Persönliche Webseite von Karim Fahmy
Wissenschaftlicher Werdegang
- seit 2019: Mitglied des Exzellenz-Clusters "Physics of Life"
- 2016-2018: Leiter der Sektion "Molekulare Biophysik" der Deutschen Biophysikalischen Gesellschaft
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Seit 2014:Honorar-Professor "Structural Dynamics of Biomolecules" Biotechnology Center (BIOTEC) der Technischen Universität Dresden
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Seit 2002:Abteilungsleiter Biophysik
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1995-1999:DFG-Stipendium, Habilitation und venia legendi in Biophysik, Universität Freiburg
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1991-1994:Howard Hughes Medical Institute Fellowship, Rockefeller University
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1991:PhD, Universität Freiburg
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1986:Studium Biologie / Physik, Universität Marburg und Bochum
Forschungsschwerpunkte
- Molekulare Biophysik der Strukturdynamik von Proteinen mittels Mutagenese Spectroskopie und Kalorimetrie
- Messung metabolischer Aktivitäten von Mikroorganismen zur Bestimmung von Radionuklidtoxizitäten
Projekte
- Metallionen-induzierte Strukturänderungen in löslichen und in Membranproteinen
- DNA-basierte nanoskalige Biomembran-Mimetika
- Kalorimetrie mikrobiellen Stoffwechsels
- Untersuchung von Biomolekülen mittels THz Strahlung
Lehrtätigkeit
- Biophysikalische Methoden, Technische Universität Dresden
- Biological Thermodynamics, Technische Universität Dresden
- Vibrational Spectroscopy and Fluorescence Spectroscopy (International Master Programme, BIOTEC, Technische Universität Dresden)
Mitgliedschaften / Gremientätigkeit
- Biophysical Society, USA
- Deutsche Gesellschaft für Biophysik / Sprecher "Sektion Molekulare Biophysik"
- HZDR Projektgruppe "European XFEL" / User Consortium European XFEL
- HZDR Projektgruppe "THz Applications in Life Sciences"
- Dresden-International- Graduate- School for Biomedicine and Bioengineering
Preise
- Hans-Griesebach Preis der Universität Freiburg
Veröffentlichungen
2024
Cold denaturation of DNA origami nanostructures
Dornbusch, D.; Hanke, M.; Tomm, E.; Grundmeier, G.; Keller, A.; Fahmy, K.; Kielar, C.
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Chemical Communications 60(2024), 5590-5593
DOI: 10.1039/D3CC05985E
2023
Large-Scale Formation of DNA Origami Lattices on Silicon
Tapio, K.; Kielar, C.; Parikka, J. M.; Keller, A.; Järvinen, H.; Fahmy, K.; Jussi Toppari, J.
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Chemistry of Materials 35(2023)5, 1961-1971
DOI: 10.1021/acs.chemmater.2c03190
Cited 10 times in Scopus
Superstructure-dependent stability of DNA origami nanostructures in the presence of chaotropic denaturants
Hanke, M.; Dornbusch, D.; Tomm, E.; Grundmeier, G.; Fahmy, K.; Keller, A.
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Nanoscale 15(2023)41, 16590-16600
DOI: 10.1039/d3nr02045b
Cited 4 times in Scopus
Exploring Antibacterial Activity and Bacterial-Mediated Allotropic Transition of Differentially Coated Selenium Nanoparticles
Ruiz-Fresneda, M. A.; Schaefer, S.; Hübner, R.; Fahmy, K.; Merroun, M. L.
Beteiligte Forschungsanlagen
- Ionenstrahlzentrum DOI: 10.17815/jlsrf-3-159
Verknüpfte Publikationen
- DOI: 10.17815/jlsrf-3-159 is cited by this (Id 37231) publication
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ACS Applied Materials and Interfaces 15(2023), 29958-29970
DOI: 10.1021/acsami.3c05100
Cited 14 times in Scopus
Special Issue “Advances in Monitoring Metabolic Activities of Microorganisms by Calorimetry”
Matulis, D.; Wadsö, L.; Fahmy, K.
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Microorganisms 11(2023)5, 1204
DOI: 10.3390/microorganisms11051204
Distinct Effects of Chemical Toxicity and Radioactivity on Metabolic Heat of Cultured Cells Revealed by “Isotope-Editing”
Oertel, J.; Sachs, S.; Flemming, K.; Hassan Obeid, M.; Fahmy, K.
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Microorganisms 11(2023)3, 584
DOI: 10.3390/microorganisms11030584
Cited 1 times in Scopus
Interdisciplinary biophysical studies of membrane proteins bacteriorhodopsin and rhodopsin
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Biophysical Reviews 15(2023), 111-125
Online First (2022) DOI: 10.1007/s12551-022-01003-y
Cited 4 times in Scopus
2022
Simple Growth–Metabolism Relations Are Revealed by Conserved Patterns of Heat Flow from Cultured Microorganisms
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Microorganisms 10(2022), 1397
DOI: 10.3390/microorganisms10071397
Cited 3 times in Scopus
Anion-specific structure and stability of guanidinium-bound DNA origami
Hanke, M.; Dornbusch, D.; Hadlich, C.; Roßberg, A.; Hansen, N.; Grundmeier, G.; Tsushima, S.; Keller, A.; Fahmy, K.
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Computational and Structural Biotechnology Journal 20(2022), 2611-2623
DOI: 10.1016/j.csbj.2022.05.037
Cited 9 times in Scopus
Salting-Out of DNA Origami Nanostructures by Ammonium Sulfate
Hanke, M.; Hansen, N.; Ruiping, C.; Grundmeier, G.; Fahmy, K.; Keller, A.
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International Journal of Molecular Sciences 23(2022)5, 2817
DOI: 10.3390/ijms23052817
Cited 10 times in Scopus
2021
Two Be or Not Two Be: The Nuclear Autoantigen La/SS-B Is able to form Dimers and Oligomers in a Redox Dependent Manner
Berndt, N.; Bippes, C. C.; Michalk, I.; Bachmann, D.; Bachmann, J.; Puentes-Cala, E.; Bartsch, T.; Loureiro, L. R.; Kegler, A.; Bergmann, R.; Gross, J. K.; Gross, T.; Kurien, B. T.; Scofield, R. H.; Farris, A. D.; James, J. A.; Schmitz, M.; Fahmy, K.; Feldmann, A.; Arndt, C.; Bachmann, M.
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International Journal of Molecular Sciences 22(2021)7, 3377
DOI: 10.3390/ijms22073377
Cited 6 times in Scopus
DNA-Mediated Stack Formation of Nanodiscs
Subramanian, M.; Kielar, C.; Tsushima, S.; Fahmy, K.; Oertel, J.
Verknüpfte Publikationen
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Data publication: DNA-Mediated Stack Formation of Nanodiscs
ROBIS: 33585 HZDR-primary research data are used by this (Id 32443) publication -
DNA Based Formation of Nanodisc-Stacks
ROBIS: 32927 HZDR-primary research data are used by this (Id 32443) publication
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Molecules 26(2021)6, 1647
DOI: 10.3390/molecules26061647
Cited 2 times in Scopus
2020
A metabolic switch regulates the transition between growth and diapause in C. elegans
Penkov, S.; Raghuraman, B. K.; Erkut, C.; Oertel, J.; Galli, R.; Ackerman, E. J. M.; Vorkel, D.; Verbavatz, J. M.; Koch, E.; Fahmy, K.; Shevchenko, A.; Kurzchalia, T. V.
Verknüpfte Publikationen
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Data for: "A metabolic switch regulates the transition between growth and …
ROBIS: 32145 HZDR-primary research data are used by this (Id 31882) publication
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BMC Biology 18(2020), 31
DOI: 10.1186/s12915-020-0760-3
Cited 22 times in Scopus
C. elegans possess a general program to enter cryptobiosis that allows dauer larvae to survive different kinds of abiotic stress
Gade, V. R.; Traikov, S.; Oertel, J.; Fahmy, K.; Kurzchalia, T. V.
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Scientific Reports 10(2020), 13466
DOI: 10.1038/s41598-020-70311-8
Cited 12 times in Scopus
2019
Calcium binding to a disordered domain of a type III-secreted protein from a coral pathogen promotes secondary structure formation and catalytic activity
Hoyer, E.; Knöppel, J.; Liebmann, M.; Steppert, M.; Raiwa, M.; Herczynski, O.; Hanspach, E.; Zehner, S.; Göttfert, M.; Tsushima, S.; Fahmy, K.; Oertel, J.
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Scientific Reports 9(2019), 7115
DOI: 10.1038/s41598-019-42898-0
Cited 9 times in Scopus
Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians
Thommen, A.; Werner, S.; Frank, O.; Philipp, J.; Knittelfelder, O.; Quek, Y.; Fahmy, K.; Shevchenko, A.; Friedrich, B. M.; Jülicher, F.; Rink, J. C.
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eLife 8(2019), e38187
DOI: 10.7554/eLife.38187
Cited 55 times in Scopus
2018
DNA-encircled lipid bilayers
Iric, K.; Subramanian, M.; Oertel, J.; Agarwal, N. P.; Matthies, M.; Periole, X.; Sakmar, T. P.; Huber, T.; Fahmy, K.; Schmidt, T.-L.
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Poster
Jahrestagung Deutsche Gesellschaft für Biophysik, 16.-19.09.2018, Düsseldorf, Deutschland -
Nanoscale 10(2018), 18463-18467
DOI: 10.1039/C8NR06505E
Cited 36 times in Scopus
Layer-by-Layer assembly of heparin and peptide-polyethylene glycol conjugates to form hybrid nanothin films of biomatrices
Thomas, A. K.; Wieduwild, R.; Zimmermann, R.; Lin, W.; Friedrichs, J.; Bickle, M.; Fahmy, K.; Werner, C.; Zhang, Y.
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ACS Applied Materials and Interfaces 10(2018)17, 14264-14270
DOI: 10.1021/acsami.8b02014
Cited 10 times in Scopus
Uranium(VI) complexes with a calix[4]arene-based 8-hydroxyquinoline ligand: Thermodynamic and structural characterization based on calorimetry, spectroscopy, and liquid-liquid extraction
Bauer, A.; Jäschke, A.; Schöne, S.; Barthen, R.; März, J.; Schmeide, K.; Patzschke, M.; Kersting, B.; Fahmy, K.; Oertel, J.; Brendler, V.; Stumpf, T.
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ChemistryOpen 7(2018)6, 467-474
DOI: 10.1002/open.201800085
Cited 9 times in Scopus
2017
Calorimetrically determined U(VI) toxicity in Brassica napus correlates with oxidoreductase activity and U(VI) speciation
Sachs, S.; Geipel, G.; Bok, F.; Oertel, J.; Fahmy, K.
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Environmental Science & Technology 51(2017)18, 10843-10849
DOI: 10.1021/acs.est.7b02564
Cited 17 times in Scopus
Dipolar Relaxation Dynamics at the Active Site of an ATPase Regulated by Membrane Lateral Pressure
Fischermeier, E.; Pospíšil, P.; Sayed, A.; Hof, M.; Solioz, M.; Fahmy, K.
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Angewandte Chemie - International Edition 56(2017)5, 1269-1272
DOI: 10.1002/anie.201611582
Cited 14 times in Scopus
Analysis of self‑assembly of S‑layer protein slp‑B53 from Lysinibacillus sphaericus
Liu, J.; Falke, S.; Drobot, B.; Oberthuer, D.; Kikhney, A.; Guenther, T.; Fahmy, K.; Svergun, D.; Betzel, C.; Raff, J.
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European Biophysics Journal 46(2017)1, 77-89
DOI: 10.1007/s00249-016-1139-9
Cited 16 times in Scopus
2016
The molecular switching mechanism at the conserved D(E)RY motif in class-A GPCRs
Sandoval, A.; Eichler, S.; Madathil, S.; Reeves, P. J.; Fahmy, K.; Boeckmann, R. A.
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Biophysical Journal 111(2016)1, 79-89
DOI: 10.1016/j.bpj.2016.06.004
Cited 13 times in Scopus
Rational Structure-Based Rescaffolding Approach to de Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics
Ruiz-Gómez, G.; Hawkins, J. C.; Philipp, J.; Künze, G.; Wodtke, R.; Löser, R.; Fahmy, K.; Pisabarro, M. T.
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PLOS ONE 11(2016)4, e0154046
DOI: 10.1371/journal.pone.0154046
Cited 2 times in Scopus
Mechanism of attenuation of uranyl toxicity by glutathione in Lactococcus lactis
Obeid, M. H.; Oertel, J.; Solioz, M.; Fahmy, K.
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Applied and Environmental Microbiology 82(2016)12, 3563-3571
DOI: 10.1128/AEM.00538-16
Cited 12 times in Scopus
Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion
Oertel, J.; Keller, A.; Prinz, J.; Schreiber, B.; Hübner, R.; Kerbusch, J.; Bald, I.; Fahmy, K.
