-D-FPHCys uptake in vitro and in vivo followed by Colo 205, PC3 and HT-29. A similar pattern of retention was observed with 14C-MET. 18F-D-FPHCys retention was strongly correlated with LAT1 expression both in vitro R2=0.85) and in vivo (R2=0.99). Downregulation of LAT1 by siRNA inhibited 18F-DFPHCys uptake, demonstrating a clear dependence on this transporter for tumour uptake. Furthermore, 18F-D-FPHCys accumulation mirrored cellular proliferation. Conclusion The favourable properties of 18F-D-FPHCys make this tracer a promising imaging probe for detection of tumours as well as for the noninvasive evaluation and monitoring of tumour growth.

Keywords: S-(3-[18F]fluoropropyl)-D-homocysteine; LAT1 amino acid transporter; In vitro uptake; Small-animal PET; Cancer imaging

Publ.-Id: 31197

High throughput static and dynamic small animal imaging using clinical PET/CT: potential preclinical applications

Aide, N.; Desmonts, C.; Beauregard, J.-M.; Beyer, T.; Kinross, K.; Roselt, P.; Neels, O.; Agostini, D.; Bardet, S.; Bouvard, G.; Hicks, R. J.

Purpose The objective of the study was to evaluate state-of-the-art clinical PET/CT technology in performing static and dynamic imaging of several mice simultaneously. Methods A mouse-sized phantom was imaged mimicking simultaneous imaging of three mice with computation of recovery coefficients (RCs) and spillover ratios (SORs). Fifteen mice harbouring abdominal or subcutaneous tumours were imaged on clinical PET/CT with point spread function (PSF) reconstruction after injection of [18F]fluorodeoxyglucose or [18F]fluorothymidine. Three of these mice were imaged alone and simultaneously at radial positions –5, 0 and 5 cm. The remaining 12 tumour-bearing mice were imaged in groups of 3 to establish the quantitative accuracy of PET data using ex vivo gamma counting as the reference. Finally, a dynamic scan was performed in three mice simultaneously after the injection of 68Ga-ethylenediaminetetraacetic acid (EDTA). Results For typical lesion sizes of 7–8 mm phantom experiments indicated RCs of 0.42 and 0.76 for ordered subsets expectation maximization (OSEM) and PSF reconstruction, respectively. For PSF reconstruction, SORair and SORwater were 5.3 and 7.5%, respectively. A strong correlation (r2=0.97, p<0.0001) between quantitative data obtained in mice imaged alone and simultaneously in a group of three was found following PSF reconstruction. The correlation between ex vivo counting and PET/CT data was better with PSF reconstruction (r2=0.98; slope=0.89, p<0.0001) than without (r2=0.96; slope=0.62, p<0.001). Valid time-activity curves of the blood pool, kidneys and bladder could be derived from 68Ga-EDTA dynamic acquisition.Conclusion New generation clinical PET/CT can be used for simultaneous imaging of multiple small animals in experiments requiring high throughput and where a dedicated small animal PET system is not available.

Keywords: Molecular imaging; PET/CT; PSF reconstruction; Cancer research; Preclinical studies

Publ.-Id: 31196

High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

Denoyer, D.; Greguric, I.; Roselt, P.; Neels, O.; Aide, N.; Taylor, S. R.; Katsifis, A.; Dorow, D. S.; Hicks, R. J.

The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18F-MEL050 was performed in murine models of melanoma. The specificity of 18F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. 18F-MEL050 PET results were compared with 18F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of 18F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs. Results: In pigmented B16-F0 grafts, 18F-MEL050 PET yielded a tumor-to-background ratio of approximately 20:1 at 1 h and greater than 50:1 at 2 and 3 h. In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for 18F-MEL050 than for 18F-FDG (50.9 ± 6.9 vs. 5.8 ± 0.5). No uptake was observed in the amelanotic melanoma xenografts. Intense uptake of 18F-MEL050 was evident in metastatic lesions in the lungs of B16-BL6 tumor–bearing mice on PET at 2 h after tracer injection, with high concordance between 18F-MEL050 accumulation on PET/CT and tumor burden determined at necroscopy. Conclusion: 18F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma.

Keywords: melanoma imaging; small-animal PET; PET/CT; high-resolution autoradiography; fluoronicotinamide analogue

Publ.-Id: 31195

Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance

Greguric, I.; Taylor, S. R.; Denoyer, D.; Ballantyne, P.; Berghofer, P.; Roselt, P.; Pham, T. Q.; Mattner, F.; Bourdier, T.; Neels, O.; Dorow, D. S.; Loch, C.; Hicks, R. J.; Katsifis, A.

The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide ([18F]2), a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [18F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [18F]2 displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclinical studies for progression into clinical trials to assess the responsiveness of therapeutic agents.

Publ.-Id: 31194

High-Performance Bismuth-Doped Nickel Aerogel Electrocatalyst for the Methanol Oxidation Reaction

Dubale, A. A.; Zheng, Y.; Wang, H.; Hübner, R.; Li, Y.; Yang, J.; Zhang, J.; Sethi, N. K.; He, L.; Zheng, Z.; Liu, W.

Low-cost, non-noble-metal electrocatalysts are required for direct methanol fuel cells, but their development has been hindered by limited activity, high onset potential, low conductivity, and poor durability. A surface electronic structure tuning strategy is presented, which involves doping of a foreign oxophilic post-transition metal onto transition metal aerogels to achieve a non-noble-metal aerogel Ni97Bi3 with unprecedented electrocatalytic activity and durability in methanol oxidation. Trace amounts of Bi are atomically dispersed on the surface of the Ni97Bi3 aerogel, which leads to an optimum shift of the d-band center of Ni, large compressive strain of Bi, and greatly increased conductivity of the aerogel. The electrocatalyst is endowed with abundant active sites, efficient electron and mass transfer, resistance to CO poisoning, and outstanding performance in methanol oxidation. This work sheds light on the design of high-performance non-noble-metal electrocatalysts

Keywords: aerogels; bismuth dopants; methanol oxidation; nickel; single atoms

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Publ.-Id: 31193

Birefringence in thermally anisotropic relativistic plasmas and its impact on laser-plasma interactions

Arefiev, A. V.; Stark, D. J.; Toncian, T.; Murakami, M.

One of the paradigm-shifting phenomena triggered in laser-plasma interactions at relativistic intensities is the so-called relativistic transparency. As the electrons become heated by the laser to relativistic energies, the plasma becomes transparent to the laser light even though the plasma density is sufficiently high to reflect the laser pulse in the non-relativistic case. This paper highlights the impact that relativistic transparency can have on laser-matter interactions by focusing on a collective phenomenon that is associated with the onset of relativistic transparency: plasma birefringence in thermally anisotropic relativistic plasmas. The optical properties of such a system become dependent on the polarization of light, and this can serve as the basis for plasma-based optical devices or novel diagnostic capalibities.


