Publications of Institute of Radiopharmaceutical Cancer Research
203 Publications2015
Convenient recycling and reuse of bombarded [18O]H2O for the production and the application of [18F]F‒
Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; et al. (7 authors)
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Applied Radiation and Isotopes 101(2015), 44-52
DOI: 10.1016/j.apradiso.2015.03.009
2014
Internal Dose Assessment of (-)-18F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results
Sattler, B.; Kranz, M.; Starke, A.; Wilke, S.; Donat, C. K.; et al. (15 authors)
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Journal of Nuclear Medicine 55(2014)11, 1885-1892
DOI: 10.2967/jnumed.114.137059
ISSN: 2159-662X
Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent
Chen, Y.-Y.; Wang, X.; Zhang, J.-M.; Deuther-Conrad, W.; Zhang, X.-J.; et al. (12 authors)
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Bioorganic & Medicinal Chemistry 22(2014), 5270-5278
DOI: 10.1016/j.bmc.2014.08.003
Novel Cyclopentadienyl Tricarbonyl 99mTc Complexes Containing 1‑Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma‑1 Receptors
Wang, X.; Li, D.; Deuther-Conrad, W.; Lu, J.; Xie, Y.; et al. (11 authors)
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Journal of Medicinal Chemistry 57(2014), 7113-7125
DOI: 10.1021/jm5009488
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
Gnad, T.; Scheibler, S.; von Kügelgen, I.; Scheele, C.; Kilic, A.; et al. (21 authors)
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Nature 516(2014), 395-399
DOI: 10.1038/nature13816
Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18 F]Flubatine in humans
Patt, M.; Becker, G. A.; Grossmann, U.; Habermann, B.; Schildan, A.; et al. (17 authors)
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Nuclear Medicine and Biology 41(2014), 489-494
DOI: 10.1016/j.nucmedbio.2014.03.018
Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490
Rötering, S.; Deuther-Conrad, W.; Cumming, P.; Donat, C. K.; Scheunemann, M.; et al. (12 authors)
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EJNMMI Research 4(2014), 1-11
DOI: 10.1186/s13550-014-0043-5
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
Donat, C. K.; Fischer, F.; Walter, B.; Deuther-Conrad, W.; Brodhun, M.; et al. (7 authors)
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Acta Neurobiologiae Experimentalis 74(2014), 197-210
ISSN: 0365-0820
Distinctive In Vivo Kinetics of the New Sigma1 Receptor Ligands (R)-(+) and (S)-(-)- 18F-Fluspidine in Porcine Brain
Brust, P.; Deuther-Conrad, W.; Becker, G.; Patt, M.; Dont, C. K.; et al. (15 authors)
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Journal of Nuclear Medicine 55(2014)10, 1730-1736
DOI: 10.2967/jnumed.114.137562
ISSN: 0161-5505
Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain
Holl, K.; Schepmann, D.; Fischer, S.; Ludwig, F. A.; Hiller, A.; et al. (9 authors)
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Pharmaceuticals 7(2014), 78-112
DOI: 10.3390/ph7010078
ISSN: 1424-8247
Synthesis and biological evaluation of both enantiomers of [18F]flubatine, promising radiotracers with fas kinetics for the imaging of α4β2-nicotinic acetylcholine receptors
Smits, R.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wenzel, B.; et al. (11 authors)
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Bioorganic & Medicinal Chemistry 22(2014), 804-812
DOI: 10.1016/j.bmc.2013.12.011
Development of 18F-labeled radiotracers for neuroreceptor imaging with positron emission tomography
Brust, P.; van den Hoff, J.; Steinbach, J.
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Neuroscience Bulletin 30(2014)5, 777-811
DOI: 10.1007/s12264-014-1460-6
ISSN: 1995-8218
Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity
Lueg, C.; Galla, F.; Frehland, B.; Schepmann, D.; Daniliuc, C. G.; et al. (8 authors)
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Archiv der Pharmazie 347(2014), 21-31
DOI: 10.1002/ardp.201300255
Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ1 receptors in brain.
