Kontakt

Prof. Dr. Jens Pietzsch

Lei­ter Radio­pharma­zeutische und Chemische Bio­logie
j.pietzschAthzdr.de
Tel.: +49 351 260 2622

Dr. Manja Kubeil

Leiterin Strahlen­for­schung an biologischen System
Research Topic Group Leader
Marie Curie Alumna
m.kubeilAthzdr.de
Tel.: +49 351 260 2442

Dr. Markus Laube

Wissen­schaftlicher Mitarbeiter
Radio­pharma­zeutische und Chemische Bio­logie
m.laubeAthzdr.de
Tel.: +49 351 260 2810
+49 351 260 3917
+49 351 260 4070

Dr. Sandra Hauser

Wissen­schaftliche Mitarbeiterin
Radio­pharma­zeutische und Chemische Bio­logie
s.hauserAthzdr.de
Tel.: +49 351 260 4046

Dr. Martin Ullrich

Wissen­schaftlicher Mitarbeiter
Radio­pharma­zeutische und Chemische Bio­logie
m.ullrichAthzdr.de
Tel.: +49 351 260 4046
+49 351 260 3989

Universität

Vorschau-Bild

Bioanorganische Chemie und Pathobiochemie (Chem-Ma-B01)

Lecturers

Prof. Dr. Jens Pietzsch (Lecturer in charge)

Dr. Manja Kubeil, Dr. Markus Laube, Dr. Sandra Hauser, Dr. Martin Ullrich

Information on the courses

The module Chem-Ma-B01 is offered in the teacher training programs GY and BS as module MN-SEGY-CHE-20F or MN-SEBS-CHE-20F.

The lecture Pathobiochemistry/Medical Biochemistry II is offered as part of the module Chem-Ma-TB07 of the consecutive Master's program in Biochemistry.

The next lectures will be offered in English from the winter semester 2025/2026.

If you are interested in internship semesters/master theses, please have a look at here.

Location/Time

Seminar room CHE/153

The lecture takes place weekly on Wednesdays in the 4th double lesson (1.00 pm to 2.30 pm; s.t. - Bioinorganic Chemistry) and in the 5th double lesson (2.50 pm to 4.20 pm; s.t. - Pathobiochemistry/Medical Biochemistry II).

Bioinorganic Chemistry: lecture finished

Pathobiochemistry/Medicinal Biochemistry II: lecture finished

Seminar: finished

Please also refer to the corresponding entries in OPAL and SELMA.

Online In the case of an online lecture, the dial-in modalities (link (Zoom/BBB)) will be announced here accordingly.
Content
  • Acquisition of knowledge on the behavior of metals in biosystems with a focus on metal centers in enzymes/proteins and electrolyte elements
  • Consideration of medical-therapeutic, toxicological and environmental aspects
  • General understanding of pathobiochemical changes in the human organism
  • Acquisition of knowledge of biochemical mechanisms in the development, manifestation and progression of selected diseases
  • Acquisition of knowledge of modern diagnostic (analytical) methods and (pharmaco)therapeutic approaches from research and clinical practice
Exams

Modules Chem-Ma-B01 / MN-SEGY-CHE-20F / MN-SEBS-CHE-20F

Oral examination (individual examination, 60 min): Dates will be arranged individually

28.03. at HZDR, Building 805, Room 265 

The oral examination can be taken in German or English.

Module Chem-Ma-TB07

Written exam: Date will be announced in time

The exam language is English.

Links

To prepare for the lecture Bioinorganic Chemistry, please use the lecture notes (scripts see below).

***

To prepare for the lecture Pathobiochemistry/Medical Biochemistry II, please use the lecture notes and the reading material for self-study (Skript). 

For both lectures, please also recapitulate the contents of previous chemistry and biochemistry lectures, especially on

  • Metabolism of amino acids, peptides and proteins
  • Metabolism of carbohydrates (glycolysis, gluconeogenesis, glycogen metabolism)
  • Metabolism of fatty acids and lipids
  • Tricarboxylic acid cycle, oxidative phosphorylation
  • Enzymes, receptors
  • Natural product chemistry
  • Chemistry of arenes and heterocycles

Course of the academic year

Pathobiochemistry schedule

  • Introduction to pathobiochemistry
  • General and special pathobiochemistry
  • Signal transduction
  • Inflammation
  • Inflammatory diseases
  • Atherogenesis
  • Diseases of the lipoprotein metabolism
  • Metabolic syndrome
  • Inflammogenesis of tumors

Bioinorganic Chemistry schedule

  Thema  

pdf

L1 - Overview

Bioinorganic chemistry, trace elements, bioligands

pdf

L2 - Basic Principles of Coordination Chemistry

pdf

L3 - Alkaline metals (sodium, potassium)

Recognition of spherical species, membrane pumps and channels

pdf

L4 - Alkaline earth metals (calcium, magnesium)

Biomineralization, messenger substances and structure formers

pdf

L5 - Zinc, Copper

enzymatic catalysis, regulatory functions

pdf

L6 - Manganese, Cobalt, Nickel

Photosynthesis, Cobalamines, Nickel - a long overlooked biometal

pdf

L7 - Iron

Oxygen transport, Heme-Fe and None-heme-Fe

pdf

L8 - Molybdenum, Vanadium, Chromium, Tungsten

Nitrogen fixation, Haloperoxidases,

Cr(III) - role in humans?

pdf

L9 - Gasotransmitters NO, CO, H2S

Biosynthesis, reactive oxygen and nitrogen species

pdf

L10 - Toxic metals

Pb, Hg, Cd, As, Chelate therapy

pdf

L11 - Inorganic drugs

Diagnostics and therapeutics

pdf

L12 - Radioactive metals in the environment and medicine

natural and artificial radioisotopes

pdf

L13 - Seminar