Publ.-Id: 31191

Power Scaling for Collimated γ-Ray Beams Generated by Structured Laser-Irradiated Targets and Its Application to Two-Photon Pair Production

Wang, T.; Ribeyre, X.; Gong, Z.; Jansen, O.; D'Humières, E.; Stutman, D.; Toncian, T.; Arefiev, A.

Using three-dimensional kinetic simulations, we examine the emission of collimated γ-ray beams from structured laser-irradiated targets with a prefilled cylindrical channel and its scaling with laser power (in the multi-PW range). The laser power is increased by increasing the laser energy and the size of the focal spot while keeping the peak intensity fixed at 5×1022W/cm2. The channel radius is increased proportionally to accommodate the change in laser spot size. The efficiency of conversion of the laser energy into a beam of MeV-level γ rays (with a 10âˆ&tild; opening angle) increases rapidly with the incident laser power P before it roughly saturates above P≈4PW. Detailed particle tracking reveals that the power scaling is a result of enhanced electron acceleration at higher laser powers. One application that directly benefits from such a strong scaling is pair production via two-photon collisions. We investigate two schemes for generating pairs through the linear Breit-Wheeler process: Colliding two γ-ray beams and colliding one γ-ray beam with black-body radiation. The two scenarios project up to 104 and 105 pairs, respectively, for the γ-ray beams generated at P=4PW. A comparison with a regime of laser-irradiated hollow channels corroborates the robustness of the setup with prefilled channels.

Publ.-Id: 31190

Direct laser ion acceleration and above-threshold ionization at intensities from 1021 W/cm2 to 3×1023 W/cm2

Yandow, A.; Toncian, T.; Ditmire, T.

Calculations on the dynamics of ions and electrons in near-infrared laser fields at intensities up to 3×1023W/cm2 are presented. We explore the acceleration of ions in a laser focus by conservation of canonical momentum during ionization events and by the ponderomotive force in the f/1 focal geometry required to reach such intensity. At intensities exceeding 1023W/cm2, highly charged ions are expelled from the laser focus before they can interact with the laser pulse at peak intensity, decreasing the predicted ionization yields of deeply bound states. We consider the interaction of a tightly focused, f/1 laser pulse with krypton at an intensity of 3×1023W/cm2 and a pulse duration of 140 fs. We find that the ions and electrons are accelerated to energies in excess of 2 MeV/nucleon and 1.4 GeV, respectively. Ponderomotive expulsion of the parent ions decreases the total number of ultrarelativistic above-threshold ionization electrons produced by tunneling ionization from the K-shell states of krypton but does not change their energy spectrum.
Viele Grüße

Publ.-Id: 31189

ARCTURUS laser: A versatile high-contrast, high-power multi-beam laser system

Cerchez, M.; Prasad, R.; Aurand, B.; Giesecke, A. L.; Spickermann, S.; Brauckmann, S.; Aktan, E.; Swantusch, M.; Toncian, M.; Toncian, T.; Willi, O.

With the latest configuration, the Ti:Sa laser system ARCTURUS (Düsseldorf University, Germany) operates with a double-chirped pulse amplification (CPA) architecture delivering pulses with an energy of 7 J before compression in each of the two high-power beams. By the implementation of a plasma mirror system, the intrinsic laser contrast is enhanced up to on a time scale of hundreds of picoseconds, before the main peak. The laser system has been used in various configurations for advanced experiments and different studies have been carried out employing the high-power laser beams as a single, high-intensity interaction beam (), in dual- and multi-beam configurations or in a pump-probe arrangement.

Keywords: high power laser pulses; laser driven particle and radiation sources; multi-beam configuration; relativistic plasmas; Ti:Sa lasers

Publ.-Id: 31188

A multihertz, kiloelectronvolt pulsed proton source from a laser irradiated continuous hydrogen cluster target

Aurand, B.; Grieser, S.; Toncian, T.; Aktan, E.; Cerchez, M.; Lessmann, L.; Prasad, R.; Khoukaz, A.; Willi, O.

A high-repetition rate laser-driven proton source from a continuously operating cryogenic hydrogen cluster target is presented. We demonstrate a debris-free, Coulomb-explosion based acceleration in the 10s of kilo-electron-volt range with a stability of about 10% in a 5 Hz operation. This acceleration mechanism, delivering short pulse proton bursts, represents an ideal acceleration scheme for various applications, for example, in materials science or as an injector source in conventional accelerators. Furthermore, the proton energy can be tuned by varying the laser and/or cluster parameters. 3D numerical particle-in-cell simulations and an analytical model support the experimental results and reveal great potential for further studies, scaling up the proton energies, which can be realized with a simple modification of the target.
Viele Grüße

Publ.-Id: 31187

Beam distortion effects upon focusing an ultrashort petawatt laser pulse to greater than 1022 W/cm2

Tiwari, G.; Gaul, E.; Martinez, M.; Dyer, G.; Gordon, J.; Spinks, M.; Toncian, T.; Bowers, B.; Jiao, X.; Kupfer, R.; Lisi, L.; Mccary, E.; Roycroft, R.; Yandow, A.; Glenn, G. D.; Donovan, M.; Ditmire, T.; Hegelich, B. M.

When an ultrashort laser pulse is tightly focused to a size approaching its central wavelength, the properties of the focused spot diverge from the diffraction-limited case. Here, we report on this change in behavior of a tightly focused petawatt-class laser beam by an f ㄍ1 off-axis parabolic mirror (OAPM). Considering the effects of residual aberration, the spatial profile of the near-field, and pointing error, we estimate the deviation in peak intensities of the focused spot from the ideal case. We verify that the estimated peak intensity values are within an acceptable error range of the measured values. With the added uncertainties in target alignment, we extend the estimation to infer on-target peak intensities of ≥1022 Wㄍcm2 for a target at the focal plane of this f ㄍ1 OAPM.

Publ.-Id: 31186

UV harmonics generated on modulated targets irradiated by high-intensity laser pulses

Giesecke, A. L.; Peth, C.; Toncian, T.; Willi, O.; Cerchez, M.