Maisonial-Besset, A.; Funke, U.; Wenzel, B.; Fischer, S.; Holl, K.; et al. (8 authors)
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Applied Radiation and Isotopes 84(2014), 1-7
DOI: 10.1016/j.apradiso.2013.10.015
Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives
Brust, P.; Deuther-Conrad, W.; Lehmkuhl, K.; Jia, H.; Wünsch, B.
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Current Medicinal Chemistry 21(2014)1, 35-69
DOI: 10.2174/09298673113209990214
Fluorine containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10A: Synthesis and in vitro evaluation of inhibition potency, selectivity and metabolism
Schwan, G.; Asskar, G. B.; Höfgen, N.; Kubicova, L.; Funke, U.; et al. (12 authors)
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ChemMedChem 9(2014)7, 1476-1487
DOI: 10.1002/cmdc.201300522
ISSN: 1860-7187
2013
Development of fluorinated CB2 receptor agonists for PET studies
Lueg, C.; Schepmann, D.; Günther, R.; Brust, P.; Wünsch, B.
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Bioorganic & Medicinal Chemistry 21(2013), 7481-7498
DOI: 10.1016/j.bmc.2013.09.040
Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers
Holl, K.; Falck, E.; Köhler, J.; Schepmann, D.; Humpf, H.-U.; et al. (7 authors)
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ChemMedChem 8(2013)12, 2047-2056
DOI: 10.1002/cmdc.201300322
Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors
Teodoro, R.; Moldovan, R.-P.; Lueg, C.; Günther, R.; Donat, C. K.; et al. (10 authors)
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Organic and Medicinal Chemistry Letters 3(2013)11
DOI: 10.1186/2191-2858-3-11
Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Patt, M.; Schildan, A.; Habermann, B.; Fischer, S.; Hiller, A.; et al. (13 authors)
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Applied Radiation and Isotopes 80(2013), 7-11
DOI: 10.1016/j.apradiso.2013.05.009
ISSN: 0969-8043
Use of 3-[18F]fluoropropanesulfonyl chloride as prosthetic agent for the radiolabelling of amines: Investigation of precursor molecules, labelling conditions and enzymatic stability of the corresponding sulfonamides
Löser, R.; Fischer, S.; Hiller, A.; Köckerling, M.; Funke, U.; et al. (8 authors)
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Beilstein Journal of Organic Chemistry 9(2013), 1002-1011
DOI: 10.3762/bjoc.9.115
Synthesis and Evaluation of Novel 18F-Labeled Spirocyclic Piperidine Derivatives as σ1 Receptor Ligands for Positron Emission Tomography Imaging
Li, Y.; Wang, X.; Zhang, J.; Deuther-Conrad, W.; Xie, F.; et al. (13 authors)
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Journal of Medicinal Chemistry 56(2013), 3478-3491
DOI: 10.1021/jm301734g
ISSN: 0022-2623
A fluoro versus a nitro derivative - a high-performance liquid chromatography study of two basic analytes with different RP and silica phases as basis for the separation of a positron emission tomography radiotracer
Wenzel, B.; Günther, R.; Brust, P.; Steinbach, J.