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Scientific Reports 6(2016), 26718
DOI: 10.1038/srep26718
Cited 7 times in Scopus
2015
A single-strand annealing protein clamps DNA to detect and secure homology
Ander, M.; Subramaniam, S.; Fahmy, K.; Stewart, F.; Schäffer, E.
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PLOS Biology 13(2015)8, A018
DOI: 10.1371/journal.pbio.1002213
Cited 21 times in Scopus
2014
The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans
Abusharkh, S. E.; Erkut, C.; Oertel, J.; Kurzchalia, T. V.; Fahmy, K.
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Langmuir 30(2014), 12897-12906
DOI: 10.1021/la502654j
Cited 17 times in Scopus
Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation
Petrovska, I.; Nüske, E.; Munder, M. C.; Kulasegaran, G.; Malinovska, L.; Kroschwald, S.; Richter, D.; Fahmy, K.; Gibson, K.; Verbavatz, J.-M.; Alberti, S.
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eLife 3(2014), 02409
DOI: 10.7554/eLife.02409
Cited 169 times in Scopus
Paramagnetic Decoration of DNA origami Nanostructures by Eu3+ Coordination
Opherden, L.; Oertel, J.; Barkleit, A.; Fahmy, K.; Keller, K.
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Langmuir 30(2014)27, 8152-8159
DOI: 10.1021/la501112a
Cited 29 times in Scopus
2013
Formic acid interaction with uranyl(VI) ion: structural and photochemical characterization
Lucks, C.; Roßberg, A.; Tsushima, S.; Foerstendorf, H.; Fahmy, K.; Bernhard, G.
Beteiligte Forschungsanlagen
- Rossendorf Beamline an der ESRF DOI: 10.1107/S1600577520014265
Verknüpfte Publikationen
- DOI: 10.1107/S1600577520014265 is cited by this (Id 18474) publication
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Dalton Transactions 42(2013)37, 13584-13589
DOI: 10.1039/C3DT51711J
Cited 28 times in Scopus
2012
3D Profile-Based Approach to Proteome-Wide Discovery of Novel Human Chemokines
Tomczak, A.; Sontheimer, J.; Drechsel, D.; Hausdorf, R.; Gentzel, M.; Shevchenko, A.; Eichler, S.; Fahmy, K.; Buchholz, F.; Pisabarro, M. T.
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PLOS ONE 7(2012)5, e36151
DOI: 10.1371/journal.pone.0036151
Cited 6 times in Scopus
How worms survive desiccation: Trehalose pro water
Erkut, C.; Penkov, S.; Fahmy, K.; Kurzchalia, T. V.
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Worm 1(2012)1, 61-65
DOI: 10.4161/worm.19040
2011
Trehalose renders dauer larva of Caenorhabditis elegans resistant to extreme desiccation
Erkut, C.; Penkov, S.; Khesbak, H.; Vorkel, D.; Verbavatz, J. M.; Fahmy, K.; Kurzchalia, T. V.
- Current Biology 21(2011)15, 1331-1336
The role of water H-bond imbalances in B-DNA substate transitions and peptide recognition revealed by time-resolved FTIR spectroscopy
Khesbak, H.; Savchuk, O.; Tsushima, S.; Fahmy, K.
- Journal of the American Chemical Society 133(2011), 5834-5842
Eu3+-Mediated Polymerization of Benzenetetracarboxylic Acid Studied by Spectroscopy, Temperature-Dependent Calorimetry, and Density Functional Theory
Barkleit, A.; Tsushima, S.; Savchuk, O.; Philipp, J.; Heim, K.; Acker, M.; Taut, S.; Fahmy, K.
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Inorganic Chemistry 50(2011)12, 5451-5459
DOI: 10.1021/ic102292j
Cited 16 times in Scopus
2010
S-Layer protein from Lysinibacillus sphaericus JG-A12 as matrix for Au-III sorption and Au-nanoparticle formation
Jankowski, U.; Merroun, M.; Selenska-Pobell, S.; Fahmy, K.
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Journal of Spectroscopy 24(2010)1-2, 177-181
DOI: 10.3233/SPE-2010-0408
ISSN: 0712-4813
Cited 20 times in Scopus
Aqueous coordination chemistry and photochemistry of uranyl(VI) oxalate revisited: a density functional theory study
Tsushima, S.; Brendler, V.; Fahmy, K.
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Dalton Transactions 39(2010)45, 10953-10958
DOI: 10.1039/C0DT00974A
Cited 28 times in Scopus
Photoluminescence of uranium(VI): quenching mechanism and role of uranium(V)
Tsushima, S.; Götz, C.; Fahmy, K.
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Chemistry - A European Journal 16(2010)27, 8029-8033
DOI: 10.1002/chem.201000408
Cited 36 times in Scopus
Heterologous expression of the S-layer-like protein SllB induces the formation of long filaments of E. coli consisting of protein stabilized outer membrane
Lederer, F.; Günther, T.; Flemming, K.; Raff, J.; Fahmy, K.; Springer, A.; Pollmann, K.
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Microbiology 156(2010), 3584-3595
DOI: 10.1099/mic.0.040808-0
Cited 8 times in Scopus
2009
Lipid Protein Interactions Couple Protonation to Conformation in a Conserved Cytosolic Domain of G-Protein-Coupled Receptors
Madathil, S.; Fahmy, K.
- Journal of Biological Chemistry 284(2009)42, 28801-28809
2008
Secondary Structure and Compliance of a Predicted Flexible Domain in Kinesin-1 Necessary for Co-operation of Motors
Crevenna, A. H.; Madathil, S.; Cohen, D. N.; Wagenbach, M.; Fahmy, K.; Howard, J.
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Biophysical Journal 95(2008), 5216-5227
DOI: 10.1529/biophysj.108.132449
Cited 19 times in Scopus
2007
Flavonoids affect actin functions in cytoplasm and nucleus
Boehl, M.; Tietze, S.; Sokoll, A.; Madathil, S.; Pfennig, F.; Apostolakis, J.; Fahmy, K.; Gutzeit, H. O.
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Biophysical Journal 93(2007), 2765-2780
DOI: 10.1529/biophysj.107.107813
Cited 50 times in Scopus
Linkage between the intramembrane H-bond network around aspartic acid 83 and the cytosolic environment of helix 8 in photoactivated rhodopsin
Lehmann, N.; Alexiev, U.; Fahmy, K.
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Journal of Molecular Biology 366(2007), 1129-1141
DOI: 10.1016/j.jmb.2006.11.098
Cited 35 times in Scopus
Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging
Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; Fahmy, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Kropp, J.; Deussen, A.; Spies, H.
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Bioconjugate Chemistry 18(2007), 216-230
ISSN: 10.1021/bc0601222
2006
Secondary structure and Pd(II) coordination in S-layer proteins from Bacillus sphaericus studied by infrared and X-ray absorption spectroscopy
Fahmy, K.; Merroun, M.; Pollmann, K.; Raff, J.; Savchuk, O.; Hennig, C.; Selenska-Pobell, S.
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Biophysical Journal 91(2006)3, 996-1007
DOI: 10.1529/biophysj.105.079137
Cited 69 times in Scopus
Structure and pH-Sensitivity of the Transmembrane Segment 3 of Rhodopsin
Madathil, S.; Furlinski, G.; Fahmy, K.
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Biopolymers 82(2006)4, 329-333
DOI: 10.1002/bip.20466
Cited 2 times in Scopus
Metal binding by bacteria from uranium mining waste piles and its technological applications
Pollmann, K.; Raff, J.; Merroun, M.; Fahmy, K.; Selenska-Pobell, S.
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Biotechnology Advances 24(2006)1, 58-68
DOI: 10.1016/j.biotechadv.2005.06.002
Cited 154 times in Scopus
2004
Conserved high-affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha 1 subunit
Breitinger, U.; Breitinger, H.-G.; Bauer, F.; Fahmy, K.; Glockenhammer, D.; Becker, C.-M.
- Journal of Biological Chemistry 279(2004)4, 1627-1636
2003
Properties and planned use of the intense THz radiation from ELBE at Dresden-Rossendorf
Fahmy, K.; Furlinski, G.; Gippner, P.; Grosse, E.; Seidel, W.; Sczepan, M.; Wohlfahrt, D.; Wolf, A.; Wünsch, R.
- Journal of Biological Physics 29:303 -307, 2003
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Poster
THz-Bridge Workshop, 29.09.-01.10.2002, Capri, Italy
2002
FTIR- and Fluorescence-Spectroscopic Analyses of Receptor G-Protein Coupling in Photoreception Curr. Org. Chem. 2002, 6, 1259-1284.
Fahmy, K.
- Curr. Org. Chem. 2002, 6, 1259-1284.