The generation of high-order harmonics in ultraviolet spectral range by targets of periodic modulation interacting with relativistic, high contrast laser pulse ( 2 = 10 20 W/cm 2 · μm 2 ) was investigated experimentally and numerically. The spectral intensity of the 2nd- and 3rd-order harmonic emission from grating of different periodicities (250, 410, and 480 nm) is presented. The enhancement of the 3rd harmonic order compared with 2nd was observed for a grating of 480 nm periodicity. The experimental results indicate the role of the grating periodicity on the emission efficiency of different higher order harmonics in the UV spectral range. The higher order harmonics are emitted at the grating surface separated from the specular reflection of the laser pulse, due of the interference effects. In addition, 2D numerical PIC simulations demonstrate a complex angular distribution of the higher harmonics (HH) spectral intensity and confirm the strong dependence of the HH efficiency of a specific order on the grating periodicity, as observed experimentally. These special features of the high harmonic emission by periodically modulated targets open the route toward the control of HH spectral composition and of the emission efficiency of the lower order harmonics. Copyright © Cambridge University Press 2019.

Keywords: high harmonic generation; High-density plasma; Laser-driven radiation source

Publ.-Id: 31185

Structured targets for detection of Megatesla-level magnetic fields through Faraday rotation of XFEL beams

Wang, T.; Toncian, T.; Wei, M. S.; Arefiev, A. V.

A solid density target irradiated by a high-intensity laser pulse can become relativistically transparent, which then allows it to sustain an extremely strong laser-driven longitudinal electron current. The current generates a filament with a slowly varying MT-level azimuthal magnetic field that has been shown to prompt efficient emission of multi-MeV photons in the form of a collimated beam required for multiple applications. This work examines the feasibility of using an x-ray beam from the European x-ray free electron laser for the detection of the magnetic field via the Faraday rotation. Post-processed three dimensional particle-in-cell simulations show that, even though the relativistic transparency dramatically reduces the rotation in a uniform target, the detrimental effect can be successfully reversed by employing a structured target containing a channel to achieve a rotation angle of 10-4rad. The channel must be relativistically transparent with an electron density that is lower than the near-solid density in the bulk. The detection setup has been optimized by varying the channel radius and focusing the laser pulse driving the magnetic field. We predict that the Faraday rotation can produce 103 photons with polarization orthogonal to the polarization of the incoming 100 fs long probe beam with 5 × 1012 x-ray photons. Based on the calculated rotation angle, the polarization purity must be much better than 10-8 in order to detect the signal above the noise level.

Publ.-Id: 31184

Microstructure and fracture toughness characterization of three 9Cr ODS EUROFER steels with different thermo-mechanical treatments

Das, A.; Chekhonin, P.; Altstadt, E.; Mcclintock, D.; Bergner, F.; Heintze, C.; Lindau, R.

Ferritic martensitic ODS steels are one of the candidate structural materials for future Gen-IV nuclear fission and fusion reactors. The dependence of fracture toughness on microstructure was investigated by comparing three 9Cr ODS EUROFER steels manufactured through different thermo-mechanical processing routes. Quasi-static fracture toughness testing was performed with sub-sized C(T) specimens and microstructural characterization was carried out using scanning electron microscopy, electron backscatter diffraction, and transmission electron microscopy. It was found that at lower test temperatures (-100 to 22 °C), the fracture toughness was primarily controlled by crack initiation at sub-micron particles and by production of secondary cracks during fracture. At higher temperatures (above 100 °C), fracture toughness was predominantly controlled by the matrix ductility and the grain boundary strength with a relatively ductile coarse-grained alloy demonstrating higher fracture toughness compared to high-strength fine-grained alloys. These results and discussion show that slight variations in thermomechanical treatments can produce significant differences in microstructure and fracture toughness behaviour of ferritic martensitic ODS steels.

Keywords: ODS steel; ferritic martensitic alloys; microstructure characterization; fracture toughness; structure-property relationship

Related publications


Publ.-Id: 31183

High PerformanceComputing: 35th International Conference, ISC High Performance 2020

Sadayappan, P.; Chamberlain, B. L.; Juckeland, G.; Ltaief, H.

This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing, ISC High Performance 2020, held in Frankfurt/Main, Germany, in June 2020.*

The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures, networks & infrastructure; artificial intelligence and machine learning; data, storage & visualization; emerging technologies; HPC algorithms; HPC applications; performance modeling & measurement; programming models & systems software.

*The conference was held virtually due to the COVID-19 pandemic.

Keywords: artificial intelligence; computer hardware; computer networks; computer programming; computer systems; distributed computer systems; microprocessor chips; parallel algorithms; parallel architectures; parallel processing

Publ.-Id: 31181

P1802 - Universal Building Blocks for Radiolabeling

Pietzsch, H.-J.; Walther, M.

The present invention describes novel chelators (multidentate ligands) and precompounds for complexation of radiometals and non-radioactive counterparts, for use in radiopharmacy. The invention includes a process and a kit involving such chelators.
Active moieties directing to a pharmaceutical target (such as peptides or proteins) can be attached to the chelator very easily via the so called “click-chemistry” forming a triazole-ring moiety. The aromatic triazole-nitrogen itself acts as a new and “soft” nucleophilic site enabling for complexation of various radiometals or non-radioactive counterparts. The chelators are capable of fast complexation at low temperature.

  • Patent
    PCT/EP2019/054954 - Offenlegung 06.09.2019; Nachanmeldungen: EP

Publ.-Id: 31180

P1801 - Method for the preparation of nanoscale DNA-encircled lipid bilayers

Fahmy, K.; TU Dresden

The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.

  • Patent
    PCT/EP2019/054271 - Offenlegung 29.08.2019; Nachanmeldungen: EP

Publ.-Id: 31179

P1714 - Verfahren zur Trennung von Mineralien

Babel, B. M.; Kupka, N.; Rudolph, M.

Die Erfindung betrifft ein Verfahren zur Trennung von Mineralien aus Mineralgemengen mittels Flotation unter Verwendung eines Drückers. Dabei ist vorgesehen, dass kolloidales Siliciumdioxid einem wässerigen, das Mineralgemenge enthaltenden Gemisch als Drücker zugesetzt wird.

  • Patent
    DE102017129673 - Erteilung 13.12.2018

Publ.-Id: 31178

P1713 - Verfahren zum Herstellen eines Probenpräparats, Probenpräparat und Verfahren zum Untersuchen eines Probenmaterials

Bartzsch, A.; Gilbricht, S.; Bachmann, K.; Heinig, T.

