Tissue Regeneration and Inflammation Imaging
The aim of this group is the development and validation of molecular imaging techniques for the investigation of inflammatory, fibrotic and carcinogenic processes. Our research consists of four main lines. First, we focus on the development of targeted compounds for the detection of early biomarkers of carcinogenesis, cancer progression or tissue regeneration by multimodal (PET, SPECT, MRI and optical) imaging. Secondly, selected compounds are tested for their suitability as targeted or adjuvant cancer theranostics. Examples of such compounds are selective cyclooxygenase-2 inhibitors for both functional characterization and therapeutic modulation of inflammatory processes. Selective transglutaminase 2 inhibitors in turn address matrix-modifying processes. Third, we develop and study three-dimensional (3D) cell models and animal models for solid, in particular therapy-resistant tumors with a distinct inflammatory and/or fibrotic matrix-associated microenvironment to improve our understanding of the disease process. Examples are pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC). Fourthly, intelligent biomaterial approaches for targeted drug delivery, combined therapies and targeted modulation of tissue regeneration are of central importance to us in this context.
- Xu Y et al., Nat Commun, 2021; 12:2407
- Rothe R et al., Biomaterials, 2021; 269:120637.
- Wetzel R. et al., Adv. Biology, 2021; 1900303 (online).
- Doctor A et al., Cancers (Basel) 12:2765, 2020.
- Hauser S et al., ACS Biomater Sci Eng. 5:5979-5989, 2019.
- Xu Y et al., Adv. Sci. (Weinh.) 6:180277, 2019.
- Hauser S et al., Trends Biotechnol. 35:265-277, 2017.
- Functional Biomaterials for Controlling Healing Processes in Bone and Skin - From Material Science to Clinical Application; DFG, Transregio Collaborative Research Centre TRR67; subproject B5.
- Interdisciplinary Innovation Project at Else Kröner-Fresenius-Center for Digital Health (EKFZ). Proof-of-concept for quantitative measurement of capillary refilling time (CRT); partners.
- In-depth spatial organisation of hepatocellular carcinoma initiation (DEEP-HCC): Förderung eines systemmedizinischen Forschungsnetzes zur Früherkennung und Prävention von Leber-Krebs (LiSyM-Krebs) im Rahmen der nationalen Dekade gegen Krebs; partners. (BMBF)
- MATRESIST: Matrix-Associated Therapy Resistance
Further literature on our hypotheses and approaches
- ref. critical-size bone defects: ⇒Topic Issue "Bone Healing" Editorial; Part I; Part II; Part III; ⇒Special Issue "Depot Delivery Systems" Part IV
- ref. bone healing imaging: 
- ref. smart hydrogel systems for controlled drug release and tissue integration: , , 
- ref. inflammation and infection imaging: