Kontakt

Dr. Christin Neuber

Wissenschaftliche Mitarbeiterin
Radiopharmazeutische und Chemische Biologie
c.neuberAthzdr.de
Tel.: +49 351 260 3097
+49 351 260 3989

Dr. Martin Ullrich

Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
m.ullrichAthzdr.de
Tel.: +49 351 260 4046
+49 351 260 3989

Prof. Dr. Jens Pietzsch

Abteilungsleiter
Radiopharmazeutische und Chemische Biologie
j.pietzschAthzdr.de
Tel.: +49 351 260 2622

Radiopharmacology and Cancer Imaging

Using small animal imaging (PET, SPECT, CT, MRI and optical) radiopharmacological characteristics and safety of novel radiolabeled compounds are evaluated in laboratory mice and rats with regard to biodistribution, metabolic fate, and excretion profiles. These investigations include small molecules, peptides, antibodies, and nanoparticles targeting extra- and intracellular targets, e.g., cyclooxygenase-2, transglutaminase‑2, SLC transporters, proteases and somatostatin receptors. Diagnostic performance of promising radiotracers as well as efficiency of anti-cancer drugs and treatment regimens are evaluated in animal models of melanoma, pheochromocytoma/paraganglioma, prostate cancer, and other tumor entities. Our research also involves functional imaging of metabolic alterations, such as hypoxia and inflammation in order to further improve our understanding of distinct tumor characteristics and to identify potential “Achilles’ heels” for targeted adjuvant, e.g. radiosensitizing treatments.

 

Key publications

Projects (multicenter)

  • The Adrenal: Central Relay in Health and Disease; DFG, Transregio Collaborative Research Centre TRR205; subproject B10
  • Consortium for personalized targeted therapy of SDHB-mutated metastatic paraganglioma and pheochromocytoma; Paradifference Foundation.

Further literature on our hypotheses (ref. pheochromocytoma spheroid models: [1], [2])


Kontakt

Dr. Christin Neuber

Wissenschaftliche Mitarbeiterin
Radiopharmazeutische und Chemische Biologie
c.neuberAthzdr.de
Tel.: +49 351 260 3097
+49 351 260 3989

Dr. Martin Ullrich

Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
m.ullrichAthzdr.de
Tel.: +49 351 260 4046
+49 351 260 3989

Prof. Dr. Jens Pietzsch

Abteilungsleiter
Radiopharmazeutische und Chemische Biologie
j.pietzschAthzdr.de
Tel.: +49 351 260 2622