Die Erfindung betrifft ein Verfahren zum Herstellen eines Probenpräparats, ein Probenpräparat und ein Verfahren zum Untersuchen eines Probenmaterials, wobei das Probenpräparat zur Untersuchung eines granularen Probenmaterials dient und herstellbar ist, indem das granulare Probenmaterial mit einem flüssigen ersten Einbettmaterial vermengt wird, das Einbettmaterial unter Ausbildung eines Vorpräparats verfestigt wird und unter Ausbildung von Trennflächen in mehrere Teilstücke zertrennt wird, die Teilstücke mit mehreren Trennflächen in einer gemeinsamen Ebene liegend in einem flüssigen zweiten Einbettmaterial eingebettet werden, und das zweite Einbettmaterial verfestigt wird.

  • Patent
    DE102017128355 - Erteilung 17.01.2019

Publ.-Id: 31177

P1712 - Method for determining the level of molten magnesium in a titanium reduction cell

Stefani, F.; Krauter, N.; Wondrak, T.; Gundrum, T.; Eckert, S.

FIELD: metallurgy. SUBSTANCE: invention relates to the metallurgy industry. Magnesium level and the skull characteristics in the titanium reduction reactor determining method, based on the EMF measurements in the receiving coil, induced by the electromagnetic field from located around the retort the exciting windings set, contains the steps, on which for the determination currents of different frequencies are used, at that, first, by the electrodynamics equations numerical solving, developing the reference base of the EMF calculated values in the located above the reactor receiving coil, with the molten magnesium different specified levels, different titanium skull given positions and sizes for the supply current given set of frequencies in the range of 1–50 Hz, and then, in the process of titanium reduction, with the same set of current parameters in the excitation coils, measuring the EMF values in the receiving coil, which are compared with the reference ones, and the least standard deviation is determined by the smallest standard deviation method, and the molten magnesium level, the titanium skull position and size are judged by it. EFFECT: increase in the molten metal level determining accuracy and the expansion in the method possibilities. 5 cl, 13 dwg

  • Patent
    RU2676845 - Erteilung 11.01.2019

Publ.-Id: 31176

P1711 - Peptid-Trägermaterialien als biofunktionalisierte Sammler

Lederer, F.; Pollmann, K.; Rudolph, M.

Die Erfindung betrifft ein Verfahren zur selektiven Abtrennung von Submikro- oder Mikropartikeln mittels eines biofunktionalisierten Sammlers, ein biofunktionalisierter Sammler umfassend mindestens ein selektiv bindendes Peptid, ein selektiv bindendes Peptid und die Verwendung eines Verfahrens oder eines biofunktionalisierten Sammlers zur Gewinnung oder Rückgewinnung von Submikro- oder Mikropartikeln.

  • Patent
    DE102017219800 - Offenlegung 09.05.2019

Publ.-Id: 31175

P1710 - 4-(Furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amin-Derivate und deren Verwendung

Moldovan, R.-P.; Lai, T. H.; Schröder, S.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Brust, P.; Fischer, S.; Ludwig, F.-A.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I worin eine Phenylgruppe oder eine Pyridylgruppe ist, R1 aus der Gruppe ausgewählt ist, die aus Wasserstoff, Halogen und -CN besteht; R2 aus der Gruppe ausgewählt ist, die aus Fluor, einer fluorierten Alkylgruppe mit 1 bis 12 Kohlenstoffatomen, einer fluorierten Alkoxygruppe mit 1 bis 12 Kohlenstoffatomen und einer fluorierten Ethergruppe besteht; Z -(CH2)n- oder -(CH2)m-C(O)-(CH2)p- ist, wobei n eine Ganzzahl von 1 bis 12 ist und wobei m und p gleich oder verschieden sein können und jeweils 0 oder eine Ganzzahl von 1 bis 12 sind.

  • Patent
    DE102017125533 - Offenlegung 02.05.2019; Nachanmeldungen: WO

Publ.-Id: 31174

P1709 - Vorrichtung und Verfahren zum Erzeugen von Ionenpulsen

Wilhelm, R. A.; Klingner, N.; Facsko, S.

Die Erfindung betrifft eine Vorrichtung und ein Verfahren zum Erzeugen von Ionenpulsen, insbesondere von ultrakurzen Ionenpulsen, wobei die Vorrichtung eine Vakuumkammer, eine in der Vakuumkammer angeordnete Kathode, einen Laser zum Erzeugen von Laserpulsen, die auf die Kathode auftreffen und aus dieser Elektronen herauslösen, eine erste Beschleunigungseinrichtung zum Beschleunigen der Elektronen unter Erzeugung von Ionenpulsen in ein Ionisationsvolumen, eine Zuführeinrichtung zum Zuführen einer zu ionisierenden Substanzen das Ionisationsvolumen und eine zweite Beschleunigungseinrichtung zum Beschleunigen der Ionen unter Ausbildung von Ionenpulsen aus dem Ionisationsvolumen heraus aufweist.

  • Patent
    DE102017218456 - Erteilung 22.11.2018

Publ.-Id: 31173

P1708 - Justiereinrichtung

Bartheld, U.

Die Erfindung betrifft eine Justiereinrichtung zur räumlichen Lageeinstellung eines Objekts (4), umfassend eine 10 Mehrzahl übereinander angeordneter Plattenelemente (11,12,13,14), die an einander zugewandten Seiten ineinandergreifende Radialführungsstrukturen (21,22) aufweisen, wobei auf einer Grundplatte (11) zumindest ein Paar von Verschiebungsplatten (12) und ein Paar von 15 Neigungsplatten (13) angeordnet sind, wobei Verschiebungsplatten (12) eine konstante Dicke aufweisen und ihre jeweilige obere Radialführungsstruktur (21) und untere Radialführungsstruktur (22) exzentrisch versetzt zueinander angeordnet sind und Neigungsplatten (13) eine variable Dicke 20 aufweisen und ihre jeweilige obere Radialführungsstruktur (21) und untere Radialführungsstruktur (22) konzentrisch zueinander angeordnet sind.

  • Patent
    DE102017123920 - Erteilung 20.12.2018; Nachanmeldungen: WO, US

Publ.-Id: 31172

P1707 - 3-Methylbenzo[e]imidazo[5,1-c][1,2,4]triazin-Derivate zur Verwendung als Inhibitoren von Phosphodiesterase 2A

Scheunemann, M.; Ritawidya, R.; Brust, P.; Schröder, S.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I oder ein pharmazeutisch akzeptables Salz davon, wobei A1, A2 und A3 unabhängig voneinander jeweils CH oder N sind; R1 -OR2 oder eine (3-Methyloxetan-3-yl)methyloxy-Gruppe ist, wobei R2 eine substituierte oder unsubstituierte Alkylgruppe mit 1 bis 12 Kohlenstoffatomen ist; X1 aus der Gruppe ausgewählt ist, die aus Wasserstoff, Halogen, Methyl -NO2 und einer kationischen Trialkylammoniumgruppe besteht; X2 aus der Gruppe ausgewählt ist, die aus Halogen, -NO2, einer Boronsäureester-Gruppe, einer Aryliodonium-Gruppe und einer spirocyclischen Iodoniumylid-Gruppe besteht, wobei die Boronsäureester-Gruppe eine Boronsäurepinakolester-Gruppe ist.