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Journal of Chromatography A 1311(2013), 98-105
DOI: 10.1016/j.chroma.2013.08.068
Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets
Bernd, W.; Eiselt, M.; Cumming, P.; Xiong, G.; Hinz, R.; et al. (8 authors)
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International Journal of Developmental Neuroscience 31(2013), 157-164
DOI: 10.1016/j.ijdevneu.2012.12.008
ISSN: 0736-5748
Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors
Rötering, S.; Scheunemann, M.; Fischer, S.; Hiller, A.; Peters, D.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry 21(2013), 2635-2642
DOI: 10.1016/j.bmc.2013.02.018
Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging
Wang, X.; Li, Y.; Deuther-Conrad, W.; Xie, F.; Chen, X.; et al. (12 authors)
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Bioorganic & Medicinal Chemistry 21(2013)1, 215-222
Online First (2012) DOI: 10.1016/j.bmc.2012.10.038
Leitlinie für die Hirnperfusions-SPECT mit Tc-99m Radiopharmaka / Hirnperfusions-SPECT with 99mTc-labelled Radiopharmaceuticals DGN-Guidance (S1 Guideline)
Kranert, T.; Menzel, C.; Bartenstein, P.; Brust, P.; Coenen, H. H.; et al. (11 authors)
- Nuklearmedizin 5(2013)52, 157-162
Radiosynthesis of racemic and enantiomerically pure (–)-[18F]flubatine – A promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors
Fischer, S.; Hiller, A.; Smits, R.; Hoepping, A.; Funke, U.; et al. (10 authors)
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Applied Radiation and Isotopes 74(2013), 128-136
DOI: 10.1016/j.apradiso.2013.01.002
ISSN: 0969-8043
Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Sridhar, D.; Nagesh, H. N.; et al. (8 authors)
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Medicinal Chemistry Research 22(2013)4, 1660-1673
Online First (2012) DOI: 10.1007/s00044-012-0164-1
2012
Synthesis and biological evaluation of a novel Tc-99m cyclopentadienyl tricarbonyl complex ([(Cp-R)Tc-99m(CO)(3)]) for sigma-2 receptor tumor imaging
Chen, X.; Cui, M. C.; Deuther-Conrad, W.; Tu, Y. F.; Ma, T.; et al. (14 authors)
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Bioorganic & Medicinal Chemistry Letters 22(2012)20, 6352-6357
DOI: 10.1016/j.bmcl.2012.08.083
ISSN: 0960-894X
Cannabinoid Receptor Type 2 (CB2) Selective N-Aryl-oxadiazolyl-propionamides: Synthesis, Radiolabeling, Molekular Modelling and Biological Evaluation
Rühl, T.; Deuther-Conrad, W.; Fischer, S.; Günther, R.; Hennig, L.; et al. (7 authors)
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Organic and Medicinal Chemistry Letters 2(2012), 32
DOI: 10.1186/2191-2858-2-32
Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Wenzel, B.; Li, Y.; Kraus, W.; Sorger, D.; Sabri, O.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry Letters 22(2012), 2163-2166
DOI: 10.1016/j.bmcl.2012.01.127
Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; et al. (17 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 39(2012)6, 1001-1011
DOI: 10.1007/s00259-012-2078-z
Development of radioligands for α7-nAChR imaging with positron emission tomography
Brust, P.; Peters, D.; Deuther-Conrad, W.
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Current Drug Targets 13(2012)5, 594-601
DOI: 10.2174/138945012800398955
ISSN: 1389-4501
Synthesis, radiofluorination and pharmacological evaluation of fluoromethyl substituted spirocyclic PET tracers for labeling of σ1 receptors in the central nervous system and comparison with longer homologues
Maisonial, A.; Grosse Maestrup, E.; Wiese, C.; Hiller, A.; Schepmann, D.; et al. (9 authors)
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Bioorganic & Medicinal Chemistry 20(2012), 257-269
DOI: 10.1016/j.bmc.2011.11.002
Radiosynthesis and Radiotracer Properties of a 7-(2-[F-18]Fluoroethoxy)-6-methoxy-pyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET
Funke, U.; Deuther-Conrad, W.; Schwan, G.; Maisonial, A.; Scheunemann, M.; et al. (9 authors)
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Pharmaceuticals 5(2012)2, 169-188
DOI: 10.3390/ph5020169
ISSN: 1424-8247
2011
Leitlinie für PET und SPECT–Untersuchungen von Hirntumoren mit radioaktiv markierten Aminosäuren
Langen, K.-J.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Drzezga, A.; et al. (12 authors)
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Nuklearmedizin 50(2011)4, 167-173
DOI: 10.3413/nuk-2011041
A 18F-labeled Fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET imaging of sigma1 receptors
Maisonial, A.; Große Maestrup, E.; Fischer, S.; Hiller, A.; Scheunemann, M.; et al. (11 authors)
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ChemMedChem 6(2011), 1401-1410
DOI: 10.1002/cmdc.201100108
Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging
Li, Z.-J.; Ren, H.-Y.; Cui, M.-C.; Deuther-Conrad, W.; Tang, R.-K.; et al. (9 authors)
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Bioorganic & Medicinal Chemistry 19(2011)9, 2911-2917
DOI: 10.1016/j.bmc.2011.03.037
In vitro binding profile and radiosynthesis of a novel 18F-labeled azaspirovesamicol analog as potential ligand for imaging of the vesicular acetylcholine transporter
Wenzel, B.; Hiller, A.; Fischer, S.; Sorger, D.; Deuther-Conrad, W.; et al. (9 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 54(2011), 426-432
DOI: 10.1002/jlcr.1891
Assessment of alpha 7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743
Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Becker, G.; Cumming, P.; et al. (10 authors)
- European Journal of Nuclear Medicine and Molecular Imaging 38(2011)8, 1541-1549
Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position
Große Maestrup, E.; Wiese, C.; Schepmann, D.; Brust, P.; Wünsch, B.
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Bioorganic & Medicinal Chemistry 19(2011), 393-405
DOI: 10.1016/j.bmc.2010.11.013
The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
Hesse, S.; Stengler, K.; Regenthal, R.; Patt, M.; Becker, G.-A.; et al. (15 authors)
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International Journal of Neuropsychopharmacology 14(2011), 1-12
DOI: 10.1017/S1461145710001604
Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine
Fischer, S.; Wiese, C.; Grosse Maestrup, E.; Hiller, A.; Deuther-Conrad, W.; et al. (10 authors)
- European Journal of Nuclear Medicine and Molecular Imaging 38(2011)3, 540-551
Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models
Hoffmeister, P.-G.; Donat, C. K.; Schuhmann, M. U.; Voigt, C.; Walter, B.; et al. (9 authors)
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Neuromolecular Medicine 13(2011)1, 44-53
DOI: 10.1007/s12017-010-8136-4
ISSN: 1535-1084
Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1’-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4’-piperidine]
Wiese, C.; Große Maestrup, E.; Schepmann, D.; Grimme, S.; Humpf, H.-U.; et al. (7 authors)
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Chirality 23(2011), 148-154
DOI: 10.1002/chir.20893
Design, Synthesis and Preliminary in vitro and in vivo Pharmacological Evaluation of 2-{4-[4-(2,5-disubstituted thiazolyl)phenylethyl] piperazin-1-yl}-1,8-naphthyridine-3- carbonitriles as Atypical Antipsychotic Agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Reddy, A. S.; Brust, P.; et al. (6 authors)
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Journal of Enzyme Inhibition And Medicinal Chemistry 26(2011)4, 561-568
DOI: 10.3109/14756366.2010.537658
2010
Accessible silanol sites - beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.
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Journal of Chromatography A 1217(2010), 7884-7890
DOI: 10.1016/j.chroma.2010.10.061
3D QSAR study, synthesis and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the Vesicular AcetylCholine Transporter (VAChT)
Kovac, M.; Mavel, S.; Deuther-Conrad, W.; Méheux, N.; Glöckner, J.; et al. (10 authors)
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Bioorganic & Medicinal Chemistry 18(2010), 7659-7667
DOI: 10.1016/j.bmc.2010.08.028
Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent
Chen, R.-Q.; Li, Y.; Zhang, Q.-Y.; Jia, H.-M.; Deuther-Conrad, W.; et al. (10 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 53(2010), 569-574
DOI: 10.1002/jlcr.1777
Design, Synthesis and in Vitro Biological Evaluation of Reference Compounds of 123I and 99Tcm Labeled Indole Radiotracers for σ2 Receptor Imaging
Li, Y.; Jia, H.-M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; et al. (6 authors)
- Journal of Nuclear and Radiochemistry 32(2010)2, 132-138
Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain
Donat, C. K.; Walter, B.; Kayser, T.; Deuther-Conrad, W.; Schliebs, R.; et al. (9 authors)
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International Journal of Developmental Neuroscience 28(2010), 31-38
DOI: 10.1016/j.ijdevneu.2009.10.001
Novel Indole Derivatives as Potential Imaging Agents for Alzheimers Disease
Yu, L.; Scheunemann, M.; Deuther-Conrad, W.; Hiller, A.; Fischer, S.; et al. (11 authors)
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Bulletin of the Korean Chemical Society 31(2010)1, 177-180
DOI: 10.5012/bkcs.2010.31.01.177
Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.
