Kontakt

Dr. Reik Löser
Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
r.loeserAthzdr.de
Tel.: +49 351 260 3658, +49 351 260 4070

Dr. Markus Laube
Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
m.laubeAthzdr.de
Tel.: +49 351 260 2810, +49 351 260 3917, +49 351 260 4070
Fax: +49 351 260 12810

Prof. Dr. Jens Pietzsch
Abteilungsleiter
Radiopharmazeutische und Chemische Biologie
j.pietzschAthzdr.de
Tel.: +49 351 260 2622
Fax: +49 351 260 12622

Radiotracer and Drug Development

Research of this group is devoted to the chemical and radiochemical development of novel radiotracers for extracellular and intracellular targets playing an important role for cancer, such as transglutaminase-2, cathepsin B and cyclooxygenase-2. For this purpose, we hold expertise in the synthesis and in vitro evaluation of novel biologically active molecules to select the most promising compounds for further developments as well as the synthesis of precursor molecules suitable for radiolabeling. This comprises the application of the entire methodological repertoire of organic chemistry. Furthermore, biochemical methods are used to study target binding and to obtain insight into the pharmacokinetic properties of potential tracer compounds. Our key competence and peculiar interest is the radiolabeling with the positron emitting nuclides fluorine-18, carbon-11 and other radionuclides including the optimization of radiosyntheses and upscaling to fully automated and remotely controlled procedures allowing for handling of high amounts of activity. In this regard we are interested in the development of novel radiotracers and innovative (radio)synthetic strategies to set the radiochemical basis for successful tracer development.


Kontakt

Dr. Reik Löser
Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
r.loeserAthzdr.de
Tel.: +49 351 260 3658, +49 351 260 4070

Dr. Markus Laube
Wissenschaftlicher Mitarbeiter
Radiopharmazeutische und Chemische Biologie
m.laubeAthzdr.de
Tel.: +49 351 260 2810, +49 351 260 3917, +49 351 260 4070
Fax: +49 351 260 12810

Prof. Dr. Jens Pietzsch
Abteilungsleiter
Radiopharmazeutische und Chemische Biologie
j.pietzschAthzdr.de
Tel.: +49 351 260 2622
Fax: +49 351 260 12622