  • Patent
    DE102017119516 - Offenlegung 28.02.2019

Publ.-Id: 31171

P1705 - Wärmeübertrager

TU Dresden; Hampel, U.

Die Erfindung betrifft einen Wärmeübertrager mit wenigstens einer Trennwand und von wenigstens einer Seite der Trennwand abstehenden und die Oberfläche der Trennwand vergrößernden Oberflächenelementen, die von einem Fluid umströmbar sind. Es ist die Aufgabe der vorliegenden Erfindung, massearme Wärmeübertrager mit großer thermischer Übertragungsleistung vorzuschlagen. Diese Aufgabe wird durch einen Wärmeübertrager gelöst, bei dem die Oberflächenelemente flossenartig von der Trennwand abstehend ausgebildet sind und die Oberflächenelemente Verstärkungswülste aufweisen, wobei sich die Verstärkungswülste bis zu der Trennwand hin erstrecken.

  • Patent
    DE102017214261 - Offenlegung: 21.02.2019; Nachanmeldungen: WO, EP, JP, US

Publ.-Id: 31170

P1704 - Vorrichtung, Anordnung und Verfahren zum Charakterisieren der Torsion, der Rotation und/oder der Positionierung einer Welle

Buchenau, D.

Die Erfindung betrifft eine Vorrichtung, eine Anordnung und ein Verfahren zum Charakterisieren der Torsion, Rotation und/oder Positionierung einer Welle, wobei von einem zwischen mindestens zwei Magnetfelddetektoren angeordneten Magnetfelderzeuger mittels eines periodischen Erregersignals ein periodisches Magnetfeld erzeugt wird, das von der Welle modifiziert wird und an jedem der Magnetfelddetektoren ein Ausgangssignal hervorruft, wobei die amplitudenmäßige oder phasenmäßige Differenz zwischen dem Erregersignal und dem ersten Ausgangssignal als erste Messgröße und zwischen dem Erregersignal und dem zweiten Ausgangssignal als zweite Messgröße erfasst wird, die Summe und/oder die Differenz der ersten und der zweiten Messgröße gebildet wird, und basierend darauf die Torsion, Rotation und/oder Positionierung der Welle charakterisiert wird.

  • Patent
    DE102017111055 - Erteilung 06.09.2018; Nachanmeldungen: WO, CN, EP, US

Publ.-Id: 31169

Moisture repelling perovskite nanowires for higher stability in energy applications

Rajbhar, M. K.; Das, P.; Satpati, B.; Möller, W.; Ramgir, N.; Chatterjee, S.

Perovskite nanowires are known to be strongly interacting with the moisture. In this work, we demonstrate that strontium manganate (SrMnO3) nanowire, an oxide perovskite, which is initially superhydrophilic, becomes a water repellent upon suitable modification by the ion beam. Highly crystalline SrMnO3 nanowires have been synthesized hydrothermally with an average diameter of about 60 nm and possess 4H crystal structure. The nanowires have been systematically irradiated with nitrogen ions at different energies and in a specific range of ion fluence. For low energy (5 keV), and at a relatively high threshold ion fluence, the nanowire surface starts to become hydrophobic, and the hydrophobicity increases with the ion fluence. However, at higher energies (50–100 keV), the sample surface becomes superhydrophobic at relatively low fluence, and beyond this point, the contact angle is almost independent of the ion fluence. Using state-of-the-art TRI3DYN computer-based simulation, and by employing density functional theory based calculations, we have shown that at low ion energy, the defects turn out to be a dominating factor for the samples to become hydrophobic. At higher ion energies, nanowelding and porous structure lead the way to become superhydrophobic.

Related publications

Publ.-Id: 31168

P1703 - Schichtanordnung, elektronisches Bauteil mit einer Schichtanordnung und Verwendung einer Schichtanordnung

TU Bergakademie Freiberg; Rebohle, L.

Gemäß verschiedenen Ausführungsformen wird eine Schichtanordnung (100) bereitgestellt, welche Folgendes aufweist: eine erste Barriereschicht (102a) und eine zweite Barriereschicht (102b), wobei die beiden Barriereschichten (102a, 102b) elektrisch isolierend sind, und eine Schichtstruktur (110), welche zwischen den beiden Barriereschichten (102a, 102b) angeordnet ist und derart eingerichtet ist, dass diese mittels eines elektrischen Feldes einer ersten Polarität (311a) und mittels eines elektrischen Feldes einer der ersten Polarität entgegengesetzten zweiten Polarität (311b) remanent polarisierbar ist, wobei die Schichtstruktur (110) mindestens eine erste Ladungsspeicherschicht (104a), eine zweite Ladungsspeicherschicht (104b) und eine zwischen der ersten Ladungsspeicherschicht (104a) und der zweiten Ladungsspeicherschicht (104b) angeordnete elektrisch isolierende Tunnelbarriereschicht (106) aufweist.

  • Patent
    DE102017109082 - Offenlegung 31.10.2018

Publ.-Id: 31167

P1702 - Vorrichtung zum Charakterisieren des elektrischen Widerstandes eines Messobjekts

Kosub, T.; Makarov, D.

Die Erfindung betrifft eine Messvorrichtung zum Charakterisieren des elektrischen Widerstandes eines Messobjekts, aufweisend eine elektrische Energiequelle mit zwei Polen, eine Spannungsmesseinrichtung mit zwei Messeingängen, vier Anschlusskontakte zum Anschließen von vier Kontaktelektroden, und eine Schalteinrichtung zum variablen paarweisen elektrischen Verbinden je eines der Pole und Messeingänge mit je einem der Anschlusskontakte unter Ausbildung unterschiedlicher Beschaltungskonfigurationen, wobei die Messvorrichtung zum Durchführen von mindestens vier Messsequenzen mit unterschiedlichen Beschaltungskonfigurationen und zum Ermitteln des Längswiderstandes des Messobjekts unter Einbeziehung von in diesen Beschaltungskonfigurationen erfassten Strom- und Spannungssignalen ausgebildet ist.

  • Patent
    DE102017105317 - Erteilung 09.05.2018, Nachanmeldungen: WO, CN, EP, US

Publ.-Id: 31166

PIConGPU setup: Gas-foil target for ion acceleration

Pausch, R.; Levy, D.; Andriyash, I.; Schultze-Makuch, A.; Bernert, C.; Zeil, K.; Bussmann, M.; Kluge, T.; Garten, M.; Steiniger, K.; Debus, A.