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Journal of Chromatography A 1217(2010), 3855-3862
DOI: 10.1016/j.chroma.2010.04.018
2009
Molecular imaging of α7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743
Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Ostergaard Nielsen, E.; Brunicardi Timmermann, D.; et al. (9 authors)
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European Journal of Nuclear Medicine and Molecular Imaging 36(2009), 791-800
DOI: 10.1007/s00259-008-1031-7
2008
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination
Funke, U.; Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; et al. (7 authors)
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Bioorganic & Medicinal Chemistry Letters 18(2008), 4727-4730
DOI: 10.1016/j.bmcl.2008.06.077
Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands
Guo, Y.; Chen, X.; Jia, H.; Deuther-Conrad, W.; Brust, P.; et al. (8 authors)
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Science in China Series B: Chemistry 51(2008)5, 457-463
DOI: 10.1007/s11426-008-0007-6
Radiosynthesis of novel 18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET
Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; Hoepping, A.; et al. (9 authors)
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Journal of Labelled Compounds and Radiopharmaceuticals 51(2008), 123-131
DOI: 10.1002/jlcr.1473
2006
[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: Synthesis, pharmacological characterization and microPET studies in rats
Zessin, J.; Deuther-Conrad, W.; Kretzschmar, M.; Wüst, F.; Pawelke, B.; et al. (8 authors)
- Nuclear Medicine and Biology 33(2006)1, 53-63
2005
Effect of Moderate Hypercapnic Hypoxia on Cerebral Dopaminergic Activity and Brain O2 Uptake in Intrauterine GrowthRestricted Newborn Piglets
Bauer, R.; Walter, B.; Vorwieger, G.; Fritz, A.; Füchtner, F.; et al. (7 authors)
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Pediatric Research 57(2005)3, 363-370
DOI: 10.1203/01.PDR.0000150800.19956.F0
2004
The Influx of Neutral Amino Acids into the Porcine Brain During Development: A Positron Emission Tomography Study
Brust, P.; Vorwieger, G.; Walter, B.; Füchtner, F.; Stark, H.; et al. (8 authors)
- Developmental Brain Research 152(2004), 241-253
Developmental changes in the activity of aromatic amino acid decarboxylase and catechol-O-methyl transferase in pigs: a positron emission tomography study
Brust, P.; Walter, B.; Hinz, R.; Füchtner, F.; Müller, M.; et al. (7 authors)
- Neuroscience Letters, 364(2004)3, 159-163
Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs
Walter, B.; Brust, P.; Füchtner, F.; Müller, M.; Hinz, R.; et al. (9 authors)
- Journal of Neurotrauma 21(2004)8, 1076-1089
2003
Impact of asymmetric intrauterine growth restriction on organ function in newborn piglets
Bauer, R.; Walter, B.; Brust, P.; Füchtner, F.; Zwiener, U.
- European Journal of Obstetrics and Gynecology and Reproductive Biology 110 (2003) S40-S49
S-[18F]fluoromethyl-(+)-McN5652, a PET Tracer for the Serotonin Transporter: Evaluation in Rats
Marjamäki, P.; Zessin, J.; Eskola, O.; Grönroos, T.; Haaparanta, M.; et al. (11 authors)
- Synapse (2003) 47: 45-53
In vivo Measurement of the Serotonin Transporter with (S)-([18F]fluoromenthyl)-(+)-McN5652
Brust, P.; Hinz, R.; Kuwabara, H.; Hesse, S.; Zessin, J.; et al. (10 authors)
- Neuropsychopharmacology (2003) 28, 2010-2019
Positron Emission Tomography Imaging of the Serotonin Transporter in the Pig Brain Using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652
Brust, P.; Zessin, J.; Kuwabara, H.; Pawelke, B.; Kretzschmar, M.; et al. (11 authors)
- Synapse (2003) 47: 143-151
Autoradiographic analyses of 5-HT1A and 5-HT2A receptors after social isolation in mice
Schiller, L.; Jähkel, M.; Kretzschmar, M.; Brust, P.; Oehler, J.
