Radiopharmacology and Cancer Imaging
Using small animal imaging (PET, SPECT, CT, MRI and optical) radiopharmacological characteristics and safety of novel radiolabeled compounds are evaluated in laboratory mice and rats with regard to biodistribution, metabolic fate, and excretion profiles. These investigations include small molecules, peptides, antibodies, and nanoparticles targeting extra- and intracellular targets, e.g., cyclooxygenase-2, transglutaminase‑2, SLC transporters, proteases and somatostatin receptors. Diagnostic performance of promising radiotracers as well as efficiency of anti-cancer drugs and treatment regimens are evaluated in animal models of melanoma, pheochromocytoma/paraganglioma, pancreatic ductal adenocarcinoma, prostate cancer, multiple myeloma, and other tumor entities. Our research also involves functional imaging of metabolic alterations, such as hypoxia and inflammation in order to further improve our understanding of distinct tumor characteristics and to identify potential “Achilles’ heels” for targeted adjuvant, e.g. radiosensitizing treatments.
- Bechmann N. et al., Endocr Relat Cancer. 27:625-640, 2020.
- Pant K. et al., Small, 16:1905013, 2020. (Front Cover, Volume 16, Issue 7) (HZDR press release)
- Ullrich M. et al., Cancers (Basel). 11:E743, 2019.
- Ullrich M. et al., Endocr Relat Cancer. 25:993-1004, 2018.
- Neuber C. et al., Molecules. 23:E444, 2018.
- The Adrenal: Central Relay in Health and Disease; DFG, Transregio Collaborative Research Centre TRR205; subproject B10.
- Consortium for personalized targeted therapy of SDHB-mutated metastatic paraganglioma and pheochromocytoma; Paradifference Foundation.
- Development of PSMA ligands for the diagnosis and therapy of prostate cancer; European Regional Development Fund (ERDF, in German: EFRE)
- Mechanisms of Radiotherapy Resistance
Further literature on our hypotheses and approaches