This data set contains the PIConGPU source code used for the simulations presented in "Gas-foil target for ion acceleration" and the setup files.

Keywords: PIConGPU

Related publications


Publ.-Id: 31165

P1701 - In vivo stable Hg-197(m) compounds, method for the production thereof and use thereof in nuclear medical diagnostics and endoradionuclide therapy (theranostics)

Pietzsch, H.-J.; Walther, M.; Wünsche, T.

The present invention relates to in vivo stable 197(m)Hg compounds according to formula (I) for use in nuclear medical diagnostics and endoradionuclide therapy (theranostics), particularly the treatment of cancer, a method for the production of the 197(m)Hg compounds comprising the step of radiolabeling of organic precursor compounds with NCA 197(m)Hg by electrophilic substitution; and the use of the 197(m)Hg compounds for nuclear medical diagnostics and endoradionuclide therapy (theranostics), particularly the treatment of cancer.

  • Patent
    PCT/EP2018/052996 - Offenlegung 16.08.2018, Nachanmeldungen: CA, EP, US

Publ.-Id: 31164

P1611 - Method and system for calibration-free determination of a flow velocity of an electrically conductive fluid

Krauter, N.; Stefani, F.; Eckert, S.; Gerbeth, G.

The present invention refers to a method and a system for calibration-free determination of a flow velocity of an electrically conductive fluid (7). Each of two field coils (1a, 1b), which are designed to be positioned at a distance from each other in the respective fluid (7) and electrically insulated from the respective fluid (7), is provided simultaneously with a pulsed electrical current, wherein the two pulsed electrical currents are oppositely directed, so that a primary magnetic field is created leading to oppositely directed eddy currents induced by the primary magnetic field in the surrounding fluid (7), thereby creating a secondary magnetic field in the respective fluid (7). The secondary magnetic field is measured after the pulsed electrical currents by two magnetic field sensors (3a, 3b), which are designed to be positioned at a distance from each other in the respective fluid (7) and electrically insulated from the respective fluid (7), wherein the flow velocity is calculated from a measured time-dependent strength of the secondary magnetic field and/or its time derivative.

  • Patent
    PCT/EP2016/076967 - Offenlegung 17.05.2018; Nachanmeldungen: EP

Publ.-Id: 31163

P1607 - Anordnung zum Charakterisieren des Füllstandes eines elektrisch leitfähigen Materials in einem Behälter

Zürner, T.; Ratajczak, M.; Wondrak, T.; Eckert, S.

Die Erfindung betrifft eine Anordnung zum Charakterisieren des Füllstandes eines elektrisch leitfähigen Materials in einem Behälter, aufweisend ein seitlich des Behälter-Innenraumes angeordnetes Sensorelement mit einer Erregerspule und zwei gradiometrisch verschalteten Empfängerspulen, wobei die Anordnung zum Beaufschlagen der Erregerspule mit einem Wechselstrom, zum Erfassen der an den gradiometrisch verschalteten Empfängerspulen resultierenden Ausgangsspannung, zum Ermitteln des Anteils der Ausgangsspannung ohne Phasenverschiebung zu dem Wechselstrom und/oder des Anteils der Ausgangsspannung mit einer Phasenverschiebung von 90° zu dem Wechselstrom, und zum Charakterisieren des Füllstandes basierend darauf ausgebildet ist.

  • Patent
    DE102016112266 - Offenlegung 11.01.2018

Publ.-Id: 31162

P1606 - Verfahren und Vorrichtung zu Ga-Rückgewinnung

FCM GmbH; TU Bergakademie Freiberg; Zeidler, O.

Die vorliegende Erfindung umfasst ein Verfahren zur selektiven Abtrennung von Ga aus Ätzabwässern mit Hilfe eines Dialyseverfahrens. Hierbei wird das besondere Komplexbildungsverhaltens des Ga ausgenutzt, welches einen instabilen Tetrahalogenokomplex bildet. Dieser bildet sich nur bei ausreichend hoher Halogenidkonzentration. Da die Halogenidkonzentration über die Membran niedriger wird, zerfällt der Ga-Tetrahalogenidokomplex in der Membran, wodurch das Ga zurückgehalten wird. Andere Metalle wie In und Fe zeigen dieses Verhalten nicht, weswegen die Tetrahalogenokomplexe dieser Metalle die Membran passieren können und somit selektiv abgetrennt werden können.

  • Patent
    DE102016210451 - Offenlegung 14.12.2017; Nachanmeldungen: TW, WO

Publ.-Id: 31161

P1605 - Verfahren und Trägermaterial zur Bereitstellung von metallionenbindenden Molekülen zur Gewinnung und Rückgewinnung von Wertmetallen

Matys, S.; Pollmann, K.; Raff, J.; Lehmann, F.

Die Erfindung betrifft ein Verfahren zur Bereitstellung von metallionenbindenden Molekülen basierend auf der Phagen-Display-Methode mittels eines planaren Trägermaterials mit immobilisierten Metallionen. Die Erfindung betrifft weiterhin ein planares Trägermaterial mit immobilisierten Metallionen, metallionenbindende Peptide erhältlich durch das erfindungsgemäße Verfahren sowie die Verwendung der metallionenbindenden Moleküle zur Gewinnung oder Rückgewinnung von Wertmetallen.

  • Patent
    DE102016208110 - Offenlegung 16.11.2017

Publ.-Id: 31160

P1604 - Verfahren und Mittel zum Betrieb eines komplementären analogen rekonfigurierbaren memristiven Widerstandsschalters sowie dessen Verwendung als künstliche Synapse

Du, N.; Li, K.; Schmidt, H.; Skorupa, I.

Die Erfindung betrifft ein Verfahren zum Betrieb eines elektronischen memristiven Bauelementes, welches aus einem komplementären analogen rekonfigurierbaren memristiven bidirektionalen Widerstandsschalter besteht, welcher eine Dreilagenschicht und zwei Elektroden aufweist. Das erfindungsgemäße Verfahren schlägt angepasste Schreibprozesse vor, die mittels der Überlagerung von Schreibpulssequenzen die Festlegung eines Zustandspaares komplementärer Widerstandszustände realisieren. In Verbindung mit Lesepulsen angepasster Polarität kann das elektronische memristive Bauelement Fuzzy-Logik umsetzen und als künstliche Synapse mit der Realisierung aller vier Lernkurven für komplementäres Lernen betrieben werden. Eine Mehrzahl von Verwendungsmöglichkeiten des erfindungsgemäß betriebenen Bauelementes wird vorgeschlagen.