- Brain Research 980 (2003) 169-178
Autoradiographic imaging of the serotonin ransporter in the brain of rats and pigs using S-([18F]Fluoromethyl)-(+)-McN5652
Kretzschmar, M.; Brust, P.; Zessin, J.; Cumming, P.; Bergmann, R.; et al. (6 authors)
- European Neuropsychopharmacology 13 (2003) 387-397
2002
Effect of hypoxia/hypercapnia on metabolism of 6-[18F]fluoro-L-DOPA in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; et al. (12 authors)
- Brain Research 934 (2002) 22-33
Tc and Re chelates of 8alpha-amino-6-methyl-ergoline: synthesis and affinity to the dopamine D2 receptor
Spies, H.; Noll, B.; Noll, S.; Findeisen, M.; Brust, P.; et al. (7 authors)
- Bioorganic and Medicinal Chemistry 10 (2002) 3523-3528
Distribution of estrone sulfatase in rat brain determined by in vitro autoradiography with 16alpha-[18F]fluoroestradiol-3,17beta-disulfamate
Rodig, H.; Brust, P.; Römer, J.; Kasch, H.; Bergmann, R.; et al. (8 authors)
- Applied Radiation and Isotopes 56 (2002) 773-780
Distribution of 16alpha-[18F]fluoro-estradiol-3,17beta-disulfamate (FESDS) in rats, tumour-bearing mice and piglets
Brust, P.; Rodig, H.; Römer, J.; Kasch, H.; Bergmann, R.; et al. (10 authors)
- Applied Radiation and Isotopes 57 (2002) 687-695
Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor
Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; et al. (12 authors)
- Nuclear Medicine and Biology 29 (2002) 375-387
2001
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 tymidine kinase gene expression
Brust, P.; Haubner, R.; Friedrich, A.; Scheunemann, M.; Anton, M.; et al. (14 authors)
- European Journal of Nuclear Medicine Vol.28, No. 6, (2001) 721-729
Synthesis of S-([18F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter
Zessin, J.; Eskola, O.; Brust, P.; Bergman, J.; Steinbach, J.; et al. (8 authors)
- Nuclear Medicine and Biology 28 (2001) 857-863
Quantitative Radioluminography of Serotonin Uptake Sites in the Porcine Brain
Cumming, P.; Kretzschmar, M.; Brust, P.; Smith, D. F.
- Synapse 39 (2001) 351-355
Intrauterine growth restriction induces up-regulation of cerebral aromatic amino acid decarboxylase activity in newborn piglets: [18F]fluorodopa positron-emission-tomographic study
Bauer, R.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; et al. (6 authors)
- Pediatric Research 49 (2001) 474-480
Reactivity of 99mTc(V) "3+1" mixed-ligand complexes towards glutathione
Gupta, A.; Seifert, S.; Syhre, R.; Scheunemann, M.; Brust, P.; et al. (6 authors)
- Radiochimica Acta 89 (2001) 43-49
2000
Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.
Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; et al. (7 authors)
- Nucl. Med. Biol. 27 (2000) 135-141
Relation between brain tissue pO2 and dopamine synthesis of basal ganglia - A 18FDOPA-PET study in newborn piglets
Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; et al. (11 authors)
- J. Perinat. Med. 28 (2000) 54-60
Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells
Brust, P.; Friedrich, A.; Krizbai, I. A.; Bergmann, R.; Roux, F.; et al. (7 authors)
- J.Neurochem. 74, (2000) 1241-1248
-
Journal of Cerebral Blood Flow and Metabolism, Vol. 19 (Suppl.1), 245
DOI: 10.1046/j.1471-4159.2000.741241.x
1999
Upregulation of the Aromatic Amino Acid Decarboxylase under Neonatal Asphyxia
Brust, P.; Bauer, R.; Vorieger, G.; Walter, B.; Bergmann, R.; et al. (9 authors)
-
Neurobiology of Disease 6, (1999) 131-139
DOI: 10.1006/nbdi.1998.0232
Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets - effect of hypoxia / hypercapnia
Bauer, R.; Bergmann, R.; Walter, B.; Brust, P.; Zwiener, U.; et al. (6 authors)
-
Developmental Brain Research 112 (1999) 89-98
DOI: 10.1016/S0165-3806(98)00167-9
Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice
Srinivas, P.; Subramanian, A. R.; Brust, P.; Raghavan, S. A. V.; Rangisetty, J. B.; et al. (9 authors)
- IL FARMACO 54 (1999) 567-572
Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT2A Receptor
Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; et al. (10 authors)
- Nuclear Medicine and Biology, 26 (1999) 865-875
Synthesis and preliminary binding affinities of 1(1,2-dihydro-2-acenaphthylenyl)piperazine - a new arylpiperazine
Srinivas, P.; Brust, P.; Subramanian, A. R.; Raghavan, S. A. V.; Rangisetty, J. B.; et al. (7 authors)
- Pharmaceutica Acta Helvetiae 74 (1999) 73-73
Efficient Synthesis of Enantiomerically Pure Thioester Precursors of [11C] MCN-5652 from Racemic MCN-5652
Zessin, J.; Gucker, P.; Ametamey, S. M.; Steinbach, J.; Brust, P.; et al. (8 authors)
- J. Labelled Cpd. Radiopharm. 42 (1999) 1301-1312
Radioligands for the Study of the 5-HT Transporter in Vivo
Brust, P.; Scheffel, U.; Szabo, Z.
- IDrugs 1999 Vol 2 No 2 , Review Radioligands 129-145
1998
TROTEC-1 a new high affinity ligand for Labeling of the dopamine transporter
Hoepping, A.; Reisgys, M.; Brust, P.; Seifert, S.; Spies, H.; et al. (7 authors)
- Journal of Medicinal Chemistry, 41(23) (1998) 4429-4432
Differentiation Between Specific and Nonspecific Effects Related to P-Glycoprotein Inhibition in Immortalized Rat Brain Endothelial Cells
Bergmann, R.; Brust, P.; Johannsen, B.
- International Journal of Clinical Pharmacology and Therapeutics, Vol. 36, No. 1, 1998 (46-49)
Simultaneous Measurement of 18F-FDOPA Metabolism and Cerebral Blood Flow in Newborn Piglets
Brust, P.; Bauer, R.; Walter, B.; Bergmann, R.; Füchtner, F.; et al. (9 authors)
-
Int. J. Devl. Neuroscience, Vol. 16, No. 5, pp 353-364, 1998
DOI: 10.1016/S0736-5748(98)00017-3
Novel Rhenium Complexes Derived from ALPHA-Tropanol as Potential Ligands for the Dopamin Transporter
Hoepping, A.; Brust, P.; Berger, R.; Leibnitz, P.; Spies, H.; et al. (8 authors)
-
Bioorganic & Medicinal Chemistry 6 (1998) 1663-1672
DOI: 10.1016/S0968-0896(98)00144-8
1997
Different response of cerebral and non-cerebral endothelial cells to cytotoxic hypoxia
Ahlemeyer, B.; Brust, P.; Johannsen, B.
- Neurochem. Int. 31 (1997) 39-44
Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake
Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; et al. (8 authors)
- European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319
1996
High-affinity binding of [3H]paroxetine to caudate nucleus and microvessels from porcine brain
Brust, P.; Bergmann, R.; Johannsen, B.
-
NeuroReport 7 (1996) pp. 1405-1408
DOI: 10.1097/00001756-199605310-00016
Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations
Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; et al. (7 authors)
-
Journal of Nuclear Medicine and Biology 23 (1996) 429-438
DOI: 10.1016/0969-8051(96)00015-7
1995
Specific binding of (3H)imipramine indicates the presence of a specific serotonin transport system on endothelial cells of porcine brain
Brust, P.; Bergmann, R.; Johannsen, B.
-
Neuroscience Letters 194 (1995) 21-24
DOI: 10.1016/0304-3940(95)11709-6
Evaluation of Radioselenium Labeled Selenomethionine, a Potential Tracer for Brain Protein Synthesis by PET
Bergmann, R.; Brust, P.; Kampf, G.; Coenen, H. H.; Stöcklin, G.
-
J. Nucl. Med. Biol. 22 (1995) 475-481
DOI: 10.1016/0969-8051(94)00123-2
1994
Characterization of serotonin uptake sites on the blood brain barrier
Brust, P.; Bergmann, R.
- Journal of Neurochemistry 63 (1994) (Suppl. 1) S13C