  • Patent
    DE102016205860 - Offenlegung: 12.10.2017; Nachanmeldungen: WO, CN, US

Publ.-Id: 31159

Towards 3D-Motion Tracking of Instrumented Flow Followers in Large Vessels

Buntkiel, L.; Reinecke, S.; Hampel, U.

A concept for 3D-motion tracking of instrumented flow-following sensor particles, equipped with a gyroscope, accelerometer, magnetometer and pressure sensor, has been developed. Consisting of an error state Kalman filter (ESKF) the algorithm can track the attitude of the sensor particle in relation to a reference coordinate system permanently, even under high acceleration, which interferes the attitude estimation because it is based on measuring the gravitational acceleration. Experimental results show, that using the ESKF for attitude estimation is giving accurate results even under high body acceleration.

Keywords: error state kalman filter; motion tracking; fluid dynamics; sensor particle; soft sensor

  • Open Access Logo Contribution to proceedings
    Sensor and Measurement Science International, 22.-25.06.2020, Nürnberg, Deutschland
    SMSI 2020 - Measurement Science, Hannover: AMA Service GmbH, 978-3-9819376-2-6, 309-310
    DOI: 10.5162/SMSI2020/E6.1


Publ.-Id: 31158

P1603 - Verfahren zur Herstellung von auf Silizium basierenden Anoden für Sekundärbatterien

TU Bergakademie Freiberg; Prucnal, S.; Skorupa, W.

Die Erfindung betrifft ein Verfahren zur Herstellung von auf Silizium basierenden Anoden für Sekundärbatterien, wobei die Sekundärbatterien zumindest aus der Anode, aus mindestens einem Elektrolyten und einer Gegenelektrode bestehen. Dabei werden folgende Schritte zur Herstellung einer Anode (20) durchgeführt:

– Abscheiden einer Silizium-Schicht (3) auf einem Korngrenzen (2) aufweisenden Metallsubstrat (1), wobei die Silizium-Schicht (3) zum Metallsubstrat (1) gerichtet eine erste Grenzfläche (14) aufweist,
– Beheizen des Metallsubstrats (1) mittels einer Heizeinheit (22) auf eine Temperatur zwischen 200°C und 1000°C,
– Tempern des Bereiches der dem Metallsubstrat (1) abgewandten zweiten Grenzfläche (15) der Silizium-Schicht (3) mittels einer energieintensiven Bestrahlung während der Beheizung,
– Erzeugen von Mehrphasen im Bereich der Silizium-Schicht (3) und des Metallsubstrats (1), bestehend aus amorphem Silizium und/oder kristallinem Silizium des Siliziums der Silizium-Schicht (3) und aus kristallinem Metall des Metallsubstrats (1) und aus Silizid und
– Erzeugen von kristallinem Metall des Metallsubstrats (1).

  • Patent
    DE102016001949 - Offenlegung 17.08.2017; Nachanmeldungen: WO, CN, EP, US

Publ.-Id: 31157

P1509 - Verfahren zum Aufarbeiten von Bleiglas und Elektronikschrott

TU Bergakademie Freiberg; Wolf, R.

Beschrieben wird ein Verfahren zum Aufarbeiten von Bleiglas und Elektronikschrott. Erfindungsgemäß umfasst dies die Schritte Zerkleinern und Vermischen des Bleiglases und des Elektronikschrottes zu einer Charge Aufschmelzen der Charge unter Zusatz einer oder mehrerer Verbindungen aus der Gruppe der Carbonate, Oxide und Hydroxide der Alkalimetalle und Reduktion des im Bleiglas enthaltenden Bleioxids durch ein Reduktionsmittel zu metallischem Blei unter Ausbildung einer Phase enthaltend eine Metallschmelze und einer Phase enthaltend eine Glasschmelze, wobei in der Glasschmelze die Konzentration von Alkalimetalloxiden im Bereich von 20 mol.-% bis 45 mol.-%
Erdalkalimetalloxiden im Bereich von 10 mol.-% bis 25 mol.-% Siliziumdioxid im Bereich von 40 mol.-% bis 50 mol.-% liegt, bezogen auf die Gesamtmenge an Alkalimetalloxiden, Erdalkalimetalloxiden und Siliziumdioxid in der Glasschmelze.

  • Patent
    DE102016220045 - Offenlegung: 19.04.2018

Publ.-Id: 31156

P1510 - Self-cleaning high temperature resistant solar selective coating

Abengoa Research S.L.; Lungwitz, F.; Neubert, M.

Estructura selectiva solar con autolimpieza resistente a altas temperaturas. La presente invención se dirige a una estructura formada por una sección superior que comprende una capa superior que comprende TiO2 dopado que presenta una alta transmitancia en el espectro visible y una alta reflectancia en la región IR y propiedades de autolimpieza, una sección intermedia absorbente y un sustrato. Debido a las propiedades mencionadas y a la resistencia a altas temperaturas, la estructura es útil como estructura selectiva solar para receptores de torre en sistemas de energía solar por concentración (CSP).

  • Patent
    ES2575746 - Offenlegung 30.06.2016; Nachanmeldungen: WO, EP

Publ.-Id: 31155

P1506 - Complementary resistance switch,contact-connected polycrystalline piezo-or ferroelectric thin-film layer,method for encrypting a bit sequence

You, T.; Schmidt, H.; Du, N.; Bürger, D.; Skorupa, I.

Disclosed is a complementary resistor switch (3) comprising two outer contacts, between which two piezo- or ferroelectric layers (11a and 11b) having an inner common contact are situated. At least one region (11', 11'') of the layers is modified, either the outer contacts are rectifying (S) and the inner contact is non-rectifying (0), or vice versa, the modified regions are formed at the rectifying contacts, the layers have different strain-dependent structural phases with different band gaps and/or different polarization charges, and the electrical conductivity of the layers is different. Also disclosed are a connectable resistor structure having at least one Schottky contact at two adjoining piezo- or ferroelectric layers, a polycrystalline piezo- or ferroelectric layer comprising modified crystallites, and a method and circuits for encrypting and decrypting a bit sequence.

  • Patent
    US20150364682 - Offenlegung 17.12.2015

Publ.-Id: 31154

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

Mausolf, E. J.; Johnstone, E. V.; Mayordomo, N.; Williams, D. L.; Guan, E. Y. Z.; Gary, C. K.

Presented are the results of 99mTc and 101Tc production via neutron irradiation of natural isotopic molybdenum (Mo) with epithermal/resonance neutrons. Neutrons were produced using a deuterium-deuterium (D-D) neutron generator with an output of 2 × 1010 n/s. The separation of Tc from an irradiated source of bulk, low-specific activity (LSA) Mo on activated carbon (AC) was demonstrated. The yields of 99mTc and 101Tc, together with their potential use in medical single-photon emission computed tomography (SPECT) procedures, have been evaluated from the perspective of commercial production, with a patient dose consisting of 740 MBq (20 mCi) of 99mTc. The number of neutron generators to meet the annual 40,000,000 world-wide procedures is estimated for each imaging modality: 99mTc versus 101Tc, D-D versus deuterium-tritium (D-T) neu-tron generator system outputs, and whether or not natural molybdenum or enriched targets are used for production. The financial implications for neutron generator production of these isotopes is also presented. The use of 101Tc as a diagnostic, therapeutic, and/or theranostic isotope for use in medical applications is proposed and compared to known commercial nuclear diagnostic and therapeutic isotopes.

Keywords: Technetium-99m; molybdenum-99; neutron generator; fusion; medical isotopes; radiopharmaceuticals; diagnostic; theranostic; special nuclear material (SNM)

Publ.-Id: 31153

New algorithm to discriminate phase distribution of gas-oil-water pipe flow with dual-modality wire-mesh sensor - Data set

de Assis Dias, F.; Nunes Dos Santos, E.; Da Silva, M. J.; Schleicher, E.; Morales, R. E. M.; Hewakandamby, B.; Hampel, U.

Data set used on the work "New Algorithm to Discriminate Phase Distribution of Gas-Oil-Water Pipe Flow with Dual-Modality Wire-Mesh Sensor".

Data were acquired using a dual-modality wire-mesh sensor designed by the Brazilian partner UTFPR. The experiments were performed at the University of Nottingham in a water-oil liquid-liquid flow loop.

However, the gas phase was introduced into the system to perform stratified three-phase flow measurements as a proof of concept. In this set of data, you find the calibrated amplitude and phase signals of nine points as well as permittivity and conductivity estimations (post-processing).

Keywords: complex impedance; flow visualization; gas-oil-water horizontal flow; three-phase; wire-mesh sensor


Publ.-Id: 31152

A review on numerical modelling of flashing flow with application to nuclear safety analysis

Liao, Y.; Lucas, D.

The flashing flow is an relevant multiphase phenomenon in many technical applications including nuclear safety analysis, which has been the subject of intense research. Numerical studies have evolved from one-dimensional to multi-dimensional. A variety of methods have been proposed, while a broad consensus was not exiting. The present work aims to present an overview of available models as well their assumptions and limitations by conducting a literature survey. The final focus was put on recent computational fluid dynamics simulations. Some consensus on modelling interfacial slip, phase change mechanism and bubble size is identified. Since flashing scenarios often accompanying with high void fraction and broad bubble size range, a poly-disperse two-fluid model is recommended. Thermal phase change model is superior to pressure phase change, relaxation and equilibrium models for practical flashing problems. Major challenges include improving closure models for interphase transfer, bubble dynamics processes, interfacial area as well two-phase turbulence. For this purpose, high-resolution high quality experimental data are important, which are lacking in many cases. Considering that heterogeneous gas structures often exist in flashing flows, multi-field approaches able to handle different shapes of gas-liquid interface are recommended.

Keywords: computational fluid dynamics; flashing flow; nuclear safety analysis; numerical modelling; literature review


Publ.-Id: 31151

Pages: [1.] [2.] [3.] [4.] [5.] [6.] [7.] [8.] [9.] [10.] [11.] [12.] [13.] [14.] [15.] [16.] [17.] [18.] [19.] [20.] [21.] [22.] [23.] [24.] [25.] [26.] [27.] [28.] [29.] [30.] [31.] [32.] [33.] [34.] [35.] [36.] [37.] [38.] [39.] [40.] [41.] [42.] [43.] [44.] [45.] [46.] [47.] [48.] [49.] [50.] [51.] [52.] [53.] [54.] [55.] [56.] [57.] [58.] [59.] [60.] [61.] [62.] [63.] [64.] [65.] [66.] [67.] [68.] [69.] [70.] [71.] [72.] [73.] [74.] [75.] [76.] [77.] [78.] [79.] [80.] [81.] [82.] [83.] [84.] [85.] [86.] [87.] [88.] [89.] [90.] [91.] [92.] [93.] [94.] [95.] [96.] [97.] [98.] [99.] [100.] [101.] [102.] [103.] [104.] [105.] [106.] [107.] [108.] [109.] [110.] [111.] [112.] [113.] [114.] [115.] [116.] [117.] [118.] [119.] [120.] [121.] [122.] [123.] [124.] [125.] [126.] [127.] [128.] [129.] [130.] [131.] [132.] [133.] [134.] [135.] [136.] [137.] [138.] [139.] [140.] [141.] [142.] [143.] [144.] [145.] [146.] [147.] [148.] [149.] [150.] [151.] [152.] [153.] [154.] [155.] [156.] [157.] [158.] [159.] [160.] [161.] [162.] [163.] [164.] [165.] [166.] [167.] [168.] [169.] [170.] [171.] [172.] [173.] [174.] [175.] [176.] [177.] [178.] [179.] [180.] [181.] [182.] [183.] [184.] [185.] [186.] [187.] [188.] [189.] [190.] [191.] [192.] [193.] [194.] [195.] [196.] [197.] [198.] [199.] [200.] [201.] [202.] [203.] [204.] [205.] [206.] [207.] [208.] [209.] [210.] [211.] [212.] [213.] [214.] [215.] [216.] [217.] [218.] [219.] [220.] [221.] [222.] [223.] [224.] [225.] [226.] [227.] [228.] [229.] [230.] [231.] [232.] [233.] [234.] [235.] [236.] [237.] [238.] [239.] [240.] [241.] [242.] [243.] [244.] [245.] [246.] [247.] [248.] [249.] [250.] [251.] [252.] [253.] [254.] [255.] [256.] [257.] [258.] [259.] [260.] [261.] [262.] [263.] [264.] [265.] [266.] [267.] [268.] [269.] [270.] [271.] [272.] [273.] [274.] [275.] [276.] [277.] [278.] [279.] [280.] [281.] [282.] [283.] [284.] [285.] [286.] [287.] [288.] [289.] [290.] [291.] [292.] [293.] [294.] [295.] [296.] [297.] [298.] [299.] [300.] [301.] [302.] [303.] [304.] [305.] [306.] [307.] [308.] [309.] [310.] [311.] [312.] [313.] [314.] [315.] [316.] [317.] [318.] [319.] [320.] [321.] [322.] [323.] [324.] [325.] [326.] [327.]